FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4180, 647 aa 1>>>pF1KE4180 647 - 647 aa - 647 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1109+/-0.000402; mu= 11.2082+/- 0.025 mean_var=142.1009+/-30.096, 0's: 0 Z-trim(116.3): 61 B-trim: 1137 in 1/54 Lambda= 0.107591 statistics sampled from 27274 (27340) to 27274 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.321), width: 16 Scan time: 11.580 The best scores are: opt bits E(85289) NP_690852 (OMIM: 615167) leucine-rich repeat and W ( 647) 4366 690.0 7.1e-198 NP_001304650 (OMIM: 615167) leucine-rich repeat an ( 495) 3376 536.2 1.1e-151 XP_016867334 (OMIM: 615167) PREDICTED: leucine-ric ( 454) 3108 494.6 3.3e-139 >>NP_690852 (OMIM: 615167) leucine-rich repeat and WD re (647 aa) initn: 4366 init1: 4366 opt: 4366 Z-score: 3673.4 bits: 690.0 E(85289): 7.1e-198 Smith-Waterman score: 4366; 99.8% identity (100.0% similar) in 647 aa overlap (1-647:1-647) 10 20 30 40 50 60 pF1KE4 MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHRPRARLAALKRPDDVPL :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_690 PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT 550 560 570 580 590 600 610 620 630 640 pF1KE4 QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM ::::::::::::::::::::::::::::::::::::::::::::::: NP_690 QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM 610 620 630 640 >>NP_001304650 (OMIM: 615167) leucine-rich repeat and WD (495 aa) initn: 3376 init1: 3376 opt: 3376 Z-score: 2844.5 bits: 536.2 E(85289): 1.1e-151 Smith-Waterman score: 3376; 99.8% identity (100.0% similar) in 495 aa overlap (153-647:1-495) 130 140 150 160 170 180 pF1KE4 NGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYGPE :::::::::::::::::::::::::::::: NP_001 MATLGPEEEAEKAQADFVKSAVRDVRYGPE 10 20 30 190 200 210 220 230 240 pF1KE4 SLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHRPRARLAALKRPDDVPLSL :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_001 SLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPLSL 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE4 SPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEP 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE4 AWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRW 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE4 SVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE4 GVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKRRV 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE4 CEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVAVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVAVV 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE4 VLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPTQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPTQI 400 410 420 430 440 450 610 620 630 640 pF1KE4 LKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM ::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM 460 470 480 490 >>XP_016867334 (OMIM: 615167) PREDICTED: leucine-rich re (454 aa) initn: 3108 init1: 3108 opt: 3108 Z-score: 2620.2 bits: 494.6 E(85289): 3.3e-139 Smith-Waterman score: 3108; 99.8% identity (100.0% similar) in 454 aa overlap (194-647:1-454) 170 180 190 200 210 220 pF1KE4 KAQADFVKSAVRDVRYGPESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAH :::::::::::::::::::::::::::::: XP_016 MISEELVAASRTQVQKANSPEKPPEAGAAH 10 20 30 230 240 250 260 270 280 pF1KE4 RPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHS .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHS 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 KNNSPQDLETQLWACAFEPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNNSPQDLETQLWACAFEPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFF 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE4 SVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPA 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE4 HETHLFTASYDKRIILWDIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HETHLFTASYDKRIILWDIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGC 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE4 EGGCCCWDVRLDQPQKRRVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGGCCCWDVRLDQPQKRRVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICL 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE4 WSWRQTWGGRGSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WSWRQTWGGRGSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVS 340 350 360 370 380 390 590 600 610 620 630 640 pF1KE4 NILKQPPLLPAALQAPTQILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NILKQPPLLPAALQAPTQILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAI 400 410 420 430 440 450 pF1KE4 WGRM :::: XP_016 WGRM 647 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:09:15 2016 done: Sun Nov 6 04:09:17 2016 Total Scan time: 11.580 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]