FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5903, 501 aa 1>>>pF1KB5903 501 - 501 aa - 501 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7574+/-0.000376; mu= 15.9577+/- 0.024 mean_var=74.9803+/-15.062, 0's: 0 Z-trim(113.4): 70 B-trim: 1251 in 1/49 Lambda= 0.148116 statistics sampled from 22654 (22724) to 22654 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.266), width: 16 Scan time: 9.220 The best scores are: opt bits E(85289) NP_002230 (OMIM: 601534) G protein-activated inwar ( 501) 3326 720.3 3.1e-207 NP_001247438 (OMIM: 601534) G protein-activated in ( 308) 2058 449.3 7.4e-126 NP_001247439 (OMIM: 601534) G protein-activated in ( 253) 1590 349.2 8e-96 NP_001247437 (OMIM: 601534) G protein-activated in ( 235) 1586 348.4 1.4e-95 XP_011541111 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1501 330.3 6.5e-90 NP_000881 (OMIM: 600734,613485,613677) G protein-a ( 419) 1501 330.3 6.5e-90 XP_011541112 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1501 330.3 6.5e-90 NP_002231 (OMIM: 600877,614098) G protein-activate ( 423) 1501 330.3 6.6e-90 NP_004974 (OMIM: 600932) G protein-activated inwar ( 393) 1478 325.4 1.9e-88 XP_016856736 (OMIM: 600932) PREDICTED: G protein-a ( 450) 1478 325.4 2.1e-88 NP_000882 (OMIM: 170390,600681,609622,613980) inwa ( 427) 1266 280.1 8.7e-75 XP_005256682 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1235 273.5 8.7e-73 NP_066292 (OMIM: 602323) ATP-sensitive inward rect ( 433) 1235 273.5 8.7e-73 XP_011522133 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1235 273.5 8.7e-73 NP_001181887 (OMIM: 613236,613239) inward rectifie ( 433) 1217 269.6 1.2e-71 XP_005276976 (OMIM: 613236,613239) PREDICTED: inwa ( 535) 1217 269.7 1.5e-71 NP_037480 (OMIM: 603953) ATP-sensitive inward rect ( 436) 1152 255.8 1.9e-67 NP_000516 (OMIM: 125853,600937,601820,606176,61058 ( 390) 1134 251.9 2.5e-66 XP_016874773 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1114 247.6 5.2e-65 NP_004973 (OMIM: 600935) ATP-sensitive inward rect ( 424) 1114 247.6 5.2e-65 XP_005253415 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1114 247.6 5.2e-65 XP_016874772 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1114 247.6 5.2e-65 NP_722451 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1048 233.5 8.1e-61 NP_722450 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1048 233.5 8.1e-61 NP_722448 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1048 233.5 8.1e-61 NP_722449 (OMIM: 241200,600359) ATP-sensitive inwa ( 389) 1048 233.5 8.5e-61 NP_000211 (OMIM: 241200,600359) ATP-sensitive inwa ( 391) 1048 233.5 8.5e-61 NP_690607 (OMIM: 600504) inward rectifier potassiu ( 445) 951 212.8 1.6e-54 NP_004972 (OMIM: 600504) inward rectifier potassiu ( 445) 951 212.8 1.6e-54 XP_006718289 (OMIM: 125853,600937,601820,606176,61 ( 303) 919 205.9 1.4e-52 NP_001159762 (OMIM: 125853,600937,601820,606176,61 ( 303) 919 205.9 1.4e-52 XP_016873169 (OMIM: 125853,600937,601820,606176,61 ( 303) 919 205.9 1.4e-52 NP_002232 (OMIM: 274600,600791,602208,612780) ATP- ( 379) 914 204.9 3.4e-52 XP_016880102 (OMIM: 605722) PREDICTED: inward rect ( 418) 912 204.5 5e-52 NP_001257351 (OMIM: 605722) inward rectifier potas ( 418) 912 204.5 5e-52 XP_011523083 (OMIM: 605722) PREDICTED: inward rect ( 418) 912 204.5 5e-52 NP_001278554 (OMIM: 605722) inward rectifier potas ( 418) 912 204.5 5e-52 NP_001278553 (OMIM: 605722) inward rectifier potas ( 418) 912 204.5 5e-52 XP_006721950 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 NP_001278552 (OMIM: 605722) inward rectifier potas ( 453) 912 204.5 5.4e-52 XP_016880099 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 NP_061128 (OMIM: 605722) inward rectifier potassiu ( 453) 912 204.5 5.4e-52 XP_006721949 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 XP_005257394 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 XP_006721948 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 NP_733937 (OMIM: 605722) inward rectifier potassiu ( 453) 912 204.5 5.4e-52 XP_016880101 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 