FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3691, 655 aa 1>>>pF1KE3691 655 - 655 aa - 655 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2959+/-0.000392; mu= 19.4236+/- 0.024 mean_var=71.7441+/-15.185, 0's: 0 Z-trim(110.7): 400 B-trim: 1820 in 3/53 Lambda= 0.151419 statistics sampled from 18606 (19062) to 18606 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.223), width: 16 Scan time: 7.620 The best scores are: opt bits E(85289) NP_277030 (OMIM: 300655) kelch-like protein 13 iso ( 655) 4429 977.5 0 XP_011529713 (OMIM: 300655) PREDICTED: kelch-like ( 655) 4429 977.5 0 NP_001161773 (OMIM: 300655) kelch-like protein 13 ( 639) 4200 927.5 0 XP_016885439 (OMIM: 300655) PREDICTED: kelch-like ( 639) 4200 927.5 0 NP_001161774 (OMIM: 300655) kelch-like protein 13 ( 639) 4200 927.5 0 NP_001161772 (OMIM: 300655) kelch-like protein 13 ( 649) 4200 927.5 0 NP_001161771 (OMIM: 300655) kelch-like protein 13 ( 658) 4200 927.5 0 XP_011529711 (OMIM: 300655) PREDICTED: kelch-like ( 661) 4200 927.5 0 XP_011529712 (OMIM: 300655) PREDICTED: kelch-like ( 661) 4200 927.5 0 NP_001161775 (OMIM: 300655) kelch-like protein 13 ( 613) 4142 914.8 0 NP_061335 (OMIM: 611201) kelch-like protein 9 [Hom ( 617) 3911 864.3 0 NP_001003760 (OMIM: 610749) kelch-like protein 31 ( 634) 1314 297.0 1.4e-79 XP_005249164 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1314 297.0 1.4e-79 XP_016866347 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1314 297.0 1.4e-79 NP_065856 (OMIM: 613772) kelch-like protein 14 [Ho ( 628) 1188 269.5 2.7e-71 XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1047 238.7 6.1e-62 XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1047 238.7 6.1e-62 XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1047 238.7 6.1e-62 NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 1040 237.2 1.6e-61 NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 1040 237.2 1.7e-61 XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1040 237.2 1.7e-61 XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 1040 237.2 1.7e-61 XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1039 237.0 2e-61 XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1039 237.0 2e-61 XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1039 237.0 2e-61 NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 1034 235.8 3.3e-61 NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 977 223.4 2.2e-57 NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 944 216.2 3.3e-55 NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 944 216.2 3.3e-55 NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 941 215.6 5.4e-55 XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 922 211.3 7.7e-54 NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 918 210.5 1.5e-53 NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 918 210.5 1.5e-53 XP_016863163 (OMIM: 605774) PREDICTED: kelch-like ( 555) 914 209.6 2.5e-53 XP_011529874 (OMIM: 605774) PREDICTED: kelch-like ( 633) 913 209.4 3.3e-53 NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 909 208.5 5.6e-53 NP_085127 (OMIM: 300980,300982) kelch-like protein ( 604) 907 208.1 7.8e-53 XP_006724581 (OMIM: 300980,300982) PREDICTED: kelc ( 604) 907 208.1 7.8e-53 NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 901 206.7 1.8e-52 NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 888 204.0 1.5e-51 NP_001289980 (OMIM: 614522) kelch-like protein 12 ( 606) 886 203.5 1.9e-51 XP_011508137 (OMIM: 614522) PREDICTED: kelch-like ( 623) 886 203.5 1.9e-51 NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 882 202.6 3.3e-51 XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 870 199.9 1.9e-50 NP_689680 (OMIM: 608778,615081) kelch-like protein ( 608) 868 199.6 2.9e-50 NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 868 199.6 2.9e-50 XP_011508139 (OMIM: 614522) PREDICTED: kelch-like ( 522) 796 183.8 1.4e-45 NP_001290038 (OMIM: 614522) kelch-like protein 12 ( 467) 792 182.9 2.3e-45 NP_569713 (OMIM: 614214) kelch-like protein 6 [Hom ( 621) 789 182.3 4.6e-45 XP_011508138 (OMIM: 614522) PREDICTED: kelch-like ( 526) 734 170.2 1.7e-41 >>NP_277030 (OMIM: 300655) kelch-like protein 13 isoform (655 aa) initn: 4429 init1: 4429 opt: 4429 Z-score: 5227.1 bits: 977.5 E(85289): 0 Smith-Waterman score: 4429; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655) 10 20 30 40 50 60 pF1KE3 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 650 >>XP_011529713 (OMIM: 300655) PREDICTED: kelch-like prot (655 aa) initn: 4429 init1: 4429 opt: 4429 Z-score: 5227.1 bits: 977.5 E(85289): 0 Smith-Waterman score: 4429; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655) 10 20 30 40 50 60 pF1KE3 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 650 >>NP_001161773 (OMIM: 300655) kelch-like protein 13 isof (639 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.9 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:18-639) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 530 540 550 560 570 580 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 590 600 610 620 630 >>XP_016885439 (OMIM: 300655) PREDICTED: kelch-like prot (639 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.9 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:18-639) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: XP_016 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 530 540 550 560 570 580 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 590 600 610 620 630 >>NP_001161774 (OMIM: 300655) kelch-like protein 13 isof (639 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.9 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:18-639) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 530 540 550 560 570 580 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 590 600 610 620 630 >>NP_001161772 (OMIM: 300655) kelch-like protein 13 isof (649 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.8 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:28-649) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: NP_001 MLRFISHLYCCSSKEDCSEDDKCILSRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 540 550 560 570 580 590 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 600 610 620 630 640 >>NP_001161771 (OMIM: 300655) kelch-like protein 13 isof (658 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.7 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:37-658) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: NP_001 LREKWAYWRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 650 >>XP_011529711 (OMIM: 300655) PREDICTED: kelch-like prot (661 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.7 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:40-661) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: XP_011 VAAILRNRRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 650 660 >>XP_011529712 (OMIM: 300655) PREDICTED: kelch-like prot (661 aa) initn: 4200 init1: 4200 opt: 4200 Z-score: 4956.7 bits: 927.5 E(85289): 0 Smith-Waterman score: 4200; 100.0% identity (100.0% similar) in 622 aa overlap (34-655:40-661) 10 20 30 40 50 60 pF1KE3 KWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKA :::::::::::::::::::::::::::::: XP_011 VAAILRNRRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 650 660 >>NP_001161775 (OMIM: 300655) kelch-like protein 13 isof (613 aa) initn: 4142 init1: 4142 opt: 4142 Z-score: 4888.7 bits: 914.8 E(85289): 0 Smith-Waterman score: 4142; 100.0% identity (100.0% similar) in 613 aa overlap (43-655:1-613) 20 30 40 50 60 70 pF1KE3 WKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN :::::::::::::::::::::::::::::: NP_001 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSN 10 20 30 80 90 100 110 120 130 pF1KE3 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE3 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE3 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE3 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE3 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE3 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD 520 530 540 550 560 570 620 630 640 650 pF1KE3 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP ::::::::::::::::::::::::::::::::::::::::::: NP_001 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 580 590 600 610 655 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:18:34 2016 done: Sun Nov 6 06:18:35 2016 Total Scan time: 7.620 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]