FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3524, 570 aa 1>>>pF1KE3524 570 - 570 aa - 570 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4860+/-0.000358; mu= 9.9720+/- 0.022 mean_var=154.3624+/-31.746, 0's: 0 Z-trim(118.7): 173 B-trim: 0 in 0/58 Lambda= 0.103229 statistics sampled from 31662 (31837) to 31662 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.373), width: 16 Scan time: 8.950 The best scores are: opt bits E(85289) NP_033664 (OMIM: 600892) single-minded homolog 2 s ( 570) 3834 583.0 8.8e-166 NP_005060 (OMIM: 600892) single-minded homolog 2 l ( 667) 3524 536.9 7.8e-152 XP_011527996 (OMIM: 600892) PREDICTED: single-mind ( 566) 2878 440.6 6.3e-123 XP_005267157 (OMIM: 601665,603128) PREDICTED: sing ( 766) 2245 346.4 1.9e-94 NP_005059 (OMIM: 601665,603128) single-minded homo ( 766) 2245 346.4 1.9e-94 XP_016866686 (OMIM: 601665,603128) PREDICTED: sing ( 766) 2245 346.4 1.9e-94 XP_011534374 (OMIM: 601665,603128) PREDICTED: sing ( 481) 2198 339.3 1.7e-92 XP_016883931 (OMIM: 600892) PREDICTED: single-mind ( 327) 2153 332.5 1.3e-90 NP_851397 (OMIM: 603348) hypoxia-inducible factor ( 735) 939 151.9 6.6e-36 NP_001521 (OMIM: 603348) hypoxia-inducible factor ( 826) 939 152.0 7.2e-36 NP_001230013 (OMIM: 603348) hypoxia-inducible fact ( 850) 939 152.0 7.3e-36 NP_001421 (OMIM: 603349,611783) endothelial PAS do ( 870) 818 134.0 2e-30 XP_011531000 (OMIM: 603349,611783) PREDICTED: endo ( 883) 818 134.0 2e-30 XP_005259212 (OMIM: 609976) PREDICTED: hypoxia-ind ( 587) 777 127.7 1e-28 XP_005259213 (OMIM: 609976) PREDICTED: hypoxia-ind ( 587) 777 127.7 1e-28 XP_016882627 (OMIM: 609976) PREDICTED: hypoxia-ind ( 663) 777 127.8 1.1e-28 NP_690007 (OMIM: 609976) hypoxia-inducible factor ( 667) 777 127.8 1.1e-28 NP_690008 (OMIM: 609976) hypoxia-inducible factor ( 669) 777 127.8 1.1e-28 XP_016882626 (OMIM: 609976) PREDICTED: hypoxia-ind ( 703) 777 127.8 1.2e-28 XP_016882625 (OMIM: 609976) PREDICTED: hypoxia-ind ( 707) 777 127.8 1.2e-28 XP_016882624 (OMIM: 609976) PREDICTED: hypoxia-ind ( 709) 777 127.8 1.2e-28 XP_016882623 (OMIM: 609976) PREDICTED: hypoxia-ind ( 711) 777 127.8 1.2e-28 XP_005259209 (OMIM: 609976) PREDICTED: hypoxia-ind ( 713) 777 127.8 1.2e-28 XP_016882622 (OMIM: 609976) PREDICTED: hypoxia-ind ( 749) 777 127.8 1.2e-28 XP_016882621 (OMIM: 609976) PREDICTED: hypoxia-ind ( 755) 777 127.8 1.2e-28 XP_011535374 (OMIM: 609430) PREDICTED: neuronal PA ( 900) 569 96.9 3e-19 XP_011535373 (OMIM: 609430) PREDICTED: neuronal PA ( 936) 569 96.9 3.1e-19 XP_011535371 (OMIM: 609430) PREDICTED: neuronal PA ( 966) 569 96.9 3.1e-19 XP_016877072 (OMIM: 609430) PREDICTED: neuronal PA ( 983) 569 96.9 3.2e-19 XP_016877075 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 543 93.0 4.1e-18 XP_016877077 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 543 93.0 4.1e-18 XP_016877076 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 543 93.0 4.1e-18 NP_071406 (OMIM: 609430) neuronal PAS domain-conta ( 901) 543 93.0 4.4e-18 NP_001159365 (OMIM: 609430) neuronal PAS domain-co ( 903) 543 93.0 4.4e-18 XP_011535372 (OMIM: 609430) PREDICTED: neuronal PA ( 918) 543 93.0 4.4e-18 NP_775182 (OMIM: 609430) neuronal PAS domain-conta ( 920) 543 93.0 4.4e-18 NP_001158221 (OMIM: 609430) neuronal PAS domain-co ( 933) 543 93.0 4.5e-18 XP_016877074 (OMIM: 609430) PREDICTED: neuronal PA ( 939) 543 93.0 4.5e-18 XP_011535369 (OMIM: 609430) PREDICTED: neuronal PA ( 950) 543 93.0 4.5e-18 XP_016877073 (OMIM: 609430) PREDICTED: neuronal PA ( 956) 543 93.0 4.6e-18 XP_005268049 (OMIM: 609430) PREDICTED: neuronal PA ( 967) 543 93.0 4.6e-18 XP_005268048 (OMIM: 609430) PREDICTED: neuronal PA ( 969) 543 93.0 4.6e-18 XP_016877071 (OMIM: 609430) PREDICTED: neuronal PA ( 986) 543 93.1 4.7e-18 NP_690009 (OMIM: 609976) hypoxia-inducible factor ( 450) 494 85.5 4e-16 XP_016882631 (OMIM: 609976) PREDICTED: hypoxia-ind ( 474) 494 85.5 4.2e-16 XP_005259210 (OMIM: 609976) PREDICTED: hypoxia-ind ( 594) 494 85.6 5e-16 NP_071907 (OMIM: 609976) hypoxia-inducible factor ( 