NP_733938 (OMIM: 605722) inward rectifier potassiu ( 453) 912 204.5 5.4e-52 XP_016880098 (OMIM: 605722) PREDICTED: inward rect ( 453) 912 204.5 5.4e-52 NP_001278551 (OMIM: 605722) inward rectifier potas ( 453) 912 204.5 5.4e-52 >>NP_002230 (OMIM: 601534) G protein-activated inward re (501 aa) initn: 3326 init1: 3326 opt: 3326 Z-score: 3841.6 bits: 720.3 E(85289): 3.1e-207 Smith-Waterman score: 3326; 100.0% identity (100.0% similar) in 501 aa overlap (1-501:1-501) 10 20 30 40 50 60 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG 430 440 450 460 470 480 490 500 pF1KB5 AARMEGNLPAKLRKMNSDRFT ::::::::::::::::::::: NP_002 AARMEGNLPAKLRKMNSDRFT 490 500 >>NP_001247438 (OMIM: 601534) G protein-activated inward (308 aa) initn: 2058 init1: 2058 opt: 2058 Z-score: 2380.5 bits: 449.3 E(85289): 7.4e-126 Smith-Waterman score: 2058; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307) 10 20 30 40 50 60 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE ::::::: NP_001 GIVETTGE >>NP_001247439 (OMIM: 601534) G protein-activated inward (253 aa) initn: 1586 init1: 1586 opt: 1590 Z-score: 1841.3 bits: 349.2 E(85289): 8e-96 Smith-Waterman score: 1590; 97.1% identity (97.1% similar) in 244 aa overlap (1-241:1-244) 10 20 30 40 50 60 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLK---SRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKVSAPRP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 TPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVV : : NP_001 FPTGRPASPKPAE 250 >>NP_001247437 (OMIM: 601534) G protein-activated inward (235 aa) initn: 1586 init1: 1586 opt: 1586 Z-score: 1837.2 bits: 348.4 E(85289): 1.4e-95 Smith-Waterman score: 1586; 100.0% identity (100.0% similar) in 234 aa overlap (1-234:1-234) 10 20 30 40 50 60 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKG 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE >>XP_011541111 (OMIM: 600734,613485,613677) PREDICTED: G (419 aa) initn: 1399 init1: 1399 opt: 1501 Z-score: 1735.2 bits: 330.3 E(85289): 6.5e-90 Smith-Waterman score: 1508; 62.8% identity (83.0% similar) in 358 aa overlap (23-364:16-370) 10 20 30 40 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQ--QLVP------------KKKRQRF :. : : . :.: . :: :: :::. XP_011 MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRY 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 VDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIA ..:.:.:::.:::. .:: ::::::::::::::::.::..: ..:::.:::.. .::.:: XP_011 MEKSGKCNVHHGNV-QETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 YTRGDLNKAHVGN--YTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLF : ::::. :::. . ::: :. .: ::::: ::::.:::::.: ::.::::::::.: XP_011 YIRGDLD--HVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 QSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMV :.::::::.::..::::.:.:::::::::::::..::::::: :: ::::::.:::::.: XP_011 QAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 SAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLS :.:: ::.::::: ::::.::.: ...:::.:: :.::::::: : : :. ::::...: XP_011 EASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 QRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQ : ... :.::.::::::.::.::::::::.:: . :::::::: ::..::.::..:::. XP_011 QAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 FHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQ :: :.:. :: .:: :: XP_011 FHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLG 360 370 380 390 400 410 >>NP_000881 (OMIM: 600734,613485,613677) G protein-activ (419 aa) initn: 1399 init1: 1399 opt: 1501 Z-score: 1735.2 bits: 330.3 E(85289): 6.5e-90 Smith-Waterman score: 1508; 62.8% identity (83.0% similar) in 358 aa overlap (23-364:16-370) 10 20 30 40 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQ--QLVP------------KKKRQRF :. : : . :.: . :: :: :::. NP_000 MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRY 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 VDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIA ..:.:.:::.:::. .:: ::::::::::::::::.::..: ..:::.:::.. .::.:: NP_000 