FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2092, 782 aa 1>>>pF1KE2092 782 - 782 aa - 782 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.1056+/-0.00066; mu= -32.9818+/- 0.041 mean_var=1060.2178+/-225.638, 0's: 0 Z-trim(122.4): 687 B-trim: 2114 in 1/58 Lambda= 0.039389 statistics sampled from 39682 (40544) to 39682 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.475), width: 16 Scan time: 15.800 The best scores are: opt bits E(85289) NP_277021 (OMIM: 176873) cyclin-dependent kinase 1 ( 782) 5169 310.3 2.1e-83 NP_076916 (OMIM: 116951) cyclin-dependent kinase 1 ( 780) 5077 305.0 7.8e-82 NP_277024 (OMIM: 176873) cyclin-dependent kinase 1 ( 748) 4935 296.9 2e-79 XP_016858415 (OMIM: 176873) PREDICTED: cyclin-depe ( 781) 4844 291.8 7.6e-78 NP_001300911 (OMIM: 116951) cyclin-dependent kinas ( 779) 4787 288.6 7.1e-77 NP_001278274 (OMIM: 176873) cyclin-dependent kinas ( 772) 4428 268.1 9.8e-71 NP_277071 (OMIM: 116951) cyclin-dependent kinase 1 ( 770) 4350 263.7 2.1e-69 XP_006711128 (OMIM: 176873) PREDICTED: cyclin-depe ( 785) 4343 263.3 2.8e-69 NP_001300825 (OMIM: 116951) cyclin-dependent kinas ( 783) 4283 259.9 3e-68 XP_016858414 (OMIM: 176873) PREDICTED: cyclin-depe ( 791) 4178 254.0 1.9e-66 NP_277025 (OMIM: 176873) cyclin-dependent kinase 1 ( 565) 3725 228.1 8.4e-59 XP_011540795 (OMIM: 176873) PREDICTED: cyclin-depe ( 794) 3666 224.9 1.1e-57 NP_001778 (OMIM: 176873) cyclin-dependent kinase 1 ( 795) 3666 224.9 1.1e-57 XP_011540794 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3665 224.8 1.1e-57 XP_011540792 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3665 224.8 1.1e-57 XP_011540793 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 3665 224.8 1.1e-57 XP_016858416 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 3662 224.6 1.2e-57 XP_011540796 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 3662 224.6 1.2e-57 XP_011540797 (OMIM: 176873) PREDICTED: cyclin-depe ( 760) 3657 224.3 1.5e-57 XP_016858417 (OMIM: 176873) PREDICTED: cyclin-depe ( 761) 3657 224.3 1.5e-57 XP_011540798 (OMIM: 176873) PREDICTED: cyclin-depe ( 578) 3473 213.7 1.8e-54 NP_277022 (OMIM: 176873) cyclin-dependent kinase 1 ( 526) 3445 212.1 4.9e-54 NP_443714 (OMIM: 603464) cyclin-dependent kinase 1 ( 360) 1224 85.7 3.8e-16 XP_006721371 (OMIM: 603464) PREDICTED: cyclin-depe ( 354) 1177 83.0 2.4e-15 XP_006721373 (OMIM: 603464) PREDICTED: cyclin-depe ( 343) 1167 82.5 3.5e-15 XP_016879296 (OMIM: 603464) PREDICTED: cyclin-depe ( 337) 1128 80.2 1.6e-14 XP_016879297 (OMIM: 603464) PREDICTED: cyclin-depe ( 289) 1031 74.6 6.5e-13 NP_001153839 (OMIM: 603464) cyclin-dependent kinas ( 289) 1031 74.6 6.5e-13 NP_001092003 (OMIM: 603464) cyclin-dependent kinas ( 283) 984 72.0 4.1e-12 XP_016879298 (OMIM: 603464) PREDICTED: cyclin-depe ( 283) 984 72.0 4.1e-12 NP_443713 (OMIM: 603464) cyclin-dependent kinase 1 ( 272) 974 71.4 5.9e-12 XP_016879299 (OMIM: 603464) PREDICTED: cyclin-depe ( 272) 974 71.4 5.9e-12 NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 912 67.9 7.3e-11 NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 905 67.5 9.5e-11 XP_005270360 (OMIM: 116940) PREDICTED: cyclin-depe ( 297) 834 63.5 1.6e-09 NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 834 63.5 1.6e-09 NP_001307847 (OMIM: 116940) cyclin-dependent kinas ( 297) 834 63.5 1.6e-09 NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 827 63.1 2.3e-09 XP_011521719 (OMIM: 603464) PREDICTED: cyclin-depe ( 261) 812 62.2 3.4e-09 NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 814 62.4 3.8e-09 NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 809 62.0 4.1e-09 XP_011521710 (OMIM: 603464) PREDICTED: cyclin-depe ( 369) 812 62.3 4.3e-09 XP_011521709 (OMIM: 603464) PREDICTED: cyclin-depe ( 375) 812 62.3 4.3e-09 XP_011521708 (OMIM: 603464) PREDICTED: cyclin-depe ( 386) 812 62.3 4.4e-09 XP_011521707 (OMIM: 603464) PREDICTED: cyclin-depe ( 392) 812 62.3 4.5e-09 XP_016874894 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 808 62.3 6.3e-09 NP_002586 (OMIM: 603440) cyclin-dependent kinase 1 ( 523) 808 62.3 6.3e-09 XP_016874895 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 808 62.3 6.3e-09 XP_011542230 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 804 62.0 7.2e-09 XP_011542229 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 804 62.0 7.2e-09 >>NP_277021 (OMIM: 176873) cyclin-dependent kinase 11B i (782 aa) initn: 5169 init1: 5169 opt: 5169 Z-score: 1618.4 bits: 310.3 E(85289): 2.1e-83 Smith-Waterman score: 5169; 100.0% identity (100.0% similar) in 782 aa overlap (1-782:1-782) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 730 740 750 760 770 780 pF1KE2 KF :: NP_277 KF >>NP_076916 (OMIM: 116951) cyclin-dependent kinase 11A i (780 aa) initn: 4322 init1: 4322 