Result of FASTA (omim) for
pFN21AE3971
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3971, 454 aa
1>>>pF1KE3971 454 - 454 aa - 454 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2687+/-0.000409; mu= -1.1374+/- 0.025
mean_var=291.1317+/-59.533, 0's: 0 Z-trim(119.5): 169 B-trim: 0 in 0/52
Lambda= 0.075167
statistics sampled from 34656 (34888) to 34656 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.378), width: 16
Scan time: 4.830
The best scores are: opt bits E(92320)
NP_001017408 (OMIM: 606845) Golgi-associated PDZ a ( 454) 2996 338.8 2e-92
NP_065132 (OMIM: 606845) Golgi-associated PDZ and ( 462) 2970 335.9 1.4e-91
XP_024302264 (OMIM: 606845) Golgi-associated PDZ a ( 293) 1946 224.7 2.8e-58
NP_006741 (OMIM: 600027) beta-2-syntrophin [Homo s ( 540) 275 43.8 0.0015
XP_011515541 (OMIM: 600026) beta-1-syntrophin isof ( 382) 263 42.3 0.0029
NP_066301 (OMIM: 600026) beta-1-syntrophin [Homo s ( 538) 263 42.5 0.0037
XP_006723386 (OMIM: 612331) protein lin-7 homolog ( 183) 250 40.6 0.0047
NP_071448 (OMIM: 612331) protein lin-7 homolog B i ( 207) 250 40.6 0.0051
NP_060832 (OMIM: 612332) protein lin-7 homolog C [ ( 197) 245 40.1 0.0072
NP_004655 (OMIM: 603380) protein lin-7 homolog A i ( 233) 244 40.0 0.0087
>>NP_001017408 (OMIM: 606845) Golgi-associated PDZ and c (454 aa)
initn: 2996 init1: 2996 opt: 2996 Z-score: 1780.9 bits: 338.8 E(92320): 2e-92
Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 454 aa overlap (1-454:1-454)
10 20 30 40 50 60
pF1KE3 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD
370 380 390 400 410 420
430 440 450
pF1KE3 THENGDLGTASETPLDDGASKLDDLHTLYHKKSY
::::::::::::::::::::::::::::::::::
NP_001 THENGDLGTASETPLDDGASKLDDLHTLYHKKSY
430 440 450
>>NP_065132 (OMIM: 606845) Golgi-associated PDZ and coil (462 aa)
initn: 2023 init1: 2023 opt: 2970 Z-score: 1765.6 bits: 335.9 E(92320): 1.4e-91
Smith-Waterman score: 2970; 98.3% identity (98.3% similar) in 462 aa overlap (1-454:1-462)
10 20 30 40 50 60
pF1KE3 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
70 80 90 100 110 120
130 140 150 160 170
pF1KE3 DQLLQLHSIQLQLHAKTGQSADSGTIKAKL--------ERELEANKKEKMKEAQLEAEVK
:::::::::::::::::::::::::::::: ::::::::::::::::::::::
NP_065 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
370 380 390 400 410 420
420 430 440 450
pF1KE3 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
::::::::::::::::::::::::::::::::::::::::::
NP_065 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
430 440 450 460
>>XP_024302264 (OMIM: 606845) Golgi-associated PDZ and c (293 aa)
initn: 1946 init1: 1946 opt: 1946 Z-score: 1167.9 bits: 224.7 E(92320): 2.8e-58
Smith-Waterman score: 1946; 100.0% identity (100.0% similar) in 293 aa overlap (162-454:1-293)
140 150 160 170 180 190
pF1KE3 QLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAE
::::::::::::::::::::::::::::::
XP_024 MKEAQLEAEVKLLRKENEALRRHIAVLQAE
10 20 30
200 210 220 230 240 250
pF1KE3 VYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGR
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE3 NDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIH
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE3 PGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 PGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDE
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE3 NVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTAS
220 230 240 250 260 270
440 450
pF1KE3 ETPLDDGASKLDDLHTLYHKKSY
:::::::::::::::::::::::
XP_024 ETPLDDGASKLDDLHTLYHKKSY
280 290
>>NP_006741 (OMIM: 600027) beta-2-syntrophin [Homo sapie (540 aa)
initn: 348 init1: 275 opt: 275 Z-score: 185.2 bits: 43.8 E(92320): 0.0015
Smith-Waterman score: 275; 41.7% identity (72.8% similar) in 103 aa overlap (260-362:95-197)
230 240 250 260 270 280
pF1KE3 NQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHE
.::. . .. . :.:.: ..:..
NP_006 PAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAG
70 80 90 100 110 120
290 300 310 320 330 340
pF1KE3 GLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILS
:::::: ::.:. .:::::.: :: ::. .:..:::::.:::..::.. : .:: :.
NP_006 GLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALK
130 140 150 160 170 180
350 360 370 380 390 400
pF1KE3 QQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKV
. :. .:: ..
NP_006 RAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRK
190 200 210 220 230 240
>>XP_011515541 (OMIM: 600026) beta-1-syntrophin isoform (382 aa)
initn: 287 init1: 255 opt: 263 Z-score: 180.1 bits: 42.3 E(92320): 0.0029
Smith-Waterman score: 263; 53.6% identity (75.0% similar) in 84 aa overlap (279-362:111-194)
250 260 270 280 290 300
pF1KE3 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS
: : .::.. :::::: ::::. .:::::
XP_011 GAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILIS
90 100 110 120 130 140
310 320 330 340 350 360
pF1KE3 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS
.: : ::. .:.::::::.:::..:::. : ::: :.. :. .:: :.
