FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8559, 1006 aa 1>>>pF1KB8559 1006 - 1006 aa - 1006 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9125+/-0.000704; mu= 10.1207+/- 0.043 mean_var=342.4803+/-73.114, 0's: 0 Z-trim(113.2): 630 B-trim: 571 in 1/51 Lambda= 0.069304 statistics sampled from 21692 (22488) to 21692 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.264), width: 16 Scan time: 10.790 The best scores are: opt bits E(85289) NP_065825 (OMIM: 608677,615092) E3 ubiquitin-prote (1006) 6891 705.2 4.4e-202 XP_016881362 (OMIM: 608677,615092) PREDICTED: E3 u ( 834) 5388 554.8 6.9e-157 XP_011524400 (OMIM: 608677,615092) PREDICTED: E3 u ( 516) 3506 366.3 2.3e-100 XP_016881364 (OMIM: 608677,615092) PREDICTED: E3 u ( 503) 3385 354.2 1e-96 XP_016881363 (OMIM: 608677,615092) PREDICTED: E3 u ( 511) 3385 354.2 1e-96 XP_016855842 (OMIM: 611141) PREDICTED: E3 ubiquiti (1276) 1685 184.9 2.5e-45 NP_001164158 (OMIM: 611141) E3 ubiquitin-protein l (1056) 1679 184.1 3.4e-45 NP_543151 (OMIM: 611141) E3 ubiquitin-protein liga (1070) 1679 184.1 3.4e-45 XP_016855855 (OMIM: 611141) PREDICTED: E3 ubiquiti ( 911) 1618 177.9 2.1e-43 XP_016855850 (OMIM: 611141) PREDICTED: E3 ubiquiti (1094) 1605 176.8 5.8e-43 XP_011539039 (OMIM: 611141) PREDICTED: E3 ubiquiti (1219) 1572 173.5 6.1e-42 NP_001164157 (OMIM: 611141) E3 ubiquitin-protein l (1066) 1309 147.1 4.7e-34 XP_016855848 (OMIM: 611141) PREDICTED: E3 ubiquiti (1144) 1079 124.2 4e-27 XP_006710435 (OMIM: 611141) PREDICTED: E3 ubiquiti (1034) 1020 118.2 2.3e-25 XP_011539043 (OMIM: 611141) PREDICTED: E3 ubiquiti (1184) 1018 118.1 2.8e-25 XP_016855839 (OMIM: 611141) PREDICTED: E3 ubiquiti (1293) 972 113.6 7.2e-24 XP_016855844 (OMIM: 611141) PREDICTED: E3 ubiquiti (1241) 968 113.1 9.3e-24 XP_011539044 (OMIM: 611141) PREDICTED: E3 ubiquiti (1183) 913 107.6 4.1e-22 XP_016855852 (OMIM: 611141) PREDICTED: E3 ubiquiti (1033) 881 104.3 3.5e-21 XP_016855851 (OMIM: 611141) PREDICTED: E3 ubiquiti (1047) 881 104.3 3.5e-21 XP_016855849 (OMIM: 611141) PREDICTED: E3 ubiquiti (1134) 881 104.4 3.7e-21 XP_016855847 (OMIM: 611141) PREDICTED: E3 ubiquiti (1148) 881 104.4 3.7e-21 XP_016855845 (OMIM: 611141) PREDICTED: E3 ubiquiti (1240) 863 102.6 1.3e-20 XP_011539033 (OMIM: 611141) PREDICTED: E3 ubiquiti (1273) 778 94.2 4.9e-18 XP_011539038 (OMIM: 611141) PREDICTED: E3 ubiquiti (1240) 774 93.7 6.4e-18 XP_016855843 (OMIM: 611141) PREDICTED: E3 ubiquiti (1264) 774 93.8 6.5e-18 XP_016855841 (OMIM: 611141) PREDICTED: E3 ubiquiti (1283) 774 93.8 6.5e-18 XP_016855840 (OMIM: 611141) PREDICTED: E3 ubiquiti (1291) 774 93.8 6.5e-18 XP_016855838 (OMIM: 611141) PREDICTED: E3 ubiquiti (1297) 774 93.8 6.6e-18 XP_016855854 (OMIM: 611141) PREDICTED: E3 ubiquiti ( 932) 707 86.9 5.7e-16 XP_016855853 (OMIM: 611141) PREDICTED: E3 ubiquiti (1029) 657 81.9 1.9e-14 NP_001164159 (OMIM: 611141) E3 ubiquitin-protein l (1005) 560 72.2 1.6e-11 NP_001164160 (OMIM: 611141) E3 ubiquitin-protein l ( 753) 555 71.5 1.9e-11 XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 499 66.5 1.5e-09 XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 499 66.5 1.5e-09 XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 499 66.5 1.5e-09 XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 499 66.5 1.5e-09 XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 499 66.5 1.5e-09 XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 496 66.2 1.8e-09 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 496 66.2 1.8e-09 XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 496 66.2 1.8e-09 XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 496 66.2 1.9e-09 XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 496 66.2 1.9e-09 NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 496 66.2 1.9e-09 XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 496 66.2 1.9e-09 XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 496 66.2 1.9e-09 XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 496 66.2 1.9e-09 XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 496 66.2 1.9e-09 XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931) 496 66.2 1.9e-09 XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020) 496 66.3 1.9e-09 >>NP_065825 (OMIM: 608677,615092) E3 ubiquitin-protein l (1006 aa) initn: 6891 init1: 6891 opt: 6891 Z-score: 3749.0 bits: 705.2 