Result of FASTA (omim) for
pFN21AE1022
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1022, 730 aa
1>>>pF1KE1022 730 - 730 aa - 730 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6393+/-0.000362; mu= 1.7751+/- 0.023
mean_var=247.0370+/-50.803, 0's: 0 Z-trim(122.6): 63 B-trim: 2664 in 2/55
Lambda= 0.081601
statistics sampled from 40797 (40871) to 40797 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.479), width: 16
Scan time: 11.840
The best scores are: opt bits E(85289)
NP_940997 (OMIM: 608252) actin filament-associated ( 730) 4815 580.1 1.1e-164
XP_006713972 (OMIM: 608252) PREDICTED: actin filam ( 751) 4815 580.1 1.1e-164
XP_016864024 (OMIM: 608252) PREDICTED: actin filam ( 748) 3457 420.2 1.5e-116
XP_016864025 (OMIM: 608252) PREDICTED: actin filam ( 555) 3425 416.3 1.6e-115
XP_011511846 (OMIM: 608252) PREDICTED: actin filam ( 814) 3425 416.5 2.2e-115
NP_001128119 (OMIM: 608252) actin filament-associa ( 814) 3425 416.5 2.2e-115
NP_001309991 (OMIM: 614410) actin filament-associa ( 735) 1581 199.4 4.5e-50
XP_011535860 (OMIM: 614410) PREDICTED: actin filam ( 628) 1460 185.1 7.7e-46
XP_016864525 (OMIM: 614410) PREDICTED: actin filam ( 734) 1460 185.1 8.7e-46
NP_689619 (OMIM: 614410) actin filament-associated ( 768) 1460 185.1 9e-46
NP_001139809 (OMIM: 614410) actin filament-associa ( 725) 1459 185.0 9.3e-46
XP_016872317 (OMIM: 612420) PREDICTED: actin filam ( 731) 919 121.4 1.3e-26
XP_016872316 (OMIM: 612420) PREDICTED: actin filam ( 735) 897 118.8 7.8e-26
XP_016872319 (OMIM: 612420) PREDICTED: actin filam ( 679) 890 118.0 1.3e-25
XP_016872313 (OMIM: 612420) PREDICTED: actin filam ( 759) 821 109.9 3.9e-23
XP_016872311 (OMIM: 612420) PREDICTED: actin filam ( 785) 821 109.9 4e-23
XP_016872307 (OMIM: 612420) PREDICTED: actin filam ( 803) 808 108.4 1.2e-22
XP_016872304 (OMIM: 612420) PREDICTED: actin filam ( 829) 808 108.4 1.2e-22
XP_016872312 (OMIM: 612420) PREDICTED: actin filam ( 763) 799 107.3 2.4e-22
XP_016872308 (OMIM: 612420) PREDICTED: actin filam ( 789) 799 107.3 2.4e-22
NP_001309992 (OMIM: 614410) actin filament-associa ( 377) 715 97.2 1.3e-19
XP_016872306 (OMIM: 612420) PREDICTED: actin filam ( 813) 667 91.8 1.2e-17
NP_115939 (OMIM: 612420) actin filament-associated ( 814) 667 91.8 1.2e-17
XP_016872305 (OMIM: 612420) PREDICTED: actin filam ( 817) 667 91.8 1.2e-17
NP_001001936 (OMIM: 612420) actin filament-associa ( 818) 667 91.8 1.2e-17
XP_016872302 (OMIM: 612420) PREDICTED: actin filam ( 831) 667 91.8 1.2e-17
XP_016872301 (OMIM: 612420) PREDICTED: actin filam ( 832) 667 91.8 1.2e-17
XP_016872300 (OMIM: 612420) PREDICTED: actin filam ( 835) 667 91.8 1.2e-17
XP_016872299 (OMIM: 612420) PREDICTED: actin filam ( 836) 667 91.8 1.2e-17
XP_011538592 (OMIM: 612420) PREDICTED: actin filam ( 840) 667 91.8 1.2e-17
XP_016872296 (OMIM: 612420) PREDICTED: actin filam ( 843) 667 91.8 1.2e-17
XP_011538591 (OMIM: 612420) PREDICTED: actin filam ( 844) 667 91.8 1.2e-17
XP_016872293 (OMIM: 612420) PREDICTED: actin filam ( 854) 667 91.8 1.2e-17
XP_005270294 (OMIM: 612420) PREDICTED: actin filam ( 858) 667 91.8 1.2e-17
XP_005270290 (OMIM: 612420) PREDICTED: actin filam ( 876) 667 91.8 1.3e-17
XP_011538588 (OMIM: 612420) PREDICTED: actin filam ( 884) 667 91.8 1.3e-17
XP_016872315 (OMIM: 612420) PREDICTED: actin filam ( 757) 660 90.9 2e-17
XP_016872314 (OMIM: 612420) PREDICTED: actin filam ( 758) 660 90.9 2e-17
XP_005270298 (OMIM: 612420) PREDICTED: actin filam ( 802) 660 91.0 2.1e-17
NP_001274753 (OMIM: 612420) actin filament-associa ( 871) 611 85.2 1.2e-15
XP_016872321 (OMIM: 612420) PREDICTED: actin filam ( 795) 578 81.3 1.7e-14
XP_016872310 (OMIM: 612420) PREDICTED: actin filam ( 785) 569 80.2 3.4e-14
XP_016872309 (OMIM: 612420) PREDICTED: actin filam ( 786) 569 80.2 3.4e-14
XP_016872303 (OMIM: 612420) PREDICTED: actin filam ( 830) 569 80.3 3.6e-14
XP_016872298 (OMIM: 612420) PREDICTED: actin filam ( 841) 569 80.3 3.6e-14
XP_016872297 (OMIM: 612420) PREDICTED: actin filam ( 842) 569 80.3 3.6e-14
XP_016872295 (OMIM: 612420) PREDICTED: actin filam ( 845) 569 80.3 3.6e-14
