Result of FASTA (omim) for
pFN21AE0645
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0645, 217 aa
1>>>pF1KE0645 217 - 217 aa - 217 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2478+/-0.00057; mu= -0.5441+/- 0.034
mean_var=423.5044+/-98.908, 0's: 0 Z-trim(115.0): 199 B-trim: 0 in 0/52
Lambda= 0.062323
statistics sampled from 25011 (25202) to 25011 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.295), width: 16
Scan time: 4.800
The best scores are: opt bits E(85289)
NP_006604 (OMIM: 604330) GRB2-related adapter prot ( 217) 1484 147.6 1.5e-35
XP_016879518 (OMIM: 604330) PREDICTED: GRB2-relate ( 217) 1484 147.6 1.5e-35
NP_002077 (OMIM: 108355) growth factor receptor-bo ( 217) 930 97.8 1.5e-20
NP_001317077 (OMIM: 604330) GRB2-related adapter p ( 205) 662 73.7 2.5e-13
NP_004801 (OMIM: 604518) GRB2-related adapter prot ( 330) 542 63.2 5.8e-10
NP_001278754 (OMIM: 604518) GRB2-related adapter p ( 330) 542 63.2 5.8e-10
NP_001278753 (OMIM: 604518) GRB2-related adapter p ( 330) 542 63.2 5.8e-10
XP_006724439 (OMIM: 604518) PREDICTED: GRB2-relate ( 258) 326 43.6 0.00036
NP_001278755 (OMIM: 604518) GRB2-related adapter p ( 258) 326 43.6 0.00036
NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 328 44.3 0.00046
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 332 45.2 0.00052
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 332 45.2 0.00053
NP_001161711 (OMIM: 164690) Abelson tyrosine-prote (1043) 328 44.8 0.00065
NP_001161710 (OMIM: 164690) Abelson tyrosine-prote (1058) 328 44.8 0.00065
NP_001129472 (OMIM: 164690) Abelson tyrosine-prote (1064) 328 44.8 0.00065
NP_001161709 (OMIM: 164690) Abelson tyrosine-prote (1079) 328 44.8 0.00066
XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyr (1146) 328 44.8 0.00068
NP_001161708 (OMIM: 164690) Abelson tyrosine-prote (1161) 328 44.8 0.00068
NP_005149 (OMIM: 164690) Abelson tyrosine-protein (1167) 328 44.8 0.00068
NP_009298 (OMIM: 164690) Abelson tyrosine-protein (1182) 328 44.9 0.00069
XP_016856524 (OMIM: 164690) PREDICTED: Abelson tyr (1182) 328 44.9 0.00069
NP_987102 (OMIM: 108355) growth factor receptor-bo ( 176) 288 39.9 0.0031
>>NP_006604 (OMIM: 604330) GRB2-related adapter protein (217 aa)
initn: 1484 init1: 1484 opt: 1484 Z-score: 759.3 bits: 147.6 E(85289): 1.5e-35
Smith-Waterman score: 1484; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
130 140 150 160 170 180
190 200 210
pF1KE0 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
:::::::::::::::::::::::::::::::::::::
NP_006 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
190 200 210
>>XP_016879518 (OMIM: 604330) PREDICTED: GRB2-related ad (217 aa)
initn: 1484 init1: 1484 opt: 1484 Z-score: 759.3 bits: 147.6 E(85289): 1.5e-35
Smith-Waterman score: 1484; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
130 140 150 160 170 180
190 200 210
pF1KE0 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
:::::::::::::::::::::::::::::::::::::
XP_016 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
190 200 210
>>NP_002077 (OMIM: 108355) growth factor receptor-bound (217 aa)
initn: 934 init1: 724 opt: 930 Z-score: 490.1 bits: 97.8 E(85289): 1.5e-20
Smith-Waterman score: 930; 59.7% identity (85.6% similar) in 216 aa overlap (1-216:1-214)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..:::::
NP_002 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
. :.: : :::.: :. : ::::::::::.::.::.::..:..::::::::...:::::
NP_002 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
: ::::::::::..:.:......:::::: : . ..: ..:: :::. :. ..:.::
NP_002 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR
130 140 150 160 170
190 200 210
pF1KE0 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
:::.:.:.. ::.::.: :..:.:::.:: ::.
NP_002 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
180 190 200 210
>>NP_001317077 (OMIM: 604330) GRB2-related adapter prote (205 aa)
initn: 680 init1: 662 opt: 662 Z-score: 360.1 bits: 73.7 E(85289): 2.5e-13
Smith-Waterman score: 662; 99.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
::::::::::::::::::::::::::::::::::::::::.
