FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4233, 850 aa 1>>>pF1KE4233 850 - 850 aa - 850 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9467+/-0.000507; mu= 18.3188+/- 0.032 mean_var=125.1541+/-25.976, 0's: 0 Z-trim(111.6): 254 B-trim: 162 in 1/48 Lambda= 0.114644 statistics sampled from 19914 (20233) to 19914 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.595), E-opt: 0.2 (0.237), width: 16 Scan time: 8.850 The best scores are: opt bits E(85289) NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 5641 945.7 0 NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 5624 942.9 0 NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 5608 940.3 0 XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase- ( 853) 5364 899.9 0 XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase- ( 872) 5364 899.9 0 XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase- ( 871) 5347 897.1 0 XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase- ( 707) 3999 674.0 6.3e-193 NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 3522 595.2 4e-169 NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 3437 581.1 6.6e-165 XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 3437 581.1 6.6e-165 XP_011533144 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 3437 581.1 6.6e-165 XP_016862460 (OMIM: 601589) PREDICTED: ras GTPase- ( 573) 3251 550.2 9.6e-156 XP_016862461 (OMIM: 601589) PREDICTED: ras GTPase- ( 442) 2953 500.8 5.5e-141 NP_001307750 (OMIM: 605182) ras GTPase-activating ( 451) 1821 313.6 1.3e-84 XP_016875927 (OMIM: 605182) PREDICTED: ras GTPase- ( 451) 1821 313.6 1.3e-84 XP_016875928 (OMIM: 605182) PREDICTED: ras GTPase- ( 451) 1821 313.6 1.3e-84 NP_008920 (OMIM: 607943) ras GTPase-activating pro ( 803) 829 149.8 4.7e-35 XP_016867150 (OMIM: 607943) PREDICTED: ras GTPase- ( 840) 816 147.7 2.2e-34 NP_004649 (OMIM: 604118) rasGAP-activating-like pr ( 804) 711 130.3 3.5e-29 XP_011537155 (OMIM: 604118) PREDICTED: rasGAP-acti ( 804) 711 130.3 3.5e-29 XP_006719705 (OMIM: 604118) PREDICTED: rasGAP-acti ( 805) 709 129.9 4.4e-29 NP_001288131 (OMIM: 604118) rasGAP-activating-like ( 805) 674 124.2 2.5e-27 XP_016875517 (OMIM: 604118) PREDICTED: rasGAP-acti ( 805) 674 124.2 2.5e-27 XP_005254007 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 672 123.8 3.1e-27 XP_011537154 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 672 123.8 3.1e-27 NP_001180449 (OMIM: 604118) rasGAP-activating-like ( 806) 672 123.8 3.1e-27 XP_006719704 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 672 123.8 3.1e-27 XP_016875520 (OMIM: 604118) PREDICTED: rasGAP-acti ( 779) 612 113.9 2.9e-24 XP_011514025 (OMIM: 607943) PREDICTED: ras GTPase- ( 682) 610 113.5 3.4e-24 XP_016875519 (OMIM: 604118) PREDICTED: rasGAP-acti ( 780) 610 113.6 3.7e-24 XP_016875518 (OMIM: 604118) PREDICTED: rasGAP-acti ( 780) 610 113.6 3.7e-24 NP_001073346 (OMIM: 607943) ras GTPase-activating ( 757) 608 113.2 4.6e-24 XP_016867151 (OMIM: 607943) PREDICTED: ras GTPase- ( 794) 608 113.2 4.7e-24 XP_011537156 (OMIM: 604118) PREDICTED: rasGAP-acti ( 447) 537 101.2 1.1e-20 NP_001180450 (OMIM: 604118) rasGAP-activating-like ( 776) 482 92.4 8.7e-18 XP_011516572 (OMIM: 609205) PREDICTED: disabled ho (1065) 398 78.6 1.6e-13 XP_016869789 (OMIM: 609205) PREDICTED: disabled ho (1065) 398 78.6 1.6e-13 XP_011516573 (OMIM: 609205) PREDICTED: disabled ho (1065) 398 78.6 1.6e-13 NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 398 78.6 1.6e-13 XP_005251781 (OMIM: 609205) PREDICTED: disabled ho (1128) 398 78.7 1.7e-13 XP_011516569 (OMIM: 609205) PREDICTED: disabled ho (1131) 398 78.7 1.7e-13 NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 398 78.7 1.7e-13 XP_016869788 (OMIM: 609205) PREDICTED: disabled ho (1141) 398 78.7 1.7e-13 XP_011516568 (OMIM: 609205) PREDICTED: disabled ho (1153) 398 78.7 1.7e-13 XP_011516567 (OMIM: 609205) PREDICTED: disabled ho (1160) 398 78.7 1.7e-13 XP_005251778 (OMIM: 609205) PREDICTED: disabled ho (1161) 398 78.7 1.7e-13 XP_016869787 (OMIM: 609205) PREDICTED: disabled ho (1164) 398 78.7 1.7e-13 XP_011516566 (OMIM: 609205) PREDICTED: disabled ho (1182) 398 78.7 1.8e-13 XP_005251776 (OMIM: 609205) PREDICTED: disabled ho (1189) 398 78.7 1.8e-13 XP_016858344 (OMIM: 606136) PREDICTED: ras GTPase- (1138) 379 75.5 1.5e-12 >>NP_001290174 (OMIM: 601589) ras GTPase-activating prot (850 aa) initn: 5641 init1: 5641 opt: 5641 Z-score: 5051.3 bits: 945.7 E(85289): 0 Smith-Waterman score: 5641; 100.0% identity (100.0% similar) in 850 aa