XP_016872294 (OMIM: 612420) PREDICTED: actin filam ( 846) 569 80.3 3.6e-14
XP_016872292 (OMIM: 612420) PREDICTED: actin filam ( 867) 569 80.3 3.7e-14
XP_016872291 (OMIM: 612420) PREDICTED: actin filam ( 868) 569 80.3 3.7e-14
>>NP_940997 (OMIM: 608252) actin filament-associated pro (730 aa)
initn: 4815 init1: 4815 opt: 4815 Z-score: 3077.7 bits: 580.1 E(85289): 1.1e-164
Smith-Waterman score: 4815; 99.9% identity (100.0% similar) in 730 aa overlap (1-730:1-730)
10 20 30 40 50 60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNGVTGKGKTLSSQPKKADPA
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_940 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK
670 680 690 700 710 720
730
pF1KE1 AKEWELKNGT
::::::::::
NP_940 AKEWELKNGT
730
>>XP_006713972 (OMIM: 608252) PREDICTED: actin filament- (751 aa)
initn: 4815 init1: 4815 opt: 4815 Z-score: 3077.5 bits: 580.1 E(85289): 1.1e-164
Smith-Waterman score: 4815; 99.9% identity (100.0% similar) in 730 aa overlap (1-730:22-751)
10 20 30
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQ
:::::::::::::::::::::::::::::::::::::::
XP_006 MRFKQEHPHPRNEAKAVTVRAMEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 SSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVP
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 LSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAF
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE1 LLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKI
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE1 TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE1 RPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE1 QTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIP
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE1 GLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMS
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE1 ASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_006 ASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE1 SNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKE
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE1 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEV
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE1 KESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAA
670 680 690 700 710 720
700 710 720 730
pF1KE1 VLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
:::::::::::::::::::::::::::::::
XP_006 VLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
730 740 750
>>XP_016864024 (OMIM: 608252) PREDICTED: actin filament- (748 aa)
initn: 4801 init1: 3423 opt: 3457 Z-score: 2213.5 bits: 420.2 E(85289): 1.5e-116
Smith-Waterman score: 4769; 97.5% identity (97.6% similar) in 748 aa overlap (1-730:1-748)
10 20 30 40 50 60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
430 440 450 460 470 480
490 500 510 520
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGS------------------LKGKKPPMASNG
:::::::::::::::::::::::::::::: :::::::.::::
XP_016 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEELKGKKPPVASNG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE1 VTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALR
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE1 NRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKES
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE1 LKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLK
670 680 690 700 710 720
710 720 730
pF1KE1 KSQAAPGSSPCRGHVLRKAKEWELKNGT
::::::::::::::::::::::::::::
XP_016 KSQAAPGSSPCRGHVLRKAKEWELKNGT
730 740
>>XP_016864025 (OMIM: 608252) PREDICTED: actin filament- (555 aa)
initn: 3423 init1: 3423 opt: 3425 Z-score: 2195.0 bits: 416.3 E(85289): 1.6e-115
Smith-Waterman score: 3425; 97.7% identity (98.3% similar) in 525 aa overlap (1-523:1-525)
10 20 30 40 50 60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
430 440 450 460 470 480
490 500 510 520 530
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKK--PPMASNGVTGKGKTLSSQPKKAD
:::::::::::::::::::::::::::::: . . : : :.
