FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0445, 491 aa 1>>>pF1KB0445 491 - 491 aa - 491 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7914+/-0.000307; mu= 16.4778+/- 0.019 mean_var=83.2515+/-16.754, 0's: 0 Z-trim(116.9): 118 B-trim: 83 in 1/56 Lambda= 0.140565 statistics sampled from 28361 (28487) to 28361 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.334), width: 16 Scan time: 9.640 The best scores are: opt bits E(85289) NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmi ( 491) 3311 681.1 1.9e-195 NP_001159392 (OMIM: 262850,613168) alpha-2-antipla ( 491) 3311 681.1 1.9e-195 XP_016880254 (OMIM: 262850,613168) PREDICTED: alph ( 495) 3311 681.1 1.9e-195 XP_005256758 (OMIM: 262850,613168) PREDICTED: alph ( 507) 3311 681.1 1.9e-195 NP_001159393 (OMIM: 262850,613168) alpha-2-antipla ( 427) 2514 519.5 7.6e-147 NP_001316832 (OMIM: 172860,613982) pigment epithel ( 418) 613 133.9 8.4e-31 NP_002606 (OMIM: 172860,613982) pigment epithelium ( 418) 613 133.9 8.4e-31 NP_000053 (OMIM: 106100,120790,606860) plasma prot ( 500) 612 133.8 1.1e-30 NP_001027466 (OMIM: 106100,120790,606860) plasma p ( 500) 612 133.8 1.1e-30 NP_001248760 (OMIM: 603357,615598) serpin B7 isofo ( 363) 466 104.1 7e-22 XP_005249241 (OMIM: 601799) PREDICTED: serpin B9 i ( 376) 450 100.9 6.8e-21 NP_004146 (OMIM: 601799) serpin B9 [Homo sapiens] ( 376) 450 100.9 6.8e-21 NP_001121175 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001121179 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001002235 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001121178 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001002236 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001121173 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_000286 (OMIM: 107400,606963,613490) alpha-1-ant ( 418) 431 97.0 1.1e-19 XP_016876859 (OMIM: 107400,606963,613490) PREDICTE ( 418) 431 97.0 1.1e-19 NP_001121174 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001121177 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001121176 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 NP_001121172 (OMIM: 107400,606963,613490) alpha-1- ( 418) 431 97.0 1.1e-19 XP_011524553 (OMIM: 615682) PREDICTED: serpin B11 ( 392) 430 96.8 1.2e-19 NP_536723 (OMIM: 615682) serpin B11 isoform a [Hom ( 392) 430 96.8 1.2e-19 NP_000176 (OMIM: 142360,612356) heparin cofactor 2 ( 499) 430 96.9 1.4e-19 NP_006208 (OMIM: 605587) serpin I2 isoform 2 precu ( 405) 427 96.2 1.8e-19 NP_001012303 (OMIM: 605587) serpin I2 isoform 1 pr ( 415) 427 96.2 1.9e-19 XP_016866430 (OMIM: 173321,613453) PREDICTED: serp ( 332) 400 90.7 7e-18 XP_011512978 (OMIM: 173321,613453) PREDICTED: serp ( 332) 400 90.7 7e-18 NP_001193943 (OMIM: 600943,610504,613848) serpin H ( 418) 401 91.0 7.3e-18 NP_001226 (OMIM: 600943,610504,613848) serpin H1 p ( 418) 401 91.0 7.3e-18 XP_011543629 (OMIM: 600943,610504,613848) PREDICTE ( 418) 401 91.0 7.3e-18 NP_004559 (OMIM: 173321,613453) serpin B6 isoform ( 376) 400 90.7 7.7e-18 XP_011512975 (OMIM: 173321,613453) PREDICTED: serp ( 376) 400 90.7 7.7e-18 NP_001258753 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18 XP_011512976 (OMIM: 173321,613453) PREDICTED: serp ( 376) 400 90.7 7.7e-18 NP_001258754 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18 NP_001284629 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18 NP_001284628 (OMIM: 173321,613453) serpin B6 isofo ( 376) 400 90.7 7.7e-18 NP_001182220 (OMIM: 173321,613453) serpin B6 isofo ( 380) 400 90.7 7.8e-18 XP_016866429 (OMIM: 173321,613453) PREDICTED: serp ( 380) 400 90.7 7.8e-18 NP_001258751 (OMIM: 173321,613453) serpin B6 isofo ( 390) 400 90.7 8e-18 NP_001258752 (OMIM: 173321,613453) serpin B6 isofo ( 395) 400 90.7 8e-18 XP_011512974 (OMIM: 173321,613453) PREDICTED: serp ( 454) 400 90.8 9e-18 NP_001076 (OMIM: 107280) alpha-1-antichymotrypsin ( 423) 398 90.3 1.1e-17 NP_001094077 (OMIM: 605271) protein Z-dependent pr ( 444) 398 90.4 1.2e-17 NP_057270 (OMIM: 605271) protein Z-dependent prote ( 444) 398 90.4 1.2e-17 XP_005267790 (OMIM: 605271) PREDICTED: protein Z-d ( 444) 398 90.4 1.2e-17 >>NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmin is (491 aa) initn: 3311 init1: 3311 opt: 3311 Z-score: 3630.0 bits: 681.1 E(85289): 1.9e-195 Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491) 