FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4406, 421 aa 1>>>pF1KE4406 421 - 421 aa - 421 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9098+/-0.000412; mu= 18.9604+/- 0.025 mean_var=54.5201+/-11.049, 0's: 0 Z-trim(109.2): 59 B-trim: 86 in 1/53 Lambda= 0.173698 statistics sampled from 17249 (17315) to 17249 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.203), width: 16 Scan time: 6.160 The best scores are: opt bits E(85289) NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 2801 710.3 2.3e-204 NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 2783 705.8 5.3e-203 NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 2517 639.1 5.6e-183 NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 2150 547.2 3.1e-155 NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 1509 386.4 4e-107 NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 895 232.7 1.4e-60 NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 832 216.9 8e-56 NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 793 207.1 6.8e-53 XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 782 204.3 4.5e-52 NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 780 203.8 6.6e-52 XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 753 197.1 7.3e-50 XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 753 197.1 7.6e-50 XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 753 197.1 7.6e-50 NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 744 194.8 2.8e-49 NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 734 192.3 1.9e-48 NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 731 191.6 4.5e-48 XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 720 188.8 2.1e-47 NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 720 188.8 2.2e-47 NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 709 186.0 1.4e-46 XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 709 186.1 1.5e-46 XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 709 186.1 1.6e-46 XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 669 176.0 1.5e-43 XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 669 176.0 1.5e-43 XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 653 172.1 2.8e-42 XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 647 170.6 8.7e-42 XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 644 169.8 1.3e-41 NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 636 167.8 6.3e-41 NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 636 167.8 6.8e-41 NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 636 167.9 7e-41 XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 636 167.9 7e-41 NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 636 167.9 7.2e-41 XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 632 166.8 1.3e-40 XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 632 166.8 1.3e-40 XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 593 156.9 7.1e-38 XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 588 155.7 1.6e-37 XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 582 154.3 6.7e-37 XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 573 152.0 3e-36 XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 573 152.0 3e-36 XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 571 151.5 3.8e-36 XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 566 150.2 9.6e-36 XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 559 148.4 2.2e-35 XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 548 145.7 1.8e-34 XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 522 139.2 1.7e-32 NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 489 130.9 6.1e-30 XP_005271562 (OMIM: 604773,611283) PREDICTED: isob ( 249) 470 126.1 1e-28 XP_016873038 (OMIM: 604773,611283) PREDICTED: isob ( 249) 470 126.1 1e-28 XP_016873037 (OMIM: 604773,611283) PREDICTED: isob ( 268) 470 126.1 1.1e-28 XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 463 124.4 5.6e-28 NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 455 122.4 2.2e-27 XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 455 122.4 2.2e-27 >>NP_000007 (OMIM: 201450,607008) medium-chain specific (421 aa) initn: 2801 init1: 2801 opt: 2801 Z-score: 3790.0 bits: 710.3 E(85289): 2.3e-204 Smith-Waterman score: 2801; 99.8% identity (100.0% similar) in 421 aa overlap (1-421:1-421) 10 20 30 40 50 60 pF1KE4 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 DEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEAT :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_000 GQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 KYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK 370 380 390 400 410 420 pF1KE4 N : NP_000 N >>NP_001120800 (OMIM: 201450,607008) medium-chain specif (425 aa) initn: 2721 init1: 2721 opt: 2783 Z-score: 3765.6 bits: 705.8 E(85289): 5.3e-203 Smith-Waterman score: 2783; 98.8% identity (99.1% similar) in 425 aa overlap (1-421:1-425) 10 20 30 40 50 pF1KE4 MAAGFGRCCR----VLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFA :::::::::: :::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAGFGRCCRCSLQVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 REEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRAL :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRAL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI 370 380 390 400 410 420 420 pF1KE4 DKYKN ::::: NP_001 DKYKN >>NP_001272971 (OMIM: 201450,607008) medium-chain specif (385 aa) initn: 2517 init1: 2517 opt: 2517 Z-score: 3406.0 bits: 639.1 E(85289): 5.6e-183 Smith-Waterman score: 2517; 99.7% identity (100.0% similar) in 382 aa overlap (40-421:4-385) 10 20 30 40 50 60 pF1KE4 RVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDK :::::::::::::::::::::::::::::: NP_001 MLQEFTEQQKEFQATARKFAREEIIPVAAEYDK 10 20 30 70 80 90 100 110 120 pF1KE4 TGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 QMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 MWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 IVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATKYALERKTF ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_001 IVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTF 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 GKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 TDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN 340 350 360 370 380 >>NP_001272972 (OMIM: 201450,607008) medium-chain specif (454 aa) initn: 2143 init1: 2143 opt: 2150 Z-score: 2907.9 bits: 547.2 E(85289): 3.1e-155 Smith-Waterman score: 2718; 92.5% identity (92.7% similar) in 453 aa overlap (2-421:2-454) 10 20 30 40 50 60 pF1KE4 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI 10 20 30 40 50 60 70 80 90 pF1KE4 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENC------------------------- ::::::::::::::::::::::::::::::::::: NP_001 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVCPLLEACTLYLDAFFLLLTGS 70 80 90 100 110 120 100 110 120 130 140 pF1KE4 --------GGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLG :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLG 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 RMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARS 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 DPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE4 AGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMA ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_001 AGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMA 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 MKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPV 370 380 390 400 410 420 390 400 410 420 pF1KE4 EKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN :::::::::::::::::::::::::::::::::: NP_001 EKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN 430 440 450 >>NP_001272973 (OMIM: 201450,607008) medium-chain specif (232 aa) initn: 1509 init1: 1509 opt: 1509 Z-score: 2044.2 bits: 386.4 E(85289): 4e-107 Smith-Waterman score: 1509; 99.6% identity (100.0% similar) in 232 aa overlap (190-421:1-232) 160 170 180 190 200 210 pF1KE4 VTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAF :::::::::::::::::::::::::::::: NP_001 MWITNGGKANWYFLLARSDPDPKAPANKAF 10 20 30 220 230 240 250 260 270 pF1KE4 TGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDK 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE4 TRPVVAAGVVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQR ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQR 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE4 AAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQI 160 170 180 190 200 210 400 410 420 pF1KE4 YEGTSQIQRLIVAREHIDKYKN :::::::::::::::::::::: NP_001 YEGTSQIQRLIVAREHIDKYKN 220 230 >>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa) initn: 720 init1: 543 opt: 895 Z-score: 1208.8 bits: 232.7 E(85289): 1.4e-60 Smith-Waterman score: 898; 37.2% identity (66.7% similar) in 411 aa overlap (13-421:15-412) 10 20 30 40 50 pF1KE4 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFARE :.. ::. :: . : :. : .. . : : ::.. NP_000 MAAALLARASGPARRALCPRAWRQLHTIYQ---------SVELPETHQMLLQTCRDFAEK 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 EIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC-- :..:.::. :: .:. ... :::. .::. :: :: . . ::.. :: NP_000 ELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCAS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA ::: ... ::: ::. :. .::. .. .: . . ..::: :::... .: : NP_000 TGVIMSVN-NSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK . .:: ...:: : ::::. .:. ..: .: .: ::....:.: :::. .:.: NP_000 RAEGDSWVLNGTKAWITNAWEASAAVVFASTD---RALQNKGISAFLVPMPTPGLTLGKK 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRAL : ..: : :.: ...::: ..::...: : :::.:: ..: : .:. ..:.:: :: NP_000 EDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTAL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI : :..:: .: .:: :.. :.:.: ::.::. .: ::. ::: :. . :.. NP_000 DCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAM 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI :: :.. :. .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . . NP_000 AKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLL 350 360 370 380 390 400 420 pF1KE4 DKYKN .:.. NP_000 RSYRS 410 >>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa) initn: 780 init1: 490 opt: 832 Z-score: 1123.2 bits: 216.9 E(85289): 8e-56 Smith-Waterman score: 832; 36.2% identity (68.5% similar) in 409 aa overlap (20-417:26-429) 10 20 30 40 pF1KE4 MAAGFGRCCRVLRSISRFHWR-SQHTKANRQREPGL-----GFSFE----FTEQ :. :.. . : : : :. : ::.. NP_001 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDE 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 QKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFD . ......:::.:.: :... .:..... .:. .. :::. .. . :: : . .. NP_001 EMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 ACLISEELAYGCTGVQTAIE-GNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEP . :. :::: ..: . : :.: . : :...:: :: ..: : . ..:..: NP_001 TVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVG-SFCLSEA 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 GAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFI ::::: ..::.:.:.:: :..::.::::... .:. ....: :: . . :..:.:. NP_001 GAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDP---TIGYKGITSFL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 VEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPV :. ::::..::. : ..: : :.: ..::.::::. :.: : :.: :.:.... : NP_001 VDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIG 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 VAAGVVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWE .:: ..:::: .: . : :: ::: : . :... ..:..: ..: ::. :: NP_001 IAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 VDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGT ...:. ::.:: .:..::.: .. .. .:: :.. .::::: .::::: ::::. NP_001 LEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGA 360 370 380 390 400 410 410 420 pF1KE4 SQIQRLIVAREHIDKYKN :.:: .:. ::: NP_001 SNIQLNTIAK-HIDAEY 420 430 >>NP_055199 (OMIM: 604773,611283) isobutyryl-CoA dehydro (415 aa) initn: 772 init1: 400 opt: 793 Z-score: 1070.6 bits: 207.1 E(85289): 6.8e-53 Smith-Waterman score: 793; 33.7% identity (68.1% similar) in 383 aa overlap (32-413:36-410) 10 20 30 40 50 60 pF1KE4 AAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEII .:..:.. :.::::: .: :: .:. NP_055 CRRFGARLGCLPGGLRVLVQTGHRSLTSCIDPSMGLN----EEQKEFQKVAFDFAAREMA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQT : ::.:. .:: ..:.: .::. ...: . :: ::. .:. .: : :: :::.. . NP_055 PNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTTA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGD : ... : ::..:..:. . . .::.::::.:::.:.. :.:.:.:: NP_055 YISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQGD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMG .::.::.: .:...:... : .. :. .:. :... ..:: :::...:.:: ..: NP_055 HYILNGSKAFISGAGESDIYVVMCRTG----GPGPKGISCIVVEKGTPGLSFGKKEKKVG 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 QRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATK . ::...::: :: : . ..: :: .:. ... : .:. .: :. .. . NP_055 WNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRD 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 YALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTY-YASIAKAF . :: ::. :. .: ..: ::.:: .. ::. . :: .. :... :.:: : NP_055 HLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK : : . ..:.:. :: :. .: :.. .::....:: ::.....:....: NP_055 ATDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQE 360 370 380 390 400 410 pF1KE4 N >>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa) initn: 658 init1: 434 opt: 782 Z-score: 1055.9 bits: 204.3 E(85289): 4.5e-52 Smith-Waterman score: 782; 34.5% identity (65.8% similar) in 403 aa overlap (18-413:3-400) 10 20 30 40 50 pF1KE4 MAAGFGRCCRVLRSISRFHWR-SQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREE : :: .: : .. : : .: .: :.. : :: .:. XP_016 MVFWWRIGQATYRLWHKGPQSVCS-SLTPEQAELRQTMAKFLQEH 10 20 30 40 60 70 80 90 100 110 pF1KE4 IIPVAAEYDKTGEYPVPLIRRAWE----LGLMNTHIPENCGGLGLGTFDACLISEEL--A . : : : :...:. .:. :. ::... : . :: ::: .. :. ::. : XP_016 LAPKAQEIDRSNEFKN--LREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 YGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIK : .:.. . ..: : .. ::. ::.::: .. . : ..::.:::::...: XP_016 SGAVGLSYGAHSN-LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMK 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 TKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQI ::::::..::.::.:.::::: :. .. :..: .::....:.:::: ::.. XP_016 LKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDL-AAVPASRGITAFIVEKGMPGFST 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 GRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQ ..: ..:.: :.: ..::: :.: :.: .. : : :...: : :.:.: .:: : XP_016 SKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQ 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 RALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYY .::.. : :..::. . . : .. .:.: .. :. .: : :. .. XP_016 AVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKD 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 ASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAR . . .... :.:.: :..: .::::. ...:. ...::::.:.: :::...::...: XP_016 CAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGR 350 360 370 380 390 400 420 pF1KE4 EHIDKYKN XP_016 AFNADFH >>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa) initn: 658 init1: 434 opt: 780 Z-score: 1052.9 bits: 203.8 E(85289): 6.6e-52 Smith-Waterman score: 780; 34.6% identity (67.8% similar) in 379 aa overlap (41-413:45-419) 20 30 40 50 60 70 pF1KE4 VLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKT ..:.:.... : :: .:.. : : : :.. NP_002 VASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRS 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 GEYPVPLIRRAWE----LGLMNTHIPENCGGLGLGTFDACLISEEL--AYGCTGVQTAIE .:. .:. :. ::... : . :: ::: .. :. ::. : : .:.. . . NP_002 NEFKN--LREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAH 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE4 GNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYI .: : .. ::. ::.::: .. . : ..::.:::::...: ::::::..:: NP_002 SN-LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYI 140 150 160 170 180 190 190 200 210 220 230 240 pF1KE4 INGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRC .::.:.::::: :. .. :..: .::....:.:::: ::.. ..: ..:.: NP_002 LNGNKFWITNGPDADVLIVYAKTDL-AAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRG 200 210 220 230 240 250 250 260 270 280 290 300 pF1KE4 SDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATKYAL :.: ..::: :.: :.: .. : : :...: : :.:.: .:: : .::.. : NP_002 SNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLH 260 270 280 290 300 310 310 320 330 340 350 360 pF1KE4 ERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDI :..::. . . : .. .:.: .. :. .: : :. .. . . .... NP_002 VREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAEC 320 330 340 350 360 370 370 380 390 400 410 420 pF1KE4 ANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN :.:.: :..: .::::. ...:. ...::::.:.: :::...::...: NP_002 ATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH 380 390 400 410 420 421 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:19:14 2016 done: Sun Nov 6 01:19:15 2016 Total Scan time: 6.160 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]