FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3121, 307 aa 1>>>pF1KE3121 307 - 307 aa - 307 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7949+/-0.000307; mu= 14.8999+/- 0.019 mean_var=92.4844+/-18.927, 0's: 0 Z-trim(119.1): 15 B-trim: 912 in 1/59 Lambda= 0.133364 statistics sampled from 32754 (32769) to 32754 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.384), width: 16 Scan time: 4.860 The best scores are: opt bits E(85289) NP_004605 (OMIM: 188250,609560,617069) thymidine k ( 265) 1840 363.5 2.7e-100 NP_001166114 (OMIM: 188250,609560,617069) thymidin ( 234) 1521 302.0 7.3e-82 NP_001258863 (OMIM: 188250,609560,617069) thymidin ( 216) 1454 289.1 5.2e-78 NP_001166115 (OMIM: 188250,609560,617069) thymidin ( 240) 1290 257.6 1.8e-68 NP_001166116 (OMIM: 188250,609560,617069) thymidin ( 247) 1162 233.0 4.7e-61 NP_001258979 (OMIM: 188250,609560,617069) thymidin ( 168) 1149 230.4 2e-60 NP_001258864 (OMIM: 188250,609560,617069) thymidin ( 146) 716 147.0 2.1e-35 NP_000779 (OMIM: 125450) deoxycytidine kinase [Hom ( 260) 321 71.2 2.5e-12 XP_011530949 (OMIM: 251880,601465,617068,617070) P ( 271) 309 68.9 1.3e-11 NP_001305791 (OMIM: 251880,601465,617068,617070) d ( 174) 302 67.4 2.3e-11 NP_001305792 (OMIM: 251880,601465,617068,617070) d ( 174) 302 67.4 2.3e-11 NP_001305789 (OMIM: 251880,601465,617068,617070) d ( 180) 289 64.9 1.4e-10 NP_001305790 (OMIM: 251880,601465,617068,617070) d ( 180) 289 64.9 1.4e-10 NP_550438 (OMIM: 251880,601465,617068,617070) deox ( 277) 289 65.1 1.9e-10 >>NP_004605 (OMIM: 188250,609560,617069) thymidine kinas (265 aa) initn: 1840 init1: 1840 opt: 1840 Z-score: 1921.6 bits: 363.5 E(85289): 2.7e-100 Smith-Waterman score: 1840; 100.0% identity (100.0% similar) in 265 aa overlap (43-307:1-265) 20 30 40 50 60 70 pF1KE3 SRRRPTAGLAVVRADSHKKEPRASGSARPAMLLWPLRGWAARALRCFGPGSRGSPASGPG :::::::::::::::::::::::::::::: NP_004 MLLWPLRGWAARALRCFGPGSRGSPASGPG 10 20 30 80 90 100 110 120 130 pF1KE3 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE 160 170 180 190 200 210 260 270 280 290 300 pF1KE3 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP 220 230 240 250 260 >>NP_001166114 (OMIM: 188250,609560,617069) thymidine ki (234 aa) initn: 1521 init1: 1521 opt: 1521 Z-score: 1590.7 bits: 302.0 E(85289): 7.3e-82 Smith-Waterman score: 1521; 100.0% identity (100.0% similar) in 224 aa overlap (84-307:11-234) 60 70 80 90 100 110 pF1KE3 RALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFS :::::::::::::::::::::::::::::: NP_001 MGAFCQRPSSDKEQEKEKKSVICVEGNIASGKTTCLEFFS 10 20 30 40 120 130 140 150 160 170 pF1KE3 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE3 MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQ 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE3 RLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN 170 180 190 200 210 220 300 pF1KE3 RDRILTPENRKHCP :::::::::::::: NP_001 RDRILTPENRKHCP 230 >>NP_001258863 (OMIM: 188250,609560,617069) thymidine ki (216 aa) initn: 1454 init1: 1454 opt: 1454 Z-score: 1521.5 bits: 289.1 E(85289): 5.2e-78 Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 213 aa overlap (95-307:4-216) 70 80 90 100 110 120 pF1KE3 GSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEP :::::::::::::::::::::::::::::: NP_001 MTSICVEGNIASGKTTCLEFFSNATDVEVLTEP 10 20 30 130 140 150 160 170 180 pF1KE3 VSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYI 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 FVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEK 