FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4030, 237 aa 1>>>pF1KE4030 237 - 237 aa - 237 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3559+/-0.000354; mu= 12.3632+/- 0.022 mean_var=207.0492+/-45.537, 0's: 0 Z-trim(121.1): 113 B-trim: 1682 in 1/50 Lambda= 0.089133 statistics sampled from 37091 (37244) to 37091 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.437), width: 16 Scan time: 7.100 The best scores are: opt bits E(85289) NP_061153 (OMIM: 612451) E3 ubiquitin-protein liga ( 228) 752 108.4 1.1e-23 NP_937761 (OMIM: 616319) E3 ubiquitin-protein liga ( 151) 298 49.8 3.1e-06 XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 151) 298 49.8 3.1e-06 XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 199) 297 49.8 4e-06 NP_001178253 (OMIM: 616319) E3 ubiquitin-protein l ( 245) 297 50.0 4.5e-06 NP_057355 (OMIM: 616319) E3 ubiquitin-protein liga ( 245) 297 50.0 4.5e-06 XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 u ( 191) 244 43.0 0.00044 XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 u ( 196) 244 43.0 0.00045 NP_060301 (OMIM: 610432,616260) E3 ubiquitin-prote ( 232) 245 43.2 0.00045 NP_004286 (OMIM: 602464) TNF receptor-associated f ( 470) 237 42.7 0.0014 XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631) 222 40.9 0.0062 XP_011524347 (OMIM: 610432,616260) PREDICTED: E3 u ( 227) 212 39.0 0.0085 >>NP_061153 (OMIM: 612451) E3 ubiquitin-protein ligase R (228 aa) initn: 616 init1: 410 opt: 752 Z-score: 546.5 bits: 108.4 E(85289): 1.1e-23 Smith-Waterman score: 752; 45.2% identity (71.7% similar) in 230 aa overlap (10-234:2-225) 10 20 30 40 50 pF1KE4 MAMFRSLVASAQQRQ-----PPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCG .::::. ::::. . : ...:::.:::::..:: . :::.::. NP_061 MAAQQRDCGGAAQLAGPAAEADPL-GRFTCPVCLEVYEKPVQV-PCGHVFCS 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 ECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHIS ::: ::. .:.: .:: . : .:...:.:. : .. :.:: :. :.:.: :.. NP_061 ACLQECLKPKKPVCGVCRSALAPGV--RAVELERQIESTETSCHGCRKNFFLSKIRSHVA 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 SCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRS .: : :. . . : .. .. : :.::: :: :::: .:.::. ::.:: : . NP_061 TCSKYQNYIMEGVK--ATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHST 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 DPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLS : . ::::::..::::::.:.:::: .:. .::.:::::::::..::: .. .: :. NP_061 DTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSII 170 180 190 200 210 220 pF1KE4 EN NP_061 DQ >>NP_937761 (OMIM: 616319) E3 ubiquitin-protein ligase R (151 aa) initn: 435 init1: 297 opt: 298 Z-score: 232.8 bits: 49.8 E(85289): 3.1e-06 Smith-Waterman score: 298; 34.3% identity (62.9% similar) in 140 aa overlap (98-237:18-150) 70 80 90 100 110 120 pF1KE4 LCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANC : :.. . : :. ..: .:... .. NP_937 MAEDLSAATSYTEDDFYCPVCQE---VLKTPVRTTACQHVNRSETST 10 20 30 40 130 140 150 160 170 180 pF1KE4 PKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSA . : : :. .. :: :: : :. .:.:. :: .: . :.:::: . NP_937 SD---NTETYQENTSS-SGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVS 50 60 70 80 90 100 190 200 210 220 230 pF1KE4 MPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN .:::::: . ::..:: .::.:.: ::. ..:::. .:.:. :.. : NP_937 LPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI 110 120 130 140 150 >>XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (151 aa) initn: 435 init1: 297 opt: 298 Z-score: 232.8 bits: 49.8 E(85289): 3.1e-06 Smith-Waterman score: 298; 34.3% identity (62.9% similar) in 140 aa overlap (98-237:18-150) 70 80 90 100 110 120 pF1KE4 LCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANC : :.. . : :. ..: .:... .. XP_005 MAEDLSAATSYTEDDFYCPVCQE---VLKTPVRTTACQHVNRSETST 10 20 30 40 130 140 150 160 170 180 pF1KE4 PKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSA . : : :. .. :: :: : :. .:.:. :: .: . :.:::: . XP_005 SD---NTETYQENTSS-SGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVS 50 60 70 80 90 100 190 200 210 220 