FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3385, 1171 aa 1>>>pF1KE3385 1171 - 1171 aa - 1171 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.3336+/-0.000595; mu= -3.9949+/- 0.037 mean_var=689.1980+/-150.056, 0's: 0 Z-trim(116.9): 892 B-trim: 0 in 0/62 Lambda= 0.048854 statistics sampled from 27333 (28470) to 27333 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.334), width: 16 Scan time: 17.150 The best scores are: opt bits E(85289) NP_001106710 (OMIM: 606868) homeodomain-interactin (1171) 7789 566.4 3.6e-160 XP_011514381 (OMIM: 606868) PREDICTED: homeodomain (1350) 7748 563.6 2.9e-159 XP_011514382 (OMIM: 606868) PREDICTED: homeodomain (1349) 7729 562.3 7.3e-159 NP_073577 (OMIM: 606868) homeodomain-interacting p (1198) 4059 303.5 5e-81 XP_011514380 (OMIM: 606868) PREDICTED: homeodomain (1376) 4032 301.7 2e-80 XP_011514383 (OMIM: 606868) PREDICTED: homeodomain (1206) 4027 301.3 2.4e-80 XP_011514379 (OMIM: 606868) PREDICTED: homeodomain (1377) 4018 300.7 4e-80 XP_006715998 (OMIM: 606868) PREDICTED: homeodomain (1191) 4010 300.1 5.5e-80 XP_016867558 (OMIM: 606868) PREDICTED: homeodomain (1191) 4010 300.1 5.5e-80 XP_006710506 (OMIM: 608003) PREDICTED: homeodomain (1247) 3349 253.5 6e-66 XP_005270668 (OMIM: 608003) PREDICTED: homeodomain (1256) 3172 241.1 3.4e-62 XP_005270670 (OMIM: 608003) PREDICTED: homeodomain (1210) 3123 237.6 3.7e-61 XP_005270669 (OMIM: 608003) PREDICTED: homeodomain (1210) 3123 237.6 3.7e-61 NP_938009 (OMIM: 608003) homeodomain-interacting p (1210) 3123 237.6 3.7e-61 XP_005270666 (OMIM: 608003) PREDICTED: homeodomain (1281) 3123 237.6 3.8e-61 NP_689909 (OMIM: 608003) homeodomain-interacting p (1075) 3117 237.1 4.6e-61 XP_016856094 (OMIM: 608003) PREDICTED: homeodomain (1209) 3114 236.9 5.7e-61 XP_005270667 (OMIM: 608003) PREDICTED: homeodomain (1280) 3114 237.0 5.9e-61 NP_001265091 (OMIM: 604424) homeodomain-interactin (1194) 3066 233.5 5.9e-60 NP_001265092 (OMIM: 604424) homeodomain-interactin (1194) 3066 233.5 5.9e-60 NP_001041665 (OMIM: 604424) homeodomain-interactin (1194) 3066 233.5 5.9e-60 XP_016872566 (OMIM: 604424) PREDICTED: homeodomain (1194) 3066 233.5 5.9e-60 XP_005252786 (OMIM: 604424) PREDICTED: homeodomain (1215) 3002 229.1 1.4e-58 NP_005725 (OMIM: 604424) homeodomain-interacting p (1215) 3002 229.1 1.4e-58 XP_016872565 (OMIM: 604424) PREDICTED: homeodomain (1215) 3002 229.1 1.4e-58 XP_011539279 (OMIM: 608003) PREDICTED: homeodomain (1241) 2944 225.0 2.3e-57 XP_016856095 (OMIM: 608003) PREDICTED: homeodomain ( 605) 2769 212.2 8.1e-54 NP_938010 (OMIM: 608003) homeodomain-interacting p ( 836) 1321 110.3 5.1e-23 NP_653286 (OMIM: 611712) homeodomain-interacting p ( 616) 1139 97.3 3.1e-19 XP_006723099 (OMIM: 611712) PREDICTED: homeodomain ( 619) 1139 97.3 3.2e-19 NP_852003 (OMIM: 608003) homeodomain-interacting p ( 816) 1133 97.1 4.9e-19 NP_569122 (OMIM: 600855,614104) dual specificity t ( 529) 769 71.1 2e-11 NP_567824 (OMIM: 600855,614104) dual specificity t ( 584) 769 71.2 2.2e-11 XP_011527787 (OMIM: 600855,614104) PREDICTED: dual ( 725) 771 71.5 2.2e-11 XP_016883775 (OMIM: 600855,614104) PREDICTED: dual ( 734) 771 71.5 2.2e-11 XP_006724042 (OMIM: 600855,614104) PREDICTED: dual ( 754) 771 71.5 2.3e-11 NP_569120 (OMIM: 600855,614104) dual specificity t ( 754) 771 71.5 2.3e-11 XP_016883774 (OMIM: 600855,614104) PREDICTED: dual ( 754) 771 71.5 2.3e-11 XP_016883773 (OMIM: 600855,614104) PREDICTED: dual ( 754) 771 71.5 2.3e-11 XP_011527786 (OMIM: 600855,614104) PREDICTED: dual ( 761) 771 71.5 2.3e-11 NP_001387 (OMIM: 600855,614104) dual specificity t ( 763) 771 71.5 2.3e-11 XP_011527785 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11 XP_006724040 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11 XP_006724041 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11 XP_006724039 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11 XP_011527784 (OMIM: 600855,614104) PREDICTED: dual ( 770) 771 71.5 2.3e-11 XP_005259455 (OMIM: 604556,615812) PREDICTED: dual ( 629) 729 68.4 1.6e-10 NP_004705 (OMIM: 604556,615812) dual specificity t ( 629) 729 68.4 1.6e-10 NP_003836 (OMIM: 609181) dual specificity tyrosine ( 520) 695 65.9 7.5e-10 NP_006474 (OMIM: 604556,615812) dual specificity t ( 589) 695 66.0 8.1e-10 >>NP_001106710 (OMIM: 606868) homeodomain-interacting pr (1171 aa) initn: 7789 init1: 7789 opt: 7789 Z-score: 2996.5 bits: 566.4 E(85289): 3.6e-160 Smith-Waterman score: 7789; 100.0% identity (100.0% similar) in 1171 aa overlap (1-1171:1-1171) 10 20 30 40 50 60 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KE3 AHQTYISASPASTVYTGYPLSPAKVNQYPYI ::::::::::::::::::::::::::::::: NP_001 AHQTYISASPASTVYTGYPLSPAKVNQYPYI 1150 1160 1170 >>XP_011514381 (OMIM: 606868) PREDICTED: homeodomain-int (1350 aa) initn: 7748 init1: 7748 opt: 7748 Z-score: 2980.3 bits: 563.6 E(85289): 2.9e-159 Smith-Waterman score: 7748; 100.0% identity (100.0% similar) in 1165 aa overlap (7-1171:186-1350) 10 20 30 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS :::::::::::::::::::::::::::::: XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS 160 170 180 190 200 210 40 50 60 70 80 90 pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV 400 410 420 430 440 450 280 290 300 310 320 330 pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS 460 470 480 490 500 510 340 350 360 370 380 390 pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 520 530 540 550 560 570 400 410 420 430 440 450 pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA 580 590 600 610 620 630 460 470 480 490 500 510 pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI 640 650 660 670 680 690 520 530 540 550 560 570 pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST 700 710 720 730 740 750 580 590 600 610 620 630 pF1KE3 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ 760 770 780 790 800 810 640 650 660 670 680 690 pF1KE3 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQL 820 830 840 850 860 870 700 710 720 730 740 750 pF1KE3 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL 880 890 900 910 920 930 760 770 780 790 800 810 pF1KE3 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA 940 950 960 970 980 990 820 830 840 850 860 870 pF1KE3 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA 1000 1010 1020 1030 1040 1050 880 890 900 910 920 930 pF1KE3 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN 1060 1070 1080 1090 1100 1110 940 950 960 970 980 990 pF1KE3 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY 1120 1130 1140 1150 1160 1170 1000 1010 1020 1030 1040 1050 pF1KE3 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV 1180 1190 1200 1210 1220 1230 1060 1070 1080 1090 1100 1110 pF1KE3 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ 1240 1250 1260 1270 1280 1290 1120 1130 1140 1150 1160 1170 pF1KE3 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1300 1310 1320 1330 1340 1350 >>XP_011514382 (OMIM: 606868) PREDICTED: homeodomain-int (1349 aa) initn: 4456 init1: 4456 opt: 7729 Z-score: 2973.1 bits: 562.3 E(85289): 7.3e-159 Smith-Waterman score: 7729; 99.9% identity (99.9% similar) in 1165 aa overlap (7-1171:186-1349) 10 20 30 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS :::::::::::::::::::::::::::::: XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS 160 170 180 190 200 210 40 50 60 70 80 90 pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV 400 410 420 430 440 450 280 290 300 310 320 330 pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS 460 470 480 490 500 510 340 350 360 370 380 390 pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 520 530 540 550 560 570 400 410 420 430 440 450 pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA 580 590 600 610 620 630 460 470 480 490 500 510 pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI 640 650 660 670 680 690 520 530 540 550 560 570 pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST 700 710 720 730 740 750 580 590 600 610 620 630 pF1KE3 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ 760 770 780 790 800 810 640 650 660 670 680 690 pF1KE3 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQL ::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::: XP_011 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-AWPSGTQQILLPPAWQQL 820 830 840 850 860 870 700 710 720 730 740 750 pF1KE3 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL 880 890 900 910 920 930 760 770 780 790 800 810 pF1KE3 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA 940 950 960 970 980 990 820 830 840 850 860 870 pF1KE3 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA 1000 1010 1020 1030 1040 1050 880 890 900 910 920 930 pF1KE3 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN 1060 1070 1080 1090 1100 1110 940 950 960 970 980 990 pF1KE3 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY 1120 1130 1140 1150 1160 1170 1000 1010 1020 1030 1040 1050 pF1KE3 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV 1180 1190 1200 1210 1220 1230 1060 1070 1080 1090 1100 1110 pF1KE3 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ 1240 1250 1260 1270 1280 1290 1120 1130 1140 1150 1160 1170 pF1KE3 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1300 1310 1320 1330 1340 >>NP_073577 (OMIM: 606868) homeodomain-interacting prote (1198 aa) initn: 3978 init1: 3939 opt: 4059 Z-score: 1575.6 bits: 303.5 E(85289): 5e-81 Smith-Waterman score: 7725; 97.7% identity (97.7% similar) in 1198 aa overlap (1-1171:1-1198) 10 20 30 40 50 60 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 490 500 510 520 530 540 550 560 570 580 590 pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQ------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 550 560 570 580 590 600 600 610 620 630 pF1KE3 ---------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP ::::::::::::::::::::::::::::::::::::::: NP_073 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE3 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE3 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE3 