XP_016 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLSRVK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE1 PAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAA
XP_016 SPPWRLMGSQEKGRL
550
>>XP_011511846 (OMIM: 608252) PREDICTED: actin filament- (814 aa)
initn: 3423 init1: 3423 opt: 3425 Z-score: 2192.6 bits: 416.5 E(85289): 2.2e-115
Smith-Waterman score: 4285; 88.8% identity (89.0% similar) in 762 aa overlap (1-678:1-762)
10 20 30 40 50 60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
430 440 450 460 470 480
490 500 510
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGS------------------------------
::::::::::::::::::::::::::::::
XP_011 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLYDNL
490 500 510 520 530 540
pF1KE1 ------------------------------------------------------LKGKKP
::::::
XP_011 PPPHIFARYSPADRKASRLSADKLSSNHYKYPASAQSVTNTSSVGRASLGLNSQLKGKKP
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE1 PMASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE1 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE1 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
::::::::::::::::::::::::::::::::::::::::::
XP_011 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
730 740 750 760 770 780
700 710 720 730
pF1KE1 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
XP_011 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
790 800 810
>--
initn: 352 init1: 352 opt: 352 Z-score: 237.5 bits: 54.7 E(85289): 1.7e-06
Smith-Waterman score: 352; 100.0% identity (100.0% similar) in 52 aa overlap (679-730:763-814)
650 660 670 680 690 700
pF1KE1 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
::::::::::::::::::::::::::::::
XP_011 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
740 750 760 770 780 790
710 720 730
pF1KE1 GSSPCRGHVLRKAKEWELKNGT
::::::::::::::::::::::
XP_011 GSSPCRGHVLRKAKEWELKNGT
800 810
>>NP_001128119 (OMIM: 608252) actin filament-associated (814 aa)
initn: 3423 init1: 3423 opt: 3425 Z-score: 2192.6 bits: 416.5 E(85289): 2.2e-115
Smith-Waterman score: 4285; 88.8% identity (89.0% similar) in 762 aa overlap (1-678:1-762)
10 20 30 40 50 60
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
430 440 450 460 470 480
490 500 510
pF1KE1 NPYLGGTSNGYAHPSGTALHYDDVPCINGS------------------------------
::::::::::::::::::::::::::::::
NP_001 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLYDNL
490 500 510 520 530 540
pF1KE1 ------------------------------------------------------LKGKKP
::::::
NP_001 PPPHIFARYSPADRKASRLSADKLSSNHYKYPASAQSVTNTSSVGRASLGLNSQLKGKKP
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE1 PMASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE1 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE1 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
::::::::::::::::::::::::::::::::::::::::::
NP_001 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
730 740 750 760 770 780
700 710 720 730
pF1KE1 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
NP_001 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
790 800 810
>--
initn: 352 init1: 352 opt: 352 Z-score: 237.5 bits: 54.7 E(85289): 1.7e-06
Smith-Waterman score: 352; 100.0% identity (100.0% similar) in 52 aa overlap (679-730:763-814)
650 660 670 680 690 700
pF1KE1 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
::::::::::::::::::::::::::::::
NP_001 GGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAP
740 750 760 770 780 790
710 720 730
pF1KE1 GSSPCRGHVLRKAKEWELKNGT
::::::::::::::::::::::
NP_001 GSSPCRGHVLRKAKEWELKNGT
800 810
>>NP_001309991 (OMIM: 614410) actin filament-associated (735 aa)
initn: 1801 init1: 680 opt: 1581 Z-score: 1020.0 bits: 199.4 E(85289): 4.5e-50
Smith-Waterman score: 2075; 46.5% identity (71.7% similar) in 766 aa overlap (1-727:7-733)
10 20 30 40 50
pF1KE1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQE
.:.:. :: .: :::::::..:. ::: ....:: :: . . .:. .
