FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3527, 429 aa 1>>>pF1KE3527 429 - 429 aa - 429 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.2546+/-0.000344; mu= 24.4307+/- 0.022 mean_var=105.3194+/-24.958, 0's: 0 Z-trim(115.8): 165 B-trim: 1606 in 1/54 Lambda= 0.124974 statistics sampled from 26311 (26567) to 26311 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.311), width: 16 Scan time: 8.500 The best scores are: opt bits E(85289) NP_942009 (OMIM: 176806) prostaglandin E2 receptor ( 374) 2475 457.1 3.4e-128 NP_942011 (OMIM: 176806) prostaglandin E2 receptor ( 418) 2467 455.7 9.9e-128 NP_942007 (OMIM: 176806) prostaglandin E2 receptor ( 390) 2422 447.6 2.6e-125 NP_001119516 (OMIM: 176806) prostaglandin E2 recep ( 390) 2422 447.6 2.6e-125 NP_942012 (OMIM: 176806) prostaglandin E2 receptor ( 390) 2422 447.6 2.6e-125 XP_011540112 (OMIM: 176806) PREDICTED: prostagland ( 410) 2422 447.6 2.7e-125 NP_942010 (OMIM: 176806) prostaglandin E2 receptor ( 365) 2414 446.1 6.9e-125 NP_942008 (OMIM: 176806) prostaglandin E2 receptor ( 388) 2408 445.0 1.5e-124 XP_016857362 (OMIM: 600563) PREDICTED: prostagland ( 291) 457 93.1 1e-18 NP_001034674 (OMIM: 600563) prostaglandin F2-alpha ( 297) 457 93.1 1e-18 NP_000950 (OMIM: 600563) prostaglandin F2-alpha re ( 359) 457 93.2 1.1e-18 NP_000946 (OMIM: 176802) prostaglandin E2 receptor ( 402) 406 84.1 7.1e-16 NP_001051 (OMIM: 188070,614009) thromboxane A2 rec ( 343) 401 83.1 1.2e-15 XP_011526516 (OMIM: 188070,614009) PREDICTED: thro ( 343) 401 83.1 1.2e-15 NP_963998 (OMIM: 188070,614009) thromboxane A2 rec ( 407) 401 83.2 1.3e-15 XP_005267948 (OMIM: 604687,607277) PREDICTED: pros ( 359) 376 78.6 2.8e-14 NP_000944 (OMIM: 604687,607277) prostaglandin D2 r ( 359) 376 78.6 2.8e-14 NP_000951 (OMIM: 600022) prostacyclin receptor [Ho ( 386) 372 78.0 4.8e-14 XP_005259152 (OMIM: 600022) PREDICTED: prostacycli ( 257) 368 77.0 6.4e-14 XP_005259150 (OMIM: 600022) PREDICTED: prostacycli ( 342) 369 77.3 6.6e-14 NP_000947 (OMIM: 176804,208550) prostaglandin E2 r ( 358) 365 76.6 1.1e-13 XP_016865148 (OMIM: 601586) PREDICTED: prostagland ( 313) 355 74.7 3.6e-13 XP_016865147 (OMIM: 601586) PREDICTED: prostagland ( 325) 355 74.8 3.7e-13 XP_016865146 (OMIM: 601586) PREDICTED: prostagland ( 326) 355 74.8 3.7e-13 XP_016865145 (OMIM: 601586) PREDICTED: prostagland ( 350) 355 74.8 3.8e-13 NP_000949 (OMIM: 601586) prostaglandin E2 receptor ( 488) 355 75.0 4.6e-13 NP_001268398 (OMIM: 604687,607277) prostaglandin D ( 296) 310 66.6 9.7e-11 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 230 52.5 2.8e-06 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 230 52.6 2.9e-06 NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489) 213 49.4 2.3e-05 XP_016872444 (OMIM: 606665) PREDICTED: melanopsin ( 539) 213 49.5 2.5e-05 XP_011532064 (OMIM: 167055) PREDICTED: oxytocin re ( 389) 206 48.0 5e-05 NP_000907 (OMIM: 167055) oxytocin receptor [Homo s ( 389) 206 48.0 5e-05 XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 199 46.8 0.00012 NP_001948 (OMIM: 131243,157300,616367) endothelin- ( 427) 180 43.4 0.0013 NP_000397 (OMIM: 138850,146110) gonadotropin-relea ( 328) 165 40.5 0.0076 XP_011535421 (OMIM: 275200,603372,603373,609152) P ( 671) 168 41.5 0.0077 XP_005268094 (OMIM: 275200,603372,603373,609152) P ( 764) 168 41.6 0.0082 NP_000360 (OMIM: 275200,603372,603373,609152) thyr ( 764) 168 41.6 0.0082 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 165 40.7 0.0088 >>NP_942009 (OMIM: 176806) prostaglandin E2 receptor EP3 (374 aa) initn: 2466 init1: 2466 opt: 2475 Z-score: 2422.4 bits: 457.1 E(85289): 3.4e-128 Smith-Waterman score: 2475; 99.5% identity (99.5% similar) in 372 aa overlap (1-370:1-372) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 RKRRLREQ--FWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASW :::::::: :: NP_942 RKRRLREQEEFWGN 370 >>NP_942011 (OMIM: 176806) prostaglandin E2 receptor EP3 (418 aa) initn: 2467 init1: 2467 opt: 2467 Z-score: 2414.2 bits: 455.7 E(85289): 9.9e-128 Smith-Waterman score: 2467; 99.7% identity (100.0% similar) in 369 aa overlap (1-369:1-369) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ ::::::::. NP_942 RKRRLREQLICSLQNSQIQRATAHCGQVQTYRVLNREEMEVLVSSINVYTRISTVKTE 370 380 390 400 410 >>NP_942007 (OMIM: 176806) prostaglandin E2 receptor EP3 (390 aa) initn: 2416 init1: 2416 opt: 2422 Z-score: 2370.6 bits: 447.6 E(85289): 2.6e-125 Smith-Waterman score: 2423; 92.2% identity (94.5% similar) in 400 aa overlap (1-400:1-386) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_942 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ : . . . .:.. :: :: : ..::: NP_942 R---YHTNNYASSSTSLPCQ--------CSST---LMWSDHLER 370 380 390 pF1KE3 VILLPQPPK >>NP_001119516 (OMIM: 176806) prostaglandin E2 receptor (390 aa) initn: 2416 init1: 2416 opt: 2422 Z-score: 2370.6 bits: 447.6 E(85289): 2.6e-125 Smith-Waterman score: 2423; 92.2% identity (94.5% similar) in 400 aa overlap (1-400:1-386) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ : . . . .:.. :: :: : ..::: NP_001 R---YHTNNYASSSTSLPCQ--------CSST---LMWSDHLER 370 380 390 pF1KE3 VILLPQPPK >>NP_942012 (OMIM: 176806) prostaglandin E2 receptor EP3 (390 aa) initn: 2416 init1: 2416 opt: 2422 Z-score: 2370.6 bits: 447.6 E(85289): 2.6e-125 Smith-Waterman score: 2423; 92.2% identity (94.5% similar) in 400 aa overlap (1-400:1-386) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_942 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ : . . . .:.. :: :: : ..::: NP_942 R---YHTNNYASSSTSLPCQ--------CSST---LMWSDHLER 370 380 390 pF1KE3 VILLPQPPK >>XP_011540112 (OMIM: 176806) PREDICTED: prostaglandin E (410 aa) initn: 2416 init1: 2416 opt: 2422 Z-score: 2370.4 bits: 447.6 E(85289): 2.7e-125 Smith-Waterman score: 2423; 92.2% identity (94.5% similar) in 400 aa overlap (1-400:1-386) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_011 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ : . . . .:.. :: :: : ..::: XP_011 R---YHTNNYASSSTSLPCQ--------CSST---LMWSDHLERRNFGEIKTCLSARITS 370 380 390 400 pF1KE3 VILLPQPPK XP_011 LEAP 410 >>NP_942010 (OMIM: 176806) prostaglandin E2 receptor EP3 (365 aa) initn: 2407 init1: 2407 opt: 2414 Z-score: 2363.1 bits: 446.1 E(85289): 6.9e-125 Smith-Waterman score: 2414; 97.8% identity (98.1% similar) in 370 aa overlap (1-370:1-363) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQ- 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ :.:: NP_942 ------EEFWGN 360 >>NP_942008 (OMIM: 176806) prostaglandin E2 receptor EP3 (388 aa) initn: 2408 init1: 2408 opt: 2408 Z-score: 2357.0 bits: 445.0 E(85289): 1.5e-124 Smith-Waterman score: 2408; 99.7% identity (100.0% similar) in 360 aa overlap (1-360:1-360) 10 20 30 40 50 60 pF1KE3 