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE3 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE3 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE3 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE3 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1150 1160 1170 1180 1190 >>XP_011514380 (OMIM: 606868) PREDICTED: homeodomain-int (1376 aa) initn: 7185 init1: 3898 opt: 4032 Z-score: 1564.7 bits: 301.7 E(85289): 2e-80 Smith-Waterman score: 7665; 97.7% identity (97.7% similar) in 1192 aa overlap (7-1171:186-1376) 10 20 30 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS :::::::::::::::::::::::::::::: XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS 160 170 180 190 200 210 40 50 60 70 80 90 pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV 400 410 420 430 440 450 280 290 300 310 320 330 pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS 460 470 480 490 500 510 340 350 360 370 380 390 pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 520 530 540 550 560 570 400 410 420 430 440 450 pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA 580 590 600 610 620 630 460 470 480 490 500 510 pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI 640 650 660 670 680 690 520 530 540 550 560 570 pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST 700 710 720 730 740 750 580 590 600 pF1KE3 STNLTMTFNNQLTTVHNQ---------------------------PSAASMAAVAQRSMP :::::::::::::::::: ::::::::::::::: XP_011 STNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMP 760 770 780 790 800 810 610 620 630 640 650 660 pF1KE3 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ 820 830 840 850 860 870 670 680 690 700 710 720 pF1KE3 IQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQPGLLAQ-AWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA 880 890 900 910 920 930 730 740 750 760 770 780 pF1KE3 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST 940 950 960 970 980 990 790 800 810 820 830 840 pF1KE3 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV 1000 1010 1020 1030 1040 1050 850 860 870 880 890 900 pF1KE3 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY 1060 1070 1080 1090 1100 1110 910 920 930 940 950 960 pF1KE3 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS 1120 1130 1140 1150 1160 1170 970 980 990 1000 1010 1020 pF1KE3 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR 1180 1190 1200 1210 1220 1230 1030 1040 1050 1060 1070 1080 pF1KE3 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT 1240 1250 1260 1270 1280 1290 1090 1100 1110 1120 1130 1140 pF1KE3 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS 1300 1310 1320 1330 1340 1350 1150 1160 1170 pF1KE3 PASTVYTGYPLSPAKVNQYPYI :::::::::::::::::::::: XP_011 PASTVYTGYPLSPAKVNQYPYI 1360 1370 >>XP_011514383 (OMIM: 606868) PREDICTED: homeodomain-int (1206 aa) initn: 3946 init1: 3907 opt: 4027 Z-score: 1563.4 bits: 301.3 E(85289): 2.4e-80 Smith-Waterman score: 7693; 97.5% identity (97.6% similar) in 1196 aa overlap (3-1171:11-1206) 10 20 30 40 50 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYS :. :::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWALKKREHKPLITGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 QSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 NLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTAT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 HPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 FSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASH 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 VSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRY 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 ISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNC 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 LDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 LDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVH 550 560 570 580 590 600 600 610 620 pF1KE3 NQ---------------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQ :: ::::::::::::::::::::::::::::::: XP_011 NQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQ 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE3 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE3 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE3 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSK 790 800 810 820 830 840 810 820 830 840 850 860 pF1KE3 RVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISS 850 860 870 880 890 900 870 880 890 900 910 920 pF1KE3 DTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDT 910 920 930 940 950 960 930 940 950 960 970 980 pF1KE3 KGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGH 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KE3 SSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYS 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 1100 pF1KE3 FPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQ 1090 1100 1110 1120 1130 1140 1110 1120 1130 1140 1150 1160 pF1KE3 HTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKV 1150 1160 1170 1180 1190 1200 1170 pF1KE3 NQYPYI :::::: XP_011 NQYPYI >>XP_011514379 (OMIM: 606868) PREDICTED: homeodomain-int (1377 aa) initn: 3898 init1: 3898 opt: 4018 Z-score: 1559.4 bits: 300.7 E(85289): 4e-80 Smith-Waterman score: 7684; 97.7% identity (97.7% similar) in 1192 aa overlap (7-1171:186-1377) 10 20 30 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS :::::::::::::::::::::::::::::: XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS 160 170 180 190 200 210 40 50 60 70 80 90 pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV 400 410 420 430 440 450 280 290 300 310 320 330 pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS 460 470 480 490 500 510 340 350 360 370 380 390 pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 520 530 540 550 560 570 400 410 420 430 440 450 pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA 580 590 600 610 620 630 460 470 480 490 500 510 pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI 640 650 660 670 680 690 520 530 540 550 560 570 pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST 700 710 720 730 740 750 580 590 600 pF1KE3 STNLTMTFNNQLTTVHNQ---------------------------PSAASMAAVAQRSMP :::::::::::::::::: ::::::::::::::: XP_011 STNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMP 760 770 780 790 800 810 610 620 630 640 650 660 pF1KE3 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ 820 830 840 850 860 870 670 680 690 700 710 720 pF1KE3 IQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA 880 890 900 910 920 930 730 740 750 760 770 780 pF1KE3 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST 940 950 960 970 980 990 790 800 810 820 830 840 pF1KE3 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV 1000 1010 1020 1030 1040 1050 850 860 870 880 890 900 pF1KE3 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY 1060 1070 1080 1090 1100 1110 910 920 930 940 950 960 pF1KE3 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS 1120 1130 1140 1150 1160 1170 970 980 990 1000 1010 1020 pF1KE3 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR 1180 1190 1200 1210 1220 1230 1030 1040 1050 1060 1070 1080 pF1KE3 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT 1240 1250 1260 1270 1280 1290 1090 1100 1110 1120 1130 1140 pF1KE3 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS 1300 1310 1320 1330 1340 1350 1150 1160 1170 pF1KE3 PASTVYTGYPLSPAKVNQYPYI :::::::::::::::::::::: XP_011 PASTVYTGYPLSPAKVNQYPYI 1360 1370 >>XP_006715998 (OMIM: 606868) PREDICTED: homeodomain-int (1191 aa) initn: 3929 init1: 3890 opt: 4010 Z-score: 1557.0 bits: 300.1 E(85289): 5.5e-80 Smith-Waterman score: 7676; 97.7% identity (97.7% similar) in 1191 aa overlap (8-1171:1-1191) 10 20 30 40 50 60 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 480 490 500 510 520 530 550 560 570 580 590 pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQ------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 540 550 560 570 580 590 600 610 620 630 pF1KE3 ---------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP ::::::::::::::::::::::::::::::::::::::: XP_006 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE3 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE3 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE3 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE3 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE3 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE3 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE3 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KE3 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KE3 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1140 1150 1160 1170 1180 1190 >>XP_016867558 (OMIM: 606868) PREDICTED: homeodomain-int (1191 aa) initn: 3929 init1: 3890 opt: 4010 Z-score: 1557.0 bits: 300.1 E(85289): 5.5e-80 Smith-Waterman score: 7676; 97.7% identity (97.7% similar) in 1191 aa overlap (8-1171:1-1191) 10 20 30 40 50 60 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 480 490 500 510 520 530 550 560 570 580 590 pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQ------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS 540 550 560 570 580 590 600 610 620 630 pF1KE3 ---------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP ::::::::::::::::::::::::::::::::::::::: XP_016 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE3 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE3 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE3 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE3 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE3 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE3 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE3 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KE3 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KE3 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1140 1150 1160 1170 1180 1190 >>XP_006710506 (OMIM: 608003) PREDICTED: homeodomain-int (1247 aa) initn: 3894 init1: 2468 