FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3773, 1743 aa 1>>>pF1KE3773 1743 - 1743 aa - 1743 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3275+/-0.000546; mu= 14.4964+/- 0.034 mean_var=578.4020+/-131.365, 0's: 0 Z-trim(116.9): 1279 B-trim: 1316 in 1/56 Lambda= 0.053328 statistics sampled from 26707 (28471) to 26707 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.334), width: 16 Scan time: 18.850 The best scores are: opt bits E(85289) XP_006724656 (OMIM: 300358) PREDICTED: serine/thre (1743) 11405 895.5 0 NP_001002838 (OMIM: 300358) serine/threonine-prote (1743) 11405 895.5 0 XP_011529104 (OMIM: 300358) PREDICTED: serine/thre (1753) 10203 803.0 0 XP_016885234 (OMIM: 300358) PREDICTED: serine/thre (1790) 8181 647.5 3.2e-184 NP_065973 (OMIM: 300358) serine/threonine-protein (1800) 8181 647.5 3.2e-184 XP_016885233 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184 XP_016885231 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184 XP_016885230 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184 XP_016885232 (OMIM: 300358) PREDICTED: serine/thre (1800) 8181 647.5 3.2e-184 XP_016870544 (OMIM: 606249) PREDICTED: serine/thre (2162) 2232 189.9 2.1e-46 XP_016870543 (OMIM: 606249) PREDICTED: serine/thre (2163) 2232 189.9 2.1e-46 XP_005252201 (OMIM: 606249) PREDICTED: serine/thre (2185) 2232 190.0 2.1e-46 XP_011517238 (OMIM: 606249) PREDICTED: serine/thre (2190) 2232 190.0 2.1e-46 XP_011517237 (OMIM: 606249) PREDICTED: serine/thre (2205) 2232 190.0 2.1e-46 XP_016870542 (OMIM: 606249) PREDICTED: serine/thre (2208) 2232 190.0 2.1e-46 XP_016870541 (OMIM: 606249) PREDICTED: serine/thre (2209) 2232 190.0 2.1e-46 XP_016870540 (OMIM: 606249) PREDICTED: serine/thre (2215) 2232 190.0 2.1e-46 NP_006639 (OMIM: 606249) serine/threonine-protein (2217) 2232 190.0 2.1e-46 XP_005252198 (OMIM: 606249) PREDICTED: serine/thre (2217) 2232 190.0 2.1e-46 XP_005252197 (OMIM: 606249) PREDICTED: serine/thre (2224) 2232 190.0 2.1e-46 XP_016870539 (OMIM: 606249) PREDICTED: serine/thre (2226) 2232 190.0 2.1e-46 XP_016870538 (OMIM: 606249) PREDICTED: serine/thre (2227) 2232 190.0 2.1e-46 XP_016870537 (OMIM: 606249) PREDICTED: serine/thre (2241) 2232 190.0 2.2e-46 XP_016870536 (OMIM: 606249) PREDICTED: serine/thre (2242) 2232 190.0 2.2e-46 XP_011517234 (OMIM: 606249) PREDICTED: serine/thre (2252) 2232 190.0 2.2e-46 XP_011517233 (OMIM: 606249) PREDICTED: serine/thre (2254) 2232 190.0 2.2e-46 XP_016870535 (OMIM: 606249) PREDICTED: serine/thre (2256) 2232 190.0 2.2e-46 XP_011517232 (OMIM: 606249) PREDICTED: serine/thre (2257) 2232 190.0 2.2e-46 XP_016870534 (OMIM: 606249) PREDICTED: serine/thre (2259) 2232 190.0 2.2e-46 XP_005252194 (OMIM: 606249) PREDICTED: serine/thre (2260) 2232 190.0 2.2e-46 XP_011517231 (OMIM: 606249) PREDICTED: serine/thre (2269) 2232 190.0 2.2e-46 XP_011517230 (OMIM: 606249) PREDICTED: serine/thre (2284) 2232 190.0 2.2e-46 NP_001269323 (OMIM: 606249) serine/threonine-prote (2297) 2232 190.0 2.2e-46 XP_011517229 (OMIM: 606249) PREDICTED: serine/thre (2301) 2232 190.0 2.2e-46 XP_011517228 (OMIM: 606249) PREDICTED: serine/thre (2302) 2232 190.0 2.2e-46 XP_016875328 (OMIM: 201300,605232,614492) PREDICTE (2043) 2141 182.9 2.7e-44 XP_011519310 (OMIM: 201300,605232,614492) PREDICTE (2108) 2141 182.9 2.7e-44 XP_011519311 (OMIM: 201300,605232,614492) PREDICTE (2107) 2135 182.5 3.7e-44 XP_016875326 (OMIM: 201300,605232,614492) PREDICTE (2136) 2129 182.0 5.1e-44 NP_061852 (OMIM: 201300,605232,614492) serine/thre (2382) 2129 182.1 5.4e-44 XP_011519308 (OMIM: 201300,605232,614492) PREDICTE (2354) 2121 181.5 8.2e-44 NP_055638 (OMIM: 201300,605232,614492) serine/thre (2134) 2120 181.3 8.3e-44 XP_016875327 (OMIM: 201300,605232,614492) PREDICTE (2135) 2120 181.3 8.3e-44 XP_016875323 (OMIM: 201300,605232,614492) PREDICTE (2228) 2120 181.4 8.4e-44 XP_006719066 (OMIM: 201300,605232,614492) PREDICTE (2381) 2120 181.4 8.7e-44 XP_016875324 (OMIM: 201300,605232,614492) PREDICTE (2201) 2118 181.2 9.3e-44 XP_011519306 (OMIM: 201300,605232,614492) PREDICTE (2548) 2117 181.2 1.1e-43 XP_011519305 (OMIM: 201300,605232,614492) PREDICTE (2549) 2117 181.2 1.1e-43 XP_011519304 (OMIM: 201300,605232,614492) PREDICTE (2641) 2117 181.3 1.1e-43 NP_001171914 (OMIM: 201300,605232,614492) serine/t (2642) 2117 181.3 1.1e-43 >>XP_006724656 (OMIM: 300358) PREDICTED: serine/threonin (1743 aa) initn: 11405 init1: 11405 opt: 11405 Z-score: 4768.9 bits: 895.5 E(85289): 0 Smith-Waterman score: 11405; 100.0% identity (100.0% similar) in 1743 aa overlap (1-1743:1-1743) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE3 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE3 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE3 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE3 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE3 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE3 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE3 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP 1690 1700 1710 1720 1730 1740 pF1KE3 GPK ::: XP_006 GPK >>NP_001002838 (OMIM: 300358) serine/threonine-protein k (1743 aa) initn: 11405 init1: 11405 opt: 11405 Z-score: 4768.9 bits: 895.5 E(85289): 0 Smith-Waterman score: 11405; 100.0% identity (100.0% similar) in 1743 aa overlap (1-1743:1-1743) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE3 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE3 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE3 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE3 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE3 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE3 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMP 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE3 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPP 1690 1700 1710 1720 1730 1740 pF1KE3 GPK ::: NP_001 GPK >>XP_011529104 (OMIM: 300358) PREDICTED: serine/threonin (1753 aa) initn: 11385 init1: 10188 opt: 10203 Z-score: 4269.1 bits: 803.0 E(85289): 0 Smith-Waterman score: 11369; 99.4% identity (99.4% similar) in 1753 aa overlap (1-1743:1-1753) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMRSAIAPD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE3 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE3 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVA 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE3 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE3 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVD 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 pF1KE3 NGIVAT----------DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLI :::::: .::::::::::::::::::::::::::::::::::::::::::: XP_011 NGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLI 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE3 KPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSF 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE3 PGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTS 1690 1700 1710 1720 1730 1740 1740 pF1KE3 SVQNPATIPPGPK ::::::::::::: XP_011 SVQNPATIPPGPK 1750 >>XP_016885234 (OMIM: 300358) PREDICTED: serine/threonin (1790 aa) initn: 11391 init1: 8154 opt: 8181 Z-score: 3428.3 bits: 647.5 E(85289): 3.2e-184 Smith-Waterman score: 11198; 97.4% identity (97.4% similar) in 1775 aa overlap (1-1728:1-1775) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR :::::::::::::::::::::::::: XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 1570 pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATDPLCVES 1570 1580 1590 1600 1610 1620 1580 1590 1600 1610 1620 1630 pF1KE3 NAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVS 1630 1640 1650 1660 1670 1680 1640 1650 1660 1670 1680 1690 pF1KE3 ENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGY 1690 1700 1710 1720 1730 1740 1700 1710 1720 1730 1740 pF1KE3 PVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::::::::::::::::: XP_016 PVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1750 1760 1770 1780 1790 >>NP_065973 (OMIM: 300358) serine/threonine-protein kina (1800 