Result of FASTA (omim) for
pFN21AB3393
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3393, 308 aa
1>>>pF1KB3393 308 - 308 aa - 308 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.2139+/-0.000396; mu= 21.6942+/- 0.025
mean_var=57.1306+/-12.190, 0's: 0 Z-trim(111.5): 16 B-trim: 300 in 3/49
Lambda= 0.169684
statistics sampled from 20068 (20083) to 20068 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.235), width: 16
Scan time: 5.920
The best scores are: opt bits E(85289)
NP_612510 (OMIM: 610057,614020) very-long-chain en ( 308) 2140 532.1 5.3e-151
XP_011526744 (OMIM: 610057,614020) PREDICTED: very ( 329) 2105 523.6 2.1e-148
NP_001308099 (OMIM: 610057,614020) very-long-chain ( 323) 2103 523.1 2.9e-148
XP_006723008 (OMIM: 610057,614020) PREDICTED: very ( 341) 2013 501.1 1.3e-141
NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-ster ( 254) 230 64.5 2.6e-10
XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-ox ( 180) 226 63.3 4.1e-10
XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-ox ( 169) 222 62.3 7.7e-10
NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 186) 203 57.7 2.1e-08
NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-d ( 259) 204 58.1 2.2e-08
NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 212) 189 54.3 2.4e-07
XP_016864090 (OMIM: 611715,612379,612713) PREDICTE ( 273) 130 40.0 0.0065
NP_078868 (OMIM: 611715,612379,612713) polyprenol ( 318) 130 40.1 0.0072
>>NP_612510 (OMIM: 610057,614020) very-long-chain enoyl- (308 aa)
initn: 2140 init1: 2140 opt: 2140 Z-score: 2831.9 bits: 532.1 E(85289): 5.3e-151
Smith-Waterman score: 2140; 100.0% identity (100.0% similar) in 308 aa overlap (1-308:1-308)
10 20 30 40 50 60
pF1KB3 MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 DEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 DEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 SSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 SSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYIN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 HPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 HPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 LLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
250 260 270 280 290 300
pF1KB3 MPIIPFLL
::::::::
NP_612 MPIIPFLL
>>XP_011526744 (OMIM: 610057,614020) PREDICTED: very-lon (329 aa)
initn: 2105 init1: 2105 opt: 2105 Z-score: 2785.2 bits: 523.6 E(85289): 2.1e-148
Smith-Waterman score: 2105; 99.7% identity (100.0% similar) in 304 aa overlap (5-308:26-329)
10 20 30
pF1KB3 MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKT
.::::::::::::::::::::::::::::::::::
XP_011 MVQQLMKAQGQDLETRVRRGGEEVCQVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB3 HPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB3 FIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB3 NIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB3 PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMT
250 260 270 280 290 300
280 290 300
pF1KB3 IWAKGKHRSYLKEFRDYPPLRMPIIPFLL
:::::::::::::::::::::::::::::
XP_011 IWAKGKHRSYLKEFRDYPPLRMPIIPFLL
310 320
>>NP_001308099 (OMIM: 610057,614020) very-long-chain eno (323 aa)
initn: 2103 init1: 2103 opt: 2103 Z-score: 2782.7 bits: 523.1 E(85289): 2.9e-148
Smith-Waterman score: 2103; 100.0% identity (100.0% similar) in 303 aa overlap (6-308:21-323)
10 20 30 40
pF1KB3 MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYP
::::::::::::::::::::::::::::::::::::::::
NP_001 MILQETKAACGIPAIPHCSRVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB3 ARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB3 YFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNC
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB3 TYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB3 RKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGK
250 260 270 280 290 300
290 300
pF1KB3 HRSYLKEFRDYPPLRMPIIPFLL
:::::::::::::::::::::::
NP_001 HRSYLKEFRDYPPLRMPIIPFLL
310 320
>>XP_006723008 (OMIM: 610057,614020) PREDICTED: very-lon (341 aa)
initn: 2019 init1: 1996 opt: 2013 Z-score: 2663.3 bits: 501.1 E(85289): 1.3e-141
Smith-Waterman score: 2013; 98.0% identity (98.6% similar) in 296 aa overlap (13-308:47-341)
10 20 30 40
pF1KB3 MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQ
: .::: .::::::::::::::::::::
XP_006 LWHSSDSSLLKGGDSGRKDKGEAVFLGQELTSLRLCF-PQVEPHATIAEIKNLFTKTHPQ
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB3 WYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIY
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB3 LLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIF
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB3 KNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAG
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB3 SKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWA
260 270 280 290 300 310
290 300
pF1KB3 KGKHRSYLKEFRDYPPLRMPIIPFLL
::::::::::::::::::::::::::
XP_006 KGKHRSYLKEFRDYPPLRMPIIPFLL
320 330 340
>>NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-steroid (254 aa)
initn: 209 init1: 178 opt: 230 Z-score: 306.0 bits: 64.5 E(85289): 2.6e-10
Smith-Waterman score: 234; 28.3% identity (58.2% similar) in 184 aa overlap (127-308:82-254)
100 110 120 130 140 150
pF1KB3 GPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTM
: :. .: .::..: . ...: .
NP_000 AWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFC--LHYFHRTFVYSLLNR--GRPY
60 70 80 90 100
160 170 180 190 200 210
pF1KB3 PLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIH--MA
: :... .. : .. ..::. . : . .. ....:..:.. ...:: .
NP_000 PAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTD-IRFSLGVFLFILGMGINIHSDYI
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB3 LRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVG
::.:: : . .:: :: :: :. :. :::.:. : ::. :.. .