600) 494 85.6 5e-16 XP_016882630 (OMIM: 609976) PREDICTED: hypoxia-ind ( 642) 494 85.6 5.3e-16 XP_016882628 (OMIM: 609976) PREDICTED: hypoxia-ind ( 642) 494 85.6 5.3e-16 XP_016882629 (OMIM: 609976) PREDICTED: hypoxia-ind ( 642) 494 85.6 5.3e-16 >>NP_033664 (OMIM: 600892) single-minded homolog 2 short (570 aa) initn: 3834 init1: 3834 opt: 3834 Z-score: 3097.3 bits: 583.0 E(85289): 8.8e-166 Smith-Waterman score: 3834; 100.0% identity (100.0% similar) in 570 aa overlap (1-570:1-570) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_033 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT 490 500 510 520 530 540 550 560 570 pF1KE3 AGSRSSHGGGWQMETEPSRFGQTCPLSASK :::::::::::::::::::::::::::::: NP_033 AGSRSSHGGGWQMETEPSRFGQTCPLSASK 550 560 570 >>NP_005060 (OMIM: 600892) single-minded homolog 2 long (667 aa) initn: 3524 init1: 3524 opt: 3524 Z-score: 2846.9 bits: 536.9 E(85289): 7.8e-152 Smith-Waterman score: 3524; 100.0% identity (100.0% similar) in 525 aa overlap (1-525:1-525) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT ::::::::::::::::::::::::::::::::::::::::::::: NP_005 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAP 490 500 510 520 530 540 550 560 570 pF1KE3 AGSRSSHGGGWQMETEPSRFGQTCPLSASK NP_005 PSFPSCGHYREEPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLL 550 560 570 580 590 600 >>XP_011527996 (OMIM: 600892) PREDICTED: single-minded h (566 aa) initn: 2878 init1: 2878 opt: 2878 Z-score: 2327.9 bits: 440.6 E(85289): 6.3e-123 Smith-Waterman score: 2878; 100.0% identity (100.0% similar) in 424 aa overlap (102-525:1-424) 80 90 100 110 120 130 pF1KE3 PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPS :::::::::::::::::::::::::::::: XP_011 MYISETASVHLGLSQVELTGNSIYEYIHPS 10 20 30 140 150 160 170 180 190 pF1KE3 DHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKI 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 RQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 VTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE3 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE3 PKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLL 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE3 YTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQW 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE3 HYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRTAGSRSSHGGGW :::::::::::::::::::::::::::::::::: XP_011 HYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYRE 400 410 420 430 440 450 560 570 pF1KE3 QMETEPSRFGQTCPLSASK XP_011 EPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGP 460 470 480 490 500 510 >>XP_005267157 (OMIM: 601665,603128) PREDICTED: single-m (766 aa) initn: 2166 init1: 2070 opt: 2245 Z-score: 1816.6 bits: 346.4 E(85289): 1.9e-94 Smith-Waterman score: 2245; 69.2% identity (84.7% similar) in 510 aa overlap (1-504:1-503) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::.:::::::.:::::::::::::::::::::::::::::::::::.:::::: XP_005 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :.:::. ::..:::.:..:::::::::::::.:::: ::::::::::::::::::::::: XP_005 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY ::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.:: XP_005 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::. XP_005 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.: XP_005 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL .:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. .. XP_005 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- . : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.: XP_005 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV : .: :. . ..: : :: : :: . .. . .:. ::. XP_005 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 ARFFLSTLPASGECQWHYANPLVP-SSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGK .:.::.: : .:. : . .: ...:: XP_005 GRYFLGT-PQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSV 480 490 500 510 520 530 >>NP_005059 (OMIM: 601665,603128) single-minded homolog (766 aa) initn: 2166 init1: 