10 20 30 40 50 60 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM 430 440 450 460 470 480 490 pF1KB0 EEDYPQFGSPK ::::::::::: NP_000 EEDYPQFGSPK 490 >>NP_001159392 (OMIM: 262850,613168) alpha-2-antiplasmin (491 aa) initn: 3311 init1: 3311 opt: 3311 Z-score: 3630.0 bits: 681.1 E(85289): 1.9e-195 Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491) 10 20 30 40 50 60 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM 430 440 450 460 470 480 490 pF1KB0 EEDYPQFGSPK ::::::::::: NP_001 EEDYPQFGSPK 490 >>XP_016880254 (OMIM: 262850,613168) PREDICTED: alpha-2- (495 aa) initn: 3311 init1: 3311 opt: 3311 Z-score: 3629.9 bits: 681.1 E(85289): 1.9e-195 Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:5-495) 10 20 30 40 50 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPRNMALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB0 PGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB0 LSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB0 DFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIH 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB0 FQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB0 SFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB0 QELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB0 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL 430 440 450 460 470 480 480 490 pF1KB0 VPPMEEDYPQFGSPK ::::::::::::::: XP_016 VPPMEEDYPQFGSPK 490 >>XP_005256758 (OMIM: 262850,613168) PREDICTED: alpha-2- (507 aa) initn: 3311 init1: 3311 opt: 3311 Z-score: 3629.8 bits: 681.1 E(85289): 1.9e-195 Smith-Waterman score: 3311; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:17-507) 10 20 30 40 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQV :::::::::::::::::::::::::::::::::::::::::::: XP_005 MHVRRVRDLCHRFTRNMALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB0 SPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB0 NLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB0 RMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLP 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB0 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB0 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQ 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB0 MDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRM 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB0 SLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFP 430 440 450 460 470 480 470 480 490 pF1KB0 RGDKLFGPDLKLVPPMEEDYPQFGSPK ::::::::::::::::::::::::::: XP_005 RGDKLFGPDLKLVPPMEEDYPQFGSPK 490 500 >>NP_001159393 (OMIM: 262850,613168) alpha-2-antiplasmin (427 aa) initn: 2507 init1: 2507 opt: 2514 Z-score: 2757.3 bits: 519.5 E(85289): 7.6e-147 Smith-Waterman score: 2736; 86.6% identity (87.0% similar) in 491 aa overlap (1-491:1-427) 10 20 30 40 50 60 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ----- 10 20 30 40 50 70 80 90 100 110 120 pF1KB0 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL ..: NP_001 -----------------------------------------------VQP---------- 130 140 150 160 170 180 pF1KB0 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --GAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB0 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB0 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB0 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB0 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB0 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM 360 370 380 390 400 410 490 pF1KB0 EEDYPQFGSPK ::::::::::: NP_001 EEDYPQFGSPK 420 >>NP_001316832 (OMIM: 172860,613982) pigment epithelium- (418 aa) initn: 605 init1: 326 opt: 613 Z-score: 674.0 bits: 133.9 E(85289): 8.4e-31 Smith-Waterman score: 613; 29.2% identity (63.8% similar) in 414 aa overlap (31-436:10-415) 10 20 30 40 50 60 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ .: : . :. .:: . :. .: . NP_001 MQALVLLLCIGALLGHSSCQNPASPP---EEGSPDPDST 10 20 30 70 80 90 100 110 pF1KB0 TALKSPPGVCSRDPTPE-QTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSH :: : .:: . ...:: :. : ::. . ..:: :..::::::: ::: NP_001 GAL-----VEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB0 LALGAQNHTLQRLQQVLHAG--SGPCLPHLLSRLCQDL-GPGA-FRLAARMYLQKGFPIK :.:::...: . ....:. :.: . ..: . . .: .. :.:. ..: . :: NP_001 LSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIK 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB0 EDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAI .:. :. .:..: :::. . :: .::.::. .::. . . .:.. .:::.. NP_001 SSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVA 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 HFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNN ::.: : .::: :. ..:.:::. :: : ::. ::. : . ..:..:. .. NP_001 HFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGS 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB0 MSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRL--PKLYLKHQMDLVATLSQ ::.. ..: . :.. . .:. . .: . ... : ::: :... ... .:.. NP_001 MSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQE 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB0 LGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVN . :: ::..::. :. . . .. :.:.. .: .: :. .. . .. ..... .. .: NP_001 MKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLN 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB0 RPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGP .::.: . . :: ::.:.. .: NP_001 QPFIFVLRDTDTGALLFIGKILDPRGP 400 410 >>NP_002606 (OMIM: 172860,613982) pigment epithelium-der (418 aa) initn: 605 init1: 326 opt: 613 Z-score: 674.0 bits: 133.9 E(85289): 8.4e-31 Smith-Waterman score: 613; 29.2% identity (63.8% similar) in 414 aa overlap (31-436:10-415) 10 20 30 40 50 60 pF1KB0 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ .: : . :. .:: . :. .: . NP_002 MQALVLLLCIGALLGHSSCQNPASPP---EEGSPDPDST 10 20 30 70 80 90 100 110 pF1KB0 TALKSPPGVCSRDPTPE-QTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSH :: : .:: . ...:: :. : ::. . ..:: :..::::::: ::: NP_002 GAL-----VEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB0 LALGAQNHTLQRLQQVLHAG--SGPCLPHLLSRLCQDL-GPGA-FRLAARMYLQKGFPIK :.:::...: . ....:. :.: . ..: . . .: .. :.:. ..: . :: NP_002 LSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIK 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB0 EDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAI .:. :. .:..: :::. . :: .::.::. .::. . . .:.. .:::.. NP_002 SSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVA 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB0 HFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNN ::.: : .::: :. ..:.:::. :: : ::. ::. : . ..:..:. .. NP_002 HFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGS 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB0 MSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRL--PKLYLKHQMDLVATLSQ ::.. ..: . :.. . .:. . .: . ... : ::: :... ... .:.. NP_002 MSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQE 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB0 LGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVN . :: ::..::. :. . . .. :.:.. .: .: :. .. . .. ..... .. .: NP_002 MKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLN 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB0 RPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGP .::.: . . :: ::.:.. .: NP_002 QPFIFVLRDTDTGALLFIGKILDPRGP 400 410 >>NP_000053 (OMIM: 106100,120790,606860) plasma protease (500 aa) initn: 482 init1: 172 opt: 612 Z-score: 671.8 bits: 133.8 E(85289): 1.1e-30 Smith-Waterman score: 612; 28.5% identity (65.4% similar) in 410 aa overlap (36-436:95-498) 10 20 30 40 50 60 pF1KB0 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK :. :. . ..: : : . .: . NP_000 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP 70 80 90 100 110 120 70 80 90 100 110 120 pF1KB0 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG .: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... :: NP_000 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB0 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS : ..: :...: . . :. . : . . . ..... . . :.. :.. : NP_000 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB0 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR . :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :. NP_000 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB0 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV . :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.:: NP_000 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV 310 320 330 340 350 310 320 330 340 350 pF1KB0 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ : : .. :.:. . .. : . :: . ::.. . ..:... . .: . NP_000 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB0 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL .. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..::: NP_000 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL 420 430 440 450 460 470 420 430 440 450 460 470 pF1KB0 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL : .... .:.:.: : .: NP_000 FVLWDQQHKFPVFMGRVYDPRA 480 490 500 >>NP_001027466 (OMIM: 106100,120790,606860) plasma prote (500 aa) initn: 482 init1: 172 opt: 612 Z-score: 671.8 bits: 133.8 E(85289): 1.1e-30 Smith-Waterman score: 612; 28.5% identity (65.4% similar) in 410 aa overlap (36-436:95-498) 10 20 30 40 50 60 pF1KB0 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK :. :. . ..: : : . .: . NP_001 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP 70 80 90 100 110 120 70 80 90 100 110 120 pF1KB0 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG .: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... :: NP_001 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB0 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS : ..: :...: . . :. . : . . . ..... . . :.. :.. : NP_001 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB0 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR . :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :. NP_001 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB0 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV . :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.:: NP_001 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV 310 320 330 340 350 310 320 330 340 350 pF1KB0 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ : : .. :.:. . .. : . :: . ::.. . ..:... . .: . NP_001 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB0 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL .. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..::: NP_001 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL 420 430 440 450 460 470 420 430 440 450 460 470 pF1KB0 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL : .... .:.:.: : .: NP_001 FVLWDQQHKFPVFMGRVYDPRA 480 490 500 >>NP_001248760 (OMIM: 603357,615598) serpin B7 isoform 2 (363 aa) initn: 263 init1: 85 opt: 466 Z-score: 513.8 bits: 104.1 E(85289): 7e-22 Smith-Waterman score: 466; 28.9% identity (63.5% similar) in 370 aa overlap (82-436:4-363) 60 70 80 90 100 110 pF1KB0 LGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPL :: : : .:: . ... :...: : NP_001 MASLAAANAEFCFNLFREMDDNQGNGNVFFSSL 10 20 30 120 130 140 150 160 170 pF1KB0 SVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKG :. ::. . ::::. .:. :. ..: : ...: . . . .. .. .: NP_001 SLFAALALVRLGAQDDSLS---QIDKSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKV 40 50 60 70 80 90 180 190 200 210 220 pF1KB0 FPIKEDFLEQSEQLFGAKP--VSLTGKQEDDLANINQWVKEATEGKIQEFLS--GLPEDT . ...:..: .:.:. :: :..:.. :: :::.::.. :.:::.. .. :. .. NP_001 YGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSA 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB0 VLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMM-QARTYPLRWFLLEQPEIQ :..:.::..:.: :.. : : : :. . : :: : : . : ..:.: .. NP_001 VMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLS--VIEDPSMK 160 170 180 190 200 290 300 310 320 330 340 pF1KB0 VAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTL----HPPLVWERPTKVRLPKLYLK . .. ....... ::.: : ..:.. .:....: .: . . ..: .:.. .. NP_001 ILELRYNGGINMYVLLP---ENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIE 210 220 230 240 250 260 350 360 370 380 390 pF1KB0 HQMDLVATLSQLGLQELFQAP--DLRGI-SEQSLVVSGVQHQSTLELSEVGVEAAAAT-- ..... : :::...:. :: :: : : .: ..:.: .:..: :.::.::: NP_001 KNYEMKQYLRALGLKDIFDESKADLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGS 270 280 290 300 310 320 400 410 420 430 440 450 pF1KB0 SIAMSRMSLSS-FSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDF .:. ... :. : ...:::: : .: . :: :.: : NP_001 NIVEKQLPQSTLFRADHPFLFVIRKD--DIILFSGKVSCP 330 340 350 360 460 470 480 490 pF1KB0 LQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK 491 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:30:51 2016 done: Sat Nov 5 22:30:53 2016 Total Scan time: 9.640 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]