FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4191, 688 aa 1>>>pF1KE4191 688 - 688 aa - 688 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6755+/-0.000355; mu= -5.7374+/- 0.022 mean_var=261.3198+/-54.654, 0's: 0 Z-trim(122.1): 87 B-trim: 0 in 0/58 Lambda= 0.079339 statistics sampled from 39589 (39681) to 39589 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.465), width: 16 Scan time: 14.650 The best scores are: opt bits E(85289) NP_002527 (OMIM: 311240) TBC1 domain family member ( 688) 4666 547.5 6e-155 NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 648 87.6 1.5e-16 NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 648 87.6 1.6e-16 XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 602 82.3 4.5e-15 XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 602 82.3 4.5e-15 XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 602 82.3 5.2e-15 XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 602 82.3 5.3e-15 XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 602 82.3 5.6e-15 XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 602 82.3 5.6e-15 XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15 XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15 XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15 XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 602 82.3 5.7e-15 NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 602 82.4 6.4e-15 NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 602 82.4 6.4e-15 XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 602 82.4 6.4e-15 NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 602 82.4 6.5e-15 XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 602 82.4 6.6e-15 XP_011522626 (OMIM: 616637) PREDICTED: TBC1 domain ( 396) 522 73.1 2.3e-12 NP_001258775 (OMIM: 616637) TBC1 domain family mem ( 278) 518 72.6 2.4e-12 NP_001258774 (OMIM: 616637) TBC1 domain family mem ( 405) 522 73.1 2.4e-12 XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain ( 462) 522 73.1 2.6e-12 XP_011522625 (OMIM: 616637) PREDICTED: TBC1 domain ( 521) 522 73.1 2.9e-12 XP_016879676 (OMIM: 616637) PREDICTED: TBC1 domain ( 543) 522 73.2 3e-12 XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain ( 599) 522 73.2 3.3e-12 XP_005257107 (OMIM: 616637) PREDICTED: TBC1 domain ( 766) 522 73.2 4e-12 XP_005257106 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 522 73.2 4e-12 NP_061893 (OMIM: 616637) TBC1 domain family member ( 767) 522 73.2 4e-12 XP_006721757 (OMIM: 616637) PREDICTED: TBC1 domain ( 767) 522 73.2 4e-12 XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain ( 639) 518 72.7 4.8e-12 XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain ( 640) 518 72.7 4.8e-12 XP_011525619 (OMIM: 616659) PREDICTED: TBC1 domain ( 501) 493 69.8 2.8e-11 NP_001258773 (OMIM: 616637) TBC1 domain family mem ( 392) 472 67.4 1.2e-10 XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain ( 753) 472 67.5 2.1e-10 XP_016880965 (OMIM: 611418) PREDICTED: small G pro ( 785) 392 58.4 1.2e-07 NP_001091979 (OMIM: 611418) small G protein signal (1006) 392 58.4 1.5e-07 XP_011522410 (OMIM: 611418) PREDICTED: small G pro (1012) 392 58.4 1.5e-07 XP_011522409 (OMIM: 611418) PREDICTED: small G pro (1042) 392 58.4 1.6e-07 XP_016880964 (OMIM: 611418) PREDICTED: small G pro (1047) 392 58.4 1.6e-07 NP_055668 (OMIM: 611418) small G protein signaling (1051) 392 58.4 1.6e-07 XP_016880963 (OMIM: 611418) PREDICTED: small G pro (1052) 392 58.4 1.6e-07 XP_011522408 (OMIM: 611418) PREDICTED: small G pro (1057) 392 58.4 1.6e-07 XP_011522407 (OMIM: 611418) PREDICTED: small G pro (1058) 392 58.4 1.6e-07 XP_011522406 (OMIM: 611418) PREDICTED: small G pro (1087) 392 58.4 1.6e-07 XP_011522405 (OMIM: 611418) PREDICTED: small G pro (1092) 392 58.4 1.6e-07 XP_011522404 (OMIM: 611418) PREDICTED: small G pro (1097) 392 58.4 1.7e-07 XP_011522403 (OMIM: 611418) PREDICTED: small G pro (1103) 392 58.4 1.7e-07 NP_001091968 (OMIM: 611417) small G protein signal (1032) 386 57.7 2.5e-07 NP_597711 (OMIM: 611417) small G protein signaling (1087) 386 57.7 2.6e-07 NP_001091967 (OMIM: 611417) small G protein signal (1093) 386 57.7 2.7e-07 >>NP_002527 (OMIM: 311240) TBC1 domain family member 25 (688 aa) initn: 4666 init1: 4666 opt: 4666 Z-score: 2902.8 bits: 547.5 E(85289): 6e-155 Smith-Waterman score: 4666; 99.7% identity (100.0% similar) in 688 aa overlap (1-688:1-688) 10 20 30 40 50 60 pF1KE4 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPEDLEFIRSTVLKDVLRTDRAHP ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: