Result of FASTA (omim) for
pFN21AE0595
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0595, 170 aa
1>>>pF1KE0595 170 - 170 aa - 170 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7456+/-0.000304; mu= 17.0927+/- 0.019
mean_var=97.2913+/-19.899, 0's: 0 Z-trim(119.4): 293 B-trim: 1003 in 2/53
Lambda= 0.130028
statistics sampled from 32921 (33286) to 32921 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.39), width: 16
Scan time: 5.410
The best scores are: opt bits E(85289)
NP_036278 (OMIM: 611441) double homeobox protein 1 ( 170) 1159 226.6 1.5e-59
NP_036281 (OMIM: 611444) double homeobox protein 5 ( 197) 1159 226.7 1.6e-59
NP_001280727 (OMIM: 606009) double homeobox protei ( 424) 926 183.4 3.7e-46
NP_001292997 (OMIM: 606009) double homeobox protei ( 424) 926 183.4 3.7e-46
XP_011529816 (OMIM: 606009) PREDICTED: double home ( 160) 890 176.2 2.2e-44
NP_001012747 (OMIM: 611168) double homeobox protei ( 204) 265 59.0 5e-09
NP_006252 (OMIM: 262600,601538) homeobox protein p ( 226) 235 53.5 2.6e-07
NP_114150 (OMIM: 609852) homeobox protein MIXL1 is ( 232) 232 52.9 3.9e-07
NP_116142 (OMIM: 605726,610362,610381,613757) reti ( 184) 227 51.9 6.5e-07
NP_001306003 (OMIM: 605726,610362,610381,613757) r ( 230) 227 52.0 7.5e-07
NP_000545 (OMIM: 120970,268000,602225,613829) cone ( 299) 228 52.3 7.7e-07
NP_055377 (OMIM: 600036) homeobox protein OTX1 [Ho ( 354) 228 52.4 8.6e-07
NP_001186699 (OMIM: 600036) homeobox protein OTX1 ( 354) 228 52.4 8.6e-07
XP_016870292 (OMIM: 604675) PREDICTED: paired meso ( 193) 221 50.8 1.5e-06
NP_057391 (OMIM: 604675) paired mesoderm homeobox ( 253) 221 50.9 1.7e-06
NP_068374 (OMIM: 600037,610125,613986) homeobox pr ( 297) 219 50.6 2.5e-06
NP_001257454 (OMIM: 600037,610125,613986) homeobox ( 297) 219 50.6 2.5e-06
NP_001128726 (OMIM: 167410,268220) paired box prot ( 505) 221 51.3 2.7e-06
NP_039236 (OMIM: 167410,268220) paired box protein ( 518) 221 51.3 2.7e-06
NP_002575 (OMIM: 167410,268220) paired box protein ( 520) 221 51.3 2.7e-06
NP_038463 (OMIM: 601881,611038) retinal homeobox p ( 346) 219 50.7 2.7e-06
NP_852126 (OMIM: 122880,148820,193500,268220,60659 ( 403) 218 50.6 3.4e-06
NP_852125 (OMIM: 122880,148820,193500,268220,60659 ( 407) 218 50.6 3.4e-06
NP_852122 (OMIM: 122880,148820,193500,268220,60659 ( 479) 218 50.7 3.8e-06
NP_001120838 (OMIM: 122880,148820,193500,268220,60 ( 483) 218 50.7 3.8e-06
NP_852123 (OMIM: 122880,148820,193500,268220,60659 ( 484) 218 50.7 3.8e-06
NP_852124 (OMIM: 122880,148820,193500,268220,60659 ( 505) 218 50.7 3.9e-06
NP_001257453 (OMIM: 600037,610125,613986) homeobox ( 289) 214 49.7 4.7e-06
NP_001257452 (OMIM: 600037,610125,613986) homeobox ( 289) 214 49.7 4.7e-06
NP_758840 (OMIM: 600037,610125,613986) homeobox pr ( 289) 214 49.7 4.7e-06
NP_005020 (OMIM: 107250,602669,610623) pituitary h ( 302) 213 49.5 5.5e-06
NP_005160 (OMIM: 602078,602753) paired mesoderm ho ( 284) 211 49.1 6.8e-06
XP_016883326 (OMIM: 122000,148300,605020,614195) P ( 280) 210 48.9 7.7e-06
XP_016862910 (OMIM: 182230,601802) PREDICTED: home ( 185) 208 48.3 7.8e-06
XP_006713442 (OMIM: 182230,601802) PREDICTED: home ( 185) 208 48.3 7.8e-06
XP_011532506 (OMIM: 182230,601802) PREDICTED: home ( 185) 208 48.3 7.8e-06
NP_003856 (OMIM: 182230,601802) homeobox expressed ( 185) 208 48.3 7.8e-06
XP_011532507 (OMIM: 182230,601802) PREDICTED: home ( 185) 208 48.3 7.8e-06
XP_005265583 (OMIM: 182230,601802) PREDICTED: home ( 185) 208 48.3 7.8e-06
NP_878314 (OMIM: 142993,610092,610093) visual syst ( 361) 211 49.2 7.9e-06
NP_001243201 (OMIM: 122000,148300,605020,614195) v ( 301) 210 48.9 8.1e-06
NP_055403 (OMIM: 122000,148300,605020,614195) visu ( 365) 210 49.0 9.1e-06
NP_115485 (OMIM: 604529) homeobox protein orthoped ( 325) 209 48.8 9.6e-06
NP_001269331 (OMIM: 609852) homeobox protein MIXL1 ( 240) 206 48.1 1.2e-05
NP_671725 (OMIM: 607410) diencephalon/mesencephalo ( 382) 208 48.7 1.2e-05
