FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4319, 325 aa 1>>>pF1KE4319 325 - 325 aa - 325 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3864+/-0.000363; mu= 15.5291+/- 0.023 mean_var=70.2915+/-14.311, 0's: 0 Z-trim(113.7): 38 B-trim: 0 in 0/49 Lambda= 0.152976 statistics sampled from 23091 (23129) to 23091 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.271), width: 16 Scan time: 7.830 The best scores are: opt bits E(85289) NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 2218 498.6 7.2e-141 NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 2218 498.6 7.2e-141 NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 2218 498.6 7.2e-141 NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 2218 498.6 7.2e-141 XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 1473 334.1 1.6e-91 XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 1473 334.1 1.6e-91 NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 1080 247.4 2.8e-65 NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1055 241.9 1.3e-63 XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 1016 233.3 5.1e-61 XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 932 214.8 2.1e-55 NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 932 214.8 2.1e-55 NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 922 212.6 9.1e-55 NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 918 211.7 1.7e-54 NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 918 211.7 1.7e-54 NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 914 210.8 3.1e-54 NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 906 209.1 1.1e-53 NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 870 201.1 2.6e-51 NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 866 200.2 4.8e-51 NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 786 182.5 9e-46 XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 631 148.3 1.7e-35 XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 567 134.1 2.1e-31 NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 567 134.1 2.1e-31 XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 497 118.6 9.4e-27 XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 492 117.7 3.1e-26 NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 485 116.1 9.1e-26 NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 418 101.3 2.5e-21 NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 356 87.5 1.8e-17 NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 334 82.6 5.2e-16 >>NP_001189342 (OMIM: 103830) alcohol dehydrogenase [NAD (325 aa) initn: 2218 init1: 2218 opt: 2218 Z-score: 2650.0 bits: 498.6 E(85289): 7.2e-141 Smith-Waterman score: 2218; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 250 260 270 280 290 300 310 320 pF1KE4 PMLTVDGKRVPRDAGHPLYPFNDPY ::::::::::::::::::::::::: NP_001 PMLTVDGKRVPRDAGHPLYPFNDPY 310 320 >>NP_001189343 (OMIM: 103830) alcohol dehydrogenase [NAD (325 aa) initn: 2218 init1: 2218 opt: 2218 Z-score: 2650.0 bits: 498.6 E(85289): 7.2e-141 Smith-Waterman score: 2218; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 250 260 270 280 290 300 310 320 pF1KE4 PMLTVDGKRVPRDAGHPLYPFNDPY ::::::::::::::::::::::::: NP_001 PMLTVDGKRVPRDAGHPLYPFNDPY 310 320 >>NP_006057 (OMIM: 103830) alcohol dehydrogenase [NADP(+ (325 aa) initn: 2218 init1: 2218 opt: 2218 Z-score: 2650.0 bits: 498.6 E(85289): 7.2e-141 Smith-Waterman score: 2218; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 250 260 270 280 290 300 310 320 pF1KE4 PMLTVDGKRVPRDAGHPLYPFNDPY ::::::::::::::::::::::::: NP_006 PMLTVDGKRVPRDAGHPLYPFNDPY 310 320 >>NP_697021 (OMIM: 103830) alcohol dehydrogenase [NADP(+ (325 aa) initn: 2218 init1: 2218 opt: 2218 Z-score: 2650.0 bits: 498.6 E(85289): 7.2e-141 Smith-Waterman score: 2218; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_697 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_697 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_697 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_697 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_697 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 250 260 270 280 290 300 310 320 pF1KE4 PMLTVDGKRVPRDAGHPLYPFNDPY ::::::::::::::::::::::::: NP_697 PMLTVDGKRVPRDAGHPLYPFNDPY 310 320 >>XP_011538794 (OMIM: 103830) PREDICTED: alcohol dehydro (214 aa) initn: 1473 init1: 1473 opt: 1473 Z-score: 1764.1 bits: 334.1 E(85289): 1.6e-91 Smith-Waterman score: 1473; 100.0% identity (100.0% similar) in 214 aa overlap (112-325:1-214) 90 100 110 120 130 140 pF1KE4 WNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYK :::::::::::::::::::::::::::::: XP_011 MHWPYAFERGDNPFPKNADGTICYDSTHYK 10 20 30 150 160 170 180 190 200 pF1KE4 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQ 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE4 ARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICI 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE4 PKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPF 160 170 180 190 200 210 pF1KE4 NDPY :::: XP_011 NDPY >>XP_011538793 (OMIM: 103830) PREDICTED: alcohol dehydro (214 aa) initn: 1473 init1: 1473 opt: 1473 Z-score: 1764.1 bits: 334.1 E(85289): 1.6e-91 Smith-Waterman score: 1473; 100.0% identity (100.0% similar) in 214 aa overlap (112-325:1-214) 90 100 110 120 130 140 pF1KE4 WNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYK :::::::::::::::::::::::::::::: XP_011 MHWPYAFERGDNPFPKNADGTICYDSTHYK 10 20 30 150 160 170 180 190 200 pF1KE4 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQ 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE4 ARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICI 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE4 PKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPF 160 170 180 190 200 210 pF1KE4 NDPY :::: XP_011 NDPY >>NP_001619 (OMIM: 103880) aldose reductase isoform 1 [H (316 aa) initn: 1076 init1: 484 opt: 1080 Z-score: 1292.8 bits: 247.4 E(85289): 2.8e-65 Smith-Waterman score: 1087; 49.5% identity (75.7% similar) in 325 aa overlap (3-325:2-316) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :: .::..: :::..::::::: :::: ::: :..::::::::: .: :: :.: :. NP_001 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAI 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER .: . ..: :::::..:::: : :. :. : .:::.::.:.::::::.::: .:. NP_001 QEKLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKP 60 70 80 90 100 110 130 140 150 160 170 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR- : . :: . .:.. ..:. .:: :.: :: .:::.:.:.:::: :.. ::. ... NP_001 GKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 -PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALA ::: :.::::::.:..:: .::..:. ::::::::: :: : :..: :::.: . :.: NP_001 KPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY :.... ::.:.:. .::... ::::.:: :: .:.::::: .: ..: : . :.::: NP_001 AKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWR- 240 250 260 270 280 290 300 310 320 pF1KE4 IVPMLTVDGKRVPRDAGHPLYPFNDPY . .:. ..: :::.. . NP_001 VCALLSC--------TSHKDYPFHEEF 300 310 >>NP_064695 (OMIM: 604707) aldo-keto reductase family 1 (316 aa) initn: 1097 init1: 486 opt: 1055 Z-score: 1263.0 bits: 241.9 E(85289): 1.3e-63 Smith-Waterman score: 1055; 51.5% identity (77.8% similar) in 297 aa overlap (3-297:2-297) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :. : : : :::..::::::: :.:: ::: :...:::::::: .: :: :.:::. NP_064 MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAI 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER .: . ::: ::.::..:::: : . :. :..::: ::.: :::.::.::: .:. NP_064 QEKIQE-KAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKS 60 70 80 90 100 110 130 140 150 160 170 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR- ::. :::. :. .. . ..:.:.: :: .:::.:::.:::. ::. .:. ... NP_064 GDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 -PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALA :.. ::::::::.:..:: .:...:. ::::::::: :: : :..: :::.: . .: NP_064 KPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY :. .. ::.:.:...::.:: ::::.::.::..::.:::: .: ::: . ..:.::: NP_064 AKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRA 240 250 260 270 280 290 300 310 320 pF1KE4 IVPMLTVDGKRVPRDAGHPLYPFNDPY NP_064 CNVLQSSHLEDYPFNAEY 300 310 >>XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto reduc (316 aa) initn: 1034 init1: 471 opt: 1016 Z-score: 1216.5 bits: 233.3 E(85289): 5.1e-61 Smith-Waterman score: 1016; 49.8% identity (77.1% similar) in 297 aa overlap (3-297:2-297) 10 20 30 40 50 60 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL :. : : : :::..:::::.: :.:: ::: :... ::::::: .: :. :.:::. XP_011 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAI 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER .: . ::: ::.::..::.: : . :. :..::: ::.: :::.::.::: .:. XP_011 QEKIQE-KAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKT 60 70 80 90 100 110 130 140 150 160 170 pF1KE4 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR- ::. :::. :.. . . ..:.:.: :: .:::.:::.:::: ::. .:. ... XP_011 GDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 -PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALA :.. ::::::::.:..:: .:...:. ::::::::: :: : :..: :::.: . .: XP_011 KPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY :. .. ::.:.:...::.: ::::.::..:..::.:::: .: ::: . ..:.::: XP_011 AKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRA 240 250 260 270 280 290 300 310 320 pF1KE4 IVPMLTVDGKRVPRDAGHPLYPFNDPY XP_011 FDFKEFSHLEDFPFDAEY 300 310 >>XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto reduc (344 aa) initn: 963 init1: 471 opt: 932 Z-score: 1115.8 bits: 214.8 E(85289): 2.1e-55 Smith-Waterman score: 932; 49.5% identity (77.7% similar) in 273 aa overlap (27-297:54-325) 10 20 30 40 50 pF1KE4 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEI :.:: ::: :... ::::::: .: :. :. XP_016 VGPLTGLKSSLLKDTTSAGPLLRPYPASLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEV 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE4 GEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY :::..: . ::: ::.::..::.: : . :. :..::: ::.: :::.::.::: XP_016 GEAIQEKIQE-KAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQ 90 100 110 120 130 140 120 130 140 150 160 170 pF1KE4 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA .:. ::. :::. :.. . . ..:.:.: :: .:::.:::.:::: ::. .:. XP_016 GFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKP 150 160 170 180 190 200 180 190 200 210 220 230 pF1KE4 SVR--PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVV ... :.. ::::::::.:..:: .:...:. ::::::::: :: : :..: :::.: . XP_016 GLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKI 210 220 230 240 250 260 240 250 260 270 280 290 pF1KE4 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK .: :. .. ::.:.:...::.: ::::.::..:..::.:::: .: ::: . ..:. XP_016 KEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNR 270 280 290 300 310 320 300 310 320 pF1KE4 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY ::: XP_016 NWRAFDFKEFSHLEDFPFDAEY 330 340 325 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:11:56 2016 done: Sat Nov 5 23:11:57 2016 Total Scan time: 7.830 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]