FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4044, 267 aa 1>>>pF1KE4044 267 - 267 aa - 267 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6466+/-0.000284; mu= 14.1152+/- 0.018 mean_var=76.7220+/-15.826, 0's: 0 Z-trim(120.5): 17 B-trim: 1020 in 2/51 Lambda= 0.146425 statistics sampled from 35829 (35846) to 35829 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.769), E-opt: 0.2 (0.42), width: 16 Scan time: 8.040 The best scores are: opt bits E(85289) NP_001139788 (OMIM: 611658) SPRY domain-containing ( 263) 1550 336.0 4.3e-92 NP_001306599 (OMIM: 611658) SPRY domain-containing ( 263) 1550 336.0 4.3e-92 NP_116030 (OMIM: 611658) SPRY domain-containing SO ( 263) 1550 336.0 4.3e-92 XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain ( 233) 783 173.9 2.3e-43 NP_543138 (OMIM: 611660) SPRY domain-containing SO ( 273) 783 174.0 2.7e-43 NP_079382 (OMIM: 611657) SPRY domain-containing SO ( 273) 754 167.8 1.9e-41 NP_001099043 (OMIM: 609112) F-box/SPRY domain-cont ( 286) 540 122.6 7.8e-28 NP_001311010 (OMIM: 611659) SPRY domain-containing ( 355) 152 40.7 0.0044 NP_543137 (OMIM: 611659) SPRY domain-containing SO ( 355) 152 40.7 0.0044 XP_005255730 (OMIM: 611659) PREDICTED: SPRY domain ( 410) 152 40.8 0.005 >>NP_001139788 (OMIM: 611658) SPRY domain-containing SOC (263 aa) initn: 1543 init1: 1543 opt: 1550 Z-score: 1774.3 bits: 336.0 E(85289): 4.3e-92 Smith-Waterman score: 1550; 88.8% identity (91.9% similar) in 260 aa overlap (1-260:1-253) 10 20 30 40 50 60 pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVW :::::::::::::::::::::::::::::::::::::::::.: ...: : . NP_001 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEP-----HSLLHLSRLCV 190 200 210 220 230 250 260 pF1KE4 DGNSSDKSRGDGPSSSLPQPLFSAGKG : .: :. :.:: : NP_001 RHNLGDTRLGQ--VSALPLPPAMKRYLLYQ 240 250 260 >>NP_001306599 (OMIM: 611658) SPRY domain-containing SOC (263 aa) initn: 1543 init1: 1543 opt: 1550 Z-score: 1774.3 bits: 336.0 E(85289): 4.3e-92 Smith-Waterman score: 1550; 88.8% identity (91.9% similar) in 260 aa overlap (1-260:1-253) 10 20 30 40 50 60 pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVW :::::::::::::::::::::::::::::::::::::::::.: ...: : . NP_001 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEP-----HSLLHLSRLCV 190 200 210 220 230 250 260 pF1KE4 DGNSSDKSRGDGPSSSLPQPLFSAGKG : .: :. :.:: : NP_001 RHNLGDTRLGQ--VSALPLPPAMKRYLLYQ 240 250 260 >>NP_116030 (OMIM: 611658) SPRY domain-containing SOCS b (263 aa) initn: 1543 init1: 1543 opt: 1550 Z-score: 1774.3 bits: 336.0 E(85289): 4.3e-92 Smith-Waterman score: 1550; 88.8% identity (91.9% similar) in 260 aa overlap (1-260:1-253) 10 20 30 40 50 60 pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 EGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 AALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVW :::::::::::::::::::::::::::::::::::::::::.: ...: : . NP_116 AIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEP-----HSLLHLSRLCV 190 200 210 220 230 250 260 pF1KE4 DGNSSDKSRGDGPSSSLPQPLFSAGKG : .: :. :.:: : NP_116 RHNLGDTRLGQ--VSALPLPPAMKRYLLYQ 240 250 260 >>XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain-con (233 aa) initn: 774 init1: 431 opt: 783 Z-score: 899.4 bits: 173.9 E(85289): 2.3e-43 Smith-Waterman score: 783; 59.0% identity (81.0% similar) in 195 aa overlap (26-217:34-227) 10 20 30 40 50 pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSE : :..::. : :..: ::.:::.: : XP_016 KLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 NIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAP :. ::. : :.:.:::::::: ::: :..::::::.:.:: .::::::::::::: :: XP_016 NVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPA--GTQGEQLEVPERLLVVLD :.. :.::.::..::::::.::..:::..:. . ::: : . : . .:. :::::: XP_016 LHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPD-EAFALPDSLLVVLD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 MEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENF :.::::.. . : ::: :::::::. :::.::::::.:.: .::. XP_016 MDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDQN 190 200 210 220 230 240 250 260 pF1KE4 LSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG >>NP_543138 (OMIM: 611660) SPRY domain-containing SOCS b (273 aa) initn: 774 init1: 431 opt: 783 Z-score: 898.4 bits: 174.0 E(85289): 2.7e-43 Smith-Waterman score: 783; 59.0% identity (81.0% similar) in 195 aa overlap (26-217:34-227) 10 20 30 40 50 pF1KE4 MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSE : :..::. : :..: ::.:::.: : NP_543 KLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 NIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAP :. ::. : :.:.:::::::: ::: :..::::::.:.:: .::::::::::::: :: NP_543 NVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPA--GTQGEQLEVPERLLVVLD :.. :.::.::..::::::.::..:::..:. . ::: : . : . .:. :::::: NP_543 LHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPD-EAFALPDSLLVVLD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 MEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENF :.::::.. . : ::: :::::::. :::.::::::.:.: .::. NP_543 MDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCR 190 200 210 220 230 240 240 250 260 pF1KE4 LSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG NP_543 RSIRSALGRQRLQDISSLPLPQSLKNYLQYQ 250 260 270 >>NP_079382 (OMIM: 611657) SPRY domain-containing SOCS b (273 aa) initn: 749 init1: 417 opt: 754 Z-score: 865.3 bits: 167.8 E(85289): 1.9e-41 Smith-Waterman score: 759; 51.5% identity (74.9% similar) in 227 aa overlap (1-217:1-227) 10 20 30 40 50 pF1KE4 MGQTALAGGSS---STPTPQALYPDLS----C-PEGLEELLSAPPPDLGAQRRHGWNPKD ::: . .: .. :: . : .:. : : :. ::. :: . .: :.:: .: NP_079 MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNND 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 CSENIEVKEGG-LYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATA : :. ::: : :.:.:::::::. ::: ::.::::.:.:.: ..::::::::::::: NP_079 RSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQ-GEQLEVPERLLVV :::.. :..:.:.: ::::::.::..:::..:. . ::: . : . ::. .::. NP_079 DAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 LDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGE :::..:::.. . : :.: :::::::. :::.::::::.:..:.::: NP_079 LDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDL 190 200 210 220 230 240 240 250 260 pF1KE4 NFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG NP_079 CRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ 250 260 270 >>NP_001099043 (OMIM: 609112) F-box/SPRY domain-containi (286 aa) initn: 515 init1: 209 opt: 540 Z-score: 620.7 bits: 122.6 E(85289): 7.8e-28 Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (45-219:111-282) 20 30 40 50 60 70 pF1KE4 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS .:... .:::.:. .:..:. ..: :.::: NP_001 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE4 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG ::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...::: NP_001 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG 150 160 170 180 190 140 150 160 170 180 190 pF1KE4 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR :.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: ::: NP_001 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR 200 210 220 230 240 250 200 210 220 230 240 250 pF1KE4 GLKGRTLYPAVSAVWGQCQVRIRYLGERRGEAWGRRGENFLSLVAVVWDGNSSDKSRGDG :: ::::::::.:. .: . :::. NP_001 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG 260 270 280 >>NP_001311010 (OMIM: 611659) SPRY domain-containing SOC (355 aa) initn: 160 init1: 77 opt: 152 Z-score: 176.3 bits: 40.7 E(85289): 0.0044 Smith-Waterman score: 152; 28.2% identity (52.8% similar) in 142 aa overlap (75-214:135-267) 50 60 70 80 90 100 pF1KE4 RHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHA : . :: . ..: : :::. :: NP_001 WVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDM 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE4 VVGVATALAPL-QTDH-YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLE .::..:. . : . : . .::: . .::: . : :.: :: . :: . NP_001 MVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSY-TGLLHH--KGDKTSFSSRFGQGSIIG 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE4 VPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRG : :: .::: . . .: : :... .:: : .. .. .... NP_001 VH------LDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASAT 230 240 250 260 270 230 240 250 260 pF1KE4 EAWGRRGENFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG NP_001 SLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAAT 280 290 300 310 320 330 >>NP_543137 (OMIM: 611659) SPRY domain-containing SOCS b (355 aa) initn: 160 init1: 77 opt: 152 Z-score: 176.3 bits: 40.7 E(85289): 0.0044 Smith-Waterman score: 152; 28.2% identity (52.8% similar) in 142 aa overlap (75-214:135-267) 50 60 70 80 90 100 pF1KE4 RHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHA : . :: . ..: : :::. :: NP_543 WVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDM 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE4 VVGVATALAPL-QTDH-YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLE .::..:. . : . : . .::: . .::: . : :.: :: . :: . NP_543 MVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSY-TGLLHH--KGDKTSFSSRFGQGSIIG 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE4 VPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRG : :: .::: . . .: : :... .:: : .. .. .... NP_543 VH------LDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASAT 230 240 250 260 270 230 240 250 260 pF1KE4 EAWGRRGENFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG NP_543 SLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAAT 280 290 300 310 320 330 >>XP_005255730 (OMIM: 611659) PREDICTED: SPRY domain-con (410 aa) initn: 160 init1: 77 opt: 152 Z-score: 175.4 bits: 40.8 E(85289): 0.005 Smith-Waterman score: 152; 28.2% identity (52.8% similar) in 142 aa overlap (75-214:190-322) 50 60 70 80 90 100 pF1KE4 RHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHA : . :: . ..: : :::. :: XP_005 WVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDM 160 170 180 190 200 210 110 120 130 140 150 160 pF1KE4 VVGVATALAPL-QTDH-YAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLE .::..:. . : . : . .::: . .::: . : :.: :: . :: . XP_005 MVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSY-TGLLHH--KGDKTSFSSRFGQGSIIG 220 230 240 250 260 270 170 180 190 200 210 220 pF1KE4 VPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRG : :: .::: . . .: : :... .:: : .. .. .... XP_005 VH------LDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASAT 280 290 300 310 320 330 230 240 250 260 pF1KE4 EAWGRRGENFLSLVAVVWDGNSSDKSRGDGPSSSLPQPLFSAGKG XP_005 SLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAAT 340 350 360 370 380 390 267 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:17:15 2016 done: Sun Nov 6 04:17:16 2016 Total Scan time: 8.040 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]