FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4064, 344 aa 1>>>pF1KE4064 344 - 344 aa - 344 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8678+/-0.000326; mu= 19.3556+/- 0.020 mean_var=70.1350+/-13.944, 0's: 0 Z-trim(115.6): 235 B-trim: 0 in 0/53 Lambda= 0.153146 statistics sampled from 25881 (26118) to 25881 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.306), width: 16 Scan time: 8.090 The best scores are: opt bits E(85289) NP_001254501 (OMIM: 609871) TBC1 domain family mem ( 468) 537 127.6 5.3e-29 XP_011517145 (OMIM: 609871) PREDICTED: TBC1 domain ( 468) 537 127.6 5.3e-29 XP_016870388 (OMIM: 609871) PREDICTED: TBC1 domain ( 483) 537 127.6 5.5e-29 NP_001254500 (OMIM: 609871) TBC1 domain family mem ( 928) 537 127.8 8.9e-29 NP_056342 (OMIM: 613620) TBC1 domain family member ( 808) 504 120.5 1.3e-26 XP_006718602 (OMIM: 610831) PREDICTED: carabin iso ( 446) 497 118.7 2.4e-26 XP_006718603 (OMIM: 610831) PREDICTED: carabin iso ( 446) 497 118.7 2.4e-26 XP_006718601 (OMIM: 610831) PREDICTED: carabin iso ( 446) 497 118.7 2.4e-26 NP_940919 (OMIM: 610831) carabin isoform 1 [Homo s ( 446) 497 118.7 2.4e-26 NP_114143 (OMIM: 610020) TBC1 domain family member ( 508) 494 118.1 4.1e-26 NP_001191169 (OMIM: 610020) TBC1 domain family mem ( 515) 485 116.1 1.7e-25 NP_060891 (OMIM: 609871) TBC1 domain family member ( 917) 485 116.4 2.5e-25 NP_001288778 (OMIM: 610440) small G protein signal ( 660) 460 110.7 9.1e-24 XP_016884266 (OMIM: 610440) PREDICTED: small G pro ( 672) 460 110.7 9.3e-24 XP_016884265 (OMIM: 610440) PREDICTED: small G pro ( 682) 460 110.7 9.4e-24 XP_011528464 (OMIM: 610440) PREDICTED: small G pro ( 686) 460 110.7 9.4e-24 XP_016884264 (OMIM: 610440) PREDICTED: small G pro ( 686) 460 110.7 9.4e-24 XP_005261632 (OMIM: 610440) PREDICTED: small G pro ( 699) 460 110.7 9.5e-24 XP_011528461 (OMIM: 610440) PREDICTED: small G pro ( 703) 460 110.7 9.6e-24 XP_011528462 (OMIM: 610440) PREDICTED: small G pro ( 703) 460 110.7 9.6e-24 XP_005261631 (OMIM: 610440) PREDICTED: small G pro ( 739) 460 110.7 9.9e-24 NP_056520 (OMIM: 610440) small G protein signaling ( 749) 460 110.8 1e-23 XP_005261630 (OMIM: 610440) PREDICTED: small G pro ( 756) 460 110.8 1e-23 XP_005261629 (OMIM: 610440) PREDICTED: small G pro ( 766) 460 110.8 1e-23 XP_011543304 (OMIM: 610831) PREDICTED: carabin iso ( 313) 445 107.1 5.2e-23 XP_011511972 (OMIM: 609850) PREDICTED: TBC1 domain ( 494) 393 95.8 2.1e-19 XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain ( 546) 393 95.8 2.3e-19 XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain (1039) 393 96.1 3.7e-19 XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 391 95.5 3.9e-19 XP_005262706 (OMIM: 609850) PREDICTED: TBC1 domain (1146) 393 96.1 3.9e-19 NP_055988 (OMIM: 609850) TBC1 domain family member (1168) 393 96.1 4e-19 XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 391 95.5 4e-19 XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain (1181) 393 96.1 4e-19 XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 391 95.5 4e-19 XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain (1188) 393 96.1 4e-19 XP_011511967 (OMIM: 609850) PREDICTED: TBC1 domain (1201) 393 96.1 4.1e-19 NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 391 95.5 4.1e-19 XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain (1222) 393 96.1 4.1e-19 XP_016863407 (OMIM: 609850) PREDICTED: TBC1 domain (1228) 393 96.1 4.1e-19 XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 391 95.5 4.2e-19 NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 391 95.5 4.2e-19 XP_011511966 (OMIM: 609850) PREDICTED: TBC1 domain (1241) 393 96.1 4.2e-19 XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain (1242) 393 96.1 4.2e-19 XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 391 95.5 4.2e-19 XP_011511964 (OMIM: 609850) PREDICTED: TBC1 domain (1255) 393 96.1 4.2e-19 XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain (1262) 393 96.1 4.2e-19 XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain (1275) 393 96.1 4.3e-19 XP_011511962 (OMIM: 609850) PREDICTED: TBC1 domain (1282) 393 96.1 4.3e-19 XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 391 95.6 4.3e-19 XP_011511961 (OMIM: 609850) PREDICTED: TBC1 domain (1295) 393 96.2 4.3e-19 >>NP_001254501 (OMIM: 609871) TBC1 domain family member (468 aa) initn: 347 init1: 242 opt: 537 Z-score: 641.6 bits: 127.6 E(85289): 5.3e-29 Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:93-394) 10 20 pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY : : . . : ::: :.. : : NP_001 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI 70 80 90 100 110 120 30 40 50 60 70 80 pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS . . : : .:. .:. : : :: : .:. .: ::: ::: ::: : NP_001 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV 130 140 150 160 170 90 100 110 120 130 pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN ..: ..:: :..:: :....: .. :. :::::::.: .: :. . : NP_001 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR 180 190 200 210 220 230 140 150 160 170 180 190 pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK ::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . . NP_001 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ 240 250 260 270 280 290 200 210 220 230 240 250 pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG .::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. :: NP_001 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 300 310 320 330 340 350 260 270 280 290 300 310 pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS .:..:: ::...: ... ::. . .: . .. .:: NP_001 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ 360 370 380 390 