aa) initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184 Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- ::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR :::::::::::::::::::::::::: NP_065 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1630 1640 1650 1660 1670 1680 1630 1640 1650 1660 1670 1680 pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::::::::::::::::: NP_065 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1750 1760 1770 1780 1790 1800 >>XP_016885233 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa) initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184 Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR :::::::::::::::::::::::::: XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1630 1640 1650 1660 1670 1680 1630 1640 1650 1660 1670 1680 pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::::::::::::::::: XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1750 1760 1770 1780 1790 1800 >>XP_016885231 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa) initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184 Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR :::::::::::::::::::::::::: XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1630 1640 1650 1660 1670 1680 1630 1640 1650 1660 1670 1680 pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::::::::::::::::: XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1750 1760 1770 1780 1790 1800 >>XP_016885230 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa) initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184 Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR :::::::::::::::::::::::::: XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1630 1640 1650 1660 1670 1680 1630 1640 1650 1660 1670 1680 pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::::::::::::::::: XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1750 1760 1770 1780 1790 1800 >>XP_016885232 (OMIM: 300358) PREDICTED: serine/threonin (1800 aa) initn: 11371 init1: 8154 opt: 8181 Z-score: 3428.2 bits: 647.5 E(85289): 3.2e-184 Smith-Waterman score: 11086; 96.7% identity (96.8% similar) in 1775 aa overlap (1-1718:1-1775) 10 20 30 40 50 60 pF1KE3 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE3 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KE3 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR :::::::::::::::::::::::::: XP_016 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KE3 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KE3 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KE3 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KE3 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 1560 pF1KE3 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1570 1580 1590 1600 1610 1620 1570 1580 1590 1600 1610 1620 pF1KE3 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK .:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1630 1640 1650 1660 1670 1680 1630 1640 1650 1660 1670 1680 pF1KE3 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE3 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK ::::::::::::::::::::::::::::::::::: XP_016 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1750 1760 1770 1780 1790 1800 >>XP_016870544 (OMIM: 606249) PREDICTED: serine/threonin (2162 aa) initn: 2890 init1: 2094 opt: 2232 Z-score: 954.0 bits: 189.9 E(85289): 2.1e-46 Smith-Waterman score: 2232; 58.6% identity (72.1% similar) in 674 aa overlap (69-725:117-774) 40 50 60 70 80 90 pF1KE3 LKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNI-PRVDKLPSNV . :. . : . : ::.. : : : . XP_016 ERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPAPDGGPREE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 LRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGA . . . : ... : .. ... :.: ..: ..:::::: .:::::::::::::. XP_016 AAATVRKEDEGAAEAKPEPGRT-RRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGS 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE3 FKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL :::::::::::::::::::::::::::: :.::::::::::::::::::::::: ::: XP_016 FKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE3 KGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLK :::.:::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 KGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLK 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE3 CDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMC ::::::::::::::::::::::: :.:::::::::::::::::::::::::::::::::: XP_016 CDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMC 330 340 350 360 370 380 340 350 360 370 380 390 pF1KE3 MLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIR ::::::::::::::::::::::::: :::::::.:: :::.:::: :: .:: :: :. XP_016 MLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIK 390 400 410 420 430 440 400 410 420 430 440 450 pF1KE3 DLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETD :::.:::::::::.:::::::: .:..::::::::::::::: ::: ::::.:.:: . XP_016 DLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKE 450 460 470 480 490 500 460 470 480 490 500 510 pF1KE3 TPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKK-PAGCLEERRD--SQCKSM ::.::: ::..:::::::: : :::::::::. :. ::. :: .:..: : :. XP_016 TPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQQDVGSPDKAR 510 520 530 540 550 560 520 530 540 550 560 570 pF1KE3 GNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAA : : ..: .: : :: :.:::. : : . .:...:. ..: . XP_016 GPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTL---PTS-ATSLASDSTFDSGQG 570 580 590 600 610 620 580 590 600 610 620 pF1KE3 SVIHSDT-SSQPSVAYSSNQTMG---SQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVS-- :...::. ::: :: .: . .: : . : .: : : : .: ::: . XP_016 STVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPS---LGAYQQPTAA 630 640 650 660 670 630 640 650 660 670 680 pF1KE3 -GLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTV---QKVP---QIKPV :: : . : : .: : :. ..: : : .:. . : .: : :. XP_016 PGLPVGS-VPAPACPPSLQ-QHFPDPAMSFAP--VLPPPSTPMPTGPGQPAPPGQQPPPL 680 690 700 710 720 730 690 700 710 720 730 740 pF1KE3 SQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKG .::. : .: :. : : : : .: . : : XP_016 AQPTPLPQ---VLAPQPVVPL-QPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQ 740 750 760 770 780 790 750 760 770 780 790 800 pF1KE3 TKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKE XP_016 VPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPA 800 810 820 830 840 850 >-- initn: 832 init1: 348 opt: 749 Z-score: 337.4 bits: 75.9 E(85289): 4.7e-12 Smith-Waterman score: 945; 25.8% identity (52.4% similar) in 1242 aa overlap (519-1676:970-2117) 490 500 510 520 530 540 pF1KE3 TPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQT--GAECEETEVDQH ::: :. : : . XP_016 PQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALP 940 950 960 970 980 990 550 560 570 580 590 600 pF1KE3 VRQQLLQRK-PQQHCSSVTGDNLSEAGAASVIHSDTSSQ-PSVAYSSNQTMGSQMVSNI- :: . :: . :.: ..: . : . :...: :.: ... . . XP_016 VRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLL 1000 1010 1020 1030 1040 1050 610 620 630 640 650 660 pF1KE3 PQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVS : : .: :. :: :. : : . : : :: : . . : ::: XP_016 PAAPELLP-QFPSSLATVSASVQSVPTQTAT-LLPPANPPLPGGPGIASPC----PTV-- 1060 1070 1080 1090 1100 1110 670 680 690 700 710 720 pF1KE3 QPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNG : : :. ... : :: . : . :. .. .::.. :: .: .. :.: XP_016 QLTVEPVQEEQASQDKPPGLPQSCESYGG-----------SDVTSGKELSDSCEGAFGGG 1120 1130 1140 1150 1160 730 740 750 760 770 pF1KE3 KQD----RIKQRRASCPRP--EKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDV . . : ..::.. : :.... .::.:.: ..::.::::::::::.::::::::. XP_016 RLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDL 1170 1180 1190 1200 1210 1220 780 790 800 810 820 830 pF1KE3 DGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDS :::::..:: :::: .:.:..:.: :.:... .. .:...: ..:.. . XP_016 DGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHL 1230 1240 1250 1260 1270 1280 840 850 860 