FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3684, 489 aa 1>>>pF1KE3684 489 - 489 aa - 489 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.0270+/-0.000381; mu= -7.1384+/- 0.024 mean_var=330.8347+/-65.864, 0's: 0 Z-trim(123.7): 23 B-trim: 881 in 2/57 Lambda= 0.070513 statistics sampled from 43955 (43978) to 43955 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.797), E-opt: 0.2 (0.516), width: 16 Scan time: 12.320 The best scores are: opt bits E(85289) NP_001276324 (OMIM: 600132,602280,613843) tubby-re ( 489) 3257 344.8 3.3e-94 NP_003313 (OMIM: 600132,602280,613843) tubby-relat ( 542) 2844 302.8 1.6e-81 NP_813977 (OMIM: 601197,616188) tubby protein homo ( 506) 1359 151.7 4.6e-36 XP_011518646 (OMIM: 601197,616188) PREDICTED: tubb ( 518) 1359 151.7 4.6e-36 XP_005253166 (OMIM: 601197,616188) PREDICTED: tubb ( 548) 1359 151.7 4.9e-36 NP_003311 (OMIM: 601197,616188) tubby protein homo ( 561) 1359 151.7 4.9e-36 NP_003315 (OMIM: 604730) tubby-related protein 3 i ( 442) 1228 138.3 4.2e-32 NP_001153880 (OMIM: 604730) tubby-related protein ( 501) 1193 134.8 5.5e-31 NP_003314 (OMIM: 602309) tubby-related protein 2 [ ( 520) 1035 118.7 3.9e-26 XP_011525557 (OMIM: 602309) PREDICTED: tubby-relat ( 487) 893 104.3 8.3e-22 XP_011525558 (OMIM: 602309) PREDICTED: tubby-relat ( 487) 893 104.3 8.3e-22 XP_011525555 (OMIM: 602309) PREDICTED: tubby-relat ( 528) 893 104.3 8.8e-22 XP_006723411 (OMIM: 602309) PREDICTED: tubby-relat ( 531) 893 104.3 8.8e-22 XP_006723410 (OMIM: 602309) PREDICTED: tubby-relat ( 531) 893 104.3 8.8e-22 XP_011525554 (OMIM: 602309) PREDICTED: tubby-relat ( 531) 893 104.3 8.8e-22 XP_011525556 (OMIM: 602309) PREDICTED: tubby-relat ( 498) 563 70.7 1.1e-11 >>NP_001276324 (OMIM: 600132,602280,613843) tubby-relate (489 aa) initn: 3257 init1: 3257 opt: 3257 Z-score: 1812.2 bits: 344.8 E(85289): 3.3e-94 Smith-Waterman score: 3257; 99.8% identity (100.0% similar) in 489 aa overlap (1-489:1-489) 10 20 30 40 50 60 pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KPGEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPGEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KALKKKGTPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEERAPSPPVEVDEPRE :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_001 KALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 FVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 SYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALS 430 440 450 460 470 480 pF1KE3 SFDGKLACE ::::::::: NP_001 SFDGKLACE >>NP_003313 (OMIM: 600132,602280,613843) tubby-related p (542 aa) initn: 2812 init1: 2812 opt: 2844 Z-score: 1584.5 bits: 302.8 E(85289): 1.6e-81 Smith-Waterman score: 2996; 89.6% identity (89.8% similar) in 521 aa overlap (22-489:22-542) 10 20 30 40 50 60 pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR ::::::::::::::::::::::::::::::::::::::: NP_003 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR 10 20 30 40 50 60 pF1KE3 KPG-----------------------------------------------------EEEE ::: :::: NP_003 KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEE 70 80 90 100 110 120 70 80 90 100 110 120 pF1KE3 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR 130 140 150 160 170 180 130 140 150 160 170 180 pF1KE3 VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG 190 200 210 220 230 240 190 200 210 220 230 240 pF1KE3 TPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_003 TPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP 250 260 270 280 290 300 250 260 270 280 290 300 pF1KE3 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS 310 320 330 340 350 360 310 320 330 340 350 360 pF1KE3 RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR 370 380 390 400 410 420 370 380 390 400 410 420 pF1KE3 MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ 430 440 450 460 470 480 430 440 450 460 470 480 pF1KE3 GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA 490 500 510 520 530 540 pF1KE3 CE :: NP_003 CE >>NP_813977 (OMIM: 601197,616188) tubby protein homolog (506 aa) initn: 1473 init1: 780 opt: 1359 Z-score: 768.5 bits: 151.7 E(85289): 4.6e-36 Smith-Waterman score: 1437; 48.6% identity (70.5% similar) in 502 aa overlap (12-489:9-506) 10 20 30 40 50 60 pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR : : ..:. . . . .:: :. .::: : . ..:: NP_813 MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPR 10 20 30 40 50 70 80 90 100 110 pF1KE3 KPGEEEEEEEDEEDEE------EEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRG . .. ::. : . . .: : . . .: . .:.:: . : NP_813 SRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 DLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVG :. : . .. .::. . . :....: .. :. :. . . : NP_813 GQGGAARKEKKGKHKGTSGPAA----LAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGG 120 130 140 150 160 170 180 190 200 210 220 pF1KE3 E---GSPDKKALKKKGTPKGA---RKEEEEEEEAATVIK-NSNQKGKAKGKGKKKAKEER : :. . ....:: .. . ::.:::.... . ::: . .. . :. . NP_813 ERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAAS 180 190 200 210 220 230 230 240 250 260 270 pF1KE3 APSP-----PV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTE-- :::: :: ::.. .::.::::::: :..::.:::::::::::::.:::::: : NP_813 APSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDG 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE3 KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRG ::::::::::::.:::.:::::.:::.:::::...::::::::.:..:::.::: :::.. NP_813 KKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKA 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE3 YSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVR :... : :::::::: ::::::::.:::.:.::.:::. .::: ::::: . ::.: NP_813 SSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLAR 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 WQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRV ::::. ::.:::.:: ::::::. ::.:::.:::::::::::::.:..::::::.::::: NP_813 WQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRV 420 430 440 450 460 470 460 470 480 pF1KE3 AEDAFTLDYRYPLCALQAFAIALSSFDGKLACE :::.::.:: :::::::::::::::::.::::: NP_813 AEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 480 490 500 >>XP_011518646 (OMIM: 601197,616188) PREDICTED: tubby pr (518 aa) initn: 1473 init1: 780 opt: 1359 Z-score: 768.4 bits: 151.7 E(85289): 4.6e-36 Smith-Waterman score: 1431; 48.8% identity (70.8% similar) in 500 aa overlap (17-489:23-518) 10 20 30 40 50 pF1KE3 MPLRDETLREVWASDSGH---EEESLSPEAPRRPKQRPAPAQRLRKKRTEAPES :: ..:. . . . .:: :. .::: : XP_011 MEPGTGAVLTEKSCCARQTSRLGHSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMV 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 PCPTGSKPRKPGEEEEEEEDEEDEE------EEAEEKKEKILLPPKKPLREKSSADLKER . ..::. .. ::. : . . .: : . . .: . . XP_011 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 RAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARK :.:: . : :. : . .. .::. . . :....: .. :. :. XP_011 RTKAAATAGGQGGAARKEKKGKHKGTSGPAA----LAEDKSEAQGPVQILTVGQSDHAQD 130 140 150 160 170 170 180 190 200 210 pF1KE3 SPAAMFLVGE---GSPDKKALKKKGTPKGA---RKEEEEEEEAATVIK-NSNQKGKAKGK . . :: :. . ....:: .. . ::.:::.... . ::: . .. . XP_011 AGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE3 GKKKAKEERAPSP-----PV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSY :. . :::: :: ::.. .::.::::::: :..::.:::::::::::::.: XP_011 RKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTY 240 250 260 270 280 290 280 290 300 310 320 pF1KE3 FLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVF ::::: : ::::::::::::.:::.:::::.:::.:::::...::::::::.:..:::. XP_011 FLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVY 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 DNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPR ::: :::.. :... : :::::::: ::::::::.:::.:.::.:::. .::: :::: XP_011 DNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPR 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE3 NASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPD : . ::.:::::. ::.:::.:: ::::::. ::.:::.:::::::::::::.:..::: XP_011 NEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPD 420 430 440 450 460 470 450 460 470 480 pF1KE3 YIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE :::.::::::::.::.:: :::::::::::::::::.::::: XP_011 YIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 