overlap (1-850:1-850) 10 20 30 40 50 60 pF1KE4 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS 790 800 810 820 830 840 850 pF1KE4 KENPIVGKAS :::::::::: NP_001 KENPIVGKAS 850 >>NP_006497 (OMIM: 601589) ras GTPase-activating protein (849 aa) initn: 4271 init1: 4271 opt: 5624 Z-score: 5036.2 bits: 942.9 E(85289): 0 Smith-Waterman score: 5624; 99.9% identity (99.9% similar) in 850 aa overlap (1-850:1-849) 10 20 30 40 50 60 pF1KE4 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILA ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_006 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPG-KDAIYTIPVKNILA 610 620 630 640 650 670 680 690 700 710 720 pF1KE4 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE4 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE4 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS 780 790 800 810 820 830 850 pF1KE4 KENPIVGKAS :::::::::: NP_006 KENPIVGKAS 840 >>NP_001290175 (OMIM: 601589) ras GTPase-activating prot (853 aa) initn: 5614 init1: 4263 opt: 5608 Z-score: 5021.8 bits: 940.3 E(85289): 0 Smith-Waterman score: 5608; 99.4% identity (99.4% similar) in 853 aa overlap (1-850:1-853) 10 20 30 40 50 60 pF1KE4 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT 550 560 570 580 590 600 610 620 630 640 650 pF1KE4 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPG---SKDAIYTIPVKN :::::::::::::::::::::::::::::::::::::::::::: ::::::::::: NP_001 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPEFIERKDAIYTIPVKN 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE4 ILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE4 SVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKME 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE4 EACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAK 790 800 810 820 830 840 840 850 pF1KE4 YGSKENPIVGKAS ::::::::::::: NP_001 YGSKENPIVGKAS 850 >>XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase-acti (853 aa) initn: 5364 init1: 5364 opt: 5364 Z-score: 4803.7 bits: 899.9 E(85289): 0 Smith-Waterman score: 5364; 100.0% identity (100.0% similar) in 805 aa overlap (46-850:49-853) 20 30 40 50 60 70 pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR :::::::::::::::::::::::::::::: XP_011 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY 260 270 280 290 300 310 320 330 340 350 360 370 pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV 320 330 340 350 360 370 380 390 400 410 420 430 pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS 380 390 400 410 420 430 440 450 460 470 480 490 pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN 440 450 460 470 480 490 500 510 520 530 540 550 pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS 500 510 520 530 540 550 560 570 580 590 600 610 pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA 560 570 580 590 600 610 620 630 640 650 660 670 pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF 620 630 640 650 660 670 680 690 700 710 720 730 pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT 680 690 700 710 720 730 740 750 760 770 780 790 pF1KE4 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD 740 750 760 770 780 790 800 810 820 830 840 850 pF1KE4 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS 800 810 820 830 840 850 >>XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase-acti (872 aa) initn: 5364 init1: 5364 opt: 5364 Z-score: 4803.6 bits: 899.9 E(85289): 0 Smith-Waterman score: 5364; 100.0% identity (100.0% similar) in 805 aa overlap (46-850:68-872) 20 30 40 50 60 70 pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR :::::::::::::::::::::::::::::: XP_016 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE 100 110 120 130 140 150 140 150 160 170 180 190 pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA 160 170 180 190 200 210 200 210 220 230 240 250 pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI 220 230 240 250 260 270 260 270 280 290 300 310 pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN 460 470 480 490 500 510 500 510 520 530 540 550 pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS 520 530 540 550 560 570 560 570 580 590 600 610 pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA 580 590 600 610 620 630 620 630 640 650 660 670 pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF 640 650 660 670 680 690 680 690 700 710 720 730 pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT 700 710 720 730 740 750 740 750 760 770 780 790 pF1KE4 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD 760 