XP_011 KIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPY
150 160 170 180 190 200
370 380 390 400 410 420
pF1KE3 DDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLG
XP_011 VKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADP
210 220 230 240 250 260
>>NP_066301 (OMIM: 600026) beta-1-syntrophin [Homo sapie (538 aa)
initn: 287 init1: 255 opt: 263 Z-score: 178.2 bits: 42.5 E(92320): 0.0037
Smith-Waterman score: 263; 53.6% identity (75.0% similar) in 84 aa overlap (279-362:111-194)
250 260 270 280 290 300
pF1KE3 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS
: : .::.. :::::: ::::. .:::::
NP_066 GAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILIS
90 100 110 120 130 140
310 320 330 340 350 360
pF1KE3 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS
.: : ::. .:.::::::.:::..:::. : ::: :.. :. .:: :.
NP_066 KIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPY
150 160 170 180 190 200
370 380 390 400 410 420
pF1KE3 DDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLG
NP_066 VKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADP
210 220 230 240 250 260
>>XP_006723386 (OMIM: 612331) protein lin-7 homolog B is (183 aa)
initn: 250 init1: 228 opt: 250 Z-score: 176.5 bits: 40.6 E(92320): 0.0047
Smith-Waterman score: 250; 41.6% identity (69.9% similar) in 113 aa overlap (272-384:61-170)
250 260 270 280 290 300
pF1KE3 KTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEH
:.: . : : : : : ::::..: ::::.
XP_006 PPQKLQALQRVLQSRFCSAIREATVAAFTASEGHAHPRVVELPKTD-EGLGFNIMGGKEQ
40 50 60 70 80
310 320 330 340 350 360
pF1KE3 GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVY
. :: ::.. :: ::: :::. :: .:.::::... .:..:: .:. .: ... ::
XP_006 NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL-VVR
90 100 110 120 130 140
370 380 390 400 410 420
pF1KE3 VAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDT
.:.: .. ....: . : :
XP_006 YTPRV-LEEMEARFEKMRSARRRQQHQSYSSLESRG
150 160 170 180
>>NP_071448 (OMIM: 612331) protein lin-7 homolog B isofo (207 aa)
initn: 250 init1: 228 opt: 250 Z-score: 175.8 bits: 40.6 E(92320): 0.0051
Smith-Waterman score: 250; 41.6% identity (69.9% similar) in 113 aa overlap (272-384:85-194)
250 260 270 280 290 300
pF1KE3 KTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEH
:.: . : : : : : ::::..: ::::.
NP_071 EQLYDTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTD-EGLGFNIMGGKEQ
60 70 80 90 100 110
310 320 330 340 350 360
pF1KE3 GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVY
. :: ::.. :: ::: :::. :: .:.::::... .:..:: .:. .: ... ::
NP_071 NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL-VVR
120 130 140 150 160 170
370 380 390 400 410 420
pF1KE3 VAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDT
.:.: .. ....: . : :
NP_071 YTPRV-LEEMEARFEKMRSARRRQQHQSYSSLESRG
180 190 200
>>NP_060832 (OMIM: 612332) protein lin-7 homolog C [Homo (197 aa)
initn: 253 init1: 229 opt: 245 Z-score: 173.1 bits: 40.1 E(92320): 0.0072
Smith-Waterman score: 245; 41.7% identity (73.8% similar) in 103 aa overlap (280-382:92-193)
250 260 270 280 290 300
pF1KE3 GRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISE
.:. : . .::::..: ::::.. :: ::.
NP_060 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISR
70 80 90 100 110 120
310 320 330 340 350 360
pF1KE3 IHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSD
: :: ::: :::. :: .:.::::... .:..:: .:. .:.... :: .:.: .
NP_060 IIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKL-VVRYTPKVLEE
130 140 150 160 170 180
370 380 390 400 410 420
pF1KE3 DENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGT
:. . .:..:
NP_060 MESRFEKMRSAKRRQQT
190
>>NP_004655 (OMIM: 603380) protein lin-7 homolog A isofo (233 aa)
initn: 252 init1: 213 opt: 244 Z-score: 171.6 bits: 40.0 E(92320): 0.0087
Smith-Waterman score: 252; 31.1% identity (60.7% similar) in 196 aa overlap (202-384:25-209)
180 190 200 210 220
pF1KE3 KLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAH--DKLW
::...: .. .. : .. . :.: ..:
NP_004 MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLK
10 20 30 40 50
230 240 250 260 270
pF1KE3 NQLEAE-------IHLHRHKTV-IRAC---RGRNDLKRPMQAPPGHDQDSLKKSQGVGPI
. :..: .. . :.:. . .: :.: : . : . :.: .
NP_004 KVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAA--------FAASEGHSHP
60 70 80 90 100
280 290 300 310 320 330
pF1KE3 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD
: : : : : ::::... ::::.. :: ::.: :: :.: :::. :: .:.::::...
NP_004 RVVELPKTD-EGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG
110 120 130 140 150 160
340 350 360 370 380 390
pF1KE3 TKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGA
.:..:: .:. . ... :: .:.: .. ....: : :
NP_004 EHHEKAVELLKAAKDSVKL-VVRYTPKV-LEEMEARFEKLRTARRRQQQQLLIQQQQQQQ
170 180 190 200 210 220
400 410 420 430 440 450
pF1KE3 SCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
NP_004 QQQTQQNHMS
230
454 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:28:54 2019 done: Thu Oct 24 21:28:55 2019
Total Scan time: 4.830 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]