FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3540, 302 aa 1>>>pF1KE3540 302 - 302 aa - 302 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2013+/-0.0003; mu= 16.3944+/- 0.019 mean_var=65.5251+/-13.321, 0's: 0 Z-trim(117.3): 15 B-trim: 0 in 0/51 Lambda= 0.158442 statistics sampled from 29084 (29099) to 29084 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.341), width: 16 Scan time: 6.530 The best scores are: opt bits E(85289) NP_003123 (OMIM: 182891) spermidine synthase [Homo ( 302) 2073 482.2 5.5e-136 XP_016857668 (OMIM: 182891) PREDICTED: spermidine ( 316) 1767 412.2 6.5e-115 NP_001245352 (OMIM: 300105,309583) spermine syntha ( 313) 220 58.6 1.8e-08 XP_011543870 (OMIM: 300105,309583) PREDICTED: sper ( 332) 220 58.6 1.9e-08 XP_005274639 (OMIM: 300105,309583) PREDICTED: sper ( 332) 220 58.6 1.9e-08 XP_016885243 (OMIM: 300105,309583) PREDICTED: sper ( 335) 220 58.6 1.9e-08 XP_016885244 (OMIM: 300105,309583) PREDICTED: sper ( 335) 220 58.6 1.9e-08 NP_004586 (OMIM: 300105,309583) spermine synthase ( 366) 220 58.7 2.1e-08 XP_016885242 (OMIM: 300105,309583) PREDICTED: sper ( 369) 220 58.7 2.1e-08 >>NP_003123 (OMIM: 182891) spermidine synthase [Homo sap (302 aa) initn: 2073 init1: 2073 opt: 2073 Z-score: 2562.4 bits: 482.2 E(85289): 5.5e-136 Smith-Waterman score: 2073; 100.0% identity (100.0% similar) in 302 aa overlap (1-302:1-302) 10 20 30 40 50 60 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND 250 260 270 280 290 300 pF1KE3 VS :: NP_003 VS >>XP_016857668 (OMIM: 182891) PREDICTED: spermidine synt (316 aa) initn: 1767 init1: 1767 opt: 1767 Z-score: 2184.0 bits: 412.2 E(85289): 6.5e-115 Smith-Waterman score: 1767; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 YPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND ::::::::::::::: XP_016 YPSGQIGFMLCSKNPVRWGCLGVGVGGKVGINRDPCPCRARWLTPVIPALWEAEAGRSQG 250 260 270 280 290 300 >>NP_001245352 (OMIM: 300105,309583) spermine synthase i (313 aa) initn: 241 init1: 93 opt: 220 Z-score: 273.0 bits: 58.6 E(85289): 1.8e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:59-298) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... NP_001 IFQEQGMAESVHTWQDHGYLATYTNKNGRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: NP_001 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . NP_001 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 150 160 170 180 190 200 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: NP_001 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 210 220 230 240 250 260 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: NP_001 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELWVFYTVWKKAKP 270 280 290 300 310 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS >>XP_011543870 (OMIM: 300105,309583) PREDICTED: spermine (332 aa) initn: 241 init1: 93 opt: 220 Z-score: 272.6 bits: 58.6 E(85289): 1.9e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:78-317) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... XP_011 GKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: XP_011 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . XP_011 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 170 180 190 200 210 220 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: XP_011 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 230 240 250 260 270 280 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: XP_011 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELWVFYTVWKKAKP 290 300 310 320 330 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS >>XP_005274639 (OMIM: 300105,309583) PREDICTED: spermine (332 aa) initn: 241 init1: 93 opt: 220 Z-score: 272.6 bits: 58.6 E(85289): 1.9e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:78-317) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... XP_005 GKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: XP_005 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . XP_005 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 170 180 190 200 210 220 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: XP_005 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 230 240 250 260 270 280 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: XP_005 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELWVFYTVWKKAKP 290 300 310 320 330 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS >>XP_016885243 (OMIM: 300105,309583) PREDICTED: spermine (335 aa) initn: 241 init1: 93 opt: 220 Z-score: 272.6 bits: 58.6 E(85289): 1.9e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:78-317) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... XP_016 GKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: XP_016 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . XP_016 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 170 180 190 200 210 220 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: XP_016 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 230 240 250 260 270 280 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: XP_016 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELYPLTVTFCCQIKAPK 290 300 310 320 330 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS >>XP_016885244 (OMIM: 300105,309583) PREDICTED: spermine (335 aa) initn: 241 init1: 93 opt: 220 Z-score: 272.6 bits: 58.6 E(85289): 1.9e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:78-317) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... XP_016 GKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: XP_016 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . XP_016 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 170 180 190 200 210 220 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: XP_016 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 230 240 250 260 270 280 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: XP_016 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELYPLTVTFCCQIKAPK 290 300 310 320 330 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS >>NP_004586 (OMIM: 300105,309583) spermine synthase isof (366 aa) initn: 241 init1: 93 opt: 220 Z-score: 272.0 bits: 58.7 E(85289): 2.1e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:112-351) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... NP_004 GKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 90 100 110 120 130 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: NP_004 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . NP_004 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 200 210 220 230 240 250 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: NP_004 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 260 270 280 290 300 310 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: NP_004 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELWVFYTVWKKAKP 320 330 340 350 360 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS >>XP_016885242 (OMIM: 300105,309583) PREDICTED: spermine (369 aa) initn: 241 init1: 93 opt: 220 Z-score: 271.9 bits: 58.7 E(85289): 2.1e-08 Smith-Waterman score: 258; 28.4% identity (57.2% similar) in 250 aa overlap (13-241:112-351) 10 20 30 pF1KE3 MEPGPDGPAASGPAAIREGWFRETCSLWP---GQALSLQVEQ : .: : . . :: :. . .... XP_016 GKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDR---YWPTADGRLVEYDIDE 90 100 110 120 130 40 50 60 70 80 90 pF1KE3 LLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLI ... . : ::.: ...:: .::.:.:.: .. .: : ..: . : . .. . . ::: XP_016 VVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESD-LAYTRAIMGSGKEDYTG-KDVLI 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE3 IGGGDGGVLREVVK-HPSVESVVQCEIDEDVIQVSKKFLP---GMAI-GYSSSKLTLHVG .::::::.: :.:: .:.. ..: :::. ::. ::.. : .. . ... . . XP_016 LGGGDGGILCEIVKLKPKMVTMV--EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIE 200 210 220 230 240 250 160 170 180 190 200 pF1KE3 DGFEFMK---QNQDAFDVIITD------SSDPMGPAESLFKESYYQLMKTALKEDGVLCC : . .: .. :: .:.: :..: . : . .: .::.:: XP_016 DCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFT 260 270 280 290 300 310 210 220 230 240 250 260 pF1KE3 QGECQWLH--LDLIKEM--RQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQE ::.: : :.: .:. : .: : : .:.: XP_016 QGNCVNLTEALSLYEEQLGRLYCPVEFS--KEIVC-VPSYLELYPLTVTFCCQIKAPK 320 330 340 350 360 270 280 290 300 pF1KE3 PVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS 302 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 14:42:27 2016 done: Mon Nov 7 14:42:28 2016 Total Scan time: 6.530 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]