Result of FASTA (omim) for
pFN21AE0477
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0477, 305 aa
1>>>pF1KE0477 305 - 305 aa - 305 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4033+/-0.000377; mu= 14.8386+/- 0.023
mean_var=62.1491+/-12.961, 0's: 0 Z-trim(112.7): 16 B-trim: 0 in 0/50
Lambda= 0.162688
statistics sampled from 21655 (21661) to 21655 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.254), width: 16
Scan time: 6.980
The best scores are: opt bits E(85289)
NP_008834 (OMIM: 609988) inorganic pyrophosphatase ( 305) 2074 495.4 6e-140
NP_789845 (OMIM: 609988) inorganic pyrophosphatase ( 334) 1084 263.0 5.8e-70
NP_789842 (OMIM: 609988) inorganic pyrophosphatase ( 232) 1077 261.3 1.3e-69
NP_789843 (OMIM: 609988) inorganic pyrophosphatase ( 168) 801 196.5 3.1e-50
NP_066952 (OMIM: 179030) inorganic pyrophosphatase ( 289) 642 159.3 8.6e-39
>>NP_008834 (OMIM: 609988) inorganic pyrophosphatase 2, (305 aa)
initn: 2074 init1: 2074 opt: 2074 Z-score: 2633.5 bits: 495.4 E(85289): 6e-140
Smith-Waterman score: 2074; 100.0% identity (100.0% similar) in 305 aa overlap (1-305:1-305)
10 20 30 40 50 60
pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
250 260 270 280 290 300
pF1KE0 HFLGK
:::::
NP_008 HFLGK
>>NP_789845 (OMIM: 609988) inorganic pyrophosphatase 2, (334 aa)
initn: 1077 init1: 1077 opt: 1084 Z-score: 1377.1 bits: 263.0 E(85289): 5.8e-70
Smith-Waterman score: 2006; 91.3% identity (91.3% similar) in 334 aa overlap (1-305:1-334)
10 20 30 40 50 60
pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
70 80 90 100 110 120
130 140 150
pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQ-----------------------------ILSC
::::::::::::::::::::::::::: ::::
NP_789 VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
250 260 270 280 290 300
280 290 300
pF1KE0 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
::::::::::::::::::::::::::::::::::
NP_789 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
310 320 330
>>NP_789842 (OMIM: 609988) inorganic pyrophosphatase 2, (232 aa)
initn: 1077 init1: 1077 opt: 1077 Z-score: 1370.7 bits: 261.3 E(85289): 1.3e-69
Smith-Waterman score: 1413; 76.1% identity (76.1% similar) in 305 aa overlap (1-305:1-232)
10 20 30 40 50 60
pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
::::::::::::::
NP_789 SPFHDIPLKVNSKE----------------------------------------------
70
130 140 150 160 170 180
pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA
:::::::::::::::::::::::::::::::::
NP_789 ---------------------------ILSCGEVIHVKILGILALIDEGETDWKLIAINA
80 90 100
190 200 210 220 230 240
pF1KE0 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE0 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
170 180 190 200 210 220
pF1KE0 HFLGK
:::::
NP_789 HFLGK
230
>>NP_789843 (OMIM: 609988) inorganic pyrophosphatase 2, (168 aa)
initn: 801 init1: 801 opt: 801 Z-score: 1022.8 bits: 196.5 E(85289): 3.1e-50
Smith-Waterman score: 854; 54.8% identity (55.1% similar) in 305 aa overlap (1-305:1-168)
10 20 30 40 50 60
pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFF--------
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
NP_789 ------------------------------------------------------------
130 140 150 160 170 180
pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA
NP_789 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE0 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 ---------NIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
60 70 80 90 100
250 260 270 280 290 300
pF1KE0 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
110 120 130 140 150 160
pF1KE0 HFLGK
:::::
NP_789 HFLGK
>>NP_066952 (OMIM: 179030) inorganic pyrophosphatase [Ho (289 aa)
initn: 1105 init1: 640 opt: 642 Z-score: 817.4 bits: 159.3 E(85289): 8.6e-39
Smith-Waterman score: 1031; 54.3% identity (74.2% similar) in 291 aa overlap (32-293:1-272)
10 20 30 40 50 60
pF1KE0 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS
:. . ::::. : : .::.:.:: :.:::
NP_066 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS
10 20 30
70 80 90 100 110 120
pF1KE0 PFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYV
::::::. .. ...:.:.::.:::.:::::::::.:.::::: :
NP_066 PFHDIPIYAD-----------------KDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDV
40 50 60 70
130 140 150
pF1KE0 KDGKLRYVANIFPYKGYIWNYGTLPQ--------------------ILSC---------G
: ::::::::.:::::::::::..:: : : :
NP_066 KKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARG
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE0 EVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLY
:.: ::.:::::.:::::::::.::::..::.:....::.:::..::::::::..::: :
NP_066 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE0 KVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFR
:::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:::.
NP_066 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFK
200 210 220 230 240 250
280 290 300
pF1KE0 CTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
: . ::..:... : ::
NP_066 CDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN
260 270 280
305 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 05:27:57 2016 done: Thu Nov 3 05:27:58 2016
Total Scan time: 6.980 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]