NP_001 MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASIL---QSLQPLPAKEVSYLYV
10 20 30 40 50
60 70 80
pF1KE1 TANSLPAPPQM-------------PLPEIPQPWLPPDSG-----------------PPPL
.. .: . :.. : ..:. :..: ::::
NP_001 NTADLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPL
60 70 80 90 100 110
90 100 110 120 130 140
pF1KE1 PTSSLPEGYYEEAVPLSPGKAPEYITS-NYDSDAMSSSYESYDEEEEDGKGKKTRHQWPS
:.. :: :::::.::.:::.::::.: : :::::::::::::::::.::. . ::::::
NP_001 PNKPPPEDYYEEALPLGPGKSPEYISSHNNDSDAMSSSYESYDEEEEEGKSPQPRHQWPS
120 130 140 150 160 170
150 160 170 180 190 200
pF1KE1 EEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNI
::::: ::.. .::::::::::::::.: : ::.. .:::::::::.::...: :. :.:
NP_001 EEASMHLVRECRICAFLLRKKRFGQWAKQLTVIREDQLLCYKSSKDRQPHLRLALDTCSI
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE1 TYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPP
:.::::..:.:::..:: .:. ::::.::.::::.:::::.:. . .: : : :
NP_001 IYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEEWLKVIREVSKPVGGAEGVEVPRSP
240 250 260 270 280 290
270 280 290 300 310
pF1KE1 SSPVHKAELEKKLSSERPSSDGEGV-VENGITTCNGKEQV---KRKKSSKSEAKGTVSKV
. : .:.:.::.:. .::...: : .. .: . .: : :::: .: ::..:..
NP_001 VL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGRRETCDHGKGKKSSLAELKGSMSRA
300 310 320 330 340 350
320 330 340 350 360 370
pF1KE1 TGKKITKIISLGKKKPSTDE-QTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHK
.:.:::.::...::: .:. ::::.::.:: ::::::: :. :.:::::.: : : :::
NP_001 AGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYLNVLVNQGWKERWCRLKCNTLYFHK
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE1 DRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLA
:. ::.::. .: :.:::: ::. .::..::.::: ::::.:::: :::::::.:.::.
NP_001 DHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRNRQEVAILEASCSEDMGRWLGLLLV
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE1 ETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTA
: :: . ::::::::.::: .:........: : . .: . .:
NP_001 EMGSRVTPEALHYDYVDVETLTSIVSAGRNSFL-----------YARSCQNQWPEPR---
480 490 500 510 520
500 510 520 530 540 550
pF1KE1 LHYDDVPCINGSLKGKKPPMASNG-VTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGK
::::: ... ..: ... : .... : . ...:: . ::: .:.: ::::::
NP_001 -VYDDVP--YEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGK
530 540 550 560 570
560 570 580 590 600 610
pF1KE1 NRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQ
::.: ::.: ...:.: :.::..:..: ::.:...:. ::. . : : .: ::: .
NP_001 NRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKA-LEEAVAT
580 590 600 610 620 630
620 630 640 650 660 670
pF1KE1 LEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAI--EPKSGTSSPQSPVFRHRT
:: .:: :: .:..:::.:. ::: :...:::: .:::.. .:::: ..
NP_001 LEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGETA----------
640 650 660 670 680
680 690 700 710 720 730
pF1KE1 LENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
:.: .: : :.::: .. :.: . . .: .:.::.::::::.:
NP_001 --NKPQNSVP----EQPLPVNCVSELRKRSPSIVASN-QGRVLQKAKEWEMKKT
690 700 710 720 730
>>XP_011535860 (OMIM: 614410) PREDICTED: actin filament- (628 aa)
initn: 1699 init1: 679 opt: 1460 Z-score: 944.0 bits: 185.1 E(85289): 7.7e-46
Smith-Waterman score: 1904; 48.4% identity (73.8% similar) in 653 aa overlap (85-727:10-626)
60 70 80 90 100 110
pF1KE1 TANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGK--APEYITSN
:. :. .::::.: :. : .:
XP_011 MVLGSDGCSPSHSIVDGYYEDADSSYPATRVNGELKSSY
10 20 30
120 130 140 150 160 170
pF1KE1 YDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKL
:::::::::::::::::.::. . ::::::::::: ::.. .::::::::::::::.:
XP_011 NDSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQ
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 LCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQ
: ::.. .:::::::::.::...: :. :.: :.::::..:.:::..:: .:. ::::.:
XP_011 LTVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQ
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE1 SKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VEN
:.::::.:::::.:. . .: : : : . : .:.:.::.:. .::...: : .