opt: 3349 Z-score: 1305.0 bits: 253.5 E(85289): 6e-66 Smith-Waterman score: 4618; 61.4% identity (79.9% similar) in 1224 aa overlap (8-1171:72-1247) 10 20 30 pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSS :::..::::: ...::::::.::::::::. XP_006 AHLLEAHRLLLQSVLCDRPRESIQLHFRLSMASQLQVFSPPSVSSSAFCSAKKLKIEPSG 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 NWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLP-YEQTIVFPG-STGHIVV ::..: .:..: :..::..: .: ...: : : ..: :.: ...:. .. :::: XP_006 -WDVSGQSSNDKYYTHSKTLPATQG---QANSSHQVANFNIPAYDQGLLLPAPAVEHIVV 110 120 130 140 150 100 110 120 130 140 150 pF1KE3 TSA-SSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMI :.: :: :.. ... . ..: .::.::::. ::::::::::::.....::::::::::.. XP_006 TAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLM 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE3 QNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV .: . .. :.:::.:.:.:.:.:..::::::::::.::::::.:::::::::::::::. XP_006 LQNRT-VVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE3 KCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTC :::::.:.:::::::::::::::::::::::::.:::.:.::.:::::.::::::::::: XP_006 KCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTC 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE3 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_006 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE3 PSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL : :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE3 FLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDH :::::::::::::::::::::::::::::::::::::::::::: . :::::::::..: XP_006 FLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEH 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE3 EAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADK : :::::::::::::::::::::::::.:::::.:::.:::::::.:::::::::::::: XP_006 ELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADK 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE3 RITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAP ::::..:::: :::::::::::::.::::::::::::::::.::::.. . . .: XP_006 RITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTASVLASSSTAAAAT 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE3 STSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPG . .: ... : .... ::: . .:::... :: ::.:::.. :::::..:::::. XP_006 LSLANSDVSLLNYQSALY-PSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPA 640 650 660 670 680 690 640 650 660 670 pF1KE3 FQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ---------------- :: ::::. .::.:. :::.:::::: :::.::::::: :.:.: XP_006 FQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVA 700 710 720 730 740 750 680 690 700 pF1KE3 -----------------------------QAWPSGTQQILLPPAWQQLTGVATHTSVQHA ::::.:::::::: .:::: ::: :.::: . XP_006 TITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPT 760 770 780 790 800 810 710 720 730 740 750 760 pF1KE3 TVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQP ..:::.:.. ::::::::.:.::..:. :::::.:::.:::: .:::::::::::.::: XP_006 AMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQ 820 830 840 850 860 870 770 780 790 800 810 820 pF1KE3 TSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSV .:. :.:.:: .. : . :. .: ::. : .: ::: .:: XP_006 SSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRTTS- 880 890 900 910 830 840 850 860 870 880 pF1KE3 TCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNV . : . . :.: :.::::::: :::::: :::::::..:. :.:. : :.:: XP_006 -----SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNV 920 930 940 950 960 970 890 900 910 920 930 940 pF1KE3 ISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVPPLK :: :::.::: :::: .::::.. .. :...... : . ::. ::::::::: XP_006 ISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVPPLK 980 990 1000 1010 1020 950 960 970 980 990 1000 pF1KE3 TQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQ :: : .: ... ..:. :.... :.:.::.::: :: :: : . XP_006 TQ----LGDC------TVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT--S 1030 1040 1050 1060 1070 1010 1020 1030 1040 1050 1060 pF1KE3 QQQPLNLSQAQQH----ITTDRTGSH--RRQQAYITPTMAQAPYSFPHNSPSHGTVHPHL ::::::: :: . .:... :::::...: ..::::.: :.:: :.: :::: XP_006 AAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGHPHL 1080 1090 1100 1110 1120 1130 1070 1080 1090 1100 1110 pF1KE3 AAAAAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQV : : : :::.: :::::.:: ::::::...::: . :::.::.. .:..:...:::: XP_006 APAPA--HLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQV 1140 1150 1160 1170 1180 1190 1120 1130 1140 1150 1160 1170 pF1KE3 PVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI :::.:: .: : .. :.:: ::: :.::..: .::.::::::::.:..:: :. XP_006 PVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1200 1210 1220 1230 1240 1171 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:38:19 2016 done: Sun Nov 6 05:38:22 2016 Total Scan time: 17.150 Total Display time: 0.670 Function used was FASTA [36.3.4 Apr, 2011]