2070 opt: 2245 Z-score: 1816.6 bits: 346.4 E(85289): 1.9e-94 Smith-Waterman score: 2245; 69.2% identity (84.7% similar) in 510 aa overlap (1-504:1-503) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::.:::::::.:::::::::::::::::::::::::::::::::::.:::::: NP_005 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :.:::. ::..:::.:..:::::::::::::.:::: ::::::::::::::::::::::: NP_005 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY ::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.:: NP_005 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::. NP_005 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.: NP_005 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL .:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. .. NP_005 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- . : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.: NP_005 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV : .: :. . ..: : :: : :: . .. . .:. ::. NP_005 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 ARFFLSTLPASGECQWHYANPLVP-SSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGK .:.::.: : .:. : . .: ...:: NP_005 GRYFLGT-PQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSV 480 490 500 510 520 530 >>XP_016866686 (OMIM: 601665,603128) PREDICTED: single-m (766 aa) initn: 2166 init1: 2070 opt: 2245 Z-score: 1816.6 bits: 346.4 E(85289): 1.9e-94 Smith-Waterman score: 2245; 69.2% identity (84.7% similar) in 510 aa overlap (1-504:1-503) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::.:::::::.:::::::::::::::::::::::::::::::::::.:::::: XP_016 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :.:::. ::..:::.:..:::::::::::::.:::: ::::::::::::::::::::::: XP_016 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY ::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.:: XP_016 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::. XP_016 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.: XP_016 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL .:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. .. XP_016 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- . : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.: XP_016 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV : .: :. . ..: : :: : :: . .. . .:. ::. XP_016 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 ARFFLSTLPASGECQWHYANPLVP-SSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGK .:.::.: : .:. : . .: ...:: XP_016 GRYFLGT-PQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSV 480 490 500 510 520 530 >>XP_011534374 (OMIM: 601665,603128) PREDICTED: single-m (481 aa) initn: 2070 init1: 2070 opt: 2198 Z-score: 1781.6 bits: 339.3 E(85289): 1.7e-92 Smith-Waterman score: 2198; 71.4% identity (85.9% similar) in 482 aa overlap (1-477:1-476) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::.:::::::.:::::::::::::::::::::::::::::::::::.:::::: XP_011 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :.:::. ::..:::.:..:::::::::::::.:::: ::::::::::::::::::::::: XP_011 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY ::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.:: XP_011 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::. XP_011 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.: XP_011 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL .:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. .. XP_011 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP- . : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.: XP_011 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV : .: :. . ..: : :: : :: . .. . .:. ::. XP_011 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 ARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKV .: XP_011 GRARSLG 480 >>XP_016883931 (OMIM: 600892) PREDICTED: single-minded h (327 aa) initn: 2153 init1: 2153 opt: 2153 Z-score: 1747.7 bits: 332.5 E(85289): 1.3e-90 Smith-Waterman score: 2153; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325) 10 