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 VIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRK 160 170 180 190 200 210 pF1KE3 HCP ::: NP_001 HCP >>NP_001166115 (OMIM: 188250,609560,617069) thymidine ki (240 aa) initn: 1339 init1: 1290 opt: 1290 Z-score: 1350.3 bits: 257.6 E(85289): 1.8e-68 Smith-Waterman score: 1616; 90.6% identity (90.6% similar) in 265 aa overlap (43-307:1-240) 20 30 40 50 60 70 pF1KE3 SRRRPTAGLAVVRADSHKKEPRASGSARPAMLLWPLRGWAARALRCFGPGSRGSPASGPG :::::::::::::::::::::::::::::: NP_001 MLLWPLRGWAARALRCFGPGSRGSPASGPG 10 20 30 80 90 100 110 120 130 pF1KE3 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR :::::::::::::::::::::: ::::::::::::: NP_001 PRRVQRRAWPPDKEQEKEKKSV-------------------------VLTEPVSKWRNVR 40 50 60 140 150 160 170 180 190 pF1KE3 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS 70 80 90 100 110 120 200 210 220 230 240 250 pF1KE3 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE 130 140 150 160 170 180 260 270 280 290 300 pF1KE3 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP 190 200 210 220 230 240 >>NP_001166116 (OMIM: 188250,609560,617069) thymidine ki (247 aa) initn: 1162 init1: 1162 opt: 1162 Z-score: 1217.1 bits: 233.0 E(85289): 4.7e-61 Smith-Waterman score: 1666; 93.2% identity (93.2% similar) in 265 aa overlap (43-307:1-247) 20 30 40 50 60 70 pF1KE3 SRRRPTAGLAVVRADSHKKEPRASGSARPAMLLWPLRGWAARALRCFGPGSRGSPASGPG :::::::::::::::::::::::::::::: NP_001 MLLWPLRGWAARALRCFGPGSRGSPASGPG 10 20 30 80 90 100 110 120 130 pF1KE3 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVE------------- 40 50 60 70 140 150 160 170 180 190 pF1KE3 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----GLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE 140 150 160 170 180 190 260 270 280 290 300 pF1KE3 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP 200 210 220 230 240 >>NP_001258979 (OMIM: 188250,609560,617069) thymidine ki (168 aa) initn: 1149 init1: 1149 opt: 1149 Z-score: 1205.9 bits: 230.4 E(85289): 2e-60 Smith-Waterman score: 1149; 100.0% identity (100.0% similar) in 168 aa overlap (140-307:1-168) 110 120 130 140 150 160 pF1KE3 EFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVS :::::::::::::::::::::::::::::: NP_001 MYHDASRWGLTLQTYVQLTMLDRHTRPQVS 10 20 30 170 180 190 200 210 220 pF1KE3 SVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPE 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE3 TCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLEL 100 110 120 130 140 150 290 300 pF1KE3 FEQNRDRILTPENRKHCP :::::::::::::::::: NP_001 FEQNRDRILTPENRKHCP 160 >>NP_001258864 (OMIM: 188250,609560,617069) thymidine ki (146 aa) initn: 716 init1: 716 opt: 716 Z-score: 756.5 bits: 147.0 E(85289): 2.1e-35 Smith-Waterman score: 716; 100.0% identity (100.0% similar) in 108 aa overlap (84-191:11-118) 60 70 80 90 100 110 pF1KE3 RALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFS :::::::::::::::::::::::::::::: NP_001 MGAFCQRPSSDKEQEKEKKSVICVEGNIASGKTTCLEFFS 10 20 30 40 120 130 140 150 160 170 pF1KE3 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE3 MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQ :::::::::::::::::: NP_001 MERSIHSARYIFVENLYRRNTWKQFTISMRSGSSKAAFSPWQPLFW 110 120 130 140 >>NP_000779 (OMIM: 125450) deoxycytidine kinase [Homo sa (260 aa) initn: 436 init1: 169 opt: 321 Z-score: 342.2 bits: 71.2 E(85289): 2.5e-12 Smith-Waterman score: 447; 33.9% identity (64.2% similar) in 254 aa overlap (78-299:6-259) 50 60 70 80 90 100 pF1KE3 LRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPP-DKEQEKEKKSVICVEGNIASGKT .:. : . .: . . : .:::::.::. NP_000 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKS 10 20 30 110 120 130 140 150 pF1KE3 TCLEFFSN-ATDVEVLTEPVSKWRNVR---------------GHNPLGLMYHDASRWGLT : ...... : ::. :::..: ::. : : : .::. ::..: NP_000 TFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFT 40 50 60 70 80 90 160 170 180 190 200 pF1KE3 LQTYV-------QLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVL .:::. ::. :. . . . : ..:::..: ::::. :::.: : :..... NP_000 FQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIY 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 SEWFDWILRNMDVSVDL--IVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEW ..: ::. .. :..: :.::...:::: .:. : :.::. ::::::: .:. :: : NP_000 QDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESW 160 170 180 190 200 210 270 280 290 300 pF1KE3 LIKGSL-----FPMAAPVLVIEADHHMERMLE-LFEQNRDRILTPENRKHCP :.. .: . . .:.:...... .. : : :. .. . : NP_000 LLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 220 230 240 250 260 >>XP_011530949 (OMIM: 251880,601465,617068,617070) PREDI (271 aa) initn: 389 init1: 164 opt: 309 Z-score: 329.5 bits: 68.9 E(85289): 1.3e-11 Smith-Waterman score: 375; 31.9% identity (65.2% similar) in 207 aa overlap (95-280:41-247) 70 80 90 100 110 120 pF1KE3 GSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNA-TDVEVLTE . .::::: ::.: ....... . .: :: XP_011 LRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATE 20 30 40 50 60 70 130 140 150 160 170 pF1KE3 PVSKWRNVRGH------------NPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSV ::. :.:... : : .::.. .::. :.::. :. : . .: .. XP_011 PVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKL 80 90 100 110 120 130 180 190 200 210 220 pF1KE3 RLMERSIHS-ARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL--IVYLRTNP .. .. ::::..::...:.. .... . ..: ...: .. . : ..::...: XP_011 LQARKPVQIFERYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQASP 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE3 ETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL---FP--MAAPVLVIEADHHM ..: .:: .: ::::: : : ::: .: :: :::. . : : ::::.... XP_011 QVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVNDDF 200 210 220 230 240 250 290 300 pF1KE3 ERMLELFEQNRDRILTPENRKHCP XP_011 SEEVTKQEDLMREVNTFVKNL 260 270 >>NP_001305791 (OMIM: 251880,601465,617068,617070) deoxy (174 aa) initn: 315 init1: 164 opt: 302 Z-score: 324.9 bits: 67.4 E(85289): 2.3e-11 Smith-Waterman score: 302; 32.7% identity (67.3% similar) in 150 aa overlap (139-280:1-150) 110 120 130 140 150 160 pF1KE3 LEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQV .::.. .::. :.::. :. : . .: NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP 10 20 30 170 180 190 200 210 220 pF1KE3 SSVRLMERSIHS-ARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL--IVYLR .. .. .. ::::..::...:.. .... . ..: ...: .. . : ..::. NP_001 EKLLQARKPVQIFERYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQ 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE3 TNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL---FP--MAAPVLVIEAD ..:..: .:: .: ::::: : : ::: .: :: :::. . : : ::::.... NP_001 ASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVN 100 110 120 130 140 150 290 300 pF1KE3 HHMERMLELFEQNRDRILTPENRKHCP NP_001 DDFSEEVTKQEDLMREVNTFVKNL 160 170 307 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:27:56 2016 done: Sun Nov 6 03:27:57 2016 Total Scan time: 4.860 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]