FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2108, 845 aa 1>>>pF1KE2108 845 - 845 aa - 845 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9712+/-0.000683; mu= 7.6631+/- 0.041 mean_var=267.1649+/-55.510, 0's: 0 Z-trim(112.3): 401 B-trim: 135 in 2/51 Lambda= 0.078467 statistics sampled from 20613 (21132) to 20613 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.248), width: 16 Scan time: 11.670 The best scores are: opt bits E(85289) NP_001018066 (OMIM: 192977,224050) very low-densit ( 845) 6114 707.5 6.5e-203 NP_003374 (OMIM: 192977,224050) very low-density l ( 873) 5506 638.7 3.5e-182 NP_001309155 (OMIM: 192977,224050) very low-densit ( 804) 5259 610.7 8.7e-174 NP_001309154 (OMIM: 192977,224050) very low-densit ( 832) 4651 541.8 4.6e-153 XP_011526312 (OMIM: 143890,606945) PREDICTED: low- ( 834) 2938 347.9 1.1e-94 NP_001182727 (OMIM: 143890,606945) low-density lip ( 858) 2938 347.9 1.1e-94 NP_000518 (OMIM: 143890,606945) low-density lipopr ( 860) 2938 347.9 1.1e-94 NP_001182728 (OMIM: 143890,606945) low-density lip ( 819) 2702 321.2 1.2e-86 NP_059992 (OMIM: 602600,608446) low-density lipopr ( 700) 2415 288.6 6.6e-77 XP_005271232 (OMIM: 602600,608446) PREDICTED: low- ( 834) 2187 262.9 4.3e-69 NP_001182732 (OMIM: 143890,606945) low-density lip ( 682) 2108 253.9 1.9e-66 NP_001182729 (OMIM: 143890,606945) low-density lip ( 692) 2086 251.4 1.1e-65 NP_001018064 (OMIM: 602600,608446) low-density lip ( 904) 2055 248.0 1.4e-64 NP_004622 (OMIM: 602600,608446) low-density lipopr ( 963) 2055 248.0 1.5e-64 XP_016857755 (OMIM: 602600,608446) PREDICTED: low- ( 842) 2041 246.4 4.1e-64 NP_150643 (OMIM: 602600,608446) low-density lipopr ( 793) 2038 246.0 5e-64 XP_006710945 (OMIM: 602600,608446) PREDICTED: low- ( 901) 2028 245.0 1.2e-63 XP_011540398 (OMIM: 602600,608446) PREDICTED: low- ( 762) 1813 220.5 2.3e-56 XP_006710944 (OMIM: 602600,608446) PREDICTED: low- ( 917) 1813 220.6 2.5e-56 XP_005271230 (OMIM: 602600,608446) PREDICTED: low- ( 976) 1813 220.7 2.6e-56 XP_005271231 (OMIM: 602600,608446) PREDICTED: low- ( 847) 1782 217.1 2.8e-55 XP_011540397 (OMIM: 602600,608446) PREDICTED: low- ( 804) 1750 213.4 3.3e-54 XP_016857754 (OMIM: 602600,608446) PREDICTED: low- ( 921) 1711 209.1 7.6e-53 XP_011540396 (OMIM: 602600,608446) PREDICTED: low- ( 934) 1543 190.1 4.1e-47 XP_016857756 (OMIM: 602600,608446) PREDICTED: low- ( 557) 1289 161.0 1.3e-38 XP_016857757 (OMIM: 602600,608446) PREDICTED: low- ( 557) 1289 161.0 1.3e-38 XP_011509485 (OMIM: 222448,600073) PREDICTED: low- (4612) 1304 163.9 1.5e-38 XP_016859831 (OMIM: 608766) PREDICTED: low-density (2883) 994 128.5 4.2e-28 XP_016859830 (OMIM: 608766) PREDICTED: low-density (4469) 994 128.8 5.6e-28 NP_061027 (OMIM: 608766) low-density lipoprotein r (4599) 994 128.8 5.7e-28 XP_011509486 (OMIM: 222448,600073) PREDICTED: low- (3892) 949 123.6 1.7e-26 NP_004516 (OMIM: 222448,600073) low-density lipopr (4655) 949 123.7 1.9e-26 XP_011543333 (OMIM: 133780,144750,166710,259770,60 (1600) 850 111.9 2.4e-23 XP_011543332 (OMIM: 133780,144750,166710,259770,60 (1624) 850 111.9 2.4e-23 XP_011543331 (OMIM: 133780,144750,166710,259770,60 (1662) 850 111.9 2.4e-23 NP_002326 (OMIM: 133780,144750,166710,259770,60181 (1615) 847 111.6 3e-23 XP_005274051 (OMIM: 133780,144750,166710,259770,60 (1653) 847 111.6 3.1e-23 XP_006719141 (OMIM: 603507,610947,616724) PREDICTE (1613) 819 108.4 2.7e-22 NP_002327 (OMIM: 603507,610947,616724) low-density (1613) 819 108.4 2.7e-22 XP_016863342 (OMIM: 131530,611718) PREDICTED: pro- ( 934) 787 104.5 2.4e-21 XP_016863340 (OMIM: 131530,611718) PREDICTED: pro- (1060) 787 104.6 2.6e-21 XP_016863339 (OMIM: 131530,611718) PREDICTED: pro- (1141) 787 104.6 2.7e-21 XP_016863338 (OMIM: 131530,611718) PREDICTED: pro- (1142) 787 104.6 2.7e-21 NP_001171601 (OMIM: 131530,611718) pro-epidermal g (1166) 787 104.6 2.7e-21 XP_011530009 (OMIM: 131530,611718) PREDICTED: pro- (1178) 787 104.6 2.7e-21 XP_016863336 (OMIM: 131530,611718) PREDICTED: pro- (1182) 787 104.6 2.7e-21 NP_001954 (OMIM: 131530,611718) pro-epidermal grow (1207) 787 104.6 2.8e-21 XP_005262853 (OMIM: 131530,611718) PREDICTED: pro- (1215) 787 104.6 2.8e-21 XP_016863335 (OMIM: 131530,611718) PREDICTED: pro- (1215) 787 104.6 2.8e-21 XP_016863334 (OMIM: 131530,611718) PREDICTED: pro- (1223) 787 104.6 2.8e-21 >>NP_001018066 (OMIM: 192977,224050) very low-density li (845 aa) initn: 6114 init1: 6114 opt: 6114 Z-score: 3763.9 bits: 707.5 E(85289): 6.5e-203 Smith-Waterman score: 6114; 100.0% identity (100.0% similar) in 845 aa overlap (1-845:1-845) 10 20 30 40 50 60 pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST 790 800 810 820 830 840 pF1KE2 DDDLA ::::: NP_001 DDDLA >>NP_003374 (OMIM: 192977,224050) very low-density lipop (873 aa) initn: 5503 init1: 5503 opt: 5506 Z-score: 3391.7 bits: 638.7 E(85289): 3.5e-182 Smith-Waterman score: 6040; 96.7% identity (96.7% similar) in 873 aa overlap (1-845:1-873) 10 20 30 40 50 60 pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 670 680 690 700 710 720 730 740 750 pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQR----------------------------I :::::::::::::::::::::::::::::: : NP_003 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE2 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 790 800 810 820 830 840 820 830 840 pF1KE2 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA ::::::::::::::::::::::::::::::::: NP_003 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 850 860 870 >>NP_001309155 (OMIM: 192977,224050) very low-density li (804 aa) initn: 4979 init1: 4979 opt: 5259 Z-score: 3241.0 bits: 610.7 E(85289): 8.7e-174 