NP_002 LLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGHRGWPVRQRHMLRPAGGGGST ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: NP_002 DDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGST 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVL 610 620 630 640 650 660 670 680 pF1KE4 RRARALFADYLQSEVWDSEEGAEATAAS :::::::::::::::::::::::::::: NP_002 RRARALFADYLQSEVWDSEEGAEATAAS 670 680 >>NP_001161694 (OMIM: 616659) TBC1 domain family member (615 aa) initn: 718 init1: 384 opt: 648 Z-score: 418.0 bits: 87.6 E(85289): 1.5e-16 Smith-Waterman score: 656; 33.2% identity (60.7% similar) in 389 aa overlap (197-576:246-599) 170 180 190 200 210 220 pF1KE4 QSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYH ::... :. ... ::.:.. ::. ::. NP_001 LPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFS 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE4 GGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED------ ::. ::::. .:..::. :..:. ....:. :: ..: .: . .:::. NP_001 GGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQW-KSVSPEQERRNSL 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . .:: ::::.. .: :::. : : :.:.: :: . : ...: :::::: :: NP_001 LHGYRSLIERDVSRTDRTNKFYEGPEN-PGLGLLNDILLTYCMYHFDLGYVQGMSDLLSP 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA :: :...: :: ::::.:. . .::. . ..: ....: :::: :: . ..:. . NP_001 ILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDS 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH .: ::.::::. .:::: : :.::. :: :..:: : : ::. . : NP_001 GSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLP-GPNLHL--LVA--CAILDM----- 460 470 480 490 500 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR .: : .: :.. . . :. ..: . :.. . . . . NP_001 ------ERDTLMLSGFGSN---EILKHI----------NELTMKLSVEDVLTRAEALHRQ 510 520 530 540 530 540 550 560 570 pF1KE4 RDPLVQLPHPAA-LISSKSLSEPLLNSPDPLLSSFSHPDSPSSS--SPPSTQEASPTGDM .::: . ... .:: .::.: : . : ::. . .:: . ...: : NP_001 LTACPELPHNVQEILGLAPPAEP--HSPSPTASPL--PLSPTRAPPTPPPSTDTAPQPDS 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE4 AVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNG NP_001 SLEILPEEEDEGADS 610 >>NP_078958 (OMIM: 616659) TBC1 domain family member 17 (648 aa) initn: 718 init1: 384 opt: 648 Z-score: 417.6 bits: 87.6 E(85289): 1.6e-16 Smith-Waterman score: 656; 33.2% identity (60.7% similar) in 389 aa overlap (197-576:279-632) 170 180 190 200 210 220 pF1KE4 QSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYH ::... :. ... ::.:.. ::. ::. NP_078 LPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFS 250 260 270 280 290 300 230 240 250 260 270 280 pF1KE4 GGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED------ ::. ::::. .:..::. :..:. ....:. :: ..: .: . .:::. NP_078 GGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQW-KSVSPEQERRNSL 310 320 330 340 350 360 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . .:: ::::.. .: :::. : : :.:.: :: . : ...: :::::: :: NP_078 LHGYRSLIERDVSRTDRTNKFYEGPEN-PGLGLLNDILLTYCMYHFDLGYVQGMSDLLSP 370 380 390 400 410 420 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA :: :...: :: ::::.:. . .::. . ..: ....: :::: :: . ..:. . NP_078 ILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDS 430 440 450 460 470 480 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH .: ::.::::. .:::: : :.::. :: :..:: : : ::. . : NP_078 GSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLP-GPNLHL--LVA--CAILDM----- 490 500 510 520 530 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR .: : .: :.. . . :. ..: . :.. . . . . NP_078 ------ERDTLMLSGFGSN---EILKHI----------NELTMKLSVEDVLTRAEALHRQ 540 550 560 570 530 540 550 560 570 pF1KE4 RDPLVQLPHPAA-LISSKSLSEPLLNSPDPLLSSFSHPDSPSSS--SPPSTQEASPTGDM .::: . ... .:: .::.: : . : ::. . .:: . ...: : NP_078 LTACPELPHNVQEILGLAPPAEP--HSPSPTASPL--PLSPTRAPPTPPPSTDTAPQPDS 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE4 AVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNG NP_078 SLEILPEEEDEGADS 640 >>XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain fam (445 aa) initn: 638 init1: 377 opt: 602 Z-score: 391.6 bits: 82.3 E(85289): 4.5e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:68-311) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_006 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_006 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_006 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_006 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_006 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 280 290 300 310 320 330 