770 780 790 800 810 800 810 820 830 840 850 pF1KE4 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS 820 830 840 850 860 870 >>XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase-acti (871 aa) initn: 3994 init1: 3994 opt: 5347 Z-score: 4788.4 bits: 897.1 E(85289): 0 Smith-Waterman score: 5347; 99.9% identity (99.9% similar) in 805 aa overlap (46-850:68-871) 20 30 40 50 60 70 pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR :::::::::::::::::::::::::::::: XP_016 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE 100 110 120 130 140 150 140 150 160 170 180 190 pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA 160 170 180 190 200 210 200 210 220 230 240 250 pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI 220 230 240 250 260 270 260 270 280 290 300 310 pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN 460 470 480 490 500 510 500 510 520 530 540 550 pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS 520 530 540 550 560 570 560 570 580 590 600 610 pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA 580 590 600 610 620 630 620 630 640 650 660 670 pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_016 QGRTRIGKKNFKKRWFCLTSRELTYHKQPG-KDAIYTIPVKNILAVEKLEESSFNKKNMF 640 650 660 670 680 690 680 690 700 710 720 730 pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT 700 710 720 730 740 750 740 750 760 770 780 790 pF1KE4 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD 760 770 780 790 800 810 800 810 820 830 840 850 pF1KE4 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS 820 830 840 850 860 870 >>XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase-acti (707 aa) initn: 3999 init1: 3999 opt: 3999 Z-score: 3584.6 bits: 674.0 E(85289): 6.3e-193 Smith-Waterman score: 3999; 100.0% identity (100.0% similar) in 601 aa overlap (46-646:68-668) 20 30 40 50 60 70 pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR :::::::::::::::::::::::::::::: XP_016 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE 100 110 120 130 140 150 140 150 160 170 180 190 pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA 160 170 180 190 200 210 200 210 220 230 240 250 pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI 220 230 240 250 260 270 260 270 280 290 300 310 pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN 460 470 480 490 500 510 500 510 520 530 540 550 pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS 520 530 540 550 560 570 560 570 580 590 600 610 pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA 580 590 600 610 620 630 620 630 640 650 660 670 pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF ::::::::::::::::::::::::::::::: XP_016 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSCVYALLWGFSWFSVKVSLPLIVTLVNPFS 640 650 660 670 680 690 680 690 700 710 720 730 pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT XP_016 NITVVYGFSH 700 >>NP_031394 (OMIM: 605182) ras GTPase-activating protein (834 aa) initn: 2923 init1: 1943 opt: 3522 Z-score: 3157.3 bits: 595.2 E(85289): 4e-169 Smith-Waterman score: 3522; 61.5% identity (87.0% similar) in 818 aa overlap (34-849:8-818) 10 20 30 40 50 60 pF1KE4 AAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCF .::.::.. :: ::::: : :: :::::. NP_031 MAVEDEGLRVFQSVKIKIGEAKNLPSYPGPSKMRDCY 10 20 30 70 80 90 100 110 120 pF1KE4 CTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAI ::.:::::::.::..::::: ::..:.:: ::::.:..::::..:..:..:: :::::: NP_031 CTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAI 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 KKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGL .:::: .. ...:::.:: ::..:::::::::::.:.:.::..:.::..:...: :.:: NP_031 QKEDLQKYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 PLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQV :..::: :::::::.:.:: :.. ::::::.::.::::.:.::::::: ::..::.:. NP_031 PIVNGQ-CDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 EEEDIEKLEIRIDLWNNGNL-VQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSK ::::..:::::.:::: .:: : ::::...:..::: .::..:::.:::::::.:: : NP_031 EEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE4 TDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVL :::::::::. ::::.:. :.::.::. ::::: ::.:.:::::.::.:.::.:..:.. NP_031 PDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAV 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE4 PLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTL :::::.::. ..::: .:.: ..: ::: ::::::::::..:.:: ::..: :::.::: NP_031 PLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE4 KPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIF :: ..:::.: : :::::.:::.:.:.::: :::: :::..:..:..:..:::::::::: NP_031 KPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIF 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE4 YSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLIS .:::. :..:: .:: :.:.:::::.:::::: :..::. :.: ::: : :: ::::::: NP_031 FSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLIS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE4 KTIQTLGSWGSLSKSKS-SFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTS ::.:::: ::::::: ::::..: :...:.:. : :::.::: :::. .. ... NP_031 KTVQTLG---SLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVE 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE4 EPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAV .:. :::: : :::::: :.: :::::::: ::..:.::::. :.. .:.::..::::: NP_031 QPIVLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQP-LYSIPIENILAV 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE4 EKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYL ::::: ::. :::::::. :. ::.::::::::..:::.: .::.:::.::. ::::.:: NP_031 EKLEEESFKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYL 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE4 NGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACG .:.::::. .... ::.:::.:.::.::.::: :::::::::::.: . ::.::.:::: NP_031 SGHWLCCRAPSDSAPGCSPCTGGLPANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACG 700 710 720 730 740 750 790 800 810 820 830 840 pF1KE4 TIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSK . .::.::..: .::.:::.: :.::..:. . . :.. : .:.. . ...::::. NP_031 SKSVYDGPEQE--EYSTFVIDDPQETYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQ 760 770 780 790 800 810 850 pF1KE4 ENPIVGKAS :.:: :. NP_031 EHPIGDKSFQNYIRQQSETSTHSI 820 830 >>NP_001307751 (OMIM: 605182) ras GTPase-activating prot (802 aa) initn: 2838 init1: 1858 opt: 3437 Z-score: 3081.6 bits: 581.1 E(85289): 6.6e-165 Smith-Waterman score: 3437; 61.5% identity (87.4% similar) in 793 aa overlap (59-849:1-786) 30 40 50 60 70 80 pF1KE4 QDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFS ::::.::.:::::::.::..::::: ::.. NP_001 MRDCYCTVNLDQEEVFRTKIVEKSLCPFYG 10 20 30 90 100 110 120 130 140 pF1KE4 EEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSE :.:: ::::.:..::::..:..:..:: ::::::.:::: .. ...:::.:: ::..:: NP_001 EDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSE 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 VQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQK :::::::::.:.:.::..:.::..:...: :.:::..::: :::::::.:.:: :.. : NP_001 VQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPYATVTLAGPFRSEAK 100 110 120 130 140 210 220 230 240 250 260 pF1KE4 KTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNL-VQDV :::::.::.::::.:.::::::: ::..::.:. ::::..:::::.:::: .:: : NP_001 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE4 FLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYG ::::...:..::: .::..:::.:::::::.:: : :::::::::. ::::.:. :.::. NP_001 FLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYS 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE4 PLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLK ::. ::::: ::.:.:::::.::.:.::.:..:..:::::.::. ..::: .:.: ..: NP_001 PLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVK 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE4 DTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGD ::: ::::::::::..:.:: ::..: :::.::::: ..:::.: : :::::.:::.:. NP_001 RTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGE 330 340 350 360 370 380 450 460 470 480 490 500 pF1KE4 NVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSF :.::: :::: :::..:..:..:..::::::::::.:::. :..:: .:: :.:.::::: NP_001 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSF 390 400 410 420 430 440 510 520 530 540 550 560 pF1KE4 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKS-SFKETFM .:::::: :..::. :.: ::: : :: :::::::::.:::: ::::::: ::::..: NP_001 IFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLG---SLSKSKSASFKESYM 450 460 470 480 490 500 570 580 590 600 610 620 pF1KE4 CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNF :...:.:. : :::.::: :::. .. ... .:. :::: : :::::: :.: ::: NP_001 ATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNF 510 520 530 540 550 560 630 640 650 660 670 680 pF1KE4 KKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYV ::::: ::..:.::::. :.. .:.::..:::::::::: ::. :::::::. :. ::. NP_001 