Result of FASTA (omim) for
pFN21AB3718
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3718, 165 aa
1>>>pF1KB3718 165 - 165 aa - 165 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7402+/-0.000333; mu= 15.1569+/- 0.021
mean_var=57.7870+/-11.569, 0's: 0 Z-trim(113.9): 23 B-trim: 114 in 1/49
Lambda= 0.168717
statistics sampled from 23444 (23467) to 23444 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.275), width: 16
Scan time: 4.730
The best scores are: opt bits E(85289)
XP_011527445 (OMIM: 609114) PREDICTED: destrin iso ( 165) 1109 277.8 5.5e-75
NP_006861 (OMIM: 609114) destrin isoform a [Homo s ( 165) 1109 277.8 5.5e-75
XP_011527444 (OMIM: 609114) PREDICTED: destrin iso ( 165) 1109 277.8 5.5e-75
XP_011527446 (OMIM: 609114) PREDICTED: destrin iso ( 148) 994 249.8 1.4e-66
NP_001011546 (OMIM: 609114) destrin isoform b [Hom ( 148) 994 249.8 1.4e-66
NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] ( 166) 780 197.7 7.1e-51
NP_619579 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 755 191.6 4.8e-49
NP_068733 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 755 191.6 4.8e-49
NP_001230574 (OMIM: 601443,610687) cofilin-2 isofo ( 149) 684 174.3 7.1e-44
XP_011534665 (OMIM: 601443,610687) PREDICTED: cofi ( 149) 684 174.3 7.1e-44
NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens ( 349) 138 41.7 0.0014
>>XP_011527445 (OMIM: 609114) PREDICTED: destrin isoform (165 aa)
initn: 1109 init1: 1109 opt: 1109 Z-score: 1467.2 bits: 277.8 E(85289): 5.5e-75
Smith-Waterman score: 1109; 100.0% identity (100.0% similar) in 165 aa overlap (1-165:1-165)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
130 140 150 160
>>NP_006861 (OMIM: 609114) destrin isoform a [Homo sapie (165 aa)
initn: 1109 init1: 1109 opt: 1109 Z-score: 1467.2 bits: 277.8 E(85289): 5.5e-75
Smith-Waterman score: 1109; 100.0% identity (100.0% similar) in 165 aa overlap (1-165:1-165)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
:::::::::::::::::::::::::::::::::::::::::::::
NP_006 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
130 140 150 160
>>XP_011527444 (OMIM: 609114) PREDICTED: destrin isoform (165 aa)
initn: 1109 init1: 1109 opt: 1109 Z-score: 1467.2 bits: 277.8 E(85289): 5.5e-75
Smith-Waterman score: 1109; 100.0% identity (100.0% similar) in 165 aa overlap (1-165:1-165)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
130 140 150 160
>>XP_011527446 (OMIM: 609114) PREDICTED: destrin isoform (148 aa)
initn: 994 init1: 994 opt: 994 Z-score: 1316.6 bits: 249.8 E(85289): 1.4e-66
Smith-Waterman score: 994; 100.0% identity (100.0% similar) in 148 aa overlap (18-165:1-148)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
:::::::::::::::::::::::::::::::::::::::::::
XP_011 MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
110 120 130 140
>>NP_001011546 (OMIM: 609114) destrin isoform b [Homo sa (148 aa)
initn: 994 init1: 994 opt: 994 Z-score: 1316.6 bits: 249.8 E(85289): 1.4e-66
Smith-Waterman score: 994; 100.0% identity (100.0% similar) in 148 aa overlap (18-165:1-148)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
:::::::::::::::::::::::::::::::::::::::::::
NP_001 MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
10 20 30 40
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
110 120 130 140
>>NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] (166 aa)
initn: 773 init1: 705 opt: 780 Z-score: 1034.3 bits: 197.7 E(85289): 7.1e-51
Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-165:1-166)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.:::::::::::
NP_005 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
: :. ::. :: :::.::::::::::..:::::.::.:.:..:::: ::::::::::::
NP_005 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV
:::::::. ::::: ::: :... : .::::::: ....:: :.
NP_005 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
130 140 150 160
>>NP_619579 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa)
initn: 753 init1: 688 opt: 755 Z-score: 1001.4 bits: 191.6 E(85289): 4.8e-49
Smith-Waterman score: 755; 68.7% identity (87.3% similar) in 166 aa overlap (1-165:1-166)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::: : ::: ..: :::::: :: ::::::::::.:::: ::. :::::.:.:::::.
NP_619 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
: :. ::. :: .:: .:::::::::..:::::.::.:.:..:::: ::::::::::::
NP_619 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDL-NRACIAEKLGGSLIVAFEGCPV
:::::::: ::::: :.:: .:. .:. ..:::::...:..:: :.
NP_619 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
130 140 150 160
>>NP_068733 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa)
initn: 753 init1: 688 opt: 755 Z-score: 1001.4 bits: 191.6 E(85289): 4.8e-49
Smith-Waterman score: 755; 68.7% identity (87.3% similar) in 166 aa overlap (1-165:1-166)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::: : ::: ..: :::::: :: ::::::::::.:::: ::. :::::.:.:::::.
NP_068 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
: :. ::. :: .:: .:::::::::..:::::.::.:.:..:::: ::::::::::::
NP_068 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
70 80 90 100 110 120
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDL-NRACIAEKLGGSLIVAFEGCPV
:::::::: ::::: :.:: .:. .:. ..:::::...:..:: :.
NP_068 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
130 140 150 160
>>NP_001230574 (OMIM: 601443,610687) cofilin-2 isoform 2 (149 aa)
initn: 682 init1: 617 opt: 684 Z-score: 908.7 bits: 174.3 E(85289): 7.1e-44
Smith-Waterman score: 684; 69.1% identity (88.6% similar) in 149 aa overlap (18-165:1-149)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::: :: ::::::::::.:::: ::. :::::.:.:::::.
NP_001 MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
: :. ::. :: .:: .:::::::::..:::::.::.:.:..:::: ::::::::::::
NP_001 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDL-NRACIAEKLGGSLIVAFEGCPV
:::::::: ::::: :.:: .:. .:. ..:::::...:..:: :.
NP_001 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
110 120 130 140
>>XP_011534665 (OMIM: 601443,610687) PREDICTED: cofilin- (149 aa)
initn: 682 init1: 617 opt: 684 Z-score: 908.7 bits: 174.3 E(85289): 7.1e-44
Smith-Waterman score: 684; 69.1% identity (88.6% similar) in 149 aa overlap (18-165:1-149)
10 20 30 40 50 60
pF1KB3 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV
::::: :: ::::::::::.:::: ::. :::::.:.:::::.
XP_011 MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
10 20 30 40
70 80 90 100 110 120
pF1KB3 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS
: :. ::. :: .:: .:::::::::..:::::.::.:.:..:::: ::::::::::::
XP_011 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
50 60 70 80 90 100
130 140 150 160
pF1KB3 KDAIKKKFQGIKHECQANGPEDL-NRACIAEKLGGSLIVAFEGCPV
:::::::: ::::: :.:: .:. .:. ..:::::...:..:: :.
XP_011 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
110 120 130 140
165 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 05:20:06 2016 done: Sat Nov 5 05:20:07 2016
Total Scan time: 4.730 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]