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_006 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 340 350 360 370 380 390 >>XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain fam (445 aa) initn: 638 init1: 377 opt: 602 Z-score: 391.6 bits: 82.3 E(85289): 4.5e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:68-311) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_011 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_011 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_011 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_011 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_011 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 280 290 300 310 320 330 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_011 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 340 350 360 370 380 390 >>XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain fam (530 aa) initn: 638 init1: 377 opt: 602 Z-score: 390.5 bits: 82.3 E(85289): 5.2e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:153-396) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 130 140 150 160 170 180 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 190 200 210 220 230 240 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 250 260 270 280 290 300 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 310 320 330 340 350 360 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 370 380 390 400 410 420 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 430 440 450 460 470 480 >>XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain fam (547 aa) initn: 638 init1: 377 opt: 602 Z-score: 390.3 bits: 82.3 E(85289): 5.3e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:170-413) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 200 210 220 230 240 250 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 320 330 340 350 360 370 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 380 390 400 410 420 430 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 440 450 460 470 480 490 >>XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain fam (575 aa) initn: 638 init1: 377 opt: 602 Z-score: 390.0 bits: 82.3 E(85289): 5.6e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:198-441) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 470 480 490 500 510 520 >>XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain fam (575 aa) initn: 638 init1: 377 opt: 602 Z-score: 390.0 bits: 82.3 E(85289): 5.6e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:198-441) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_016 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_016 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_016 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_016 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_016 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_016 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 470 480 490 500 510 520 >>XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain fam (592 aa) initn: 638 init1: 377 opt: 602 Z-score: 389.8 bits: 82.3 E(85289): 5.7e-15 Smith-Waterman score: 602; 38.8% identity (67.3% similar) in 245 aa overlap (196-435:215-458) 170 180 190 200 210 220 pF1KE4 TQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIY . :.: :. .. ::.. .... :. XP_011 IPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE4 HGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRASPED----- .::. .::: .:..::. .: : .:: . .:.:. :: ..: .: . .. .. XP_011 RGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE4 LEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASP :. :: . ::: ::::.. .: : .:.: : :::.: :: . ...: :::::: :: XP_011 LRDYRSLIEKDVNRTDRTNKFYEG-QDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSP 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE4 ILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGA .: ::..: :: :: . : .. ::. . ..: :.. .:. ::: : : .::. . XP_011 LLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE4 DDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADTGFGGH :.::.::::...::::.: : ::. :: :. :: XP_011 GYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHY 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 RGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSR XP_011 GFNEILKHINELSMKIDVEDILCKAEAISLQMVKCKELPQAVCEILGLQGSEVTTPDSDV 490 500 510 520 530 540 688 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:10:16 2016 done: Sat Nov 5 17:10:18 2016 Total Scan time: 14.650 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]