FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4203, 710 aa 1>>>pF1KE4203 710 - 710 aa - 710 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6502+/-0.000353; mu= -7.4585+/- 0.022 mean_var=365.0365+/-74.812, 0's: 0 Z-trim(125.0): 102 B-trim: 0 in 0/62 Lambda= 0.067128 statistics sampled from 47544 (47664) to 47544 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.559), width: 16 Scan time: 15.140 The best scores are: opt bits E(85289) NP_001030300 (OMIM: 616743) ral guanine nucleotide ( 710) 4755 474.4 6.5e-133 NP_001155088 (OMIM: 616743) ral guanine nucleotide ( 716) 4733 472.3 2.9e-132 NP_001035827 (OMIM: 601619) ral guanine nucleotide ( 859) 985 109.4 6.1e-23 NP_001258703 (OMIM: 601619) ral guanine nucleotide ( 885) 985 109.4 6.3e-23 NP_001258705 (OMIM: 601619) ral guanine nucleotide ( 902) 985 109.4 6.4e-23 NP_001258704 (OMIM: 601619) ral guanine nucleotide ( 913) 985 109.4 6.4e-23 NP_006257 (OMIM: 601619) ral guanine nucleotide di ( 914) 985 109.4 6.4e-23 NP_001230667 (OMIM: 602306) ral guanine nucleotide ( 695) 719 83.6 3e-15 NP_004752 (OMIM: 602306) ral guanine nucleotide di ( 777) 719 83.6 3.2e-15 XP_011513087 (OMIM: 602306) PREDICTED: ral guanine ( 496) 703 81.9 6.7e-15 XP_011513083 (OMIM: 602306) PREDICTED: ral guanine ( 670) 661 77.9 1.4e-13 NP_705843 (OMIM: 612214) ral-GDS-related protein i ( 473) 616 73.5 2.2e-12 XP_016856245 (OMIM: 605667) PREDICTED: ral guanine ( 683) 607 72.7 5.4e-12 XP_011507643 (OMIM: 605667) PREDICTED: ral guanine ( 718) 607 72.7 5.6e-12 NP_001316353 (OMIM: 612214) ral-GDS-related protei ( 580) 603 72.3 6.2e-12 XP_011507644 (OMIM: 605667) PREDICTED: ral guanine ( 620) 598 71.8 9.1e-12 NP_001284601 (OMIM: 605667) ral guanine nucleotide ( 739) 598 71.9 1e-11 NP_001284598 (OMIM: 605667) ral guanine nucleotide ( 766) 598 71.9 1.1e-11 NP_001284599 (OMIM: 605667) ral guanine nucleotide ( 766) 598 71.9 1.1e-11 NP_001284600 (OMIM: 605667) ral guanine nucleotide ( 768) 598 71.9 1.1e-11 NP_055964 (OMIM: 605667) ral guanine nucleotide di ( 803) 598 71.9 1.1e-11 XP_011507641 (OMIM: 605667) PREDICTED: ral guanine ( 803) 598 71.9 1.1e-11 NP_001177659 (OMIM: 614444) ras-specific guanine n ( 305) 306 43.3 0.0017 XP_016870839 (OMIM: 614444) PREDICTED: ras-specifi ( 384) 306 43.4 0.002 XP_011517540 (OMIM: 614444) PREDICTED: ras-specifi ( 474) 306 43.4 0.0024 NP_001309253 (OMIM: 614444) ras-specific guanine n ( 514) 306 43.5 0.0026 XP_011517538 (OMIM: 614444) PREDICTED: ras-specifi ( 515) 306 43.5 0.0026 XP_016870837 (OMIM: 614444) PREDICTED: ras-specifi ( 527) 306 43.5 0.0026 NP_001177657 (OMIM: 614444) ras-specific guanine n ( 529) 306 43.5 0.0026 NP_001177658 (OMIM: 614444) ras-specific guanine n ( 537) 306 43.5 0.0027 NP_001309249 (OMIM: 614444) ras-specific guanine n ( 537) 306 43.5 0.0027 XP_016870835 (OMIM: 614444) PREDICTED: ras-specifi ( 549) 306 43.5 0.0027 NP_055451 (OMIM: 614444) ras-specific guanine nucl ( 557) 306 43.5 0.0027 XP_016870836 (OMIM: 614444) PREDICTED: ras-specifi ( 557) 306 43.5 0.0027 XP_016870834 (OMIM: 614444) PREDICTED: ras-specifi ( 569) 306 43.5 0.0028 NP_001309251 (OMIM: 614444) ras-specific guanine n ( 576) 306 43.5 0.0028 NP_001309250 (OMIM: 614444) ras-specific guanine n ( 584) 306 43.5 0.0028 XP_011517535 (OMIM: 614444) PREDICTED: ras-specifi ( 585) 306 43.5 0.0028 XP_011517534 (OMIM: 614444) PREDICTED: ras-specifi ( 590) 306 43.5 0.0029 XP_011517533 (OMIM: 614444) PREDICTED: ras-specifi ( 591) 306 43.5 0.0029 NP_001309254 (OMIM: 614444) ras-specific guanine n ( 607) 306 43.5 0.0029 XP_016870831 (OMIM: 614444) PREDICTED: ras-specifi ( 638) 306 43.5 0.003 XP_011517530 (OMIM: 614444) PREDICTED: ras-specifi ( 639) 306 43.5 0.003 XP_011517528 (OMIM: 614444) PREDICTED: ras-specifi ( 653) 306 43.5 0.0031 XP_011517527 (OMIM: 614444) PREDICTED: ras-specifi ( 660) 306 43.5 0.0031 XP_011517537 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031 XP_011517532 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031 XP_016870832 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031 XP_006717391 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031 XP_011517531 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031 >>NP_001030300 (OMIM: 616743) ral guanine nucleotide dis (710 aa) initn: 4755 init1: 4755 opt: 4755 Z-score: 2507.2 bits: 474.4 E(85289): 6.5e-133 Smith-Waterman score: 4755; 99.7% identity (99.9% similar) in 710 aa overlap (1-710:1-710) 10 