Result of FASTA (omim) for
pFN21AB4651
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4651, 278 aa
1>>>pF1KB4651 278 - 278 aa - 278 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7734+/-0.000372; mu= 18.4166+/- 0.023
mean_var=70.4683+/-14.157, 0's: 0 Z-trim(113.8): 68 B-trim: 0 in 0/53
Lambda= 0.152784
statistics sampled from 23194 (23262) to 23194 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.273), width: 16
Scan time: 6.820
The best scores are: opt bits E(85289)
NP_060294 (OMIM: 610637) E3 ubiquitin-protein liga ( 278) 1906 429.1 4.5e-120
XP_011538188 (OMIM: 610637) PREDICTED: E3 ubiquiti ( 204) 1312 298.0 9.3e-81
NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402) 170 46.6 9.1e-05
XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 161 44.5 0.00028
NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291) 161 44.5 0.00028
XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 161 44.5 0.00028
NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291) 161 44.5 0.00028
XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 161 44.7 0.00046
XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 161 44.7 0.00046
XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 161 44.7 0.00046
XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 161 44.7 0.00046
XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 161 44.7 0.00046
NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573) 161 44.7 0.00046
NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272) 157 43.6 0.0005
XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 157 43.6 0.00051
XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 157 43.6 0.00051
NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289) 157 43.6 0.00052
XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289) 157 43.6 0.00052
XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545) 157 43.8 0.00082
NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410) 153 42.8 0.0012
NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346) 152 42.6 0.0013
>>NP_060294 (OMIM: 610637) E3 ubiquitin-protein ligase M (278 aa)
initn: 1906 init1: 1906 opt: 1906 Z-score: 2276.7 bits: 429.1 E(85289): 4.5e-120
Smith-Waterman score: 1906; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278)
10 20 30 40 50 60
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 VMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 SIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTIL
190 200 210 220 230 240
250 260 270
pF1KB4 GGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
::::::::::::::::::::::::::::::::::::::
NP_060 GGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
250 260 270
>>XP_011538188 (OMIM: 610637) PREDICTED: E3 ubiquitin-pr (204 aa)
initn: 1312 init1: 1312 opt: 1312 Z-score: 1570.9 bits: 298.0 E(85289): 9.3e-81
Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 199 aa overlap (80-278:6-204)
50 60 70 80 90 100
pF1KB4 WVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSI
::::::::::::::::::::::::::::::
XP_011 MHKQRGPVVYVLDLADRLISKACPFAAAGIMVGSI
10 20 30
110 120 130 140 150 160
pF1KB4 YWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLW
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB4 RKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFS
100 110 120 130 140 150
230 240 250 260 270
pF1KB4 SVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
160 170 180 190 200
>>NP_001096032 (OMIM: 613338) E3 ubiquitin-protein ligas (402 aa)
initn: 152 init1: 129 opt: 170 Z-score: 206.6 bits: 46.6 E(85289): 9.1e-05
Smith-Waterman score: 189; 26.3% identity (53.2% similar) in 171 aa overlap (14-180:170-323)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .:: :. .: . :::: ::....:
NP_001 ETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQ---GELLNPCRCDGSVRYTH
140 150 160 170 180 190
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAG
: :: .:..: ::. : : : .: .. :. ... :. :. .:
NP_001 QLCLLKWISE--RGSWT----CELCCYRYHVIAIKMKQPCQWQSISITLVEKVQMIA---
200 210 220 230 240
110 120 130 140 150 160
pF1KB4 IMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLL-IGLPTIPVMLILGKMIRWE
...::.. : .:: . . . : .: : :: . :. . .. .: ...
NP_001 VILGSLFLIA----SVTWLLWSAFSP-YAVWQRKDILFQICYGMYGFMDLVCIGLIVHEG
250 260 270 280 290 300
170 180 190 200 210
pF1KB4 DYVLRL---WRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
: :. :: . . ..::
NP_001 AAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPTQL
310 320 330 340 350 360
>>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa)
initn: 120 init1: 120 opt: 161 Z-score: 197.7 bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
XP_011 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
XP_011 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
110 120 130 140 150 160
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
XP_011 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
170 180 190 200 210
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
XP_011 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
220 230 240 250 260 270
>>NP_001002266 (OMIM: 613335) E3 ubiquitin-protein ligas (291 aa)
initn: 120 init1: 120 opt: 161 Z-score: 197.7 bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
NP_001 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
NP_001 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
110 120 130 140 150 160
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
NP_001 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
170 180 190 200 210
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
NP_001 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
220 230 240 250 260 270
>>XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa)
initn: 120 init1: 120 opt: 161 Z-score: 197.7 bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
XP_016 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
XP_016 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
110 120 130 140 150 160
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
XP_016 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
170 180 190 200 210
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
XP_016 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
220 230 240 250 260 270
>>NP_659458 (OMIM: 613335) E3 ubiquitin-protein ligase M (291 aa)
initn: 120 init1: 120 opt: 161 Z-score: 197.7 bits: 44.5 E(85289): 0.00028
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:80-242)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
NP_659 SKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDE--SPLITPCHCTGSLHFVH
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
NP_659 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
110 120 130 140 150 160
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
NP_659 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
170 180 190 200 210
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
NP_659 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
220 230 240 250 260 270
>>XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa)
initn: 120 init1: 120 opt: 161 Z-score: 193.9 bits: 44.7 E(85289): 0.00046
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:362-524)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
XP_011 STEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE--SPLITPCHCTGSLHFVH
340 350 360 370 380
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
XP_011 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
390 400 410 420 430 440
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
XP_011 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
450 460 470 480 490
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
XP_011 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
500 510 520 530 540 550
>>XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa)
initn: 120 init1: 120 opt: 161 Z-score: 193.9 bits: 44.7 E(85289): 0.00046
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:362-524)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
XP_011 STEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE--SPLITPCHCTGSLHFVH
340 350 360 370 380
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
XP_011 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
390 400 410 420 430 440
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
XP_011 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
450 460 470 480 490
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
XP_011 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
500 510 520 530 540 550
>>XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa)
initn: 120 init1: 120 opt: 161 Z-score: 193.9 bits: 44.7 E(85289): 0.00046
Smith-Waterman score: 164; 23.9% identity (48.3% similar) in 180 aa overlap (14-189:362-524)
10 20 30 40
pF1KB4 MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVH
: .: .:. . . ::.: :: ..::
XP_005 STEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE--SPLITPCHCTGSLHFVH
340 350 360 370 380
50 60 70 80 90 100
pF1KB4 QACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYV--LDLADRLISKA-CPFA
:::::.:. .:. : :. :. :. :: :. :.... : : .
XP_005 QACLQQWI------KSSDTRCCELCKYEF-IMETKLKPLRKWEKLQMTSSERRKIMCSVT
390 400 410 420 430 440
110 120 130 140 150
pF1KB4 AAGIMVGSIYWTAVTYGAVTVMQVV-GHKEGLDVMERADPLFLLIGLPTIPVMLILGKMI
: . . :. . :. .. :. : ..: :.. . . .: : :
XP_005 FHVIAITCVVWSLYVLIDRTAEEIKQGQATG--ILEW--PFWTKLVVVAIGFTGGLLFMY
450 460 470 480 490
160 170 180 190 200 210
pF1KB4 RWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTI
..::.. :. : .. .::
XP_005 VQCKVYVQLWKR----LKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSD
500 510 520 530 540 550
278 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 05:57:07 2016 done: Sat Nov 5 05:57:08 2016
Total Scan time: 6.820 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]