FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4016, 195 aa 1>>>pF1KE4016 195 - 195 aa - 195 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0983+/-0.000384; mu= 14.9392+/- 0.024 mean_var=82.7363+/-15.354, 0's: 0 Z-trim(113.7): 192 B-trim: 34 in 1/55 Lambda= 0.141002 statistics sampled from 22937 (23162) to 22937 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.272), width: 16 Scan time: 5.570 The best scores are: opt bits E(85289) NP_009167 (OMIM: 606988) calcineurin B homologous ( 195) 1261 265.9 2.9e-71 XP_016877368 (OMIM: 606988) PREDICTED: calcineurin ( 123) 766 165.1 4.2e-41 NP_000936 (OMIM: 601302) calcineurin subunit B typ ( 170) 289 68.2 8.6e-12 XP_016875021 (OMIM: 611585) PREDICTED: calcineurin ( 251) 284 67.3 2.3e-11 NP_671709 (OMIM: 613821) calcineurin subunit B typ ( 173) 257 61.7 7.9e-10 NP_060369 (OMIM: 611585) calcineurin B homologous ( 214) 253 60.9 1.6e-09 XP_016875022 (OMIM: 611585) PREDICTED: calcineurin ( 216) 224 55.0 9.8e-08 XP_011536805 (OMIM: 611585) PREDICTED: calcineurin ( 202) 210 52.2 6.7e-07 NP_006374 (OMIM: 605564,609439,614869) calcium and ( 187) 200 50.1 2.6e-06 XP_005254183 (OMIM: 605564,609439,614869) PREDICTE ( 210) 198 49.7 3.7e-06 NP_775285 (OMIM: 604661) Kv channel-interacting pr ( 227) 186 47.3 2.2e-05 NP_473454 (OMIM: 610645) calcium and integrin-bind ( 187) 173 44.6 0.00012 NP_001161797 (OMIM: 611585) calcineurin B homologo ( 187) 167 43.4 0.00027 NP_001258818 (OMIM: 605564,609439,614869) calcium ( 138) 155 40.8 0.0012 NP_001258817 (OMIM: 605564,609439,614869) calcium ( 144) 155 40.8 0.0012 XP_006720437 (OMIM: 605564,609439,614869) PREDICTE ( 144) 155 40.8 0.0012 NP_001288153 (OMIM: 605564,609439,614869) calcium ( 192) 155 40.9 0.0015 XP_011519463 (OMIM: 605564,609439,614869) PREDICTE ( 167) 153 40.5 0.0018 NP_004335 (OMIM: 300006) centrin-2 [Homo sapiens] ( 172) 150 39.9 0.0028 XP_011512186 (OMIM: 608182) PREDICTED: Kv channel- ( 236) 150 40.0 0.0035 XP_011512187 (OMIM: 608182) PREDICTED: Kv channel- ( 232) 148 39.6 0.0046 NP_004057 (OMIM: 603187) centrin-1 [Homo sapiens] ( 172) 146 39.1 0.005 XP_011512191 (OMIM: 608182) PREDICTED: Kv channel- ( 195) 146 39.1 0.0054 XP_011512189 (OMIM: 608182) PREDICTED: Kv channel- ( 195) 146 39.1 0.0054 NP_004267 (OMIM: 605563) calcium-binding protein 1 ( 167) 145 38.9 0.0056 XP_011512188 (OMIM: 608182) PREDICTED: Kv channel- ( 223) 146 39.2 0.006 NP_112482 (OMIM: 605563) calcium-binding protein 1 ( 227) 146 39.2 0.0061 XP_011512185 (OMIM: 608182) PREDICTED: Kv channel- ( 240) 146 39.2 0.0063 NP_001122298 (OMIM: 603315) neuronal calcium senso ( 172) 144 38.7 0.0066 XP_011512184 (OMIM: 608182) PREDICTED: Kv channel- ( 257) 146 39.2 0.0066 NP_055101 (OMIM: 603315) neuronal calcium sensor 1 ( 190) 144 38.7 0.0071 XP_006715136 (OMIM: 600364,602093) PREDICTED: guan ( 128) 141 37.9 0.0081 >>NP_009167 (OMIM: 606988) calcineurin B homologous prot (195 aa) initn: 1261 init1: 1261 opt: 1261 Z-score: 1400.5 bits: 265.9 E(85289): 2.9e-71 Smith-Waterman score: 1261; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195) 10 20 30 40 50 60 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL 130 140 150 160 170 180 190 pF1KE4 EKVDVEQKMSIRFLH ::::::::::::::: NP_009 EKVDVEQKMSIRFLH 190 >>XP_016877368 (OMIM: 606988) PREDICTED: calcineurin B h (123 aa) initn: 765 init1: 765 opt: 766 Z-score: 858.9 bits: 165.1 E(85289): 4.2e-41 Smith-Waterman score: 766; 95.9% identity (97.5% similar) in 122 aa overlap (1-122:1-122) 10 20 30 40 50 60 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::. . XP_016 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHLEEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL : XP_016 RYI >>NP_000936 (OMIM: 601302) calcineurin subunit B type 1 (170 aa) initn: 436 init1: 287 opt: 289 Z-score: 332.7 bits: 68.2 E(85289): 8.6e-12 Smith-Waterman score: 431; 43.2% identity (69.8% similar) in 169 aa overlap (23-191:15-168) 10 20 30 40 50 60 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN :. ..: :: .:: .:: ..:.:: :.:. .::: : NP_000 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQN 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR :: .:.:. : .:. .:.:. :.. ...: :.:. ::.:::: NP_000 PLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQ---------------KLRFAFR 60 70 80 90 130 140 150 160 170 180 pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL .::.::: :: ::.:::.:::: :..: :: .:.:.:: .::.:::. ::: :: :. NP_000 IYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVV 100 110 120 130 140 150 190 pF1KE4 EKVDVEQKMSIRFLH .:...:: . NP_000 GGLDIHKKMVVDV 160 170 >>XP_016875021 (OMIM: 611585) PREDICTED: calcineurin B h (251 aa) initn: 357 init1: 102 opt: 284 Z-score: 325.0 bits: 67.3 E(85289): 2.3e-11 Smith-Waterman score: 346; 33.0% identity (66.5% similar) in 206 aa overlap (1-195:54-243) 10 20 30 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITR ::. :. .::..:.. .:::: .:: . XP_016 RTRGQSRRCAAEASAGPERDARPGAPAAGTMGAAHSA---SEEVRELEGKTGFSSDQIEQ 30 40 50 60 70 80 40 50 60 70 80 pF1KE4 LYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFF--------PEG-EDQVNFR :. :: .:. :.. :. .:.:. .:.: .::. ..:. ::: : : :..::. XP_016 LHRRFKQLS-GDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFE 90 100 110 120 130 90 100 110 120 130 140 pF1KE4 GFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRM :. ...::::. . ..:. ::..::.: :..:: :.: .:. .: .:.. XP_016 DFLTIMSYFRPIDTTMDEEQVEL-----SRKEKLRFLFHMYDSDSDGRITLEEYRNVVEE 140 150 160 170 180 190 150 160 170 180 190 pF1KE4 MVGVN--ISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH ... : : :. :::: ...:: ... . ... . .:.: :: .:::. XP_016 LLSGNPHIEKESARSIADGAMMEA-----ASVCMGQMI--WQGIDIETKMHVRFLNMETM 200 210 220 230 240 XP_016 ALCH 250 >>NP_671709 (OMIM: 613821) calcineurin subunit B type 2 (173 aa) initn: 400 init1: 257 opt: 257 Z-score: 297.4 bits: 61.7 E(85289): 7.9e-10 Smith-Waterman score: 399; 41.3% identity (68.9% similar) in 167 aa overlap (23-189:18-169) 10 20 30 40 50 60 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN :....: :: :: .:: ..:.:: :.:. .::: : NP_671 MSTMGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHN 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFR :: :.:..: .:. .:.:. :. ..: .:.: : .::.::: NP_671 PLVRRVIDVFDTDGDGEVDFKEFILGTSQF----------SVKGDEE-----QKLRFAFS 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 LYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVL .::.::: :: ::.:::.:::: :..: :: ...:.:: :.:::. ::: :: :. NP_671 IYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVV 110 120 130 140 150 160 190 pF1KE4 EKVDVEQKMSIRFLH . .....:. NP_671 RDLEIHKKLVLIV 170 >>NP_060369 (OMIM: 611585) calcineurin B homologous prot (214 aa) initn: 334 init1: 102 opt: 253 Z-score: 291.8 bits: 60.9 E(85289): 1.6e-09 Smith-Waterman score: 376; 34.0% identity (67.0% similar) in 215 aa overlap (1-195:1-206) 10 20 30 40 50 60 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN ::. :. .::..:.. .:::: .:: .:. :: .:. :.. :. .:.:. .:.: .: NP_060 MGAAHSA---SEEVRELEGKTGFSSDQIEQLHRRFKQLS-GDQPTIRKENFNNVPDLELN 10 20 30 40 50 70 80 90 100 110 pF1KE4 PLGDRIINAFF--------PEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR :. ..:. ::: : : :..::. :. ...::::. . ..:. :: NP_060 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVEL-----SR 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVN--ISDEQLGSIADRTIQEA------ ..::.: :..:: :.: .:. .: .:.. ... : : :. :::: ...:: NP_060 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMG 120 130 140 150 160 170 170 180 190 pF1KE4 DQDGDSA---ISFTEFVKVLEKVDVEQKMSIRFLH ... :.. :.: .:.:. . .:.: :: .:::. NP_060 QMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH 180 190 200 210 >>XP_016875022 (OMIM: 611585) PREDICTED: calcineurin B h (216 aa) initn: 286 init1: 102 opt: 224 Z-score: 259.9 bits: 55.0 E(85289): 9.8e-08 Smith-Waterman score: 286; 35.4% identity (68.0% similar) in 147 aa overlap (1-138:54-191) 10 20 30 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITR ::. :. .::..:.. .:::: .:: . XP_016 RTRGQSRRCAAEASAGPERDARPGAPAAGTMGAAHSA---SEEVRELEGKTGFSSDQIEQ 30 40 50 60 70 80 40 50 60 70 80 pF1KE4 LYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFF--------PEG-EDQVNFR :. :: .:. :.. :. .:.:. .:.: .::. ..:. ::: : : :..::. XP_016 LHRRFKQLS-GDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFE 90 100 110 120 130 90 100 110 120 130 140 pF1KE4 GFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRM :. ...::::. . ..:. ::..::.: :..:: :.: .:. .: .: XP_016 DFLTIMSYFRPIDTTMDEEQVEL-----SRKEKLRFLFHMYDSDSDGRITLEEYRNVKWS 140 150 160 170 180 190 150 160 170 180 190 pF1KE4 MVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH XP_016 RSCCRETLTSRRSPLAPSPTGP 200 210 >>XP_011536805 (OMIM: 611585) PREDICTED: calcineurin B h (202 aa) initn: 288 init1: 102 opt: 210 Z-score: 244.9 bits: 52.2 E(85289): 6.7e-07 Smith-Waterman score: 333; 33.3% identity (66.1% similar) in 192 aa overlap (24-195:9-194) 10 20 30 40 50 60 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN : .:: .:. :: .:. :.. :. .:.:. .:.: .: XP_011 MESSQEHVSSDQIEQLHRRFKQLS-GDQPTIRKENFNNVPDLELN 10 20 30 40 70 80 90 100 110 pF1KE4 PLGDRIINAFF--------PEG-EDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR :. ..:. ::: : : :..::. :. ...::::. . ..:. :: XP_011 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVEL-----SR 50 60 70 80 90 120 130 140 150 160 pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVN--ISDEQLGSIADRTIQEA------ ..::.: :..:: :.: .:. .: .:.. ... : : :. :::: ...:: XP_011 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMG 100 110 120 130 140 150 170 180 190 pF1KE4 DQDGDSA---ISFTEFVKVLEKVDVEQKMSIRFLH ... :.. :.: .:.:. . .:.: :: .:::. XP_011 QMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH 160 170 180 190 200 >>NP_006374 (OMIM: 605564,609439,614869) calcium and int (187 aa) initn: 264 init1: 142 opt: 200 Z-score: 234.3 bits: 50.1 E(85289): 2.6e-06 Smith-Waterman score: 234; 26.7% identity (60.4% similar) in 202 aa overlap (1-192:1-186) 10 20 30 40 50 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSRED---------F ::.. .:.. .:.:.. . : :....: .:.::: : . :.. . NP_006 MGNK-QTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLI 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 QRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR ..::: ::. .::. :: .:: ...: :. : . .. .:. : NP_006 IQMPELRENPFKERIVAAFSEDGEGNLTFNDFV---DMFSVLCES-------APREL--- 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAI : ..::..::.. :. : ...: .: .. ....:.. . :..:.::: :::. . NP_006 --KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKL 110 120 130 140 150 160 180 190 pF1KE4 SFTEFVKVLEKV-DVEQKMSIRFLH .:..: .. :. : . . :: NP_006 GFADFEDMIAKAPDFLSTFHIRI 170 180 >>XP_005254183 (OMIM: 605564,609439,614869) PREDICTED: c (210 aa) initn: 250 init1: 142 opt: 198 Z-score: 231.4 bits: 49.7 E(85289): 3.7e-06 Smith-Waterman score: 232; 26.7% identity (60.7% similar) in 191 aa overlap (1-182:1-175) 10 20 30 40 50 pF1KE4 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSRED---------F ::.. .:.. .:.:.. . : :....: .:.::: : . :.. . XP_005 MGNK-QTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLI 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 QRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSR ..::: ::. .::. :: .:: ...: :. : . . ..:. : XP_005 IQMPELRENPFKERIVAAFSEDGEGNLTFNDFVD---MFSVLCE-------SAPREL--- 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 SNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAI : ..::..::.. :. : ...: .: .. ....:.. . :..:.::: :::. . XP_005 --KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKL 110 120 130 140 150 160 180 190 pF1KE4 SFTEFVKVLEKVDVEQKMSIRFLH .:..: .. : XP_005 GFADFEDMIAKAPDFLRCCHYRGRAWAGQSRAGRDVGAEAPITRYL 170 180 190 200 210 195 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:21:22 2016 done: Sun Nov 6 04:21:23 2016 Total Scan time: 5.570 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]