NP_000 LRQLRKPGEISYRIPQGG------LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFS
170 180 190 200 210 220
280 290 300
pF1KB3 FTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL
. . . : .:: ::: :.::: : .:::..
NP_000 LCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
230 240 250
>>XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (180 aa)
initn: 209 init1: 178 opt: 226 Z-score: 302.6 bits: 63.3 E(85289): 4.1e-10
Smith-Waterman score: 226; 27.4% identity (58.7% similar) in 179 aa overlap (133-308:13-180)
110 120 130 140 150 160
pF1KB3 LLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGT-MPLRNI
:... .: .. .:. ..: .: :
XP_011 MTSQGMPRTANHCQKLGTLKTFVYSLL----NRGRPYPAILI
10 20 30
170 180 190 200 210
pF1KB3 FKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIH--MALRDLR
... .. : .. ..::. . : . .. ....:..:.. ...:: . ::.::
XP_011 LRGTAFCTGNGVLQGYYLIYCAEYPDGWYTD-IRFSLGVFLFILGMGINIHSDYILRQLR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB3 PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMT
: . .:: :: :: :. :. :::.:. : ::. :.. .. .
XP_011 KPGEISYRIPQGG------LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLG
100 110 120 130 140 150
280 290 300
pF1KB3 IWAKGKHRSYLKEFRDYPPLRMPIIPFLL
. : .:: ::: :.::: : .:::..
XP_011 LRAFHHHRFYLKMFEDYPKSRKALIPFIF
160 170 180
>>XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (169 aa)
initn: 209 init1: 178 opt: 222 Z-score: 297.7 bits: 62.3 E(85289): 7.7e-10
Smith-Waterman score: 222; 29.3% identity (59.3% similar) in 150 aa overlap (161-308:27-169)
140 150 160 170 180 190
pF1KB3 CICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYG
:... .. : .. ..::. . : .
XP_011 MRSWSLTYRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWY
10 20 30 40 50
200 210 220 230 240
pF1KB3 AQQVKLALAIFVICQLGNFSIH--MALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNY
.. ....:..:.. ...:: . ::.:: : . .:: :: :: :.
XP_011 TD-IRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG------LFTYVSGANF
60 70 80 90 100
250 260 270 280 290 300
pF1KB3 TYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL
:. :::.:. : ::. :.. .. . . : .:: ::: :.::: : .:::..
XP_011 LGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
110 120 130 140 150 160
>>NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (186 aa)
initn: 198 init1: 163 opt: 203 Z-score: 272.0 bits: 57.7 E(85289): 2.1e-08
Smith-Waterman score: 203; 27.9% identity (52.5% similar) in 179 aa overlap (135-308:16-186)
110 120 130 140 150 160
pF1KB3 FYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKN
:: . ::. :. . .: :. .
NP_001 MTLPWRTWSEWKQITSFTVFPALLRCLIYPFLMRGGKPM--PLLA
10 20 30 40
170 180 190 200 210
pF1KB3 CTYYWGFAAWMAY----YINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLR
::. : . .: :..: .:. . ....... .: :. ::.::
NP_001 CTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLR
50 60 70 80 90 100
220 230 240 250 260 270
pF1KB3 PAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMT
:. ::: :: :. :: :. : :.:. . . : :.. : ..
NP_001 KPGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLS
110 120 130 140 150
280 290 300
pF1KB3 IWAKGKHRSYLKEFRDYPPLRMPIIPFLL
:: .:. ::..:..:: .: :::::.
NP_001 GRAKEHHEWYLRKFEEYPKFRKIIIPFLF
160 170 180
>>NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-dehyd (259 aa)
initn: 225 init1: 163 opt: 204 Z-score: 271.5 bits: 58.1 E(85289): 2.2e-08
Smith-Waterman score: 205; 28.7% identity (52.2% similar) in 178 aa overlap (137-308:94-259)
110 120 130 140 150 160
pF1KB3 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I
:: .: : :. : . ::: .
NP_001 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMR-GGKPMPLLACTMAIM
70 80 90 100 110 120
170 180 190 200 210 220
pF1KB3 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP
: .:. : .. :..: .:. . ....... .: :. ::.::
NP_001 FCTCNGY-----LQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK
130 140 150 160 170
230 240 250 260 270 280
pF1KB3 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI
:. ::: :: :. :: :. : :.:. . . : :.. : ..
NP_001 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG
180 190 200 210 220 230
290 300
pF1KB3 WAKGKHRSYLKEFRDYPPLRMPIIPFLL
:: .:. ::..:..:: .: :::::.
NP_001 RAKEHHEWYLRKFEEYPKFRKIIIPFLF
240 250
>>NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (212 aa)
initn: 198 init1: 163 opt: 189 Z-score: 252.8 bits: 54.3 E(85289): 2.4e-07
Smith-Waterman score: 189; 31.9% identity (57.5% similar) in 113 aa overlap (196-308:106-212)
170 180 190 200 210 220
pF1KB3 TYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKT
....... .: :. ::.:: :.
NP_001 RSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTG
80 90 100 110 120 130
230 240 250 260 270 280
pF1KB3 RKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGK
::: :: :. :: :. : :.:. . . : :.. : .. :: .
NP_001 YKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEH
140 150 160 170 180
290 300
pF1KB3 HRSYLKEFRDYPPLRMPIIPFLL
:. ::..:..:: .: :::::.
NP_001 HEWYLRKFEEYPKFRKIIIPFLF
190 200 210
308 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:57:24 2016 done: Sat Nov 5 04:57:25 2016
Total Scan time: 5.920 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]