MEKSGKCNVHHGNV-QETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 YTRGDLNKAHVGN--YTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLF : ::::. :::. . ::: :. .: ::::: ::::.:::::.: ::.::::::::.: NP_000 YIRGDLD--HVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 QSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMV :.::::::.::..::::.:.:::::::::::::..::::::: :: ::::::.:::::.: NP_000 QAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 SAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLS :.:: ::.::::: ::::.::.: ...:::.:: :.::::::: : : :. ::::...: NP_000 EASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 QRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQ : ... :.::.::::::.::.::::::::.:: . :::::::: ::..::.::..:::. NP_000 QAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 FHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQ :: :.:. :: .:: :: NP_000 FHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLG 360 370 380 390 400 410 >>XP_011541112 (OMIM: 600734,613485,613677) PREDICTED: G (419 aa) initn: 1399 init1: 1399 opt: 1501 Z-score: 1735.2 bits: 330.3 E(85289): 6.5e-90 Smith-Waterman score: 1508; 62.8% identity (83.0% similar) in 358 aa overlap (23-364:16-370) 10 20 30 40 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQ--QLVP------------KKKRQRF :. : : . :.: . :: :: :::. XP_011 MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRY 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 VDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIA ..:.:.:::.:::. .:: ::::::::::::::::.::..: ..:::.:::.. .::.:: XP_011 MEKSGKCNVHHGNV-QETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 YTRGDLNKAHVGN--YTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLF : ::::. :::. . ::: :. .: ::::: ::::.:::::.: ::.::::::::.: XP_011 YIRGDLD--HVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 QSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMV :.::::::.::..::::.:.:::::::::::::..::::::: :: ::::::.:::::.: XP_011 QAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 SAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLS :.:: ::.::::: ::::.::.: ...:::.:: :.::::::: : : :. ::::...: XP_011 EASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 QRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQ : ... :.::.::::::.::.::::::::.:: . :::::::: ::..::.::..:::. XP_011 QAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNT 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 FHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQ :: :.:. :: .:: :: XP_011 FHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLG 360 370 380 390 400 410 >>NP_002231 (OMIM: 600877,614098) G protein-activated in (423 aa) initn: 1505 init1: 1403 opt: 1501 Z-score: 1735.1 bits: 330.3 E(85289): 6.6e-90 Smith-Waterman score: 1501; 59.1% identity (83.5% similar) in 369 aa overlap (25-387:29-396) 10 20 30 40 50 pF1KB5 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQ--DPQQQLVP----KKKRQRFVDKN ::. : : : . . :.: ::.: :. NP_002 MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 GRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRG :.:::.:::. :: :::.:.::::::::::.::.::...:::.:::.. .::.::: :: NP_002 GKCNVHHGNV-RETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRG 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 DLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGS :... . ..::::.:. .: ::::: ::::.::::::: :::::::::::.:.::.::: NP_002 DMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 IVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRC ::.::..::::.:.::::::::::.:: ::::::::::: ::::::.:::::.: :.:: NP_002 IVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 KLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQT ::.::.:: ::::.::.: ...::. :: :.::::::: : : :. .:::...:. .. NP_002 KLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPK 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 EQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFE :..::::::::.::.::::::::.:: .:.:::.:: ::..::.::..:::..:: :.: NP_002 EELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 VPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGRE . :: :.:: :. . .. ..... ..: .: NP_002 TSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLEN 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 DFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADL NP_002 ESKV 420 >>NP_004974 (OMIM: 600932) G protein-activated inward re (393 aa) initn: 1509 init1: 1369 opt: 1478 Z-score: 1709.0 bits: 325.4 E(85289): 1.9e-88 Smith-Waterman score: 1478; 63.3% identity (87.7% similar) in 332 aa overlap (33-363:10-340) 10 20 30 40 50 60 pF1KB5 ALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKK-RQRFVDKNGRCNVQHGNLG : :. :... :::.:.:.::::::.::. NP_004 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNV- 10 20 30 70 80 90 100 110 120 pF1KB5 SETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYT :: :::.:::::::::.:: .:..:.:.:...:::....::.::: ::::.. . .: NP_004 RETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 PCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMF ::: :. .: .:::: ::::.:::::.: :::.:::::.:.:.:.::::.:.::..:::: NP_004 PCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 IKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEG .:.:::.::: ::.:: :::.:.:::.: ::::::.::.::.: :.:: ::..:::: :: NP_004 VKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB5 EFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEG ::.:: : .:.:::.:: :.:::::::.: : ::: :::.. :.:... ..::::::::: NP_004 EFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB5 IVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQ .::.::::::::.:: ::::::::: :..::.::..:::..:: ::::::: :..: NP_004 MVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSAREL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB5 EEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSS : NP_004 AEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGGEAGADKEQNGCLPPPESESKV 340 350 360 370 380 390 >>XP_016856736 (OMIM: 600932) PREDICTED: G protein-activ (450 aa) initn: 1516 init1: 1369 opt: 1478 Z-score: 1708.1 bits: 325.4 E(85289): 2.1e-88 Smith-Waterman score: 1483; 58.8% identity (82.9% similar) in 374 aa overlap (5-363:25-397) 10 20 30 pF1KB5 MSALRRKFGDDYQVVTTSSSGS----GLQPQGP-----GQ ::..: . ... :::: : . : .: XP_016 MPRASPSPEGPLIRQTFIKPLQDPRRRLGAQRRAAGGSSSGPRRTPGARSARPDAAAMAQ 10 20 30 40 50 60 40 50 60 70 80 pF1KB5 D-----PQQQLVPKKK-RQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLF . : :. :... :::.:.:.::::::.::. :: :::.:::::::::.:: .:. XP_016 ENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNV-RETYRYLTDLFTTLVDLQWRLSLL 70 80 90 100 110 90 100 110 120 130 140 pF1KB5 IFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIG .:.:.:...:::....::.::: ::::.. . .:::: :. .: .:::: ::::.::: XP_016 FFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIG 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB5 YGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMR ::.: :::.:::::.:.:.:.::::.:.::..::::.:.:::.::: ::.:: :::.:.: XP_016 YGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLR 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB5 DGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLV ::.: ::::::.::.::.: :.:: ::..:::: ::::.:: : .:.:::.:: :.:::: XP_016 DGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLV 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB5 SPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGH :::.: : ::: :::.. :.:... ..:::::::::.::.::::::::.:: ::::::: XP_016 SPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGH 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB5 RFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNS :: :..::.::..:::..:: ::::::: :..: : XP_016 RFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEKVE 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB5 VECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPG XP_016 EEGAGEGAGGEAGADKEQNGCLPPPESESKV 420 430 440 450 501 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:36:55 2016 done: Sun Nov 6 20:36:57 2016 Total Scan time: 9.220 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]