FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4124, 512 aa 1>>>pF1KE4124 512 - 512 aa - 512 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1229+/-0.000379; mu= 9.8926+/- 0.023 mean_var=208.0794+/-45.941, 0's: 0 Z-trim(119.5): 448 B-trim: 477 in 2/56 Lambda= 0.088912 statistics sampled from 32901 (33590) to 32901 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.394), width: 16 Scan time: 11.680 The best scores are: opt bits E(85289) NP_001135931 (OMIM: 603383,615054) ankyrin repeat ( 467) 3187 422.0 1.9e-117 NP_001135932 (OMIM: 603383,615054) ankyrin repeat ( 429) 2531 337.8 3.9e-92 NP_543147 (OMIM: 603383,615054) ankyrin repeat and ( 452) 2465 329.3 1.4e-89 NP_057200 (OMIM: 605761) ankyrin repeat and SOCS b ( 426) 726 106.2 1.9e-22 NP_543139 (OMIM: 615056) ankyrin repeat and SOCS b ( 453) 607 91.0 8e-18 XP_016867792 (OMIM: 605761) PREDICTED: ankyrin rep ( 368) 555 84.2 7.1e-16 NP_665879 (OMIM: 605761) ankyrin repeat and SOCS b ( 349) 501 77.3 8.4e-14 NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 372 61.4 1.7e-08 XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 372 61.4 1.7e-08 XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 (1223) 371 61.3 1.9e-08 XP_011542148 (OMIM: 603303) PREDICTED: tankyrase-1 (1301) 371 61.3 2e-08 XP_006716326 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 371 61.3 2e-08 XP_011542147 (OMIM: 603303) PREDICTED: tankyrase-1 (1316) 371 61.3 2e-08 NP_003738 (OMIM: 603303) tankyrase-1 [Homo sapiens (1327) 371 61.3 2e-08 XP_016872190 (OMIM: 607128) PREDICTED: tankyrase-2 ( 506) 340 56.8 1.7e-07 XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187) 340 57.3 3e-07 XP_005270242 (OMIM: 607128) PREDICTED: tankyrase-2 (1190) 340 57.3 3e-07 NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 314 54.1 3.8e-06 XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 314 54.1 3.9e-06 XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 314 54.1 3.9e-06 XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 314 54.1 3.9e-06 XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 314 54.1 3.9e-06 XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 314 54.1 3.9e-06 XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 314 54.2 3.9e-06 NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 314 54.2 4e-06 NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 314 54.2 4e-06 NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 314 54.2 4e-06 XP_011542804 (OMIM: 182900,612641) PREDICTED: anky (1889) 314 54.2 4.1e-06 XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 314 54.2 4.1e-06 NP_001135918 (OMIM: 182900,612641) ankyrin-1 isofo (1897) 314 54.2 4.1e-06 XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 314 54.2 4.1e-06 XP_011542803 (OMIM: 182900,612641) PREDICTED: anky (1913) 314 54.2 4.1e-06 XP_011542802 (OMIM: 182900,612641) PREDICTED: anky (1914) 314 54.2 4.1e-06 XP_005273533 (OMIM: 182900,612641) PREDICTED: anky (1921) 314 54.2 4.1e-06 XP_016868813 (OMIM: 182900,612641) PREDICTED: anky (1922) 314 54.2 4.1e-06 XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 314 54.2 4.1e-06 XP_016868811 (OMIM: 182900,612641) PREDICTED: anky (1937) 314 54.2 4.1e-06 XP_016868810 (OMIM: 182900,612641) PREDICTED: anky (1940) 314 54.2 4.1e-06 XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 314 54.2 4.1e-06 XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 314 54.2 4.1e-06 XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 314 54.2 4.1e-06 XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 314 54.2 4.1e-06 XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 314 54.2 4.1e-06 XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 314 54.2 4.2e-06 XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 314 54.2 4.2e-06 NP_001162003 (OMIM: 300890) ankyrin repeat and SOC ( 262) 285 49.4 1.5e-05 NP_076992 (OMIM: 300890) ankyrin repeat and SOCS b ( 262) 285 49.4 1.5e-05 NP_001026909 (OMIM: 300890) ankyrin repeat and SOC ( 294) 285 49.5 1.6e-05 XP_005274503 (OMIM: 300890) PREDICTED: ankyrin rep ( 294) 285 49.5 1.6e-05 XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 297 51.9 1.7e-05 >>NP_001135931 (OMIM: 603383,615054) ankyrin repeat and (467 aa) initn: 3187 init1: 3187 opt: 3187 Z-score: 2229.4 bits: 422.0 E(85289): 1.9e-117 Smith-Waterman score: 3187; 100.0% identity (100.0% similar) in 467 aa overlap (46-512:1-467) 20 30 40 50 60 70 pF1KE4 CLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEK :::::::::::::::::::::::::::::: NP_001 MLMSWSPEECKGQGEPLDDRHPLCARLVEK 10 20 30 80 90 100 110 120 130 pF1KE4 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVV 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE4 QLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL 400 410 420 430 440 450 500 510 pF1KE4 PPRLLRYLQLDFEGVLY ::::::::::::::::: NP_001 