XP_006711451 (OMIM: 167420,202650) PREDICTED: pair ( 198) 204 47.6 1.4e-05
NP_757379 (OMIM: 607410) diencephalon/mesencephalo ( 377) 207 48.5 1.4e-05
XP_016855778 (OMIM: 607410) PREDICTED: diencephalo ( 377) 207 48.5 1.4e-05
XP_011538970 (OMIM: 607410) PREDICTED: diencephalo ( 377) 207 48.5 1.4e-05
NP_003915 (OMIM: 209880,603851,613013) paired meso ( 314) 206 48.2 1.4e-05
>>NP_036278 (OMIM: 611441) double homeobox protein 1 [Ho (170 aa)
initn: 1159 init1: 1159 opt: 1159 Z-score: 1190.3 bits: 226.6 E(85289): 1.5e-59
Smith-Waterman score: 1159; 100.0% identity (100.0% similar) in 170 aa overlap (1-170:1-170)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
130 140 150 160 170
>>NP_036281 (OMIM: 611444) double homeobox protein 5 [Ho (197 aa)
initn: 1159 init1: 1159 opt: 1159 Z-score: 1189.6 bits: 226.7 E(85289): 1.6e-59
Smith-Waterman score: 1159; 100.0% identity (100.0% similar) in 170 aa overlap (1-170:28-197)
10 20 30
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDA
:::::::::::::::::::::::::::::::::
NP_036 MPAEVHGSPPASLCPCQSVKFRPGLPEMALLTALDDTLPEEAQGPGRRMILLSTPSQSDA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 GRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQS
130 140 150 160 170 180
160 170
pF1KE0 GRAPTQASIRCNAAPIG
:::::::::::::::::
NP_036 GRAPTQASIRCNAAPIG
190
>>NP_001280727 (OMIM: 606009) double homeobox protein 4 (424 aa)
initn: 1124 init1: 926 opt: 926 Z-score: 949.7 bits: 183.4 E(85289): 3.7e-46
Smith-Waterman score: 926; 81.8% identity (90.0% similar) in 170 aa overlap (1-170:1-170)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
::: : :.::: ::.: ::: :. :::::.::::::::: ::::::.:.:::.: :::
NP_001 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:::::::::::: :::::::.:::::::: : .:::::::.:::::::::::::::::::
NP_001 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
::::::::::::::::::::::::::::: ::.::::.::. :.::: :
NP_001 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF
130 140 150 160 170 180
NP_001 AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA
190 200 210 220 230 240
>>NP_001292997 (OMIM: 606009) double homeobox protein 4 (424 aa)
initn: 1124 init1: 926 opt: 926 Z-score: 949.7 bits: 183.4 E(85289): 3.7e-46
Smith-Waterman score: 926; 81.8% identity (90.0% similar) in 170 aa overlap (1-170:1-170)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
::: : :.::: ::.: ::: :. :::::.::::::::: ::::::.:.:::.: :::
NP_001 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:::::::::::: :::::::.:::::::: : .:::::::.:::::::::::::::::::
NP_001 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
::::::::::::::::::::::::::::: ::.::::.::. :.::: :
NP_001 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAF
130 140 150 160 170 180
NP_001 AHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFA
190 200 210 220 230 240
>>XP_011529816 (OMIM: 606009) PREDICTED: double homeobox (160 aa)
initn: 1088 init1: 890 opt: 890 Z-score: 917.9 bits: 176.2 E(85289): 2.2e-44
Smith-Waterman score: 890; 83.6% identity (91.2% similar) in 159 aa overlap (1-159:1-159)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
::: : :.::: ::.: ::: :. :::::.::::::::: ::::::.:.:::.: :::
XP_011 MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
:::::::::::: :::::::.:::::::: : .:::::::.:::::::::::::::::::
XP_011 PRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
::::::::::::::::::::::::::::: ::.::::.:
XP_011 IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQV
130 140 150 160
>>NP_001012747 (OMIM: 611168) double homeobox protein A (204 aa)
initn: 233 init1: 233 opt: 265 Z-score: 283.1 bits: 59.0 E(85289): 5e-09
Smith-Waterman score: 363; 43.6% identity (63.8% similar) in 149 aa overlap (20-157:16-164)
10 20 30 40 50 60
pF1KE0 MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
:: : : : :... ::: :::..:: :. :
NP_001 MAEDTYSHKMVKTNHRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEE
10 20 30 40 50
70 80 90 100
pF1KE0 PRVQIWFQNERSCQLRQHR----------RQSRPWPGRR-DPQKGRRKRTAITGSQTALL
:.::::::.:. . :.: :.. :: . . ...:: ::. ..:: :
NP_001 SRIQIWFQNRRARHGFQKRPEAETLESSQSQGQDQPGVEFQSREARRCRTTYSASQLHTL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 LRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPI
..:: :. .::: .:::::.: :.::::.::::::::.: : : :
NP_001 IKAFMKNPYPGIDSREELAKEIGVPESRVQIWFQNRRSRLLLQRKREPVASLEQEEQGKI
120 130 140 150 160 170
170
pF1KE0 G
NP_001 PEGLQGAEDTQNGTNFTSDSHFSGARTW
180 190 200
>>NP_006252 (OMIM: 262600,601538) homeobox protein proph (226 aa)
initn: 222 init1: 222 opt: 235 Z-score: 252.2 bits: 53.5 E(85289): 2.6e-07
Smith-Waterman score: 235; 49.3% identity (72.0% similar) in 75 aa overlap (79-152:53-127)
50 60 70 80 90 100
pF1KE0 KEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRD-PQKGRRKRTAITGSQTA
: . : :.: :.. ::.::... :
NP_006 PERHPATGTPTTTVDSSAPPCRRLPGAGGGRSRFSPQGGQRGRPHSRRRHRTTFSPVQLE
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE0 LLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAA
: :: ....: : ::: :::.::: :.:::.:::::::..: :
NP_006 QLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPAA
90 100 110 120 130 140
170
pF1KE0 PIG
NP_006 FSSFLPESTACPYSYAAPPPPVTCFPHPYSHALPSQPSTGGAFALSHQSEDWYPTLHPAP
150 160 170 180 190 200
>>NP_114150 (OMIM: 609852) homeobox protein MIXL1 isofor (232 aa)
initn: 251 init1: 228 opt: 232 Z-score: 249.0 bits: 52.9 E(85289): 3.9e-07
Smith-Waterman score: 232; 51.4% identity (71.6% similar) in 74 aa overlap (84-156:75-148)
60 70 80 90 100 110
pF1KE0 QGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKG-RRKRTAITGSQTALLLRA
: : :. . :::::.... : :: .
NP_114 AGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 FEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
:.. :.: : ::.:: : :::::::.:::::::. : :::..
NP_114 FRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAP
110 120 130 140 150 160
NP_114 GTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEH
170 180 190 200 210 220
>>NP_116142 (OMIM: 605726,610362,610381,613757) retina a (184 aa)
initn: 221 init1: 206 opt: 227 Z-score: 245.1 bits: 51.9 E(85289): 6.5e-07
Smith-Waterman score: 227; 46.6% identity (68.2% similar) in 88 aa overlap (86-168:18-104)
60 70 80 90 100 110
pF1KE0 IDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKG-RRKRTAITGSQTALLLRAFE
::.. :.: ::.::..: : : ::::
NP_116 MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFE
10 20 30 40
120 130 140 150 160 170
pF1KE0 KDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQ----SGRAPTQASIRCNAAPIG
...: . .::::: .. ::: :.:.:::::::. : : :: . . :. : ::
NP_116 ASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAV-AAPRLPEAPAL
50 60 70 80 90 100
NP_116 PFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASL
110 120 130 140 150 160
>>NP_001306003 (OMIM: 605726,610362,610381,613757) retin (230 aa)
initn: 206 init1: 206 opt: 227 Z-score: 244.0 bits: 52.0 E(85289): 7.5e-07
Smith-Waterman score: 227; 46.6% identity (68.2% similar) in 88 aa overlap (86-168:64-150)
60 70 80 90 100 110
pF1KE0 IDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKG-RRKRTAITGSQTALLLRAFE
::.. :.: ::.::..: : : ::::
NP_001 PPSVPLPSHQVGAMFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFE
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE0 KDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQ----SGRAPTQASIRCNAAPIG
...: . .::::: .. ::: :.:.:::::::. : : :: . . :. : ::
NP_001 ASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAV-AAPRLPEAPAL
100 110 120 130 140 150
NP_001 PFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASL
160 170 180 190 200 210
170 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 20:48:06 2016 done: Wed Nov 2 20:48:07 2016
Total Scan time: 5.410 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]