KKRWFRLTNHEFTYHKSKGDQP-LYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYI 570 580 590 600 610 620 690 700 710 720 730 740 pF1KE4 QANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVP ::::::::..:::.: .::.:::.::. ::::.::.:.::::. .... ::.:::.:.: NP_001 QANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLP 630 640 650 660 670 680 750 760 770 780 790 800 pF1KE4 ADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVT :.::.::: :::::::::::.: . ::.::.::::. .::.::..: .::.:::.: NP_001 ANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQE--EYSTFVIDDPQE 690 700 710 720 730 740 810 820 830 840 850 pF1KE4 TFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS :.::..:. . . :.. : .:.. . ...::::.:.:: :. NP_001 TYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI 750 760 770 780 790 800 >>XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase-acti (802 aa) initn: 2838 init1: 1858 opt: 3437 Z-score: 3081.6 bits: 581.1 E(85289): 6.6e-165 Smith-Waterman score: 3437; 61.5% identity (87.4% similar) in 793 aa overlap (59-849:1-786) 30 40 50 60 70 80 pF1KE4 QDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFS ::::.::.:::::::.::..::::: ::.. XP_011 MRDCYCTVNLDQEEVFRTKIVEKSLCPFYG 10 20 30 90 100 110 120 130 140 pF1KE4 EEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSE :.:: ::::.:..::::..:..:..:: ::::::.:::: .. ...:::.:: ::..:: XP_011 EDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSE 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 VQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQK :::::::::.:.:.::..:.::..:...: :.:::..::: :::::::.:.:: :.. : XP_011 VQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPYATVTLAGPFRSEAK 100 110 120 130 140 210 220 230 240 250 260 pF1KE4 KTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNL-VQDV :::::.::.::::.:.::::::: ::..::.:. ::::..:::::.:::: .:: : XP_011 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE4 FLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYG ::::...:..::: .::..:::.:::::::.:: : :::::::::. ::::.:. :.::. XP_011 FLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYS 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE4 PLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLK ::. ::::: ::.:.:::::.::.:.::.:..:..:::::.::. ..::: .:.: ..: XP_011 PLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVK 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE4 DTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGD ::: ::::::::::..:.:: ::..: :::.::::: ..:::.: : :::::.:::.:. XP_011 RTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGE 330 340 350 360 370 380 450 460 470 480 490 500 pF1KE4 NVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSF :.::: :::: :::..:..:..:..::::::::::.:::. :..:: .:: :.:.::::: XP_011 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSF 390 400 410 420 430 440 510 520 530 540 550 560 pF1KE4 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKS-SFKETFM .:::::: :..::. :.: ::: : :: :::::::::.:::: ::::::: ::::..: XP_011 IFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLG---SLSKSKSASFKESYM 450 460 470 480 490 500 570 580 590 600 610 620 pF1KE4 CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNF :...:.:. : :::.::: :::. .. ... .:. :::: : :::::: :.: ::: XP_011 ATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNF 510 520 530 540 550 560 630 640 650 660 670 680 pF1KE4 KKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYV ::::: ::..:.::::. :.. .:.::..:::::::::: ::. :::::::. :. ::. XP_011 KKRWFRLTNHEFTYHKSKGDQP-LYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYI 570 580 590 600 610 620 690 700 710 720 730 740 pF1KE4 QANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVP ::::::::..:::.: .::.:::.::. ::::.::.:.::::. .... ::.:::.:.: XP_011 QANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLP 630 640 650 660 670 680 750 760 770 780 790 800 pF1KE4 ADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVT :.::.::: :::::::::::.: . ::.::.::::. .::.::..: .::.:::.: XP_011 ANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQE--EYSTFVIDDPQE 690 700 710 720 730 740 810 820 830 840 850 pF1KE4 TFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS :.::..:. . . :.. : .:.. . ...::::.:.:: :. XP_011 TYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI 750 760 770 780 790 800 850 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 9 12:20:12 2016 done: Wed Nov 9 12:20:13 2016 Total Scan time: 8.850 Total Display time: 0.320 Function used was FASTA [36.3.4 Apr, 2011]