20 30 40 50 60 pF1KE4 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAP ::::::::::::::::::::::::::::::::::::::::: :.:::::::::::::::: NP_001 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFLGWAAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD 610 620 630 640 650 660 670 680 690 700 710 pF1KE4 YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 670 680 690 700 710 >>NP_001155088 (OMIM: 616743) ral guanine nucleotide dis (716 aa) initn: 3666 init1: 3666 opt: 4733 Z-score: 2495.6 bits: 472.3 E(85289): 2.9e-132 Smith-Waterman score: 4733; 98.9% identity (99.0% similar) in 716 aa overlap (1-710:1-716) 10 20 30 40 50 60 pF1KE4 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAP ::::::::::::::::::::::::::::::::::::::::: :.:::::::::::::::: NP_001 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFLGWAAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 PGDPSSPTSS------VSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP :::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_001 PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE4 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE4 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS 670 680 690 700 710 >>NP_001035827 (OMIM: 601619) ral guanine nucleotide dis (859 aa) initn: 1554 init1: 617 opt: 985 Z-score: 532.8 bits: 109.4 E(85289): 6.1e-23 Smith-Waterman score: 1320; 37.1% identity (57.9% similar) in 776 aa overlap (61-696:53-826) 40 50 60 70 80 90 pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP :.: :::...:. ::.:: .:: . . .: NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL 30 40 50 60 70 80 100 110 120 130 140 pF1KE4 SFMPAFLATYRTFVPTACLLGFLLP------PMPPPPPPGVEIKKTAVQDLSFNKNLR-A :.. :: :::.:. : .: .:. . : : . .: . . .:. : NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGC-ILPYSDEDGGPQDQLKNA 90 100 110 120 130 140 150 160 170 180 190 pF1KE4 VVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EA . :.::.::... .:: .:: : .. ... ::: ..:. :: .. . :: NP_001 ISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEA 150 160 170 180 190 200 200 210 pF1KE4 EREQ-------------------------------EEEP-----------------PQVW : : : :: :.. NP_001 EPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQ 210 220 230 240 250 260 220 230 pF1KE4 TGP-PRV--------------AQTSDPDSSEACAEE-------------------EEGLM .: : : : .:: :.. : :.:: NP_001 QAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLS 270 280 290 300 310 320 240 250 260 270 280 290 pF1KE4 PQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQ . :.:: : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.: NP_001 EEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQ 330 340 350 360 370 380 300 310 320 330 340 350 pF1KE4 FNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYR ::.:..::. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.: NP_001 FNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHR 390 400 410 420 430 440 360 370 380 390 400 410 pF1KE4 LKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPP ::..: :::. . :.:::.:::::::. :::.:..: ... . : : : ..: NP_001 LKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPK 450 460 470 480 490 500 420 430 440 450 460 470 pF1KE4 P-----GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSY : :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..: NP_001 ETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY 510 520 530 540 550 560 480 490 500 510 520 530 pF1KE4 TLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLARE ...: . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : NP_001 SIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPS 570 580 590 600 610 620 540 550 560 pF1KE4 KSSSPSGS------------P----GDPSSPTSSVSPGSP------------PSSPRSRD : ::: : :: .. : : :: : :: ... NP_001 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQE 630 640 650 660 670 680 570 580 590 600 610 pF1KE4 -----APAGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQ . . : : . : .. :.. : .: : . : .: .:: :: NP_001 KKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQ 690 700 710 720 730 740 620 630 640 650 660 670 pF1KE4 SSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGD .. .::::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: : NP_001 VGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDD 750 760 770 780 790 800 680 690 700 710 pF1KE4 RVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS : : ::.::::::::. .: ::.:. NP_001 RKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF 810 820 830 840 850 >>NP_001258703 (OMIM: 601619) ral guanine nucleotide dis (885 aa) initn: 1566 init1: 617 opt: 985 Z-score: 532.6 bits: 109.4 E(85289): 6.3e-23 Smith-Waterman score: 1330; 37.7% identity (58.1% similar) in 769 aa overlap (61-696:91-852) 40 50 60 70 80 90 pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP :.: :::...:. ::.:: .:: . . .: NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE4 SFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGS :.. :: :::.:. : .: .:. . : . : . :: :: :. :.::. NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGCILPYSDE--DGGPQDQL--KN--AISSILGT 130 140 150 160 170 160 170 180 190 200 pF1KE4 WLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EAEREQ--- ::... .:: .:: : .. ... ::: ..:. :: .. . ::: : NP_001 WLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSP 180 190 200 210 220 230 210 pF1KE4 ----------------------------EEEP-----------------PQVWTGP-PRV : :: :.. .: : : NP_001 VPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAV 240 250 260 270 280 290 220 230 240 pF1KE4 --------------AQTSDPDSSEACAEE-------------------EEGLMPQGPQLL : .:: :.. : :.:: . :.:: NP_001 GLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLL 300 310 320 330 340 350 250 260 270 280 290 300 pF1KE4 DFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGC : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:::.:..: NP_001 VFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANC 360 370 380 390 400 410 310 320 330 340 350 360 pF1KE4 VLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGA :. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:::..: NP_001 VITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWED 420 430 440 450 460 470 370 380 390 400 410 pF1KE4 VSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----G :::. . :.:::.:::::::. :::.:..: ... . : : : ..: : NP_001 VSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQG 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE4 PVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPP :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:...: NP_001 TVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQ 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE4 ILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSG . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : : :: NP_001 FGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSG 600 610 620 630 640 650 540 550 560 pF1KE4 S------------P----GDPSSPTSSVSPGSP------------PSSPRSRD-----AP : : :: .. : : :: : :: ... . NP_001 SSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESA 660 670 680 690 700 710 570 580 590 600 610 pF1KE4 AGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQSSEARVI . : : . : .. :.. : .: : . : .: .:: :: .. .: NP_001 SQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCII 720 730 740 750 760 770 620 630 640 650 660 670 pF1KE4 RVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPD :::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :: : ::. NP_001 RVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPE 780 790 800 810 820 830 680 690 700 710 pF1KE4 NANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS ::::::::. .: ::.:. NP_001 NANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF 840 850 860 870 880 >>NP_001258705 (OMIM: 601619) ral guanine nucleotide dis (902 aa) initn: 1566 init1: 617 opt: 985 Z-score: 532.5 bits: 109.4 E(85289): 6.4e-23 Smith-Waterman score: 1330; 37.7% identity (58.1% similar) in 769 aa overlap (61-696:108-869) 40 50 60 70 80 90 pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP :.: :::...:. ::.:: .:: . . .: NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE4 SFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGS :.. :: :::.:. : .: .:. . : . : . :: :: :. :.::. NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGCILPYSDE--DGGPQDQL--KN--AISSILGT 140 150 160 170 180 190 160 170 180 190 200 pF1KE4 WLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EAEREQ--- ::... .:: .:: : .. ... ::: ..:. :: .. . ::: : NP_001 WLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSP 200 210 220 230 240 250 210 pF1KE4 ----------------------------EEEP-----------------PQVWTGP-PRV : :: :.. .: : : NP_001 VPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAV 260 270 280 290 300 310 220 230 240 pF1KE4 --------------AQTSDPDSSEACAEE-------------------EEGLMPQGPQLL : .:: :.. : :.:: . :.:: NP_001 GLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLL 320 330 340 350 360 370 250 260 270 280 290 300 pF1KE4 DFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGC : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:::.:..: NP_001 VFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANC 380 390 400 410 420 430 310 320 330 340 350 360 pF1KE4 VLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGA :. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:::..: NP_001 VITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWED 440 450 460 470 480 490 370 380 390 400 410 pF1KE4 VSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----G :::. . :.:::.:::::::. :::.:..: ... . : : : ..: : NP_001 VSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQG 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE4 PVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPP :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:...: NP_001 TVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQ 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE4 ILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSG . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : : :: NP_001 FGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSG 620 630 640 650 660 670 540 550 560 pF1KE4 S------------P----GDPSSPTSSVSPGSP------------PSSPRSRD-----AP : : :: .. : : :: : :: ... . NP_001 SSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESA 680 690 700 710 720 730 570 580 590 600 610 pF1KE4 AGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQSSEARVI . : : . : .. :.. : .: : . : .: .:: :: .. .: NP_001 SQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCII 740 750 760 770 780 790 620 630 640 650 660 670 pF1KE4 RVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPD :::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :: : ::. NP_001 RVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPE 800 810 820 830 840 850 680 690 700 710 pF1KE4 NANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS ::::::::. .: ::.:. NP_001 NANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF 860 870 880 890 900 >>NP_001258704 (OMIM: 601619) ral guanine nucleotide dis (913 aa) initn: 1554 init1: 617 opt: 985 Z-score: 532.4 bits: 109.4 E(85289): 6.4e-23 Smith-Waterman score: 1320; 37.1% identity (57.9% similar) in 776 aa overlap (61-696:107-880) 40 50 60 70 80 90 pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP :.: :::...:. ::.:: .:: . . .: NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL 80 90 100 110 120 130 100 110 120 130 140 pF1KE4 SFMPAFLATYRTFVPTACLLGFLLP------PMPPPPPPGVEIKKTAVQDLSFNKNLR-A :.. :: :::.:. : .: .:. . : : . .: . . .:. : NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGC-ILPYSDEDGGPQDQLKNA 140 150 160 170 180 190 150 160 170 180 190 pF1KE4 VVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EA . :.::.::... .:: .:: : .. ... ::: ..:. :: .. . :: NP_001 ISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEA 200 210 220 230 240 250 200 210 pF1KE4 EREQ-------------------------------EEEP-----------------PQVW : : : :: :.. NP_001 EPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQ 260 270 280 290 300 310 220 230 pF1KE4 TGP-PRV--------------AQTSDPDSSEACAEE-------------------EEGLM .: : : : .:: :.. : :.:: NP_001 QAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLS 320 330 340 350 360 370 240 250 260 270 280 290 pF1KE4 PQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQ . :.:: : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.: NP_001 EEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQ 380 390 400 410 420 430 300 310 320 330 340 350 pF1KE4 FNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYR ::.:..::. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.: NP_001 FNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHR 440 450 460 470 480 490 360 370 380 390 400 410 pF1KE4 LKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPP ::..: :::. . :.:::.:::::::. :::.:..: ... . : : : ..: NP_001 LKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPK 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE4 P-----GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSY : :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..: NP_001 ETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE4 TLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLARE ...: . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : NP_001 SIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPS 620 630 640 650 660 670 540 550 560 pF1KE4 KSSSPSGS------------P----GDPSSPTSSVSPGSP------------PSSPRSRD : ::: : :: .. : : :: : :: ... NP_001 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQE 680 690 700 710 720 730 570 580 590 600 610 pF1KE4 -----APAGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQ . . : : . : .. :.. : .: : . : .: .:: :: NP_001 KKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQ 740 750 760 770 780 790 620 630 640 650 660 670 pF1KE4 SSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGD .. .::::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: : NP_001 VGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDD 800 810 820 830 840 850 680 690 700 710 pF1KE4 RVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS : : ::.::::::::. .: ::.:. NP_001 RKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF 860 870 880 890 900 910 >>NP_006257 (OMIM: 601619) ral guanine nucleotide dissoc (914 aa) initn: 1554 init1: 617 opt: 985 Z-score: 532.4 bits: 109.4 E(85289): 6.4e-23 Smith-Waterman score: 1320; 37.1% identity (57.9% similar) in 776 aa overlap (61-696:108-881) 40 50 60 70 80 90 pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP :.: :::...:. ::.:: .:: . . .: NP_006 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL 80 90 100 110 120 130 100 110 120 130 140 pF1KE4 SFMPAFLATYRTFVPTACLLGFLLP------PMPPPPPPGVEIKKTAVQDLSFNKNLR-A :.. :: :::.:. : .: .:. . : : . .: . . .:. : NP_006 SYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGC-ILPYSDEDGGPQDQLKNA 140 150 160 170 180 190 150 160 170 180 190 pF1KE4 VVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EA . :.::.::... .:: .:: : .. ... ::: ..:. :: .. . :: NP_006 ISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEA 200 210 220 230 240 250 200 210 pF1KE4 EREQ-------------------------------EEEP-----------------PQVW : : : :: :.. NP_006 EPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQ 260 270 280 290 300 310 220 230 pF1KE4 TGP-PRV--------------AQTSDPDSSEACAEE-------------------EEGLM .: : : : .:: :.. : :.:: NP_006 QAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLS 320 330 340 350 360 370 240 250 260 270 280 290 pF1KE4 PQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQ . :.:: : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.: NP_006 EEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQ 380 390 400 410 420 430 300 310 320 330 340 350 pF1KE4 FNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYR ::.:..::. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.: NP_006 FNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHR 440 450 460 470 480 490 360 370 380 390 400 410 pF1KE4 LKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPP ::..: :::. . :.:::.:::::::. :::.:..: ... . : : : ..: NP_006 LKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPK 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE4 P-----GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSY : :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..: NP_006 ETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE4 TLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLARE ...: . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : NP_006 SIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPS 620 630 640 650 660 670 540 550 560 pF1KE4 KSSSPSGS------------P----GDPSSPTSSVSPGSP------------PSSPRSRD : ::: : :: .. : : :: : :: ... NP_006 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQE 680 690 700 710 720 730 570 580 590 600 610 pF1KE4 -----APAGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQ . . : : . : .. :.. : .: : . : .: .:: :: NP_006 KKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQ 740 750 760 770 780 790 620 630 640 650 660 670 pF1KE4 SSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGD .. .::::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: : NP_006 VGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDD 800 810 820 830 840 850 680 690 700 710 pF1KE4 RVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS : : ::.::::::::. .: ::.:. NP_006 RKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF 860 870 880 890 900 910 >>NP_001230667 (OMIM: 602306) ral guanine nucleotide dis (695 aa) initn: 1285 init1: 649 opt: 719 Z-score: 394.9 bits: 