20 30 40 50 60 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL ::::::::::::::::::::::::: XP_016 RGGWVWVQSYATVVHNSRSSRPHCIGD 310 320 >>NP_851397 (OMIM: 603348) hypoxia-inducible factor 1-al (735 aa) initn: 972 init1: 436 opt: 939 Z-score: 765.7 bits: 151.9 E(85289): 6.6e-36 Smith-Waterman score: 939; 39.9% identity (71.6% similar) in 391 aa overlap (2-385:19-394) 10 20 30 40 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASII ::::..::..:: ::. :::::. :::: ..:.:::::.. NP_851 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 RLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMY ::: :::..: .. : : : . ... :..:::::.:...:: ..: NP_851 RLTISYLRVRKLLDAGDLDIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLR ::.... ..::.: ::::.:.... :: ::.:: .:: .. : .. .: . .:::::: NP_851 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLR 120 130 140 150 160 170 170 180 190 200 210 pF1KE3 MKCVLAKRN--AGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLP :::.:..:. .. . .::.::.:.... : . . . :. .. :: . . .: NP_851 MKCTLTSRGRTMNIKSATWKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIP 180 190 200 210 220 220 230 240 250 260 270 pF1KE3 -PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHL :: : :: : :. :. : :::.:. . : :.::. ::::..:. ...:.. :. : :: NP_851 HPSNI-EIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHL 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE3 RYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEY .:: ...:::::: ::.:.::::.:::.. :::..:...:.:.::: ::::.. : NP_851 TKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQ 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE3 KELQLSLEQVSTA-KSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM ..: .::.:. . : .: . .. .: :. . .... ::. .: NP_851 HDLIFSLQQTECVLKPVES--SDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE3 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSS NP_851 DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSS 410 420 430 440 450 460 >>NP_001521 (OMIM: 603348) hypoxia-inducible factor 1-al (826 aa) initn: 972 init1: 436 opt: 939 Z-score: 765.0 bits: 152.0 E(85289): 7.2e-36 Smith-Waterman score: 939; 39.9% identity (71.6% similar) in 391 aa overlap (2-385:19-394) 10 20 30 40 pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASII ::::..::..:: ::. :::::. :::: ..:.:::::.. NP_001 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 RLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMY ::: :::..: .. : : : . ... :..:::::.:...:: ..: NP_001 RLTISYLRVRKLLDAGDLDIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLR ::.... ..::.: ::::.:.... :: ::.:: .:: .. : .. .: . .:::::: NP_001 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLR 120 130 140 150 160 170 170 180 190 200 210 pF1KE3 MKCVLAKRN--AGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLP :::.:..:. .. . .::.::.:.... : . . . :. .. :: . . .: NP_001 MKCTLTSRGRTMNIKSATWKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIP 180 190 200 210 220 220 230 240 250 260 270 pF1KE3 -PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHL :: : :: : :. :. : :::.:. . : :.::. ::::..:. ...:.. :. : :: NP_001 HPSNI-EIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHL 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE3 RYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEY .:: ...:::::: ::.:.::::.:::.. :::..:...:.:.::: ::::.. : NP_001 TKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQ 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE3 KELQLSLEQVSTA-KSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM ..: .::.:. . : .: . .. .: :. . .... ::. .: NP_001 HDLIFSLQQTECVLKPVES--SDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE3 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSS NP_001 DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSS 410 420 430 440 450 460 570 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:54:49 2016 done: Fri Nov 4 13:54:51 2016 Total Scan time: 8.950 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]