FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3407, 284 aa 1>>>pF1KE3407 284 - 284 aa - 284 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5657+/-0.000744; mu= 14.1402+/- 0.045 mean_var=72.4312+/-14.345, 0's: 0 Z-trim(108.7): 24 B-trim: 0 in 0/51 Lambda= 0.150699 statistics sampled from 10342 (10365) to 10342 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.318), width: 16 Scan time: 2.380 The best scores are: opt bits E(32554) CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 1924 427.2 6.7e-120 CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 1111 250.4 9.4e-67 CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 602 139.8 2.8e-33 CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 597 138.7 6e-33 CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 549 128.3 8.9e-30 CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 259 65.1 5.5e-11 CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 ( 291) 259 65.2 6.4e-11 >>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa) initn: 1924 init1: 1924 opt: 1924 Z-score: 2266.1 bits: 427.2 E(32554): 6.7e-120 Smith-Waterman score: 1924; 100.0% identity (100.0% similar) in 284 aa overlap (1-284:1-284) 10 20 30 40 50 60 pF1KE3 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV 190 200 210 220 230 240 250 260 270 280 pF1KE3 NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS :::::::::::::::::::::::::::::::::::::::::::: CCDS43 NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS 250 260 270 280 >>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa) initn: 1111 init1: 1111 opt: 1111 Z-score: 1311.9 bits: 250.4 E(32554): 9.4e-67 Smith-Waterman score: 1507; 84.2% identity (84.2% similar) in 284 aa overlap (1-284:1-239) 10 20 30 40 50 60 pF1KE3 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK ::::::::::::::: CCDS77 HWTTREFEELRSCRE--------------------------------------------- 70 130 140 150 160 170 180 pF1KE3 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE3 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV 140 150 160 170 180 190 250 260 270 280 pF1KE3 NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS :::::::::::::::::::::::::::::::::::::::::::: CCDS77 NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS 200 210 220 230 >>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa) initn: 712 init1: 517 opt: 602 Z-score: 710.8 bits: 139.8 E(32554): 2.8e-33 Smith-Waterman score: 602; 47.9% identity (69.7% similar) in 211 aa overlap (64-269:162-372) 40 50 60 70 80 90 pF1KE3 QQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCR-EFEDQKLT--MLEAGCGV :... .:. : :: .. : .::.:::: CCDS58 GPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGV 140 150 160 170 180 190 100 110 120 130 140 pF1KE3 GNCLFPLLE--EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPP :: .::.:. .::..:.: :::: ::: :. : :: :: .: :: .. :: CCDS58 GNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPK 200 210 220 230 240 250 150 160 170 180 190 200 pF1KE3 ESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGE :.:...:::::::: ::::. ... . ..:::: ::.:::: :: :.:::: .. :. CCDS58 GSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSG 260 270 280 290 300 310 210 220 230 240 250 260 pF1KE3 NFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLK ::::: :::: ::::.. : :: .: :.: : : ::. . : . ::..: :. : CCDS58 NFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCK 320 330 340 350 360 370 270 280 pF1KE3 PPKNPSPVVLGLDPKS : CCDS58 PLLSSTS >>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa) initn: 707 init1: 512 opt: 597 Z-score: 705.0 bits: 138.7 E(32554): 6e-33 Smith-Waterman score: 597; 46.9% identity (69.7% similar) in 211 aa overlap (64-269:162-372) 40 50 60 70 80 90 pF1KE3 QQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCR-EFEDQKLT--MLEAGCGV :... .:. : :: .. : .::.:::: CCDS45 GPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGV 140 150 160 170 180 190 100 110 120 130 140 pF1KE3 GNCLFPLLE--EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPP :: .::.:. .::..:.: :::: ::: :. : :: :: .: :: .. :: CCDS45 GNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPK 200 210 220 230 240 250 150 160 170 180 190 200 pF1KE3 ESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGE :.:...:::::::. ::::. ... . ..:::: .:.:::: :: :.:::: .. :. CCDS45 GSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSG 260 270 280 290 300 310 210 220 230 240 250 260 pF1KE3 NFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLK ::::: :::: ::::.. : :: .: :.: : : ::. . : . ::..: :. : CCDS45 NFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCK 320 330 340 350 360 370 270 280 pF1KE3 PPKNPSPVVLGLDPKS : CCDS45 PLLSSTS >>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa) initn: 675 init1: 488 opt: 549 Z-score: 648.1 bits: 128.3 E(32554): 8.9e-30 Smith-Waterman score: 549; 45.3% identity (70.5% similar) in 190 aa overlap (83-269:200-389) 60 70 80 90 100 pF1KE3 STNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLL---EEDPNIFAYAC .::.:::.:: .::.: :..:. : : : CCDS22 ESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCC 170 180 190 200 210 220 110 120 130 140 150 160 pF1KE3 DFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMH ::. :.: ::.. : . .: .: :. : : : .::..:.::::..:::.:. CCDS22 DFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQ 230 240 250 260 270 280 170 180 190 200 210 220 pF1KE3 LVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQ :.. . :.:::: .:::::: ::...:::: . :.:::::: ::::.:::: . . CCDS22 GVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHS 290 300 310 320 330 340 230 240 250 260 270 280 pF1KE3 LFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS .: .. .: : : ::.:. . . ::..:.:: :: CCDS22 MFCKASLDEKQNLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD 350 360 370 380 390 400 >>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa) initn: 385 init1: 198 opt: 259 Z-score: 310.8 bits: 65.1 E(32554): 5.5e-11 Smith-Waterman score: 259; 41.3% identity (68.5% similar) in 92 aa overlap (83-171:150-241) 60 70 80 90 100 pF1KE3 STNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLL---EEDPNIFAYAC .::.:::.:: .::.: :..:. : : : CCDS82 ESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCC 120 130 140 150 160 170 110 120 130 140 150 160 pF1KE3 DFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMH ::. :.: ::.. : . .: .: :. : : : .::..:.::::..:::. CCDS82 DFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTL 180 190 200 210 220 230 170 180 190 200 210 220 pF1KE3 LVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQ .. CCDS82 FI 240 >>CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 (291 aa) initn: 385 init1: 198 opt: 259 Z-score: 309.5 bits: 65.2 E(32554): 6.4e-11 Smith-Waterman score: 259; 41.3% identity (68.5% similar) in 92 aa overlap (83-171:200-291) 60 70 80 90 100 pF1KE3 STNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLL---EEDPNIFAYAC .::.:::.:: .::.: :..:. : : : CCDS82 ESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCC 170 180 190 200 210 220 110 120 130 140 150 160 pF1KE3 DFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMH ::. :.: ::.. : . .: .: :. : : : .::..:.::::..:::. CCDS82 DFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTL 230 240 250 260 270 280 170 180 190 200 210 220 pF1KE3 LVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQ .. CCDS82 FI 290 284 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:46:53 2016 done: Fri Nov 4 12:46:53 2016 Total Scan time: 2.380 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]