opt: 5077 Z-score: 1590.2 bits: 305.0 E(85289): 7.8e-82 Smith-Waterman score: 5077; 98.6% identity (99.2% similar) in 782 aa overlap (1-782:1-780) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_076 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::.::::::::::: ::.:::::::: NP_076 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK ::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_076 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: NP_076 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK :::::::::::::::::::::::::::.:::::::::::.::::::::::::::::.::: NP_076 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 720 730 740 750 760 770 pF1KE2 KF :: NP_076 KF 780 >>NP_277024 (OMIM: 176873) cyclin-dependent kinase 11B i (748 aa) initn: 4935 init1: 4935 opt: 4935 Z-score: 1546.8 bits: 296.9 E(85289): 2e-79 Smith-Waterman score: 4935; 99.6% identity (100.0% similar) in 748 aa overlap (35-782:1-748) 10 20 30 40 50 60 pF1KE2 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRN ...::::::::::::::::::::::::::: NP_277 MSQSDDRDSKRDSLEEGELRDHRMEITIRN 10 20 30 70 80 90 100 110 120 pF1KE2 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 DRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 DRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 VTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNW 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 ILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYST 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE2 AVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 AVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFS 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE2 EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPT 640 650 660 670 680 690 730 740 750 760 770 780 pF1KE2 WPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 WPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 700 710 720 730 740 >>XP_016858415 (OMIM: 176873) PREDICTED: cyclin-dependen (781 aa) initn: 4113 init1: 4113 opt: 4844 Z-score: 1518.6 bits: 291.8 E(85289): 7.6e-78 Smith-Waterman score: 5040; 97.6% identity (97.6% similar) in 791 aa overlap (1-782:1-781) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::::::::::::::: : XP_016 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K 70 80 90 100 110 130 140 150 160 170 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL ::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_016 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE2 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA 720 730 740 750 760 770 780 pF1KE2 SAAGPGFSLKF ::::::::::: XP_016 SAAGPGFSLKF 780 >>NP_001300911 (OMIM: 116951) cyclin-dependent kinase 11 (779 aa) initn: 4081 init1: 4081 opt: 4787 Z-score: 1501.1 bits: 288.6 E(85289): 7.1e-77 Smith-Waterman score: 4956; 96.3% identity (96.8% similar) in 791 aa overlap (1-782:1-779) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::.::::::::::: : NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K 70 80 90 100 110 130 140 150 160 170 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL ::::: :::::::::::::::::::::::::::::::::::::: :::::: NP_001 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE2 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: NP_001 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPK 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE2 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE2 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE2 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYR 530 540 550 560 570 580 600 610 620 630 640 650 pF1KE2 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG ::::::::::::::::::::::::::::::::::::.:::::::::::.::::::::::: NP_001 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPG 590 600 610 620 630 640 660 670 680 690 700 710 pF1KE2 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 650 660 670 680 690 700 720 730 740 750 760 770 pF1KE2 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA 710 720 730 740 750 760 780 pF1KE2 SAAGPGFSLKF ::::::::::: NP_001 SAAGPGFSLKF 770 >>NP_001278274 (OMIM: 176873) cyclin-dependent kinase 11 (772 aa) initn: 4377 init1: 4377 opt: 4428 Z-score: 1390.9 bits: 268.1 E(85289): 9.8e-71 Smith-Waterman score: 5068; 98.7% identity (98.7% similar) in 782 aa overlap (1-782:1-772) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 720 730 740 750 760 770 pF1KE2 KF :: NP_001 KF >>NP_277071 (OMIM: 116951) cyclin-dependent kinase 11A i (770 aa) initn: 4333 init1: 4333 opt: 4350 Z-score: 1367.0 bits: 263.7 E(85289): 2.1e-69 Smith-Waterman score: 4984; 97.4% identity (98.0% similar) in 782 aa overlap (1-782:1-770) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_277 