E(85289): 4.4e-202 Smith-Waterman score: 6891; 100.0% identity (100.0% similar) in 1006 aa overlap (1-1006:1-1006) 10 20 30 40 50 60 pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB8 RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ 910 920 930 940 950 960 970 980 990 1000 pF1KB8 TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY :::::::::::::::::::::::::::::::::::::::::::::: NP_065 TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY 970 980 990 1000 >>XP_016881362 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (834 aa) initn: 5386 init1: 5386 opt: 5388 Z-score: 2937.6 bits: 554.8 E(85289): 6.9e-157 Smith-Waterman score: 5388; 97.8% identity (98.7% similar) in 816 aa overlap (191-1006:19-834) 170 180 190 200 210 220 pF1KB8 VDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQD :.: . : . . .:..:::::::: XP_016 MEVYSMSCPMFLYFMDHCSSADLGWARWLTPVIPALWEAQSDLKCVQD 10 20 30 40 230 240 250 260 270 280 pF1KB8 AKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLT 50 60 70 80 90 100 290 300 310 320 330 340 pF1KB8 TTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQ 110 120 130 140 150 160 350 360 370 380 390 400 pF1KB8 VCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKV 170 180 190 200 210 220 410 420 430 440 450 460 pF1KB8 ASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG 230 240 250 260 270 280 470 480 490 500 510 520 pF1KB8 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS 290 300 310 320 330 340 530 540 550 560 570 580 pF1KB8 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA 350 360 370 380 390 400 590 600 610 620 630 640 pF1KB8 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAA 410 420 430 440 450 460 650 660 670 680 690 700 pF1KB8 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 470 480 490 500 510 520 710 720 730 740 750 760 pF1KB8 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA 530 540 550 560 570 580 770 780 790 800 810 820 pF1KB8 ANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECM 590 600 610 620 630 640 830 840 850 860 870 880 pF1KB8 VCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQP 650 660 670 680 690 700 890 900 910 920 930 940 pF1KB8 CGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDN 710 720 730 740 750 760 950 960 970 980 990 1000 pF1KB8 TNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIE 770 780 790 800 810 820 pF1KB8 RRILLY :::::: XP_016 RRILLY 830 >>XP_011524400 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (516 aa) initn: 3506 init1: 3506 opt: 3506 Z-score: 1922.7 bits: 366.3 E(85289): 2.3e-100 Smith-Waterman score: 3506; 100.0% identity (100.0% similar) in 513 aa overlap (494-1006:4-516) 470 480 490 500 510 520 pF1KB8 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL :::::::::::::::::::::::::::::: XP_011 MVLDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 10 20 30 530 540 550 560 570 580 pF1KB8 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 40 50 60 70 80 90 590 600 610 620 630 640 pF1KB8 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 100 110 120 130 140 150 650 660 670 680 690 700 pF1KB8 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 160 170 180 190 200 210 710 720 730 740 750 760 pF1KB8 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG 220 230 240 250 260 270 770 780 790 800 810 820 pF1KB8 ADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCS 280 290 300 310 320 330 830 840 850 860 870 880 pF1KB8 DMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGH 340 350 360 370 380 390 890 900 910 920 930 940 pF1KB8 MCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNV 400 410 420 430 440 450 950 960 970 980 990 1000 pF1KB8 NADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRI 460 470 480 490 500 510 pF1KB8 LLY ::: XP_011 LLY >>XP_016881364 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (503 aa) initn: 3385 init1: 3385 opt: 3385 Z-score: 1857.4 bits: 354.2 E(85289): 1e-96 Smith-Waterman score: 3385; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK ::::::::::::: XP_016 KLLLKQNVDVEAEFYLVEWYEIS 490 500 >>XP_016881363 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (511 aa) initn: 3385 init1: 3385 opt: 3385 Z-score: 1857.4 bits: 354.2 E(85289): 1e-96 Smith-Waterman score: 3385; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK ::::::::::::: XP_016 KLLLKQNVDVEAEGNLKELFWKVDCLHILTY 