400 410 320 330 340 pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA NP_001 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA 420 430 440 450 460 >>XP_011517145 (OMIM: 609871) PREDICTED: TBC1 domain fam (468 aa) initn: 347 init1: 242 opt: 537 Z-score: 641.6 bits: 127.6 E(85289): 5.3e-29 Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:93-394) 10 20 pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY : : . . : ::: :.. : : XP_011 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI 70 80 90 100 110 120 30 40 50 60 70 80 pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS . . : : .:. .:. : : :: : .:. .: ::: ::: ::: : XP_011 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV 130 140 150 160 170 90 100 110 120 130 pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN ..: ..:: :..:: :....: .. :. :::::::.: .: :. . : XP_011 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR 180 190 200 210 220 230 140 150 160 170 180 190 pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK ::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . . XP_011 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ 240 250 260 270 280 290 200 210 220 230 240 250 pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG .::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. :: XP_011 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 300 310 320 330 340 350 260 270 280 290 300 310 pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS .:..:: ::...: ... ::. . .: . .. .:: XP_011 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ 360 370 380 390 400 410 320 330 340 pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA XP_011 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA 420 430 440 450 460 >>XP_016870388 (OMIM: 609871) PREDICTED: TBC1 domain fam (483 aa) initn: 347 init1: 242 opt: 537 Z-score: 641.4 bits: 127.6 E(85289): 5.5e-29 Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:108-409) 10 20 pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY : : . . : ::: :.. : : XP_016 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI 80 90 100 110 120 130 30 40 50 60 70 80 pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS . . : : .:. .:. : : :: : .:. .: ::: ::: ::: : XP_016 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV 140 150 160 170 180 190 90 100 110 120 130 pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN ..: ..:: :..:: :....: .. :. :::::::.: .: :. . : XP_016 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR 200 210 220 230 240 250 140 150 160 170 180 190 pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK ::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . . XP_016 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ 260 270 280 290 300 310 200 210 220 230 240 250 pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG .::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. :: XP_016 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 320 330 340 350 360 370 260 270 280 290 300 310 pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS .:..:: ::...: ... ::. . .: . .. .:: XP_016 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ 380 390 400 410 420 430 320 330 340 pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA XP_016 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA 440 450 460 470 480 >>NP_001254500 (OMIM: 609871) TBC1 domain family member (928 aa) initn: 347 init1: 242 opt: 537 Z-score: 637.6 bits: 127.8 E(85289): 8.9e-29 Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:553-854) 10 20 pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY : : . . : ::: :.. : : NP_001 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI 530 540 550 560 570 580 30 40 50 60 70 80 pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS . . : : .:. .:. : : :: : .:. .: ::: ::: ::: : NP_001 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV 590 600 610 620 630 90 100 110 120 130 pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN ..: ..:: :..:: :....: .. :. :::::::.: .: :. . : NP_001 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR 640 650 660 670 680 690 140 150 160 170 180 190 pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK ::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . . NP_001 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ 700 710 720 730 740 750 200 210 220 230 240 250 pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG .::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. :: NP_001 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG 760 770 780 790 800 810 260 270 280 290 300 310 pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS .:..:: ::...: ... ::. . .: . .. .:: NP_001 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ 820 830 840 850 860 870 320 330 340 pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA NP_001 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA 880 890 900 910 920 >>NP_056342 (OMIM: 613620) TBC1 domain family member 10B (808 aa) initn: 544 init1: 264 opt: 504 Z-score: 599.0 bits: 120.5 E(85289): 1.3e-26 Smith-Waterman score: 504; 32.1% identity (59.6% similar) in 287 aa overlap (11-293:303-583) 10 20 30 40 pF1KE4 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLT . : ::: ... . . :: : .. NP_056 VSLMSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGS----LESSIPVDVA 280 290 300 310 320 50 60 70 80 90 pF1KE4 R-RAIKWSRLLQGGGVPRSRT---VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYH : : .:: .... :: :: :::.: ::..:. ::... ..:::: .. NP_056 RQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFE 330 340 350 360 370 380 100 110 120 130 140 150 pF1KE4 QLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQG .: .. .:. :.:. ::.: :: . : . :. :: .: :: . ::::. NP_056 ELERAPGDPKWLDVIEKDLHRQFPFHEMF-AARGGHGQQDLYRILKAYTIYRPDEGYCQA 390 400 410 420 430 440 160 170 180 190 200 210 pF1KE4 MNFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVG . .:. : :. :..:: : . . :: ::: .. ... : :.. :.: : . NP_056 QAPVAAVL-LMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 450 460 470 480 490 500 220 230 240 250 260 270 pF1KE4 ALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQEL ..: . .: ...::.:.:. :: .:::.:: .: :: ::::::::.:... NP_056 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 510 520 530 540 550 560 280 290 300 310 320 330 pF1KE4 ILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPSQGAPPHLQPGGCSDHPEG . . : . . ..:. NP_056 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 570 580 590 600 610 620 >>XP_006718602 (OMIM: 610831) PREDICTED: carabin isoform (446 aa) initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26 Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293) 10 20 30 40 50 60 pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV . .: .:: .. . :: :: XP_006 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF :::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . : XP_006 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI . :. : .:: :: . ::::... .:. : :. ::.:: : . XP_006 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE :: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. :: XP_006 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF ::::.:: ...::....:::.:::.. XP_006 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA 270 280 290 300 310 320 >>XP_006718603 (OMIM: 610831) PREDICTED: carabin isoform (446 aa) initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26 Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293) 10 20 30 40 50 60 pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV . .: .:: .. . :: :: XP_006 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF :::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . : XP_006 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI . :. : .:: :: . ::::... .:. : :. ::.:: : . XP_006 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE :: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. :: XP_006 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF ::::.:: ...::....:::.:::.. XP_006 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA 270 280 290 300 310 320 >>XP_006718601 (OMIM: 610831) PREDICTED: carabin isoform (446 aa) initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26 Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293) 10 20 30 40 50 60 pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV . .: .:: .. . :: :: XP_006 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF :::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . : XP_006 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI . :. : .:: :: . ::::... .:. : :. ::.:: : . XP_006 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE :: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. :: XP_006 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF ::::.:: ...::....:::.:::.. XP_006 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA 270 280 290 300 310 320 >>NP_940919 (OMIM: 610831) carabin isoform 1 [Homo sapie (446 aa) initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26 Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293) 10 20 30 40 50 60 pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV . .: .:: .. . :: :: NP_940 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF :::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . : NP_940 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI . :. : .:: :: . ::::... .:. : :. ::.:: : . NP_940 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE :: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. :: NP_940 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF ::::.:: ...::....:::.:::.. NP_940 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA 270 280 290 300 310 320 >>NP_114143 (OMIM: 610020) TBC1 domain family member 10A (508 aa) initn: 467 init1: 261 opt: 494 Z-score: 589.8 bits: 118.1 E(85289): 4.1e-26 Smith-Waterman score: 494; 33.6% identity (60.0% similar) in 265 aa overlap (11-272:54-313) 10 20 30 40 pF1KE4 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLT ::: .:: . ..: :. : .: NP_114 ESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEV---PLEVLR 30 40 50 60 70 80 50 60 70 80 90 pF1KE4 RRAIKWSRLLQGGG---VPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQ .: :: .:.. . . . .. .::.: :.:.:. :::......:::: . . NP_114 QRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE4 LLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGM : .. .:. :.:. ::.: :: . : . :. :. :: :: . ::::.. NP_114 LDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHG-QQDLFRVLKAYTLYRPEEGYCQAQ 150 160 170 180 190 160 170 180 190 200 210 pF1KE4 NFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGA ::. : :. :..:: : . . :: ::: . ... : :.: :.. :.. NP_114 APIAAVL-LMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE4 LMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELI . : . : ...::.: : :: .:::.:: .: :: ::::::.:.:.:. NP_114 HLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSP 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE4 LEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPSQGAPPHLQPGGCSDHPEGA NP_114 EKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGE 320 330 340 350 360 370 344 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:44:41 2016 done: Sun Nov 6 01:44:42 2016 Total Scan time: 8.090 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]