FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3508, 703 aa 1>>>pF1KE3508 703 - 703 aa - 703 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6466+/-0.000451; mu= -10.8961+/- 0.028 mean_var=330.7591+/-69.270, 0's: 0 Z-trim(119.4): 41 B-trim: 35 in 1/55 Lambda= 0.070521 statistics sampled from 33309 (33350) to 33309 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.391), width: 16 Scan time: 13.930 The best scores are: opt bits E(85289) NP_005480 (OMIM: 604722) SH2 domain-containing pro ( 703) 4663 488.9 2.9e-137 NP_001239263 (OMIM: 604722) SH2 domain-containing ( 792) 4591 481.6 5.1e-135 XP_011516417 (OMIM: 604722) PREDICTED: SH2 domain- ( 804) 4560 478.4 4.6e-134 XP_011516416 (OMIM: 604722) PREDICTED: SH2 domain- ( 804) 4560 478.4 4.6e-134 NP_733745 (OMIM: 604722) SH2 domain-containing pro ( 860) 4560 478.4 4.9e-134 NP_001136006 (OMIM: 604722) SH2 domain-containing ( 700) 4492 471.5 5e-132 NP_001136005 (OMIM: 604722) SH2 domain-containing ( 702) 4480 470.2 1.2e-131 NP_001136003 (OMIM: 604722) SH2 domain-containing ( 506) 3345 354.7 5.2e-97 NP_001136004 (OMIM: 604722) SH2 domain-containing ( 506) 3345 354.7 5.2e-97 XP_016869663 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 3345 354.7 5.2e-97 XP_011516419 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 3345 354.7 5.2e-97 XP_005251696 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 3345 354.7 5.2e-97 NP_001295180 (OMIM: 604704) breast cancer anti-est ( 501) 1156 132.0 5.6e-30 XP_011540553 (OMIM: 604704) PREDICTED: breast canc ( 605) 1156 132.0 6.6e-30 NP_005481 (OMIM: 604721) SH2 domain-containing pro ( 576) 877 103.6 2.2e-21 XP_016857969 (OMIM: 604704) PREDICTED: breast canc ( 825) 780 93.8 2.8e-18 NP_003558 (OMIM: 604704) breast cancer anti-estrog ( 825) 780 93.8 2.8e-18 NP_001248337 (OMIM: 604704) breast cancer anti-est ( 825) 780 93.8 2.8e-18 NP_001248338 (OMIM: 604704) breast cancer anti-est ( 825) 780 93.8 2.8e-18 NP_001248339 (OMIM: 604704) breast cancer anti-est ( 734) 770 92.8 5.1e-18 XP_011525911 (OMIM: 604721) PREDICTED: SH2 domain- ( 510) 491 64.3 1.3e-09 XP_011525910 (OMIM: 604721) PREDICTED: SH2 domain- ( 510) 491 64.3 1.3e-09 XP_005259524 (OMIM: 604721) PREDICTED: SH2 domain- ( 605) 491 64.4 1.5e-09 XP_005259529 (OMIM: 604721) PREDICTED: SH2 domain- ( 483) 485 63.7 1.9e-09 XP_016881612 (OMIM: 604721) PREDICTED: SH2 domain- ( 399) 368 51.7 6.4e-06 XP_016881613 (OMIM: 604721) PREDICTED: SH2 domain- ( 327) 355 50.4 1.4e-05 XP_006722665 (OMIM: 604721) PREDICTED: SH2 domain- ( 485) 338 48.7 6.2e-05 >>NP_005480 (OMIM: 604722) SH2 domain-containing protein (703 aa) initn: 4663 init1: 4663 opt: 4663 Z-score: 2585.3 bits: 488.9 E(85289): 2.9e-137 Smith-Waterman score: 4663; 100.0% identity (100.0% similar) in 703 aa overlap (1-703:1-703) 10 20 30 40 50 60 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE 610 620 630 640 650 660 670 680 690 700 pF1KE3 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL ::::::::::::::::::::::::::::::::::::::::::: NP_005 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 670 680 690 700 >>NP_001239263 (OMIM: 604722) SH2 domain-containing prot (792 aa) initn: 4591 init1: 4591 opt: 4591 Z-score: 2544.9 bits: 481.6 E(85289): 5.1e-135 Smith-Waterman score: 4591; 99.4% identity (99.4% similar) in 697 aa overlap (7-703:96-792) 10 20 30 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYIL ::: : :::::::::::::::::::::: NP_001 APWLVSWQRRGFPPSSFCPGPLRTEKLRAGRCPLLLCGGAAGEPEAGSDYVKFSKEKYIL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE3 DSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYV 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE3 LTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGA 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE3 IIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTR 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE3 SDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPS 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE3 ATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSG 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE3 HYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSF 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE3 NPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT 490 500 510 520 530 540 460 470 480 490 500 510 pF1KE3 LMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAA 550 560 570 580 590 600 520 530 540 550 560 570 pF1KE3 ELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGK 610 620 630 640 650 660 580 590 600 610 620 630 pF1KE3 EGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLY 670 680 690 700 710 720 640 650 660 670 680 690 pF1KE3 HTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 730 740 750 760 770 780 700 pF1KE3 AVRSSEL ::::::: NP_001 AVRSSEL 790 >>XP_011516417 (OMIM: 604722) PREDICTED: SH2 domain-cont (804 aa) initn: 4560 init1: 4560 opt: 4560 Z-score: 2527.8 bits: 478.4 E(85289): 4.6e-134 Smith-Waterman score: 4560; 99.7% identity (99.9% similar) in 691 aa overlap (13-703:114-804) 10 20 30 40 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEK :. ::::::::::::::::::::::::::: XP_011 NPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEK 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE3 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE3 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV 210 220 230 240 250 260 170 180 190 200 210 220 pF1KE3 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT 270 280 290 300 310 320 230 240 250 260 270 280 pF1KE3 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA 330 340 350 360 370 380 290 300 310 320 330 340 pF1KE3 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ 390 400 410 420 430 440 350 360 370 380 390 400 pF1KE3 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ 450 460 470 480 490 500 410 420 430 440 450 460 pF1KE3 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW 510 520 530 540 550 560 470 480 490 500 510 520 pF1KE3 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM 570 580 590 600 610 620 530 540 550 560 570 580 pF1KE3 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS 630 640 650 660 670 680 590 600 610 620 630 640 pF1KE3 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV 690 700 710 720 730 740 650 660 670 680 690 700 pF1KE3 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE 750 760 770 780 790 800 pF1KE3 L : XP_011 L >>XP_011516416 (OMIM: 604722) PREDICTED: SH2 domain-cont (804 aa) initn: 4560 init1: 4560 opt: 4560 Z-score: 2527.8 bits: 478.4 E(85289): 4.6e-134 Smith-Waterman score: 4560; 99.7% identity (99.9% similar) in 691 aa overlap (13-703:114-804) 10 20 30 40 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEK :. ::::::::::::::::::::::::::: XP_011 NPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEK 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE3 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE3 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV 210 220 230 240 250 260 170 180 190 200 210 220 pF1KE3 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT 270 280 290 300 310 320 230 240 250 260 270 280 pF1KE3 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA 330 340 350 360 370 380 290 300 310 320 330 340 pF1KE3 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ 390 400 410 420 430 440 350 360 370 380 390 400 pF1KE3 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ 450 460 470 480 490 500 410 420 430 440 450 460 pF1KE3 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW 510 520 530 540 550 560 470 480 490 500 510 520 pF1KE3 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM 570 580 590 600 610 620 530 540 550 560 570 580 pF1KE3 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS 630 640 650 660 670 680 590 600 610 620 630 640 pF1KE3 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV 690 700 710 720 730 740 650 660 670 680 690 700 pF1KE3 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE 750 760 770 780 790 800 pF1KE3 L : XP_011 L >>NP_733745 (OMIM: 604722) SH2 domain-containing protein (860 aa) initn: 4560 init1: 4560 opt: 4560 Z-score: 2527.4 bits: 478.4 E(85289): 4.9e-134 Smith-Waterman score: 4560; 99.7% identity (99.9% similar) in 691 aa overlap (13-703:170-860) 10 20 30 40 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEK :. ::::::::::::::::::::::::::: NP_733 NPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEK 140 150 160 170 180 190 50 60 70 80 90 100 pF1KE3 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR 200 210 220 230 240 250 110 120 130 140 150 160 pF1KE3 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV 260 270 280 290 300 310 170 180 190 200 210 220 pF1KE3 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT 320 330 340 350 360 370 230 240 250 260 270 280 pF1KE3 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA 380 390 400 410 420 430 290 300 310 320 330 340 pF1KE3 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ 440 450 460 470 480 490 350 360 370 380 390 400 pF1KE3 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ 500 510 520 530 540 550 410 420 430 440 450 460 pF1KE3 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW 560 570 580 590 600 610 470 480 490 500 510 520 pF1KE3 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM 620 630 640 650 660 670 530 540 550 560 570 580 pF1KE3 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS 680 690 700 710 720 730 590 600 610 620 630 640 pF1KE3 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV 740 750 760 770 780 790 650 