NP_001 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNHLGPALPRPSLTSQPRTPRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
NP_001 SASAVATSLRSWSAQTPTGGGAGPAGALASSHGVTCSPCTCEQPGGRSGQRAFLQELRSR
130 140 150 160 170 180
>>NP_004801 (OMIM: 604518) GRB2-related adapter protein (330 aa)
initn: 676 init1: 326 opt: 542 Z-score: 299.9 bits: 63.2 E(85289): 5.8e-10
Smith-Waterman score: 542; 52.7% identity (82.7% similar) in 150 aa overlap (1-150:1-147)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::.:: ..: :. :::.:. ::.::::. ....:.:::: . ::..:::.: .. :
NP_004 MEAVAKFDFTASGEDELSFHTGDVLKILS--NQEEWFKAELGSQEGYVPKNFIDIQFPKW
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
. .::. ::..:: .. .: :.:: :.::::.::.:: . :.::::::.:. .:.:::
NP_004 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
: ::: :::.:::.:::..:....::::::
NP_004 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
120 130 140 150 160 170
>>NP_001278754 (OMIM: 604518) GRB2-related adapter prote (330 aa)
initn: 676 init1: 326 opt: 542 Z-score: 299.9 bits: 63.2 E(85289): 5.8e-10
Smith-Waterman score: 542; 52.7% identity (82.7% similar) in 150 aa overlap (1-150:1-147)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::.:: ..: :. :::.:. ::.::::. ....:.:::: . ::..:::.: .. :
NP_001 MEAVAKFDFTASGEDELSFHTGDVLKILS--NQEEWFKAELGSQEGYVPKNFIDIQFPKW
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
. .::. ::..:: .. .: :.:: :.::::.::.:: . :.::::::.:. .:.:::
NP_001 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
: ::: :::.:::.:::..:....::::::
NP_001 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
120 130 140 150 160 170
>>NP_001278753 (OMIM: 604518) GRB2-related adapter prote (330 aa)
initn: 676 init1: 326 opt: 542 Z-score: 299.9 bits: 63.2 E(85289): 5.8e-10
Smith-Waterman score: 542; 52.7% identity (82.7% similar) in 150 aa overlap (1-150:1-147)
10 20 30 40 50 60
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
::.:: ..: :. :::.:. ::.::::. ....:.:::: . ::..:::.: .. :
NP_001 MEAVAKFDFTASGEDELSFHTGDVLKILS--NQEEWFKAELGSQEGYVPKNFIDIQFPKW
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
. .::. ::..:: .. .: :.:: :.::::.::.:: . :.::::::.:. .:.:::
NP_001 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
: ::: :::.:::.:::..:....::::::
NP_001 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE
120 130 140 150 160 170
>>XP_006724439 (OMIM: 604518) PREDICTED: GRB2-related ad (258 aa)
initn: 481 init1: 326 opt: 326 Z-score: 195.9 bits: 43.6 E(85289): 0.00036
Smith-Waterman score: 326; 63.4% identity (90.1% similar) in 71 aa overlap (80-150:5-75)
50 60 70 80 90 100
pF1KE0 KNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFK
.: :.:: :.::::.::.:: . :.:::::
XP_006 MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFK
10 20 30
110 120 130 140 150 160
pF1KE0 VLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDF
:.:. .:.:::: ::: :::.:::.:::..:....::::::
XP_006 VMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQG
40 50 60 70 80 90
170 180 190 200 210
pF1KE0 SAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
XP_006 GPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHH
100 110 120 130 140 150
>>NP_001278755 (OMIM: 604518) GRB2-related adapter prote (258 aa)
initn: 481 init1: 326 opt: 326 Z-score: 195.9 bits: 43.6 E(85289): 0.00036
Smith-Waterman score: 326; 63.4% identity (90.1% similar) in 71 aa overlap (80-150:5-75)
50 60 70 80 90 100
pF1KE0 KNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFK
.: :.:: :.::::.::.:: . :.:::::
NP_001 MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFK
10 20 30
110 120 130 140 150 160
pF1KE0 VLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDF
:.:. .:.:::: ::: :::.:::.:::..:....::::::
NP_001 VMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQG
40 50 60 70 80 90
170 180 190 200 210
pF1KE0 SAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
NP_001 GPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHH
100 110 120 130 140 150
>>NP_001129473 (OMIM: 164690) Abelson tyrosine-protein k (542 aa)
initn: 300 init1: 135 opt: 328 Z-score: 193.9 bits: 44.3 E(85289): 0.00046
Smith-Waterman score: 328; 35.6% identity (68.1% similar) in 160 aa overlap (4-158:92-248)
10 20 30
pF1KE0 MESVALYSFQATESDELAFNKGDTLKILNMEDD
::::.: :. .. :...::. :..:.....
NP_001 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
70 80 90 100 110 120
40 50 60 70 80
pF1KE0 QNWYKAELRGVEGFIPKNYIR----VKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESE
.: ... .. .:..:.::: .. : :: : .::. :: .: . . :.::.::::
NP_001 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESE
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE0 SSPGEFSVSVNYGDQVQHFKVLREASGK-YFLWEEKFNSLNELVDFYRTTTIAKKRQIFL
::::..:.:. : .: :... :.:: : : .:..: ::: . .:.: :
NP_001 SSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHH--STVADGLVTTL
190 200 210 220 230
150 160 170 180 190 200
pF1KE0 RDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFP
. : ..:
NP_001 HYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTL
240 250 260 270 280 290
217 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:11:32 2016 done: Wed Nov 2 19:11:33 2016
Total Scan time: 4.800 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]