Result of FASTA (omim) for
pFN21AB4989
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4989, 261 aa
1>>>pF1KB4989 261 - 261 aa - 261 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0055+/-0.000438; mu= 12.3423+/- 0.028
mean_var=101.1470+/-19.736, 0's: 0 Z-trim(114.0): 103 B-trim: 654 in 2/51
Lambda= 0.127526
statistics sampled from 23583 (23688) to 23583 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.634), E-opt: 0.2 (0.278), width: 16
Scan time: 6.480
The best scores are: opt bits E(85289)
NP_004920 (OMIM: 114050) calbindin [Homo sapiens] ( 261) 1717 326.2 3.7e-89
NP_001731 (OMIM: 114051) calretinin isoform 1 [Hom ( 271) 1034 200.6 2.5e-51
NP_009019 (OMIM: 114051) calretinin isoform 22k [H ( 192) 642 128.3 1e-29
NP_008929 (OMIM: 609202) secretagogin [Homo sapien ( 276) 561 113.5 4e-25
XP_016865670 (OMIM: 609202) PREDICTED: secretagogi ( 222) 488 100.0 3.8e-21
>>NP_004920 (OMIM: 114050) calbindin [Homo sapiens] (261 aa)
initn: 1717 init1: 1717 opt: 1717 Z-score: 1721.7 bits: 326.2 E(85289): 3.7e-89
Smith-Waterman score: 1717; 100.0% identity (100.0% similar) in 261 aa overlap (1-261:1-261)
10 20 30 40 50 60
pF1KB4 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGLELSPEMKT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIET
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 FQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMA
190 200 210 220 230 240
250 260
pF1KB4 LSDGGKLYRTDLALILCAGDN
:::::::::::::::::::::
NP_004 LSDGGKLYRTDLALILCAGDN
250 260
>>NP_001731 (OMIM: 114051) calretinin isoform 1 [Homo sa (271 aa)
initn: 1227 init1: 702 opt: 1034 Z-score: 1042.4 bits: 200.6 E(85289): 2.5e-51
Smith-Waterman score: 1034; 58.7% identity (86.9% similar) in 259 aa overlap (5-258:10-267)
10 20 30 40 50
pF1KB4 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGL---
.:. . .:::::.::: ::::::.::.:::::.:..:::..::: .:.
NP_001 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB4 --ELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKY
... .:: :...: . .:::: ..:::..::::::::: :: :.. : :::..::::
NP_001 SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFR-QHVGSSAEFMEAWRKY
70 80 90 100 110
120 130 140 150 160 170
pF1KB4 DTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARL
:::.::.::..:::.::.:::.:::. :. :: :::. .:..:: :.:::: :.::.::
NP_001 DTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 LPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINN
:::::::::::::.:. ..::: : .::.: .:::::.::::::::: ::::....:..
NP_001 LPVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQ
180 190 200 210 220 230
240 250 260
pF1KB4 ITTYKKNIMALSDGGKLYRTDLALILCAGDN
.:.:.:..:.:...::::: :: ..::.
NP_001 LTNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM
240 250 260 270
>>NP_009019 (OMIM: 114051) calretinin isoform 22k [Homo (192 aa)
initn: 644 init1: 310 opt: 642 Z-score: 654.7 bits: 128.3 E(85289): 1e-29
Smith-Waterman score: 642; 56.7% identity (84.8% similar) in 171 aa overlap (5-170:10-179)
10 20 30 40 50
pF1KB4 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQARKKAGL---
.:. . .:::::.::: ::::::.::.:::::.:..:::..::: .:.
NP_009 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB4 --ELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKY
... .:: :...: . .:::: ..:::..::::::::: :: :.. : :::..::::
NP_009 SDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFR-QHVGSSAEFMEAWRKY
70 80 90 100 110
120 130 140 150 160 170
pF1KB4 DTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARL
:::.::.::..:::.::.:::.:::. :. :: :::. .:..:: :.:::: :.::.:.
NP_009 DTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 LPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDINN
NP_009 EAATLTSMSWMPF
180 190
>>NP_008929 (OMIM: 609202) secretagogin [Homo sapiens] (276 aa)
initn: 352 init1: 352 opt: 561 Z-score: 572.0 bits: 113.5 E(85289): 4e-25
Smith-Waterman score: 561; 37.6% identity (66.5% similar) in 263 aa overlap (11-259:12-271)
10 20 30 40 50
pF1KB4 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQ----NLIQELQQARKKAGLELS
. :. :...: .:::: .::.: :::. .....: .:
NP_008 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB4 PEMKTFVDQYGQRDDGKIGIVELAHVLPTE-ENFLLLFRCQQ-LKSCEEFMKTWRKYDTD
. :. ::.: . ::: .. .: :::::::: .. : : :::. :::::.:
NP_008 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB4 HSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPV
:::: . ::.:::.::. . .:.....:: ::: :.:.:: :.::.:.:...::.: .
NP_008 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL
130 140 150 160 170 180
180 190 200 210 220
pF1KB4 QENFLLKFQGIKMCGKE-----FNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDI
::::::.:. . :. : :.: : :: . .: .. :.:...::. : . ...
NP_008 QENFLLQFK-MDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISG
190 200 210 220 230
230 240 250 260
pF1KB4 NNITTYKKNIMALSD---GGKLYRTDLALILCAGDN
.. ... .. : ::. ...:: :: :
NP_008 VDLDKFREILLRHCDVNKDGKIQKSELA--LCLGLKINP
240 250 260 270
>>XP_016865670 (OMIM: 609202) PREDICTED: secretagogin is (222 aa)
initn: 352 init1: 352 opt: 488 Z-score: 500.7 bits: 100.0 E(85289): 3.8e-21
Smith-Waterman score: 488; 39.8% identity (68.7% similar) in 211 aa overlap (59-259:10-217)
30 40 50 60 70 80
pF1KB4 GYLEGKELQNLIQELQQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTE-EN
. :. ::.: . ::: .. .: ::
XP_016 MKANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDEN
10 20 30
90 100 110 120 130 140
pF1KB4 FLLLFRCQQ-LKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEY
:::::: .. : : :::. :::::.: :::: . ::.:::.::. . .:.....:: ::
XP_016 FLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEY
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB4 TDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKE-----FNKAFELYDQD
: :.:.:: :.::.:.:...::.: .::::::.:. . :. : :.: : :: .
XP_016 TGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFK-MDACSTEERKRDFEKIFAYYDVS
100 110 120 130 140 150
210 220 230 240 250
pF1KB4 GNGYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMALSD---GGKLYRTDLALILCA
.: .. :.:...::. : . ... .. ... .. : ::. ...:: ::
XP_016 KTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELA--LCL
160 170 180 190 200 210
260
pF1KB4 GDN
:
XP_016 GLKINP
220
261 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:11:55 2016 done: Sat Nov 5 06:11:56 2016
Total Scan time: 6.480 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]