660 670 680 690 700 pF1KE3 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE 800 810 820 830 840 850 pF1KE3 L : NP_733 L 860 >>NP_001136006 (OMIM: 604722) SH2 domain-containing prot (700 aa) initn: 4492 init1: 4492 opt: 4492 Z-score: 2491.3 bits: 471.5 E(85289): 5e-132 Smith-Waterman score: 4492; 97.6% identity (98.7% similar) in 697 aa overlap (7-703:4-700) 10 20 30 40 50 60 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS :: .. .::. ...:.:::::::::::::::::::::::::::::::: NP_001 MTERCSLWSALSAAACCFYRGSFVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE3 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE 600 610 620 630 640 650 670 680 690 700 pF1KE3 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL ::::::::::::::::::::::::::::::::::::::::::: NP_001 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 660 670 680 690 700 >>NP_001136005 (OMIM: 604722) SH2 domain-containing prot (702 aa) initn: 4480 init1: 4480 opt: 4480 Z-score: 2484.7 bits: 470.2 E(85289): 1.2e-131 Smith-Waterman score: 4480; 99.9% identity (100.0% similar) in 677 aa overlap (27-703:26-702) 10 20 30 40 50 60 pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS :.:::::::::::::::::::::::::::::::: NP_001 MTERCSLWSALSAAACCFYRGSFVQVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE3 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE 600 610 620 630 640 650 670 680 690 700 pF1KE3 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL ::::::::::::::::::::::::::::::::::::::::::: NP_001 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 660 670 680 690 700 >>NP_001136003 (OMIM: 604722) SH2 domain-containing prot (506 aa) initn: 3345 init1: 3345 opt: 3345 Z-score: 1862.7 bits: 354.7 E(85289): 5.2e-97 Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 506 aa overlap (198-703:1-506) 170 180 190 200 210 220 pF1KE3 LRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLP :::::::::::::::::::::::::::::: NP_001 MKRRSVTMTDGLTADKVTRSDGCPTSTSLP 10 20 30 230 240 250 260 270 280 pF1KE3 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE3 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE3 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE3 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE3 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE3 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP 340 350 360 370 380 390 590 600 610 620 630 640 pF1KE3 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF 400 410 420 430 440 450 650 660 670 680 690 700 pF1KE3 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 460 470 480 490 500 >>NP_001136004 (OMIM: 604722) SH2 domain-containing prot (506 aa) initn: 3345 init1: 3345 opt: 3345 Z-score: 1862.7 bits: 354.7 E(85289): 5.2e-97 Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 506 aa overlap (198-703:1-506) 170 180 190 200 210 220 pF1KE3 LRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLP :::::::::::::::::::::::::::::: NP_001 MKRRSVTMTDGLTADKVTRSDGCPTSTSLP 10 20 30 230 240 250 260 270 280 pF1KE3 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE3 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE3 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE3 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE3 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE3 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP 340 350 360 370 380 390 590 600 610 620 630 640 pF1KE3 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF 400 410 420 430 440 450 650 660 670 680 690 700 pF1KE3 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 460 470 480 490 500 >>XP_016869663 (OMIM: 604722) PREDICTED: SH2 domain-cont (506 aa) initn: 3345 init1: 3345 opt: 3345 Z-score: 1862.7 bits: 354.7 E(85289): 5.2e-97 Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 506 aa overlap (198-703:1-506) 170 180 190 200 210 220 pF1KE3 LRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLP :::::::::::::::::::::::::::::: XP_016 MKRRSVTMTDGLTADKVTRSDGCPTSTSLP 10 20 30 230 240 250 260 270 280 pF1KE3 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE3 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE3 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE3 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE3 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE3 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP 340 350 360 370 380 390 590 600 610 620 630 640 pF1KE3 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF 400 410 420 430 440 450 650 660 670 680 690 700 pF1KE3 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 460 470 480 490 500 703 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:37:20 2016 done: Sat Nov 5 02:37:22 2016 Total Scan time: 13.930 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]