FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3101, 267 aa 1>>>pF1KE3101 267 - 267 aa - 267 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8194+/-0.000312; mu= 13.2140+/- 0.019 mean_var=91.1985+/-17.884, 0's: 0 Z-trim(118.8): 25 B-trim: 141 in 1/54 Lambda= 0.134301 statistics sampled from 31993 (32030) to 31993 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.376), width: 16 Scan time: 5.900 The best scores are: opt bits E(85289) NP_005445 (OMIM: 603777) cerberus precursor [Homo ( 267) 1840 366.0 4e-101 NP_689867 (OMIM: 609068) DAN domain family member ( 189) 260 59.8 4.4e-09 NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 242 56.1 3.3e-08 NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 241 56.0 4.5e-08 NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 241 56.1 5.5e-08 XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 241 56.1 6.3e-08 XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 241 56.2 6.7e-08 XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 223 52.6 5.7e-07 NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 223 52.6 5.7e-07 XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 223 52.6 6.2e-07 NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05 NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05 NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05 NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 190 46.2 5.1e-05 NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05 NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05 NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 190 46.3 5.8e-05 NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 190 46.3 5.9e-05 NP_002448 (OMIM: 158370) mucin-2 precursor [Homo s (5289) 191 47.5 0.00062 >>NP_005445 (OMIM: 603777) cerberus precursor [Homo sapi (267 aa) initn: 1840 init1: 1840 opt: 1840 Z-score: 1936.5 bits: 366.0 E(85289): 4e-101 Smith-Waterman score: 1840; 98.5% identity (99.6% similar) in 267 aa overlap (1-267:1-267) 10 20 30 40 50 60 pF1KE3 MHLLLFQLLVLLPLGKTTWHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLLVAV :::::::::::::::::: :::::::::::::::::::::::::::::::::::::.::: NP_005 MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMK ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 MEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKIV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_005 MEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQ 190 200 210 220 230 240 250 260 pF1KE3 CKVKTEHEDGHILHAGSQDSFIPGVSA ::::::::::::::::::::::::::: NP_005 CKVKTEHEDGHILHAGSQDSFIPGVSA 250 260 >>NP_689867 (OMIM: 609068) DAN domain family member 5 pr (189 aa) initn: 234 init1: 213 opt: 260 Z-score: 284.1 bits: 59.8 E(85289): 4.4e-09 Smith-Waterman score: 260; 28.1% identity (58.1% similar) in 167 aa overlap (84-244:22-188) 60 70 80 90 100 110 pF1KE3 PDLLVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLI :: . : . . ... . ::. . NP_689 MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPL 10 20 30 40 50 120 130 140 150 160 170 pF1KE3 QPIDGMKMEKSPLR-EEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTIT : ... :. : ..:... . : .: ::.. .:: :..::: :... NP_689 VPASALGSWKAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFS 60 70 80 90 100 110 180 190 200 210 220 pF1KE3 HEGCEKIVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSV--- . :: : ..:.::::.:.:...::. . :. :.::. . : : ::. NP_689 RPGCSAIRLRNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRR 120 130 140 150 160 170 230 240 250 260 pF1KE3 -IKV-VMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA .:. .::.: :.:. : NP_689 RVKISTMLIEGCHCSPKA 180 >>NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [Homo (114 aa) initn: 205 init1: 117 opt: 242 Z-score: 268.3 bits: 56.1 E(85289): 3.3e-08 Smith-Waterman score: 242; 35.8% identity (65.1% similar) in 106 aa overlap (141-241:3-108) 120 130 140 150 160 170 pF1KE3 SLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQT .: . :.. . . .. . :.: :..:: NP_001 MSRTAYTVGALHVTERKYLKRDWCKTQPLKQT 10 20 30 180 190 200 210 220 pF1KE3 ITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCSHCLPAKFTTMHLPLNCTELS : .:::.. .. : .:.:.:.: ..: .. : ::: : : ::::: . ::: ::. NP_001 IHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQ 40 50 60 70 80 90 230 240 250 260 pF1KE3 --SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA . : : :..:.: NP_001 PPTKKKRVTRVKQCRCISIDLD 100 110 >>NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 precur (143 aa) initn: 227 init1: 117 opt: 241 Z-score: 265.9 bits: 56.0 E(85289): 4.5e-08 Smith-Waterman score: 245; 37.2% identity (62.8% similar) in 113 aa overlap (141-241:25-137) 120 130 140 150 160 pF1KE3 SLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILP-------IKSHEVHWETCR : .:::.: : . . .. . :. NP_001 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKALHVTERKYLKRDWCK 10 20 30 40 50 170 180 190 200 210 220 pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCSHCLPAKFTTMHLP : :..::: .:::.. .. : .:.:.:.: ..: .. : ::: : : ::::: . NP_001 TQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVT 60 70 80 90 100 110 230 240 250 260 pF1KE3 LNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA ::: ::. . : : :..:.: NP_001 LNCPELQPPTKKKRVTRVKQCRCISIDLD 120 130 140 >>NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precursor (184 aa) initn: 272 init1: 131 opt: 241 Z-score: 264.4 bits: 56.1 E(85289): 5.5e-08 Smith-Waterman score: 255; 29.6% identity (54.3% similar) in 186 aa overlap (63-241:14-178) 40 50 60 70 80 90 pF1KE3 VLLPRNQRELPTGNHEEAEEKPDLLVAVPHLVGTS-PAGEGQRQREKMLSRFGRFWKKPE :.:: ::.::... . : . :. NP_037 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPD 10 20 30 100 110 120 130 140 150 pF1KE3 REMHPSRDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVIL . .: . .. . : ::... . : : . : ... : . NP_037 KAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VT 40 50 60 70 80 160 170 180 190 200 pF1KE3 PIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCS : . : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : ::: NP_037 ERKYLKRDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCS 90 100 110 120 130 140 210 220 230 240 250 260 pF1KE3 HCLPAKFTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGV : : ::::: . ::: ::. . : : :..:.: NP_037 FCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD 150 160 170 180 pF1KE3 SA >>XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 isofo (221 aa) initn: 256 init1: 131 opt: 241 Z-score: 263.3 bits: 56.1 E(85289): 6.3e-08 Smith-Waterman score: 255; 29.6% identity (54.3% similar) in 186 aa overlap (63-241:51-215) 40 50 60 70 80 90 pF1KE3 VLLPRNQRELPTGNHEEAEEKPDLLVAVPHLVGTS-PAGEGQRQREKMLSRFGRFWKKPE :.:: ::.::... . : . :. XP_016 GWSIRRIHDVCICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPD 30 40 50 60 70 100 110 120 130 140 150 pF1KE3 REMHPSRDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVIL . .: . .. . : ::... . : : . : ... : . XP_016 KAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VT 80 90 100 110 120 160 170 180 190 200 pF1KE3 PIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCS : . : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : ::: XP_016 ERKYLKRDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCS 130 140 150 160 170 210 220 230 240 250 260 pF1KE3 HCLPAKFTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGV : : ::::: . ::: ::. . : : :..:.: XP_016 FCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD 180 190 200 210 220 pF1KE3 SA >>XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 isofo (240 aa) initn: 256 init1: 131 opt: 241 Z-score: 262.8 bits: 56.2 E(85289): 6.7e-08 Smith-Waterman score: 255; 29.6% identity (54.3% similar) in 186 aa overlap (63-241:70-234) 40 50 60 70 80 90 pF1KE3 VLLPRNQRELPTGNHEEAEEKPDLLVAVPHLVGTS-PAGEGQRQREKMLSRFGRFWKKPE :.:: ::.::... . : . :. XP_005 QRHASKAQAPRTRRTDSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPD 40 50 60 70 80 90 100 110 120 130 140 150 pF1KE3 REMHPSRDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVIL . .: . .. . : ::... . : : . : ... : . XP_005 KAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VT 100 110 120 130 140 160 170 180 190 200 pF1KE3 PIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCS : . : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : ::: XP_005 ERKYLKRDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCS 150 160 170 180 190 210 220 230 240 250 260 pF1KE3 HCLPAKFTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGV : : ::::: . ::: ::. . : : :..:.: XP_005 FCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD 200 210 220 230 240 pF1KE3 SA >>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa) initn: 151 init1: 136 opt: 223 Z-score: 246.1 bits: 52.6 E(85289): 5.7e-07 Smith-Waterman score: 223; 27.4% identity (64.6% similar) in 113 aa overlap (134-241:45-157) 110 120 130 140 150 160 pF1KE3 PFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCR :.: . . .:: ... . . .. . :. XP_011 LVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCK 20 30 40 50 60 70 170 180 190 200 210 220 pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFP---GAAQHSHTSCSHCLPAKFTTMHLP : :. ::...:::.. .. : .:.:.:.: ..: ..: ::. : : . :.. . XP_011 TQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVE 80 90 100 110 120 130 230 240 250 260 pF1KE3 LNCTELSSV--IKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA :.: :. .: .. :..:.: XP_011 LECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ 140 150 160 >>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa) initn: 151 init1: 136 opt: 223 Z-score: 246.1 bits: 52.6 E(85289): 5.7e-07 Smith-Waterman score: 223; 27.4% identity (64.6% similar) in 113 aa overlap (134-241:45-157) 110 120 130 140 150 160 pF1KE3 PFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCR :.: . . .:: ... . . .. . :. NP_071 LVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCK 20 30 40 50 60 70 170 180 190 200 210 220 pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFP---GAAQHSHTSCSHCLPAKFTTMHLP : :. ::...:::.. .. : .:.:.:.: ..: ..: ::. : : . :.. . NP_071 TQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVE 80 90 100 110 120 130 230 240 250 260 pF1KE3 LNCTELSSV--IKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA :.: :. .: .. :..:.: NP_071 LECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ 140 150 160 >>XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 isofo (186 aa) initn: 136 init1: 136 opt: 223 Z-score: 245.5 bits: 52.6 E(85289): 6.2e-07 Smith-Waterman score: 223; 27.4% identity (64.6% similar) in 113 aa overlap (134-241:63-175) 110 120 130 140 150 160 pF1KE3 PFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCR :.: . . .:: ... . . .. . :. XP_005 LVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCK 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFP---GAAQHSHTSCSHCLPAKFTTMHLP : :. ::...:::.. .. : .:.:.:.: ..: ..: ::. : : . :.. . XP_005 TQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVE 100 110 120 130 140 150 230 240 250 260 pF1KE3 LNCTELSSV--IKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA :.: :. .: .. :..:.: XP_005 LECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ 160 170 180 267 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:51:48 2016 done: Sun Nov 6 04:51:49 2016 Total Scan time: 5.900 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]