490 500 510 >>XP_016855842 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1276 aa) initn: 2046 init1: 581 opt: 1685 Z-score: 934.9 bits: 184.9 E(85289): 2.5e-45 Smith-Waterman score: 2012; 35.8% identity (61.2% similar) in 1015 aa overlap (58-1006:321-1275) 30 40 50 60 70 pF1KB8 KQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTG--------IK :.. :::. : .::. .. XP_016 TGSGASRTAARAAWARWWSLAATAAPRHPTAQWSCSGTRA-RAPTTAPATRARTTCCCVR 300 310 320 330 340 80 90 100 110 120 130 pF1KB8 HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES : . .:: :... . :.:::: : .::::: :: .::.: : : : : :. : : XP_016 HPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSP 350 360 370 380 390 400 140 150 160 170 180 190 pF1KB8 RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN :. .: :::: ::.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : . XP_016 RQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWAD 410 420 430 440 450 460 200 210 220 230 240 250 pF1KB8 GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLG-----EQNGNRNPGGLQIGDLVNI :. :.:::: .: ::::: .: :: .:.:: : :: .. . . .: :: :. XP_016 GTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKC 470 480 490 500 510 520 260 270 280 290 300 310 pF1KB8 DLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKA :: .... .:.:::::. : : . :::: : . :. ::. .::::.:..::: XP_016 LLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKH 530 540 550 560 570 580 320 330 340 350 360 370 pF1KB8 NIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQ . .: :::.:.: ::. .: :: :::::.. : :.::.::.: . XP_016 H----------------SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVK 590 600 610 620 630 380 390 400 410 420 pF1KB8 IYSDSDLKVEVCGTSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQES ...:..:.: : : ::..:. : .:. ... . : :.: : :: . . XP_016 VFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSD 640 650 660 670 680 690 430 440 450 460 470 480 pF1KB8 GDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNV . .:: .: :..:.. :::.: .:. . :.::.:.:. :.:....:::. . XP_016 PEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARA 700 710 720 730 740 750 490 500 510 520 530 540 pF1KB8 DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKT :. : .:. :.:.::.:.. . .:: .. .: :. ..: ::.::..: :.::.. XP_016 GVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRA 760 770 780 790 800 810 550 560 570 580 590 600 pF1KB8 LLDFGCHPSLQDSEGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAAL : . :: .: :...:::::.::: . :. :: :. . ::: ::..::. ::::.: XP_016 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 820 830 840 850 860 870 610 620 630 640 650 660 pF1KB8 RGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVN .:. :.: .:.. . .:: ::.::.::::::::::: :::..:...: .....: . XP_016 KGHALAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRK 880 890 900 910 920 930 670 680 690 700 710 pF1KB8 QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL------------S :. :::::.. :. .: ::: :: ... .:..::: :: ::..: : . XP_016 LQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPG 940 950 960 970 980 990 720 730 740 750 pF1KB8 QLRQLQDMQDVG----KV--DAAWEPSKNTLIMGL---------GTQG-AEKKSAASIAC :. :. .: .: ::. :. . :. : : :: .:..:: XP_016 PLQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCPAAQLQASGLPGSAELTVGAAVAC 1000 1010 1020 1030 1040 1050 760 770 780 790 800 pF1KB8 FLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC---HKEKVSG---QVGSR----SPS ::: .:::.: :..:.::::: . . ::: : .:. .: : : .:. XP_016 FLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPN 1060 1070 1080 1090 1100 1110 810 820 830 840 850 860 pF1KB8 MISN------DSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRT ..: . ::.:::.. .::.:: : ..: : XP_016 TVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCE------------GEWGAPGW 1120 1130 1140 1150 870 880 890 900 910 920 pF1KB8 KIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSED . ... :.:: .:: ::::..:..:: ... : XP_016 GGPASRAAANR--ALLF---------AECARRMKKCIRCQVVVSKKL----------RPD 1160 1170 1180 1190 930 940 950 960 970 980 pF1KB8 ATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGT ... :.. : .. :..::.. ....:. ::.:.: ..: ::::. XP_016 GSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPICIDSHIRLVFQCGHGA 1200 1210 1220 1230 1240 1250 990 1000 pF1KB8 CQLCGDRMSECPICRKAIERRILLY : ::. .: :::::. :. :: .. XP_016 