PPRLLRYLQLDFEGVLY 460 >>NP_001135932 (OMIM: 603383,615054) ankyrin repeat and (429 aa) initn: 2527 init1: 2527 opt: 2531 Z-score: 1775.1 bits: 337.8 E(85289): 3.9e-92 Smith-Waterman score: 2855; 91.9% identity (91.9% similar) in 467 aa overlap (46-512:1-429) 20 30 40 50 60 70 pF1KE4 CLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEK :::::::::::::::::::::::::::::: NP_001 MLMSWSPEECKGQGEPLDDRHPLCARLVEK 10 20 30 80 90 100 110 120 130 pF1KE4 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRT 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATT 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTP 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVV :::::::::::::::::::::::::::::::::::::: NP_001 LHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK---------------------- 340 350 360 440 450 460 470 480 490 pF1KE4 QLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL :::::::::::::::::::::::::::::::::::::::::::: NP_001 ----------------KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPL 370 380 390 400 410 500 510 pF1KE4 PPRLLRYLQLDFEGVLY ::::::::::::::::: NP_001 PPRLLRYLQLDFEGVLY 420 >>NP_543147 (OMIM: 603383,615054) ankyrin repeat and SOC (452 aa) initn: 2445 init1: 2445 opt: 2465 Z-score: 1729.1 bits: 329.3 E(85289): 1.4e-89 Smith-Waterman score: 2482; 82.1% identity (88.7% similar) in 468 aa overlap (48-512:1-452) 20 30 40 50 60 70 pF1KE4 SVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGEPLD--DRHPLCARLVEK : :. . :. : : : :. . NP_543 MPWGKNSSPHWGHHLGCLPSAPAC-RIWRP 10 20 80 90 100 110 120 130 pF1KE4 PSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTS :: . : . :.:.. . .:. .:. .::.. ..... ::. : .... NP_543 HSRPAWEPPR--PSPLLCQD-----MALQNALYTGDLARLQELFPPHSTA---DLLLESR 30 40 50 60 70 140 150 160 170 180 190 pF1KE4 DPE-RWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR : :: . . :. ::::::::::::::::::::::::::::::::::::::::::: NP_543 AAEPRWSSHQ---RG--LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE4 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 140 150 160 170 180 190 260 270 280 290 300 310 pF1KE4 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE4 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 260 270 280 290 300 310 380 390 400 410 420 430 pF1KE4 PLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 PLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSV 320 330 340 350 360 370 440 450 460 470 480 490 pF1KE4 VQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 VQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLP 380 390 400 410 420 430 500 510 pF1KE4 LPPRLLRYLQLDFEGVLY :::::::::::::::::: NP_543 LPPRLLRYLQLDFEGVLY 440 450 >>NP_057200 (OMIM: 605761) ankyrin repeat and SOCS box p (426 aa) initn: 563 init1: 265 opt: 726 Z-score: 523.8 bits: 106.2 E(85289): 1.9e-22 Smith-Waterman score: 731; 33.1% identity (61.8% similar) in 432 aa overlap (85-512:10-426) 60 70 80 90 100 110 pF1KE4 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC ::: . .: :. : .:. ..: : NP_057 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK 10 20 30 120 130 140 150 160 170 pF1KE4 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG .. :: . . . :.::.. : ... . : .:. . . : ::... : NP_057 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG 40 50 60 70 80 180 190 200 210 220 230 pF1KE4 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL :.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::. NP_057 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF 90 100 110 120 130 140 240 250 260 270 280 290 pF1KE4 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA : :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. :: NP_057 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA 150 160 170 180 190 200 300 310 320 330 340 350 pF1KE4 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH . ::: : . . : .: . : .: .::. :...: :.: . ::: : NP_057 HMETPL-AIAAYWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL ......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: . NP_057 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE4 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALV-RQPRSL ::.. .::..:::..:.: .. . . . :.:. :: :::.. .::.: NP_057 HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTL 330 340 350 360 370 380 480 490 500 510 pF1KE4 QHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY .::::::.: :.. .:.: : :: : .:: :. ::..: NP_057 MHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 390 400 410 420 >>NP_543139 (OMIM: 615056) ankyrin repeat and SOCS box p (453 aa) initn: 867 init1: 410 opt: 607 Z-score: 441.0 bits: 91.0 E(85289): 8e-18 Smith-Waterman score: 847; 38.9% identity (62.5% similar) in 419 aa overlap (94-511:54-452) 70 80 90 100 110 120 pF1KE4 DRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSS :. ::. ::...:.. :. .. : NP_543 EWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--QALFSGNLQQVQALFQDEE 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE4 TGLAPDSVFDT-SDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLR : . . .: :. : . .: :: . . :.:: .:..::.:. : :.: NP_543 ---AANMIVETVSNQLAWSAEQ------GFWVLTPKTKQTAPLAIATARGYTDCARHLIR 90 100 110 120 130 190 200 210 220 230 240 pF1KE4 RRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECA . :. :. :::.::::::: .. ::..::. :: :. ..: ::::: : .:.:: NP_543 QGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE4 ELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD .:::. :: :. . : .:::::::: : . . : :..:: :...: : : .:: NP_543 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC- 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE4 VRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCG . ... .. : :: ::::: :: . .. ::: :: : ....:::: : NP_543 ----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYG 260 270 280 290 300 370 380 390 400 410 420 pF1KE4 VSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCP . :.. . .::::. ::::. . :: . :::..:: : : ..:.. .. : NP_543 ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFP 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE4 RTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHL :..:::.:.: : : : : :: ..:. :::: . .: :::.::::.: :.:..: NP_543 RALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARL 370 380 390 400 410 420 490 500 510 pF1KE4 EGSLPQALPRLPLPPRLLRYLQLDFEGVLY . :. :::::: : :: : :: . NP_543 GSRCRQGATRLPLPPLLRDYLLLRVEGCIQ 430 440 450 >>XP_016867792 (OMIM: 605761) PREDICTED: ankyrin repeat (368 aa) initn: 529 init1: 231 opt: 555 Z-score: 406.0 bits: 84.2 E(85289): 7.1e-16 Smith-Waterman score: 560; 32.2% identity (61.5% similar) in 351 aa overlap (85-432:10-345) 60 70 80 90 100 110 pF1KE4 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC ::: . .: :. : .:. ..: : XP_016 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK 10 20 30 120 130 140 150 160 170 pF1KE4 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG .. :: . . . :.::.. : ... . : .:. . . : ::... : XP_016 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG 40 50 60 70 80 180 190 200 210 220 230 pF1KE4 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL :.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::. XP_016 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF 90 100 110 120 130 140 240 250 260 270 280 290 pF1KE4 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA : :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. :: XP_016 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA 150 160 170 180 190 200 300 310 320 330 340 350 pF1KE4 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH . ::: : . . : .: . : .: .::. :...: :.: . ::: : XP_016 HMETPLAIAA-YWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL ......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: . XP_016 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE4 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQ ::.. .::..:::..:.: XP_016 HKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEGIRK 330 340 350 360 >>NP_665879 (OMIM: 605761) ankyrin repeat and SOCS box p (349 aa) initn: 488 init1: 218 opt: 501 Z-score: 368.8 bits: 77.3 E(85289): 8.4e-14 Smith-Waterman score: 506; 31.7% identity (59.5% similar) in 341 aa overlap (85-422:10-331) 60 70 80 90 100 110 pF1KE4 CKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGC ::: . .: :. : .:. ..: : NP_665 MDGTTAPVTKSGAAKLVKRN-------FLEALKSNDFGK 10 20 30 120 130 140 150 160 170 pF1KE4 VSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELT--TPLHVAASRG .. :: . . . :.::.. : ... . : .:. . . : ::... : NP_665 LKAILIQRQIDV--DTVFEVED----ENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFG 40 50 60 70 80 180 190 200 210 220 230 pF1KE4 HTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL :.: : .:: . : . :.:.: :: :: ... ::..: :: : . .:. ::. NP_665 HVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHF 90 100 110 120 130 140 240 250 260 270 280 290 pF1KE4 CRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDARNA : :... ::. :. :: :. ... ..::::::.::..: ::. . ...:: :. :: NP_665 CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA 150 160 170 180 190 200 300 310 320 330 340 350 pF1KE4 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH . ::: : . . : .: . : .: .::. :...: :.: . ::: : NP_665 HMETPL-AIAAYWALRFKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCD 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 AAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGAL ......: :. :: :: .: . .. .:. .. : .:: . ::::::.:..: . NP_665 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQF 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE4 PKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQ :: :: NP_665 