870 880 890 pF1KE3 NSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQH-SMSA .. :..:. . ..... . .... ... :: : : . .. ..: : .:. XP_016 STCGLGTGEESRQSQANAPVYQQNVLHTGK--RW-FIICPVAEHPAPEAPESSPPLPLSS 1290 1300 1310 1320 1330 900 910 920 930 940 950 pF1KE3 VPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQ .: :. .... .: : . :. : : :. . . : . .. XP_016 LP-------PEASQDSAPYKDQLSSKEQ-PSFLASQQLLSQ-AGPSNPPGAPPAPLAPSS 1340 1350 1360 1370 1380 960 970 980 990 1000 1010 pF1KE3 PAILYQVEDNRQIMAPVTNS---SSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQ : . .:. ::.:.. . .:.: . :. .:::.. :. :.. XP_016 PPVTALPQDG---AAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLA 1390 1400 1410 1420 1430 1440 1020 1030 1040 1050 1060 pF1KE3 ADALM-----SHPG-ESTQTSGNS-----LTTLAFDQKPQTLSVQQPAMDAEFISQEGET .. :. :. :...: : : : . .:.. .. :::. . . XP_016 VQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHS-GTPQPALGQPAPLLPAAV 1450 1460 1470 1480 1490 1500 1070 1080 1090 1100 1110 1120 pF1KE3 TVNTEASSPKTVIPTQTPGLEPTTL-QPTTVLESDGERPP-KLEFADNRIKTLDEKLRNL . . :.: .: .: : ::. :: ..:::::: :: .. :.:. ::.::::::.: XP_016 GAVSLATSQ---LP--SPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTL 1510 1520 1530 1540 1550 1130 1140 1150 1160 pF1KE3 LYQEH----SISSIYPESQKDTQSIDSPFSSSAEDTLSC-------PVTEVIAISHCGIK ::::: : :. : : . :. .. . : :: . . .. . XP_016 LYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLP 1560 1570 1580 1590 1600 1610 1170 1180 1190 1200 1210 1220 pF1KE3 DSPVQSPNFQQTGSKLL-----SNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDAS . :.. .. : . .. :... :.: .. . :: ....::. XP_016 QPLVEKSELAPTRGAVMEQGTSSSMTESSPRSMLGYDRDG------------RQVASDSH 1620 1630 1640 1650 1660 1230 1240 1250 1260 1270 1280 pF1KE3 L-PGDPEAYPAAVSSGGAIHL-QTGVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMS . :. :. :: : . . . : :. : . :. . . ... ..:. .:.. XP_016 VVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLG-ARALG 1670 1680 1690 1700 1710 1720 1290 1300 1310 1320 1330 1340 pF1KE3 GSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQN . .: . : .. : . .. :.. .:. .: . .: ... .: . : .. : .. XP_016 SPRKRPEQQDVSSPAKTVGR---FSV--VSTQDEWTLASPHSLRYSAPPD-VYLDEAPSS 1730 1740 1750 1760 1770 1780 1350 1360 1370 1380 1390 1400 pF1KE3 PKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSM : .... .. :. . . . : : ..:. . . : .. ..:: XP_016 PDVKLAVRRAQT-ASSIEVGVGEPVSSDS-------GDEGPRARPPVQKQASLPVSGSV- 1790 1800 1810 1820 1830 1410 1420 1430 1440 1450 1460 pF1KE3 QSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQ ..... : .: ..:: ::: :::. : . . . XP_016 --AGDFVKKATAFL---QRPSR--------AGS------LGPET----PSRVGMKVPTIS 1840 1850 1860 1470 1480 1490 1500 1510 1520 pF1KE3 SSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSI . :.: :: .:::..::.:: :.: ::: :::::..:. .::.::..:.. ::.:: XP_016 VTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLG-- 1870 1880 1890 1900 1910 1920 1530 1540 1550 1560 1570 pF1KE3 KDSKTQSTEIPLPPASPRRPRSFKSKLRS--------RPQSLTHVDNGIVATDPLCV--E : . . : . :: .. ::::.. : ... ..: : ::. : XP_016 KPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTG-SALKRLCLGKE 1930 1940 1950 1960 1970 1980 1580 1590 1600 1610 pF1KE3 SNAASCQQS----------PA-----------SKKGMFTDDLHKLVDDWTKEAVGNSLIK .. : .: :: .::: ::::::::::.::...:: . .: XP_016 HSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLK 1990 2000 2010 2020 2030 2040 1620 1630 1640 1650 1660 pF1KE3 PSLNQLKQSQHKLETE---NWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQG---- :.::::::.:. . : .: .: : ... . : : . :.. : XP_016 PTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPT 2050 2060 2070 2080 2090 2100 1670 1680 1690 1700 1710 1720 pF1KE3 LSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNM ::.:. : :.. XP_016 LSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQRVGSKTASFAASDPVRS 2110 2120 2130 2140 2150 2160 1743 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:36:33 2016 done: Sat Nov 5 22:36:36 2016 Total Scan time: 18.850 Total Display time: 1.530 Function used was FASTA [36.3.4 Apr, 2011]