XP_011 SREQAEEWLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGD
160 170 180 190 200 210
300 310 320 330 340
pF1KE1 GITTCNGKEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEED
. .: . .: : :::: .: ::..:...:.:::.::...::: .:. ::::.::.
XP_011 NCSTLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEE
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE1 VPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPL
:: ::::::: :. :.:::::.: : : ::::. ::.::. .: :.:::: ::. .::.
XP_011 VPCCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPF
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE1 TFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAK
.::.::: ::::.:::: :::::::.:.::.: :: . ::::::::.::: .:......
XP_011 AFRILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGR
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE1 QTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNG-VTGK
..: : . .: . .: ::::: ... ..: ... : .
XP_011 NSFL-----------YARSCQNQWPEPRV----YDDVP--YEKMQDEEPERPTGAQVKRH
400 410 420 430 440
530 540 550 560 570 580
pF1KE1 GKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLA
... : . ...:: . ::: .:.: ::::::::.: ::.: ...:.: :.::..:..:
XP_011 ASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELI
450 460 470 480 490 500
590 600 610 620 630 640
pF1KE1 QLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKA
::.:...:. ::. . : : .: ::: . :: .:: :: .:..:::.:. ::: :...
XP_011 ALRQEKRELKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQS
510 520 530 540 550 560
650 660 670 680 690 700
pF1KE1 LAGGVTLGLAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKS
:::: .:::.. .:::: .. :.: .: : :.::: .. :.:
XP_011 LAGGPALGLSVSSKPKSGETA------------NKPQNSVP----EQPLPVNCVSELRKR
570 580 590 600
710 720 730
pF1KE1 QAAPGSSPCRGHVLRKAKEWELKNGT
. . .: .:.::.::::::.:
XP_011 SPSIVASN-QGRVLQKAKEWEMKKT
610 620
>>XP_016864525 (OMIM: 614410) PREDICTED: actin filament- (734 aa)
initn: 1699 init1: 679 opt: 1460 Z-score: 943.0 bits: 185.1 E(85289): 8.7e-46
Smith-Waterman score: 1953; 46.9% identity (71.0% similar) in 710 aa overlap (62-727:59-732)
40 50 60 70 80
pF1KE1 TNILLRIQSSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQ-PWLPPDSG-PPPLPTSSL
: . ::. . : : . :::::..
XP_016 HSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPP
30 40 50 60 70 80
90 100 110
pF1KE1 PEGYYEEAVPLSPGKAPEYITSNY----------------------------------DS
:: :::::.::.:::.::::.:. ::
XP_016 PEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDS
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE1 DAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCV
:::::::::::::::.::. . ::::::::::: ::.. .::::::::::::::.: : :
XP_016 DAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTV
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE1 IKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKE
:.. .:::::::::.::...: :. :.: :.::::..:.:::..:: .:. ::::.::.:
XP_016 IREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSRE
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE1 QAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGIT
:::.:::::.:. . .: : : : . : .:.:.::.:. .::...: : .. .
XP_016 QAEEWLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCS
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE1 TCNGKEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPT
: . .: : :::: .: ::..:...:.:::.::...::: .:. ::::.::.::
XP_016 TLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPC
330 340 350 360 370 380
360 370 380 390 400 410
pF1KE1 CGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFR
::::::: :. :.:::::.: : : ::::. ::.::. .: :.:::: ::. .::..::
XP_016 CGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFR
390 400 410 420 430 440
420 430 440 450 460 470
pF1KE1 LLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTF
.::: ::::.:::: :::::::.:.::.: :: . ::::::::.::: .:........:
XP_016 ILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSF
450 460 470 480 490 500
480 490 500 510 520
pF1KE1 CFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNG-VTGKGKT
: . .: . .: ::::: ... ..: ... : ....