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_942 MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQ NP_942 ANAVSSCSNDGQKGQPISLSNEIIQTEA 370 380 >>XP_016857362 (OMIM: 600563) PREDICTED: prostaglandin F (291 aa) initn: 530 init1: 386 opt: 457 Z-score: 457.1 bits: 93.1 E(85289): 1e-18 Smith-Waterman score: 541; 34.9% identity (66.9% similar) in 272 aa overlap (50-321:28-284) 20 30 40 50 60 70 pF1KE3 SYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRR .:: : . .. .:...:.::. .. ..:.: XP_016 MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQR 10 20 30 40 50 80 90 100 110 120 130 pF1KE3 RESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTV ..: : :::: . :..::. :.:.. ... :: : ..: ..: :. ::..::. :. XP_016 FRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVF 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE3 FGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQY :: :...:.::.:: ... : ...... .. .. .: :: : .. .::::.:: .: XP_016 SGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDY 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE3 TVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSR .: :::: .: . ..: . :. :.::::::: :.. :: : .:. : XP_016 KIQASRTWCFYNT-------EDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLL-R 180 190 200 210 220 260 270 280 290 300 310 pF1KE3 CRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHT . : ::. : : .:::..:::: .::::.: . ..:.: :. :.. XP_016 VKFK---SQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLGY--RIILNGK--EKYKVYE 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE3 EKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQFWRPASSGSGC :. XP_016 EQSDFLHRK 290 >>NP_001034674 (OMIM: 600563) prostaglandin F2-alpha rec (297 aa) initn: 530 init1: 386 opt: 457 Z-score: 457.0 bits: 93.1 E(85289): 1e-18 Smith-Waterman score: 541; 34.9% identity (66.9% similar) in 272 aa overlap (50-321:28-284) 20 30 40 50 60 70 pF1KE3 SYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRR .:: : . .. .:...:.::. .. ..:.: NP_001 MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQR 10 20 30 40 50 80 90 100 110 120 130 pF1KE3 RESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTV ..: : :::: . :..::. :.:.. ... :: : ..: ..: :. ::..::. :. NP_001 FRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVF 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE3 FGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQY :: :...:.::.:: ... : ...... .. .. .: :: : .. .::::.:: .: NP_001 SGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDY 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE3 TVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSR .: :::: .: . ..: . :. :.::::::: :.. :: : .:. : NP_001 KIQASRTWCFYNT-------EDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLL-R 180 190 200 210 220 260 270 280 290 300 310 pF1KE3 CRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHT . : ::. : : .:::..:::: .::::.: . ..:.: :. :.. NP_001 VKFK---SQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLGY--RIILNGK--EKYKVYE 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE3 EKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQFWRPASSGSGC :. NP_001 EQSDFLHRLQWPTLE 290 429 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:42:47 2016 done: Fri Nov 4 17:42:48 2016 Total Scan time: 8.500 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]