230 pF1KE4 MPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN .:::::: . ::..:: .::.:.: ::. ..:::. .:.:. :.. : XP_005 LPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI 110 120 130 140 150 >>XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (199 aa) initn: 468 init1: 297 opt: 297 Z-score: 230.9 bits: 49.8 E(85289): 4e-06 Smith-Waterman score: 388; 33.2% identity (58.0% similar) in 193 aa overlap (69-237:8-198) 40 50 60 70 80 90 pF1KE4 VYHRPVAIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKV---DKATHVEKQLSSYK ::::: .. ..: .:. . ... XP_005 MRESGAHCPLCRGNVTRRERACPERALDLENIMRKFS 10 20 30 100 110 120 130 140 pF1KE4 APCRGCNKKVTLAKMRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRS------- . :: : :.. . .:: : .:: : :.... ...: :: .: ::: XP_005 GSCRCCAKQIKFYRMRHHYKSCKKYQDEYG-VSSIIPNFQISQDSVGN-SNRSETSTSDN 40 50 60 70 80 90 150 160 170 180 190 pF1KE4 --------------TFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPS :: :: : :. .:.:. :: .: . :.:::: ..:::::: XP_005 TETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPS 100 110 120 130 140 150 200 210 220 230 pF1KE4 YKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN . ::..:: .::.:.: ::. ..:::. .:.:. :.. : XP_005 QITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI 160 170 180 190 >>NP_001178253 (OMIM: 616319) E3 ubiquitin-protein ligas (245 aa) initn: 578 init1: 297 opt: 297 Z-score: 230.0 bits: 50.0 E(85289): 4.5e-06 Smith-Waterman score: 499; 32.9% identity (57.8% similar) in 237 aa overlap (25-237:10-244) 10 20 30 40 50 60 pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQP : : .. ::.: :: . :: .: :.:: .:. NP_001 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLT 10 20 30 40 70 80 90 100 110 pF1KE4 CLQVPSPLCPLCRLPFDPKKV---DKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSC .. . ::::: .. ..: .:. . .... :: : :.. . .:: : .:: NP_001 AMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSC 50 60 70 80 90 100 120 130 140 150 pF1KE4 LKVQEQMANCPKFVPVVPTSQPIPSNIPNRS---------------------TFACPYCG : :.... ...: :: .: ::: :: :: : NP_001 KKYQDEYG-VSSIIPNFQISQDSVGN-SNRSETSTSDNTETYQENTSSSGHPTFKCPLCQ 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE4 ARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFV :. .:.:. :: .: . :.:::: ..:::::: . ::..:: .::.:.: :: NP_001 ESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFV 170 180 190 200 210 220 220 230 pF1KE4 DYSIDEEAAFQAALALSLSEN . ..:::. .:.:. :.. : NP_001 NLQLDEETQYQTAVEESFQVNI 230 240 >>NP_057355 (OMIM: 616319) E3 ubiquitin-protein ligase R (245 aa) initn: 578 init1: 297 opt: 297 Z-score: 230.0 bits: 50.0 E(85289): 4.5e-06 Smith-Waterman score: 499; 32.9% identity (57.8% similar) in 237 aa overlap (25-237:10-244) 10 20 30 40 50 60 pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQP : : .. ::.: :: . :: .: :.:: .:. NP_057 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLT 10 20 30 40 70 80 90 100 110 pF1KE4 CLQVPSPLCPLCRLPFDPKKV---DKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSC .. . ::::: .. ..: .:. . .... :: : :.. . .:: : .:: NP_057 AMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSC 50 60 70 80 90 100 120 130 140 150 pF1KE4 LKVQEQMANCPKFVPVVPTSQPIPSNIPNRS---------------------TFACPYCG : :.... ...: :: .: ::: :: :: : NP_057 KKYQDEYG-VSSIIPNFQISQDSVGN-SNRSETSTSDNTETYQENTSSSGHPTFKCPLCQ 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE4 ARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFV :. .:.:. :: .: . :.:::: ..:::::: . ::..:: .::.:.: :: NP_057 ESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFV 170 180 190 200 210 220 220 230 pF1KE4 DYSIDEEAAFQAALALSLSEN . ..:::. .:.:. :.. : NP_057 NLQLDEETQYQTAVEESFQVNI 230 240 >>XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (191 aa) initn: 236 init1: 109 opt: 244 Z-score: 194.2 bits: 43.0 E(85289): 0.00044 Smith-Waterman score: 298; 30.9% identity (52.7% similar) in 165 aa overlap (12-176:23-164) 10 20 30 40 pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSC ..:. : :. ... : .:::: :.:: : XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPV-------TSFDCAVCLEVLHQPVRT-RC 