XP_016 L-----------YARSCQNQWPEPRV----YDDVP--YEKMQDEEPERPTGAQVKRHASS
510 520 530 540 550
530 540 550 560 570 580
pF1KE1 LSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLR
: . ...:: . ::: .:.: ::::::::.: ::.: ...:.: :.::..:..: ::
XP_016 CSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALR
560 570 580 590 600 610
590 600 610 620 630 640
pF1KE1 KERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAG
.:...:. ::. . : : .: ::: . :: .:: :: .:..:::.:. ::: :...:::
XP_016 QEKRELKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAG
620 630 640 650 660
650 660 670 680 690 700
pF1KE1 GVTLGLAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAA
: .:::.. .:::: .. :.: .: : :.::: .. :.: . .
XP_016 GPALGLSVSSKPKSGETA------------NKPQNSVP----EQPLPVNCVSELRKRSPS
670 680 690 700 710
710 720 730
pF1KE1 PGSSPCRGHVLRKAKEWELKNGT
.: .:.::.::::::.:
XP_016 IVASN-QGRVLQKAKEWEMKKT
720 730
>>NP_689619 (OMIM: 614410) actin filament-associated pro (768 aa)
initn: 1785 init1: 679 opt: 1460 Z-score: 942.8 bits: 185.1 E(85289): 9e-46
Smith-Waterman score: 1953; 46.9% identity (71.0% similar) in 710 aa overlap (62-727:93-766)
40 50 60 70 80
pF1KE1 TNILLRIQSSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQ-PWLPPDSG-PPPLPTSSL
: . ::. . : : . :::::..
NP_689 HSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPP
70 80 90 100 110 120
90 100 110
pF1KE1 PEGYYEEAVPLSPGKAPEYITSNY----------------------------------DS
:: :::::.::.:::.::::.:. ::
NP_689 PEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDS
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE1 DAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCV
:::::::::::::::.::. . ::::::::::: ::.. .::::::::::::::.: : :
NP_689 DAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTV
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE1 IKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKE
:.. .:::::::::.::...: :. :.: :.::::..:.:::..:: .:. ::::.::.:
NP_689 IREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSRE
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE1 QAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGIT
:::.:::::.:. . .: : : : . : .:.:.::.:. .::...: : .. .
NP_689 QAEEWLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCS
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE1 TCNGKEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPT
: . .: : :::: .: ::..:...:.:::.::...::: .:. ::::.::.::
NP_689 TLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPC
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE1 CGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFR
::::::: :. :.:::::.: : : ::::. ::.::. .: :.:::: ::. .::..::
NP_689 CGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFR
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE1 LLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTF
.::: ::::.:::: :::::::.:.::.: :: . ::::::::.::: .:........:
NP_689 ILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSF
490 500 510 520 530 540
480 490 500 510 520
pF1KE1 CFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPMASNG-VTGKGKT
: . .: . .: ::::: ... ..: ... : ....
NP_689 L-----------YARSCQNQWPEPRV----YDDVP--YEKMQDEEPERPTGAQVKRHASS
550 560 570 580
530 540 550 560 570 580
pF1KE1 LSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLR
: . ...:: . ::: .:.: ::::::::.: ::.: ...:.: :.::..:..: ::
NP_689 CSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALR
590 600 610 620 630 640
590 600 610 620 630 640
pF1KE1 KERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAG
.:...:. ::. . : : .: ::: . :: .:: :: .:..:::.:. ::: :...:::
NP_689 QEKRELKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAG
650 660 670 680 690 700
650 660 670 680 690 700
pF1KE1 GVTLGLAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAA
: .:::.. .:::: .. :.: .: : :.::: .. :.: . .
NP_689 GPALGLSVSSKPKSGETA------------NKPQNSVP----EQPLPVNCVSELRKRSPS
710 720 730 740
710 720 730
pF1KE1 PGSSPCRGHVLRKAKEWELKNGT
.: .:.::.::::::.:
NP_689 IVASN-QGRVLQKAKEWEMKKT
750 760
730 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 07:25:58 2016 done: Sat Nov 5 07:26:00 2016
Total Scan time: 11.840 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]