CAPCGSALSACPICRQPIRDRIQIFV 1260 1270 >>NP_001164158 (OMIM: 611141) E3 ubiquitin-protein ligas (1056 aa) initn: 2320 init1: 627 opt: 1679 Z-score: 932.4 bits: 184.1 E(85289): 3.4e-45 Smith-Waterman score: 2308; 38.5% identity (64.0% similar) in 1025 aa overlap (14-1006:112-1055) 10 20 30 40 pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVR--- :: ::::: :::::.:::::: :::: NP_001 LKAARRATGRPDRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELG 90 100 110 120 130 140 50 60 70 80 90 pF1KB8 ---SFESPEEVVVV-WDNGTAANYRCS--GAYDLRILDSAPTGIKHDGTMCDTCRQQPII : .:...::: ::.:: .::: . ::.:: . :.: :..: . .:: :... . NP_001 RHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLR 150 160 170 180 190 200 100 110 120 130 140 150 pF1KB8 GIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAG :.:::: : .::::: :: .::.: : : : : :. : : :. .: :::: : NP_001 GMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQG 210 220 230 240 250 260 160 170 180 190 200 210 pF1KB8 ARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSD :.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .:. :.:::: .: : NP_001 AKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVD 270 280 290 300 310 320 220 230 240 250 260 pF1KB8 LKCVQDAKGGSFYRDHCPVLGEQ-------NGNRNPGGLQIGDLVNIDLDLEIVQSLQHG :::: .: :: .:.:: : ::. ... .: .: :: :. :: .... .:.: NP_001 LKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQP--FQHGDKVKCLLDTDVLREMQEG 330 340 350 360 370 270 280 290 300 310 320 pF1KB8 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAE ::::. : : . :::: : . :. ::. .::::.:..::: . NP_001 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHH------------ 380 390 400 410 420 330 340 350 360 370 380 pF1KB8 GGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG .: :::.:.: ::. .: :: :::::.. : :.::.::.: ....:..:.: : : NP_001 ----SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAG 430 440 450 460 470 480 390 400 410 420 430 440 pF1KB8 TSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQESGDLNEELVKAAAN ::..:. : .:. ... . : :.: : :: . . . .:: .: NP_001 QRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL 490 500 510 520 530 540 450 460 470 480 490 500 pF1KB8 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAV :..:.. :::.: .:. . :.::.:.:. :.:....:::. . :. : .:. :. NP_001 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 550 560 570 580 590 600 510 520 530 540 550 560 pF1KB8 HHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS :.::.:.. . .:: .. .: :. ..: ::.::..: :.::..: . :: .: :. NP_001 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 610 620 630 640 650 660 570 580 590 600 610 pF1KB8 EGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK ..:::::.::: . :. :: :. . ::: ::..::. ::::.:.:. :.: .:.. NP_001 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 670 680 690 700 710 720 620 630 640 650 660 670 pF1KB8 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH . .:: ::.::.::::::::::: :::..:...: .....: . :. :::::.. : NP_001 ARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH 730 740 750 760 770 780 680 690 700 710 720 730 pF1KB8 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL . .: ::: :: ... .:..::: :: ::..: : : . : :. .:. : NP_001 VGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL--VAD-------GAGGDPGPLQL 790 800 810 820 830 740 750 760 770 780 790 pF1KB8 IMGLGTQG----AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC-- . : ..: :: .:..::::: .:::.: :..:.::::: . . ::: : NP_001 LSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQ 840 850 860 870 880 890 800 810 820 830 840 850 pF1KB8 -HKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCL .:. .: :. .:. .:: . .... . :: NP_001 RFRERQAG--GGAAPG----PRQTLGTPNTVTNLHVGAAPGP------------------ 900 910 920 860 870 880 890 900 910 pF1KB8 ICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFI . ::.:::. :::.:: : .::.:: ::::..:..:: ... NP_001 ----------EAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKL--- 930 940 950 960 970 920 930 940 950 960 970 pF1KB8 MCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLK :... :.. : .. :..::.. ....:. ::.:.: NP_001 -------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPICIDSHI 980 990 1000 1010 1020 980 990 1000 pF1KB8 NMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY ..: ::::.: ::. .: :::::. :. :: .. NP_001 RLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1030 1040 1050 >>NP_543151 (OMIM: 611141) E3 ubiquitin-protein ligase M (1070 aa) initn: 2320 init1: 627 opt: 1679 Z-score: 932.4 bits: 184.1 E(85289): 3.4e-45 Smith-Waterman score: 2308; 38.5% identity (64.0% similar) in 1025 aa overlap (14-1006:126-1069) 10 20 30 40 pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVR--- :: ::::: :::::.:::::: :::: NP_543 RAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELG 100 110 120 130 140 150 50 60 70 80 90 pF1KB8 ---SFESPEEVVVV-WDNGTAANYRCS--GAYDLRILDSAPTGIKHDGTMCDTCRQQPII : .:...::: ::.:: .::: . ::.:: . :.: :..: . .:: :... . NP_543 RHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLR 160 170 180 190 200 210 100 110 120 130 140 150 pF1KB8 GIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAG :.:::: : .::::: :: .::.: : : : : :. : : :. .: :::: : NP_543 GMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQG 220 230 240 250 260 270 160 170 180 190 200 210 pF1KB8 ARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSD :.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .:. :.:::: .: : NP_543 AKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVD 280 290 300 310 320 330 220 230 240 250 260 pF1KB8 LKCVQDAKGGSFYRDHCPVLGEQ-------NGNRNPGGLQIGDLVNIDLDLEIVQSLQHG :::: .: :: .:.:: : ::. ... .: .: :: :. :: .... .:.: NP_543 LKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQP--FQHGDKVKCLLDTDVLREMQEG 340 350 360 370 380 390 270 280 290 300 310 320 pF1KB8 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAE ::::. : : . :::: : . :. ::. .::::.:..::: . NP_543 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHH------------ 400 410 420 430 440 330 340 350 360 370 380 pF1KB8 GGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG .: :::.:.: ::. .: :: :::::.. : :.::.::.: ....:..:.: : : NP_543 ----SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAG 450 460 470 480 490 390 400 410 420 430 440 pF1KB8 TSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQESGDLNEELVKAAAN ::..:. : .:. ... . : :.: : :: . . . .:: .: NP_543 QRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL 500 510 520 530 540 550 450 460 470 480 490 500 pF1KB8 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAV :..:.. :::.: .:. . :.::.:.:. :.:....:::. . :. : .:. :. NP_543 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560 570 580 590 600 610 510 520 530 540 550 560 pF1KB8 HHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS :.::.:.. . .:: .. .: :. ..: ::.::..: :.::..: . :: .: :. NP_543 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620 630 640 650 660 670 570 580 590 600 610 pF1KB8 EGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK ..:::::.::: . :. :: :. . ::: ::..::. ::::.:.:. :.: .:.. NP_543 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680 690 700 710 720 730 620 630 640 650 660 670 pF1KB8 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH . .:: ::.::.::::::::::: :::..:...: .....: . :. :::::.. : NP_543 ARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH 740 750 760 770 780 790 680 690 700 710 720 730 pF1KB8 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL . .: ::: :: ... .:..::: :: ::..: : : . : :. .:. : NP_543 VGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL--VAD-------GAGGDPGPLQL 800 810 820 830 840 740 750 760 770 780 790 pF1KB8 IMGLGTQG----AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC-- . : ..: :: .:..::::: .:::.: :..:.::::: . . ::: : NP_543 LSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQ 850 860 870 880 890 900 800 810 820 830 840 850 pF1KB8 -HKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCL .:. .: :. .:. .:: . .... . :: NP_543 RFRERQAG--GGAAPG----PRQTLGTPNTVTNLHVGAAPGP------------------ 910 920 930 940 860 870 880 890 900 910 pF1KB8 ICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFI . ::.:::. :::.:: : .::.:: ::::..:..:: ... NP_543 ----------EAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKL--- 950 960 970 980 920 930 940 950 960 970 pF1KB8 MCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLK :... :.. : .. :..::.. ....:. ::.:.: NP_543 -------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPICIDSHI 990 1000 1010 1020 1030 980 990 1000 pF1KB8 NMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY ..: ::::.: ::. .: :::::. :. :: .. NP_543 RLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1040 