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 GHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAK ::.:: :. :. . :: :: . :.. :: : :...: : :. : :.. XP_011 GHVFCRSCIATSLKNNKWTCPYCR-AYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 MRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHC ::.:: .: : . :. :. . . ::.: :.: .. :. :: XP_011 MRAHIRTCQKYID------KYGPLQELEETAARCV-------CPFC-QRELYEDSLLDHC 120 130 140 150 170 180 190 200 210 220 pF1KE4 VESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAA . :::. XP_011 ITHHRSERRPVDNNTKIHLSCCCPRPHFHPQVPQ 160 170 180 190 >>XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (196 aa) initn: 268 init1: 109 opt: 244 Z-score: 194.1 bits: 43.0 E(85289): 0.00045 Smith-Waterman score: 298; 30.9% identity (52.7% similar) in 165 aa overlap (12-176:23-164) 10 20 30 40 pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSC ..:. : :. ... : .:::: :.:: : XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPV-------TSFDCAVCLEVLHQPVRT-RC 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 GHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAK ::.:: :. :. . :: :: . :.. :: : :...: : :. : :.. XP_011 GHVFCRSCIATSLKNNKWTCPYCR-AYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 MRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHC ::.:: .: : . :. :. . . ::.: :.: .. :. :: XP_011 MRAHIRTCQKYID------KYGPLQELEETAARCV-------CPFC-QRELYEDSLLDHC 120 130 140 150 170 180 190 200 210 220 pF1KE4 VESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAA . :::. XP_011 ITHHRSERRPVDFNIIEEALIRRVLDRSLLEYVNHSNTT 160 170 180 190 >>NP_060301 (OMIM: 610432,616260) E3 ubiquitin-protein l (232 aa) initn: 403 init1: 189 opt: 245 Z-score: 194.1 bits: 43.2 E(85289): 0.00045 Smith-Waterman score: 438; 32.9% identity (55.6% similar) in 225 aa overlap (12-236:23-224) 10 20 30 40 pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSC ..:. : :. ... : .:::: :.:: : NP_060 MGSVLSTDSGKSAPASATARALERRRDPELPV-------TSFDCAVCLEVLHQPVRT-RC 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 GHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAK ::.:: :. :. . :: :: . :.. :: : :...: : :. : :.. NP_060 GHVFCRSCIATSLKNNKWTCPYCR-AYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 MRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHC ::.:: .: : . :. :. . . ::.: :.: .. :. :: NP_060 MRAHIRTCQKYID------KYGPLQELEETAARCV-------CPFC-QRELYEDSLLDHC 120 130 140 150 170 180 190 200 210 220 pF1KE4 VESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAA . :::. : ::.: .: .:: :.....:: : . :: :.:..: ::: .. . NP_060 ITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRV 160 170 180 190 200 210 230 pF1KE4 LALSLSEN : :: : NP_060 LDRSLLEYVNHSNTT 220 230 >>NP_004286 (OMIM: 602464) TNF receptor-associated facto (470 aa) initn: 213 init1: 161 opt: 237 Z-score: 185.4 bits: 42.7 E(85289): 0.0014 Smith-Waterman score: 239; 25.7% identity (54.0% similar) in 187 aa overlap (33-211:18-186) 10 20 30 40 50 60 pF1KE4 MFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCL ::.: . ...:: ...::: :: ::: : NP_004 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFL 10 20 30 40 70 80 90 100 110 pF1KE4 QVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPC----RGCNKKVTLAKMRVHISSCL . :: .::.: :. ..: :. . : .:: . : ... :...: NP_004 SEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTC- 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 KVQEQMANCPKFVPVVPTSQPIPSNI----PNRSTFACPYCGARNLDQQELVKHCVESHR . .. ::. :. . . .:... :.: . : .:: .. . :::. NP_004 --SFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRR-LKCEFCGC------DFSGEAYESHE 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 SDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSL . .:: :.. . .: ....:: .: : NP_004 G-----MCPQESVYC---ENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQS 160 170 180 190 200 pF1KE4 SEN NP_004 HQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARH 210 220 230 240 250 260 237 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:18:53 2016 done: Sun Nov 6 04:18:54 2016 Total Scan time: 7.100 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]