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::.::::::::::: : NP_277 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK ::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE2 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE2 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_277 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE2 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE2 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE2 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: NP_277 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE2 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK :::::::::::::::::::::::::::.:::::::::::.::::::::::::::::.::: NP_277 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE2 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE2 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 710 720 730 740 750 760 pF1KE2 KF :: NP_277 KF 770 >>XP_006711128 (OMIM: 176873) PREDICTED: cyclin-dependen (785 aa) initn: 3470 init1: 3470 opt: 4343 Z-score: 1364.7 bits: 263.3 E(85289): 2.8e-69 Smith-Waterman score: 5028; 97.0% identity (97.1% similar) in 795 aa overlap (1-782:1-785) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::::::::::::::: : XP_006 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 180 190 200 210 220 230 250 260 270 280 pF1KE2 ERFELGDGRKP-------------VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG ::::::::::: .::::::::::::::::::::::::::::::::::: XP_006 ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE2 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE2 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE2 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE2 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE2 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE2 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE2 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE2 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT 720 730 740 750 760 770 770 780 pF1KE2 NQGASAAGPGFSLKF ::::::::::::::: XP_006 NQGASAAGPGFSLKF 780 >>NP_001300825 (OMIM: 116951) cyclin-dependent kinase 11 (783 aa) initn: 3438 init1: 3438 opt: 4283 Z-score: 1346.3 bits: 259.9 E(85289): 3e-68 Smith-Waterman score: 4944; 95.7% identity (96.4% similar) in 795 aa overlap (1-782:1-783) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK ::::::::::::::::::::::::::::::::::::.::::::::::: : NP_001 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKW----------K 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK ::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HARVK--EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 170 180 190 200 210 220 250 260 270 280 pF1KE2 ERFELGDGRKP-------------VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG ::::::::::: .::::::::::::::::::::::::::::::::::: NP_001 ERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_001 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE2 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE2 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVK 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE2 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE2 LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK :::::::::::::::::::::::::::::::::::::::.:::::::::::.::::::: NP_001 QWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEK 590 600 610 620 630 640 650 660 670 680 690 700 pF1KE2 IWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKH 650 660 670 680 690 700 710 720 730 740 750 760 pF1KE2 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTT 710 720 730 740 750 760 770 780 pF1KE2 NQGASAAGPGFSLKF ::::::::::::::: NP_001 NQGASAAGPGFSLKF 770 780 >>XP_016858414 (OMIM: 176873) PREDICTED: cyclin-dependen (791 aa) initn: 4113 init1: 4113 opt: 4178 Z-score: 1314.0 bits: 254.0 E(85289): 1.9e-66 Smith-Waterman score: 5141; 98.9% identity (98.9% similar) in 791 aa overlap (1-782:1-791) 10 20 30 40 50 60 pF1KE2 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGK 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL ::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_016 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE2 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE2 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE2 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE2 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE2 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE2 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA 730 740 750 760 770 780 780 pF1KE2 SAAGPGFSLKF ::::::::::: XP_016 SAAGPGFSLKF 790 782 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:48:41 2016 done: Sun Nov 6 05:48:44 2016 Total Scan time: 15.800 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]