83.6 E(85289): 3e-15 Smith-Waterman score: 1283; 38.4% identity (61.9% similar) in 693 aa overlap (67-709:8-659) 40 50 60 70 80 90 pF1KE4 QRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQ--DPSFMP : :::. :: :: .:. : . : ::: NP_001 MPPPRSSRRLRAGTLEALVRHLL-DTRTSGTDVSFMS 10 20 30 100 110 120 130 140 150 pF1KE4 AFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQ :::::.:.:. : :::.. . : :...:. ....:::..:: NP_001 AFLATHRAFTSTPALLGLMADRLEALESHPTDELERTT----------EVAISVLSTWLA 40 50 60 70 80 160 170 180 190 200 210 pF1KE4 DHPQDFRDPPVHSDLGSVRTFL---GWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQV .::.:: ....: ...:: :.:: :.. . . :.... ... ::. NP_001 SHPEDF-GSEAKGQLDRLESFLLQTGYAA-GKGVGGGSADLIRNLRSRVD-------PQA 90 100 110 120 130 220 230 240 250 260 pF1KE4 WTGPPRVAQTSDPDSSEACAEEEEGLMPQGP-QLLDFSVDEVAEQLTLIDLELFSKVRLY : .: .:: : : ..: : .:..::::::.: ::: .. NP_001 PDLPKPLALPGDP--------------PADPTDVLVFLADHLAEQLTLLDAELFLNLIPS 140 150 160 170 180 270 280 290 300 310 pF1KE4 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGA------PG------LAA .:::..:..::::: . :.:::::.::: :.: :..::::: :: : NP_001 QCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRP 190 200 210 220 230 240 320 330 340 350 360 370 pF1KE4 PQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLS ::::. ::::::.:..:: ::::::. :..:::::.::.::. .:: ..:. : .: .: NP_001 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC 250 260 270 280 290 300 380 390 400 410 420 430 pF1KE4 QIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTA ::::.:.:. .:::.: :: .. : . . .. : :::::::: ::::::.: NP_001 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA 310 320 330 340 350 360 440 450 460 470 480 490 pF1KE4 LPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYR : ::. :::.:::::. .:.....:: .:..:.:.: : :.. ::: ::.: NP_001 SKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHR 370 380 390 400 410 420 500 510 520 530 540 pF1KE4 LSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSP------SGSPGD--PSSPT- .: .:::..: : .::. : . .. . :. .: .. :: :..:. NP_001 VSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAP 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE4 --SSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPF-----ALPLGS . .. : : :. : :. .: :: :: :::: . :: NP_001 LLTRLAQHMKWPSVSSLDSALESSPSLHSPADPS---HLSPPASSPRPSRGHRRSASCGS 490 500 510 520 530 540 610 620 630 640 pF1KE4 PRIPLPAQQS--------------SEARVIRVSID-NDHGNLYRSILLTSQDKAPSVVRR : . : :. :.:::... .. :..:.:::.:::::::::. : NP_001 PLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISR 550 560 570 580 590 600 650 660 670 680 690 700 pF1KE4 ALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLS .:.:.: . : .:.: :.:::.: : :: .:::::::. : .::.::.. : . . NP_001 VLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDG-ASHDFLLRQR---RRSST 610 620 630 640 650 710 pF1KE4 VSPS ..: NP_001 ATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 660 670 680 690 >>NP_004752 (OMIM: 602306) ral guanine nucleotide dissoc (777 aa) initn: 1285 init1: 649 opt: 719 Z-score: 394.2 bits: 83.6 E(85289): 3.2e-15 Smith-Waterman score: 1331; 38.0% identity (60.8% similar) in 748 aa overlap (12-709:53-741) 10 20 30 40 pF1KE4 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSP ::.. : :: :::::..:. :. : NP_004 FRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEE-EDGAVFTVTSRQYR------ 30 40 50 60 70 50 60 70 80 90 pF1KE4 AEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQ--DPSFMPAFLAT : .: : :.: : :::. :: :: .:. : . : ::: ::::: NP_004 ---PLDPLVPMPPP------RSS--RRLRAGTLEALVRHLL-DTRTSGTDVSFMSAFLAT 80 90 100 110 120 100 110 120 130 140 150 pF1KE4 YRTFVPTACLLGFLLPPMPP-PPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQD .:.:. : :::.. . : :...:. ....:::..:: .::.: NP_004 HRAFTSTPALLGLMADRLEALESHPTDELERTT----------EVAISVLSTWLASHPED 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 FRDPPVHSDLGSVRTFL---GWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPP : ....: ...:: :.:: :.. . . :.... ... ::. : NP_004 F-GSEAKGQLDRLESFLLQTGYAA-GKGVGGGSADLIRNLRSRVD-------PQAPDLPK 180 190 200 210 220 220 230 240 250 260 270 pF1KE4 RVAQTSDPDSSEACAEEEEGLMPQGP-QLLDFSVDEVAEQLTLIDLELFSKVRLYECLGS .: .:: : : ..: : .:..::::::.: ::: .. .:::. NP_004 PLALPGDP--------------PADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGG 230 240 250 260 270 280 290 300 310 320 pF1KE4 VWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGA------PG------LAAPQRAQ .:..::::: . :.:::::.::: :.: :..::::: :: : ::::. NP_004 LWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRAR 280 290 300 310 320 330 330 340 350 360 370 380 pF1KE4 RLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSD ::::::.:..:: ::::::. :..:::::.::.::. .:: ..:. : .: .: ::::. NP_004 LLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSE 340 350 360 370 380 390 390 400 410 420 430 440 pF1KE4 ENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDML :.:. .:::.: :: .. : . . .. : :::::::: ::::::.: : : NP_004 EDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDEL 400 410 420 430 440 450 450 460 470 480 490 500 pF1KE4 EGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVI :. :::.:::::. .:.....:: .:..:.:.: : :.. ::: ::.:.: . NP_004 ENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEV 460 470 480 490 500 510 510 520 530 540 550 pF1KE4 EPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSP------SGSPGD--PSSPT---SSV :::..: : .::. : . .. . :. .: .. :: :..:. . . NP_004 EPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRL 520 530 540 550 560 570 560 570 580 590 600 pF1KE4 SPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPF-----ALPLGSPRIPL . : : :. : :. .: :: :: :::: . ::: NP_004 AQHMKWPSVSSLDSALESSPSLHSPADPSH---LSPPASSPRPSRGHRRSASCGSPLSGG 580 590 600 610 620 610 620 630 640 650 pF1KE4 PAQQS--------------SEARVIRVSID-NDHGNLYRSILLTSQDKAPSVVRRALQKH . : :. :.:::... .. :..:.:::.:::::::::. :.:.:. NP_004 AEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKN 630 640 650 660 670 680 660 670 680 690 700 710 pF1KE4 NVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS : . : .:.: :.:::.: : :: .:::::::. : .::.::.. : . ...: NP_004 NRDSAVASEYELVQLLPGERELTIPASANVFYAMDG-ASHDFLLRQR---RRSSTATPGV 690 700 710 720 730 740 NP_004 TSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 750 760 770 >>XP_011513087 (OMIM: 602306) PREDICTED: ral guanine nuc (496 aa) initn: 1023 init1: 647 opt: 703 Z-score: 388.5 bits: 81.9 E(85289): 6.7e-15 Smith-Waterman score: 1020; 39.5% identity (64.0% similar) in 509 aa overlap (67-556:8-481) 40 50 60 70 80 90 pF1KE4 QRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQ--DPSFMP : :::. :: :: .:. : . : ::: XP_011 MPPPRSSRRLRAGTLEALVRHLL-DTRTSGTDVSFMS 10 20 30 100 110 120 130 140 150 pF1KE4 AFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQ :::::.:.:. : :::.. . : :...:. ....:::..:: XP_011 AFLATHRAFTSTPALLGLMADRLEALESHPTDELERTT----------EVAISVLSTWLA 40 50 60 70 80 160 170 180 190 200 210 pF1KE4 DHPQDFRDPPVHSDLGSVRTFL---GWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQV .::.:: ....: ...:: :.:: :.. . . :.... ... ::. XP_011 SHPEDF-GSEAKGQLDRLESFLLQTGYAA-GKGVGGGSADLIRNLRSRVD-------PQA 90 100 110 120 130 220 230 240 250 260 pF1KE4 WTGPPRVAQTSDPDSSEACAEEEEGLMPQGP-QLLDFSVDEVAEQLTLIDLELFSKVRLY : .: .:: : : ..: : .:..::::::.: ::: .. XP_011 PDLPKPLALPGDP--------------PADPTDVLVFLADHLAEQLTLLDAELFLNLIPS 140 150 160 170 180 270 280 290 300 310 pF1KE4 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGA------PG------LAA .:::..:..::::: . :.:::::.::: :.: :..::::: :: : XP_011 QCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRP 190 200 210 220 230 240 320 330 340 350 360 370 pF1KE4 PQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLS ::::. ::::::.:..:: ::::::. :..:::::.::.::. .:: ..:. : .: .: XP_011 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC 250 260 270 280 290 300 380 390 400 410 420 430 pF1KE4 QIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTA ::::.:.:. .:::.: :: .. : . . .. : :::::::: ::::::.: XP_011 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA 310 320 330 340 350 360 440 450 460 470 480 490 pF1KE4 LPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYR : ::. :::.:::::. .:.....:: .:..:.:.: : :.. ::: ::.: XP_011 SKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHR 370 380 390 400 410 420 500 510 520 530 540 550 pF1KE4 LSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSVSPGSPP .: .:::..: : .::. : . .. . :. .: : ::. .. .: .: XP_011 VSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTG-GDEAPTTPA 430 440 450 460 470 480 560 570 580 590 600 610 pF1KE4 SSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQSSEARVI XP_011 PLLTRLAQSHVVCS 490 710 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:29:11 2016 done: Sun Nov 6 03:29:13 2016 Total Scan time: 15.140 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]