1050 1060 1070 >>XP_016855855 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (911 aa) initn: 1986 init1: 521 opt: 1618 Z-score: 900.1 bits: 177.9 E(85289): 2.1e-43 Smith-Waterman score: 1945; 36.3% identity (61.6% similar) in 971 aa overlap (96-1006:1-910) 70 80 90 100 110 120 pF1KB8 YDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFY .:::: : .::::: :: .::.: : : XP_016 MRWKCRVCLDYDLCTQCYMHNKHELAHAFD 10 20 30 130 140 150 160 170 180 pF1KB8 RITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWS : : :. : : :. .: :::: ::.:::: ::.: .::::.:. :.:..:. :. XP_016 RYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWD 40 50 60 70 80 90 190 200 210 220 230 pF1KB8 ASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQ-------N . . .:.: : : .:. :.:::: .: ::::: .: :: .:.:: : ::. . XP_016 VETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVS 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB8 GNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQY .. .: .: :: :. :: .... .:.:::::. : : . :::: : . :. ::. XP_016 ADSQP--FQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQF 160 170 180 190 200 300 310 320 330 340 350 pF1KB8 PSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEW .::::.:..::: . .: :::.:.: ::. .: :: ::::: XP_016 NHETRWTFHPGALTKHH----------------SFWVGDVVRVIGDLDTVKRLQAGHGEW 210 220 230 240 250 360 370 380 390 400 410 pF1KB8 AEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPA---AVSKVASAGSAISNASGERL .. : :.::.::.: ....:..:.: : : ::..:. : .:. ... . : XP_016 TDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENK 260 270 280 290 300 310 420 430 440 450 460 470 pF1KB8 SQL---LKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAAS :.: : :: . . . .:: .: :..:.. :::.: .:. . :.::.:.:. XP_016 SSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAA 320 330 340 350 360 370 480 490 500 510 520 530 pF1KB8 QNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQT :.:....:::. . :. : .:. :.:.::.:.. . .:: .. .: :. ..: XP_016 YLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQST 380 390 400 410 420 430 540 550 560 570 580 pF1KB8 PLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR--DDILAVLLEA-GADV ::.::..: :.::..: . :: .: :...:::::.::: . :. :: :. . :: XP_016 ALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDV 440 450 460 470 480 490 590 600 610 620 630 640 pF1KB8 TITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE : ::..::. ::::.:.:. :.: .:.. . .:: ::.::.::::::::::: :::. XP_016 TATNSQGFTLLHHASLKGHALAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVAQ 500 510 520 530 540 550 650 660 670 680 690 700 pF1KB8 LLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH .:...: .....: . :. :::::.. :. .: ::: :: ... .:..::: :: ::.. XP_016 ILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR 560 570 580 590 600 610 710 720 730 740 pF1KB8 HTL------------SQLRQLQDMQDVG----KV--DAAWEPSKNTLIMGL--------- : : . :. :. .: .: ::. :. . :. XP_016 HQLLPLVADGAGGDPGPLQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCPAAQLQAS 620 630 640 650 660 670 750 760 770 780 790 pF1KB8 GTQG-AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC---HKEKVS : : :: .:..::::: .:::.: :..:.::::: . . ::: : .:. . XP_016 GLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQA 680 690 700 710 720 730 800 810 820 830 840 pF1KB8 G---QVGSR----SPSMISN------DSETLEECMVCSDMKRDTLFGPCGHIATCSLCSP : : : .:. ..: . ::.:::.. .::.:: : ..: XP_016 GGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCE---- 740 750 760 770 780 850 860 870 880 890 900 pF1KB8 RVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVE : . ... :.:: .:: ::::..:..:: XP_016 --------GEWGAPGWGGPASRAAANR--ALLFA---------ECARRMKKCIRCQVVVS 790 800 810 820 910 920 930 940 950 960 pF1KB8 RRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPV ... :... :.. : .. :..::.. ....:. ::. XP_016 KKL----------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPI 830 840 850 860 970 980 990 1000 pF1KB8 CLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY :.: ..: ::::.: ::. .: :::::. :. :: .. XP_016 CIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 870 880 890 900 910 >>XP_016855850 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1094 aa) initn: 2297 init1: 627 opt: 1605 Z-score: 892.3 bits: 176.8 E(85289): 5.8e-43 Smith-Waterman score: 2267; 38.2% identity (63.5% similar) in 