480 490 500 510 >>XP_005253166 (OMIM: 601197,616188) PREDICTED: tubby pr (548 aa) initn: 1483 init1: 780 opt: 1359 Z-score: 768.0 bits: 151.7 E(85289): 4.9e-36 Smith-Waterman score: 1449; 48.8% identity (70.9% similar) in 502 aa overlap (12-489:51-548) 10 20 30 40 pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRL :. :: ..:. . . . .:: :. XP_005 PAPPPPAEPRAEPEAAMEGVSSHRTLSYSRWSYDSVLDDEGRNLRQQKLDRQRALLEQKQ 30 40 50 60 70 80 50 60 70 80 90 pF1KE3 RKKRTEAPESPCPTGSKPRKPGEEEEEEEDEEDEE------EEAEEKKEKILLPPKKPLR .::: : . ..::. .. ::. : . . .: : . XP_005 KKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGA 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 EKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKD . .: . .:.:: . : :. : . .. .::. . . :....: .. XP_005 TRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAA----LAEDKSEAQGPVQIL 150 160 170 180 190 160 170 180 190 200 pF1KE3 PSGSPASARKSPAAMFLVGE---GSPDKKALKKKGTPKGA---RKEEEEEEEAATVIK-N :. :. . . :: :. . ....:: .. . ::.:::.... . : XP_005 TVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE3 SNQKGKAKGKGKKKAKEERAPSP-----PV--EVDEPREFVLRPAPQGRTVRCRLTRDKK :: . .. . :. . :::: :: ::.. .::.::::::: :..::.::::: XP_005 SNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKK 260 270 280 290 300 310 270 280 290 300 310 pF1KE3 GMDRGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRS ::::::::.:::::: : ::::::::::::.:::.:::::.:::.:::::...:::::: XP_005 GMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 320 330 340 350 360 370 320 330 340 350 360 370 pF1KE3 NLLGNRFTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSA ::.:..:::.::: :::.. :... : :::::::: ::::::::.:::.:.::.:::. XP_005 NLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNM 380 390 400 410 420 430 380 390 400 410 420 430 pF1KE3 ENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKN .::: ::::: . ::.:::::. ::.:::.:: ::::::. ::.:::.:::::::::: XP_005 VHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKN 440 450 460 470 480 490 440 450 460 470 480 pF1KE3 FQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE :::.:..::::::.::::::::.::.:: :::::::::::::::::.::::: XP_005 FQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 500 510 520 530 540 >>NP_003311 (OMIM: 601197,616188) tubby protein homolog (561 aa) initn: 1473 init1: 780 opt: 1359 Z-score: 767.9 bits: 151.7 E(85289): 4.9e-36 Smith-Waterman score: 1431; 48.1% identity (69.6% similar) in 516 aa overlap (4-489:52-561) 10 20 pF1KE3 MPLRDETLREVWASDSGHE------EESLSPEA : : :. : :.: .:. . . NP_003 FPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKE--GREIARVLDDEGRNLRQ 30 40 50 60 70 30 40 50 60 70 80 pF1KE3 PRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGEEEEEEEDEEDEE------EEAEE . .:: :. .::: : . ..::. .. ::. : . . NP_003 QKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQ 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE3 KKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKM .: : . . .: . .:.:: . : :. : . .. .::. . NP_003 VQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAA----L 140 150 160 170 180 190 150 160 170 180 190 pF1KE3 RKTKKKGSGEADKDPSGSPASARKSPAAMFLVGE---GSPDKKALKKKGTPKGA---RKE . :....: .. :. :. . . :: :. . ....:: .. . : NP_003 AEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDE 200 210 220 230 240 250 200 210 220 230 240 pF1KE3 EEEEEEAATVIK-NSNQKGKAKGKGKKKAKEERAPSP--P-----VEVDEPREFVLRPAP :.:::.... . ::: . .. . :. . :::: : :::.. .::.::::: NP_003 EDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAP 260 270 280 290 300 310 250 260 270 280 290 300 pF1KE3 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTN :: :..::.:::::::::::::.:::::: : ::::::::::::.:::.:::::.:::. NP_003 QGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTD 320 330 340 350 360 370 310 320 330 340 350 360 pF1KE3 LSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFR :::::...::::::::.:..:::.::: :::.. :... : :::::::: ::::::::. NP_003 LSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFK 380 390 400 410 420 430 370 380 390 400 410 420 pF1KE3 GPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYT :::.:.::.:::. .::: ::::: . ::.:::::. ::.:::.:: ::::::. ::. NP_003 GPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYV 440 450 460 470 480 490 430 440 450 460 470 480 pF1KE3 LNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFD :::.:::::::::::::.:..::::::.::::::::.::.:: ::::::::::::::::: NP_003 LNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFD 500 510 520 530 540 550 pF1KE3 GKLACE .::::: NP_003 SKLACE 560 >>NP_003315 (OMIM: 604730) tubby-related protein 3 isofo (442 aa) initn: 1237 init1: 754 opt: 1228 Z-score: 697.3 bits: 138.3 E(85289): 4.2e-32 Smith-Waterman score: 1228; 56.6% identity (82.7% similar) in 318 aa overlap (180-489:125-442) 150 160 170 180 190 200 pF1KE3 GEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEE--EEAATVIK .. :.:. ... .:: . ..: . . NP_003 PDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLER 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 -NSNQKGKAKGKGKKKAKEERAPSPPV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMD :: .. .. : . . :. . ..:. ..:: ::::: :::::. :::.::: NP_003 PNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMD 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE3 RGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLL ::..:.:...:. : .:.::::.::::.::::::::::::..::: ::...:::::::. NP_003 RGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLM 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE3 GNRFTVFDNGQNPQRGYS-TNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENER :..:::.: : :..: . ...: ::::::. ::::::::.:::.:.::::::. .... NP_003 GTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQ 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE3 VPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIV .: .:.: :.:: ::::.:.:.:.::::: ::::.:. ::.:::.:::::::::::::: NP_003 IPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIV 340 350 360 370 380 390 450 460 470 480 pF1KE3 HADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE : .::::::.::::::.:.::::: :::::.:::.:.:::::.::::: NP_003 HKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDSKLACE 400 410 420 430 440 >>NP_001153880 (OMIM: 604730) tubby-related protein 3 is (501 aa) initn: 1202 init1: 719 opt: 1193 Z-score: 677.3 bits: 134.8 E(85289): 5.5e-31 Smith-Waterman score: 1193; 56.1% identity (82.4% similar) in 312 aa overlap (180-483:125-436) 150 160 170 180 190 200 pF1KE3 GEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEE--EEAATVIK .. :.:. ... .:: . ..: . . NP_001 PDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLER 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 -NSNQKGKAKGKGKKKAKEERAPSPPV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMD :: .. .. : . . :. . ..:. ..:: ::::: :::::. :::.::: NP_001 PNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMD 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE3 RGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLL ::..:.:...:. : .:.::::.::::.::::::::::::..::: ::...:::::::. NP_001 RGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLM 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE3 GNRFTVFDNGQNPQRGYS-TNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENER :..:::.: : :..: . ...: ::::::. ::::::::.:::.:.::::::. .... NP_001 GTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQ 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE3 VPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIV .: .:.: :.:: ::::.:.:.:.::::: ::::.:. ::.:::.:::::::::::::: NP_001 IPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIV 340 350 360 370 380 390 450 460 470 480 pF1KE3 HADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE : .::::::.::::::.:.::::: :::::.:::.:.::::: NP_001 HKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDKCIQTLRMQELCELHRQH 400 410 420 430 440 450 NP_001 HSAASLVHRTVCQRWVGHPWRLLPQTSLLWTDLSPPPVVPAPHQISM 460 470 480 490 500 >>NP_003314 (OMIM: 602309) tubby-related protein 2 [Homo (520 aa) initn: 977 init1: 524 opt: 1035 Z-score: 590.2 bits: 118.7 E(85289): 3.9e-26 Smith-Waterman score: 1035; 40.7% identity (68.3% similar) in 454 aa overlap (41-483:77-520) 20 30 40 50 60 pF1KE3 VWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAP-ESPCPTGSKPRKPGEEEEEE :::: .:: : .. . : . . : NP_003 QANPDASPWLWRSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGE 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE3 EDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPP--KPLR . . :: .. . : . : ..:.:.:.: .. :: .::: . : NP_003 RGLPTPRTEAVFRNLGLQSPFLSWLPDNSDAELEEVSVEN-------GSVSPPPFKQSPR 110 120 130 140 150 130 140 150 160 170 180 pF1KE3 VRNK--EAPAGEGTKMR-KTKKKGSGEADKDPSGSPASARKSPAAMF-LVGEGSPDKKAL .: : .: ::. . .. .. :.: :.:. .: . . .. :. . : . NP_003 IRRKGWQAHQRPGTRAEGESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKK 160 170 180 190 200 210 190 200 210 220 230 240 pF1KE3 KKKGTPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEE-RAPSPPVEVDEPREFV .. . :. . ..:: . ..:. . : . . ...:. :.: : .: : . .: NP_003 REASESTGTNSSAAHNEELSKALKG--EGGTDSDHMRHEASLAIRSPCPGLEEDM-EAYV 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE3 LRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKV--FLLAGRKRKRSKTANYLIS :::: : ..: :::::.:.:.:..: :.:.:.: .. ::::::::.::::.::::: NP_003 LRPALPGTMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLIS 280 290 300 310 320 330 310 320 330 340 350 pF1KE3 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYST-NVASLRQELAAVIYETNV .:::.::: :.::.::.:::.....::.:::: ::.: . : :.: .::::.:: :: :: NP_003 LDPTHLSRDGDNFVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNV 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE3 LGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDS ::. :::.::::.:: ...:.:. ..: : ...:: :.: ..:. :::: : :. .. NP_003 LGYLGPRKMTVILPGTNSQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKEN 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE3 GSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIAL : :::::.::::.::::::::: ...:::::::. :.::.:. .:. ::::.: : NP_003 GVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFSPLQAFSICL 460 470 480 490 500 510 480 pF1KE3 SSFDGKLACE :::. NP_003 SSFN 520 >>XP_011525557 (OMIM: 602309) PREDICTED: tubby-related p (487 aa) initn: 976 init1: 393 opt: 893 Z-score: 512.5 bits: 104.3 E(85289): 8.3e-22 Smith-Waterman score: 1010; 40.2% identity (67.1% similar) in 465 aa overlap (41-483:33-487) 20 30 40 50 60 pF1KE3 VWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAP-ESPCPTGSKPRKPGEEEEEE :::: .:: : .. . : . . : XP_011 QANPDASPWLWRSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 EDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPP--KPLR . . :: .. . : . : ..:.:.:.: .. :: .::: . : XP_011 RGLPTPRTEAVFRNLGLQSPFLSWLPDNSDAELEEVSVEN-------GSVSPPPFKQSPR 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 VRNK--EAPAGEGTKMR-KTKKKGSGEADKDPSGSPASARKSPAAMF-LVGEGSPDKKAL .: : .: ::. . .. .. :.: :.:. .: . . .. :. . : . XP_011 IRRKGWQAHQRPGTRAEGESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 KKKGTPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEE-RAPSPPVEVDEPREFV .. . :. . ..:: . ..:. . : . . ...:. :.: : .: : . .: XP_011 REASESTGTNSSAAHNEELSKALKG--EGGTDSDHMRHEASLAIRSPCPGLEEDM-EAYV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 LRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKV--FLLAGRKRKRSKTANYLIS :::: : ..: :::::.:.:.:..: :.:.:.: .. ::::::::.::::.::::: XP_011 LRPALPGTMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLIS 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYST-NVASLRQELAAVIYETNV .:::.::: :.::.::.:::.....::.:::: ::.: . : :.: .::::.:: :: :: XP_011 LDPTHLSRDGDNFVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 LGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDS ::. :::.::::.:: ...:.:. ..: : ...:: :.: ..:. :::: : :. .. XP_011 LGYLGPRKMTVILPGTNSQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKEN 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 GSYTLNFQGRVTQASVKNFQIV---H--------ADDPDYIVLQFGRVAEDAFTLDYRYP : :::::.::::.::::::::: : : ...:::::::. :.::.:. .: XP_011 GVYTLNFHGRVTRASVKNFQIVDPKHRELLETSLAGPEEHLVLQFGRVGPDTFTMDFCFP 420 430 440 450 460 470 470 480 pF1KE3 LCALQAFAIALSSFDGKLACE . ::::.: ::::. XP_011 FSPLQAFSICLSSFN 480 489 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:17:16 2016 done: Sun Nov 6 06:17:18 2016 Total Scan time: 12.320 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]