HKV----RLCPVVSRLRKIQMAALSEISK 330 340 >>NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens] (1166 aa) initn: 422 init1: 169 opt: 372 Z-score: 273.4 bits: 61.4 E(85289): 1.7e-08 Smith-Waterman score: 372; 34.3% identity (54.7% similar) in 254 aa overlap (162-403:59-301) 140 150 160 170 180 pF1KE4 FDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR----RARP .:::: ::. :. .:.. ::. .:: NP_079 FEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARD 30 40 50 60 70 80 190 200 210 220 230 240 pF1KE4 DSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR : :: ::.::. ::. :..:: ::::: :. . ::: : .. .::. NP_079 D---GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE4 FGAR-----VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC- ::. .:::. . : :. :. . .:: . . . ::: . : NP_079 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 150 160 170 180 190 200 310 320 330 340 350 pF1KE4 --DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL : : .. : : ... .:::. :::. : :. ::: :: :: :.:::. NP_079 ASDGRKSTPLHLAAGYNR-VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWS . :. .:.:: :::: : ... .: ::..:: NP_079 KHGACVNAMDLWQFTPLH-------EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 270 280 290 300 310 420 430 440 450 460 470 pF1KE4 TCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALR NP_079 PTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYP 320 330 340 350 360 370 >>XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 iso (1169 aa) initn: 422 init1: 169 opt: 372 Z-score: 273.4 bits: 61.4 E(85289): 1.7e-08 Smith-Waterman score: 372; 34.3% identity (54.7% similar) in 254 aa overlap (162-403:59-301) 140 150 160 170 180 pF1KE4 FDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR----RARP .:::: ::. :. .:.. ::. .:: XP_016 FEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARD 30 40 50 60 70 80 190 200 210 220 230 240 pF1KE4 DSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR : :: ::.::. ::. :..:: ::::: :. . ::: : .. .::. XP_016 D---GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE4 FGAR-----VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC- ::. .:::. . : :. :. . .:: . . . ::: . : XP_016 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 150 160 170 180 190 200 310 320 330 340 350 pF1KE4 --DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL : : .. : : ... .:::. :::. : :. ::: :: :: :.:::. XP_016 ASDGRKSTPLHLAAGYNR-VKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 210 220 230 240 250 260 360 370 380 390 400 410 pF1KE4 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWS . :. .:.:: :::: : ... .: ::..:: XP_016 KHGACVNAMDLWQFTPLH-------EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 270 280 290 300 310 420 430 440 450 460 470 pF1KE4 TCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALR XP_016 PTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYP 320 330 340 350 360 370 >>XP_011542149 (OMIM: 603303) PREDICTED: tankyrase-1 iso (1223 aa) initn: 424 init1: 171 opt: 371 Z-score: 272.5 bits: 61.3 E(85289): 1.9e-08 Smith-Waterman score: 379; 31.1% identity (50.9% similar) in 334 aa overlap (162-480:217-532) 140 150 160 170 180 pF1KE4 FDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRR----RARP ..::: ::. :. .:.. ::. .:: XP_011 LEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 190 200 210 220 230 240 190 200 210 220 230 240 pF1KE4 DSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR : :: ::.::. ::. : .:: ::::: :. . ::: : .. .::. XP_011 D---GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 250 260 270 280 290 300 250 260 270 280 290 300 pF1KE4 FGA-----RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC- :: .::.: . : :. :. . .:: . . . ::: . : XP_011 HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 310 320 330 340 350 360 310 320 330 340 350 pF1KE4 --DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL : : .. : : ... .:::. :::. : :. ::: :: :: :.:::: XP_011 ASDGRKSTPLHLAAGYNR-VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLL 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE4 SCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWS . :. .:.:: :::: : ... .: ::.::: . . : . XP_011 KHGACVNAMDLWQFTPLH-------EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 430 440 450 460 470 420 430 440 450 460 470 pF1KE4 TCPRTIEVLMNTY---SVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRC :. : : . :..: .:: : : .. . . .::.: . .: XP_011 PTPELRERLTYEFKGHSLLQAAREA-------DLAKVKKTLALEIINFKQPQSHETALHC 480 490 500 510 520 480 490 500 510 pF1KE4 ALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY :. : XP_011 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD 530 540 550 560 570 580 512 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:27:01 2016 done: Sun Nov 6 02:27:03 2016 Total Scan time: 11.680 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]