1040 aa overlap (14-1006:126-1093) 10 20 30 40 pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVR--- :: ::::: :::::.:::::: :::: XP_016 RAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELG 100 110 120 130 140 150 50 60 70 80 90 pF1KB8 ---SFESPEEVVVV-WDNGTAANYRCS--GAYDLRILDSAPTGIKHDGTMCDTCRQQPII : .:...::: ::.:: .::: . ::.:: . :.: :..: . .:: :... . XP_016 RHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLR 160 170 180 190 200 210 100 110 120 130 140 150 pF1KB8 GIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAG :.:::: : .::::: :: .::.: : : : : :. : : :. .: :::: : XP_016 GMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQG 220 230 240 250 260 270 160 170 180 190 200 210 pF1KB8 ARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSD :.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .:. :.:::: .: : XP_016 AKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVD 280 290 300 310 320 330 220 230 240 250 260 pF1KB8 LKCVQDAKGGSFYRDHCPVLGEQ-------NGNRNPGGLQIGDLVNIDLDLEIVQSLQHG :::: .: :: .:.:: : ::. ... .: .: :: :. :: .... .:.: XP_016 LKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQP--FQHGDKVKCLLDTDVLREMQEG 340 350 360 370 380 390 270 280 290 300 310 320 pF1KB8 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAE ::::. : : . :::: : . :. ::. .::::.:..::: . XP_016 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHH------------ 400 410 420 430 440 330 340 350 360 370 380 pF1KB8 GGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG .: :::.:.: ::. .: :: :::::.. : :.::.::.: ....:..:.: : : XP_016 ----SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAG 450 460 470 480 490 390 400 410 420 430 440 pF1KB8 TSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQESGDLNEELVKAAAN ::..:. : .:. ... . : :.: : :: . . . .:: .: XP_016 QRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL 500 510 520 530 540 550 450 460 470 480 490 500 pF1KB8 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAV :..:.. :::.: .:. . :.::.:.:. :.:....:::. . :. : .:. :. XP_016 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560 570 580 590 600 610 510 520 530 540 550 560 pF1KB8 HHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS :.::.:.. . .:: .. .: :. ..: ::.::..: :.::..: . :: .: :. XP_016 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620 630 640 650 660 670 570 580 590 600 610 pF1KB8 EGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK ..:::::.::: . :. :: :. . ::: ::..::. ::::.:.:. :.: .:.. XP_016 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680 690 700 710 720 730 620 630 640 650 660 670 pF1KB8 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH . .:: ::.::.::::::::::: :::..:...: .....: . :. :::::.. : XP_016 ARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH 740 750 760 770 780 790 680 690 700 710 720 730 pF1KB8 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL . .: ::: :: ... .:..::: :: ::..: : : . : :. .:. : XP_016 VGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL--VAD-------GAGGDPGPLQL 800 810 820 830 840 740 750 760 770 780 790 pF1KB8 IMGLGTQG----AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC-- . : ..: :: .:..::::: .:::.: :..:.::::: . . ::: : XP_016 LSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQ 850 860 870 880 890 900 800 810 820 830 pF1KB8 -HKEKVSG---QVGSR----SPSMISN------DSETLEECMVCSDMKRDTLFGPCGHIA .:. .: : : .:. ..: . ::.:::.. .::.:: : . XP_016 RFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRT 910 920 930 940 950 960 840 850 860 870 880 890 pF1KB8 TCS--LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKK .: .: ::. .. :.:: .:: ::: XP_016 VCEGEWGAPGWGG-------PASRAAANR---------ALLFA---------ECARRMKK 970 980 990 1000 900 910 920 930 940 950 pF1KB8 CVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQD :..:..:: ... :... :.. : .. :..::.. .. XP_016 CIRCQVVVSKKL----------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQ 1010 1020 1030 1040 960 970 980 990 1000 pF1KB8 IKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY ..:. ::.:.: ..: ::::.: ::. .: :::::. :. :: .. XP_016 MEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1050 1060 1070 1080 1090 1006 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:44:17 2016 done: Sun Nov 6 05:44:18 2016 Total Scan time: 10.790 Total Display time: 0.310 Function used was FASTA [36.3.4 Apr, 2011]