Smith-Waterman score: 5691; 95.0% identity (95.1% similar) in 845 aa overlap (1-845:1-804) 10 20 30 40 50 60 pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC ::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCR----------- 70 80 90 100 130 140 150 160 170 180 pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS :::::::::::::::::::::::::::::: NP_001 ------------------------------NITCSPDEFTCSSGRCISRNFVCNGQDDCS 110 120 130 190 200 210 220 230 240 pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 440 450 460 470 480 490 550 560 570 580 590 600 pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 560 570 580 590 600 610 670 680 690 700 710 720 pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 620 630 640 650 660 670 730 740 750 760 770 780 pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL 680 690 700 710 720 730 790 800 810 820 830 840 pF1KE2 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST 740 750 760 770 780 790 pF1KE2 DDDLA ::::: NP_001 DDDLA 800 >>NP_001309154 (OMIM: 192977,224050) very low-density li (832 aa) initn: 4368 init1: 4368 opt: 4651 Z-score: 2868.9 bits: 541.8 E(85289): 4.6e-153 Smith-Waterman score: 5617; 91.9% identity (92.0% similar) in 873 aa overlap (1-845:1-832) 10 20 30 40 50 60 pF1KE2 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC ::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCR----------- 70 80 90 100 130 140 150 160 170 180 pF1KE2 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS :::::::::::::::::::::::::::::: NP_001 ------------------------------NITCSPDEFTCSSGRCISRNFVCNGQDDCS 110 120 130 190 200 210 220 230 240 pF1KE2 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE2 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE2 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE2 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE2 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE2 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 440 450 460 470 480 490 550 560 570 580 590 600 pF1KE2 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE2 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 560 570 580 590 600 610 670 680 690 700 710 720 pF1KE2 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 620 630 640 650 660 670 730 740 750 pF1KE2 PAPQINDHSPKYTCSCPSGYNVEENGRDCQR----------------------------I :::::::::::::::::::::::::::::: : NP_001 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI 680 690 700 710 720 730 760 770 780 790 800 810 pF1KE2 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 740 750 760 770 780 790 820 830 840 pF1KE2 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA ::::::::::::::::::::::::::::::::: NP_001 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 800 810 820 830 >>XP_011526312 (OMIM: 143890,606945) PREDICTED: low-dens (834 aa) initn: 2755 init1: 1284 opt: 2938 Z-score: 1820.9 bits: 347.9 E(85289): 1.1e-94 Smith-Waterman score: 3086; 51.0% identity (75.1% similar) in 816 aa overlap (68-845:23-834) 40 50 60 70 80 90 pF1KE2 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC : : ...: :..:.:. .: :::. .: XP_011 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC 10 20 30 40 50 100 110 120 130 140 150 pF1KE2 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD .:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: : XP_011 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE2 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD :: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: : XP_011 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE2 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP : : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: :: XP_011 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA 180 190 200 210 220 230 280 290 300 310 320 330 pF1KE2 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI :::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: . XP_011 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE2 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC .::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. : XP_011 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC 300 310 320 330 340 350 400 410 420 430 440 450 pF1KE2 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI ::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::. XP_011 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM 360 370 380 390 400 410 460 470 480 490 500 510 pF1KE2 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK--VGRHVKMID-N :.:.:: .:. .:::.::::...:.....:.::::. : :...: :. . .:. . XP_011 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRD 420 430 440 450 460 470 520 530 540 550 560 570 pF1KE2 VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVY . : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. ::.: XP_011 IQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMY 480 490 500 510 520 530 580 590 600 610 620 630 pF1KE2 WSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNG :.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:.:: XP_011 WTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNG 540 550 560 570 580 590 640 650 660 670 680 690 pF1KE2 QDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . .:. XP_011 GNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM 600 610 620 630 640 650 700 710 720 730 740 750 pF1KE2 IVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ ...:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :.: XP_011 VLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 660 670 680 690 700 710 760 770 pF1KE2 ---------------RINVT-TAVSE---VSVPPKGTSAAWAILPLL------------L :..:. ::: .. : :: . : : : XP_011 TEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQVL 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE2 LVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVS ::. .: .:.:.::. ::..:.::::::: ::::... : :. . :..::. ..:: XP_011 LVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHIC---HNQD-GYSYPSRQMVS 780 790 800 810 820 840 pF1KE2 TDDDLA .::.: XP_011 LEDDVA 830 >>NP_001182727 (OMIM: 143890,606945) low-density lipopro (858 aa) initn: 2755 init1: 1284 opt: 2938 Z-score: 1820.7 bits: 347.9 E(85289): 1.1e-94 Smith-Waterman score: 3018; 50.2% identity (73.3% similar) in 815 aa overlap (68-816:23-835) 40 50 60 70 80 90 pF1KE2 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC : : ...: :..:.:. .: :::. .: NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC 10 20 30 40 50 100 110 120 130 140 150 pF1KE2 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD .:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: : NP_001 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE2 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD :: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: : NP_001 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE2 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP : : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: :: NP_001 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA 180 190 200 210 220 230 280 290 300 310 320 330 pF1KE2 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI :::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: . NP_001 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE2 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC .::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. : NP_001 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC 300 310 320 330 340 350 400 410 420 430 440 450 pF1KE2 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI ::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::. NP_001 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM 360 370 380 390 400 410 460 470 480 490 500 510 pF1KE2 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYN :.:.:: .:. .:::.::::...:.....:.::::. : :...: : :. :.: . NP_001 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHG--VSSYDTVIS 420 430 440 450 460 470 520 530 540 550 560 pF1KE2 -----PAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGF : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. :: NP_001 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGF 480 490 500 510 520 530 570 580 590 600 610 620 pF1KE2 VYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL .::.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:. NP_001 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV 540 550 560 570 580 590 630 640 650 660 670 680 pF1KE2 NGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQ :: .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . . NP_001 NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPE 600 610 620 630 640 650 690 700 710 720 730 740 pF1KE2 DIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD :....:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :. NP_001 DMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRS 660 670 680 690 700 710 750 760 pF1KE2 CQ---------------RINVT-TAV-----SEVSVP----------------------- : :..:. ::: . :: NP_001 CLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ 720 730 740 750 760 770 770 780 790 800 810 pF1KE2 -------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK :... : .::..:::. .: .:.:.::. ::..:.::::::: : NP_001 ALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQK 780 790 800 810 820 830 820 830 840 pF1KE2 TTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA :::.. NP_001 TTEDEVHICHNQDGYSYPSMVSLEDDVA 840 850 >>NP_000518 (OMIM: 143890,606945) low-density lipoprotei (860 aa) initn: 2755 init1: 1284 opt: 2938 Z-score: 1820.7 bits: 347.9 E(85289): 1.1e-94 Smith-Waterman score: 3018; 50.2% identity (73.3% similar) in 815 aa overlap (68-816:23-835) 40 50 60 70 80 90 pF1KE2 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC : : ...: :..:.:. .: :::. .: NP_000 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC 10 20 30 40 50 100 110 120 130 140 150 pF1KE2 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD .:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: : NP_000 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE2 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD :: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: : NP_000 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE2 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP : : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: :: NP_000 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA 180 190 200 210 220 230 280 290 300 310 320 330 pF1KE2 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI :::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: . NP_000 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE2 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC .::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. : NP_000 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC 300 310 320 330 340 350 400 410 420 430 440 450 pF1KE2 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI ::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::. NP_000 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM 360 370 380 390 400 410 460 470 480 490 500 510 pF1KE2 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYN :.:.:: .:. .:::.::::...:.....:.::::. : :...: : :. :.: . NP_000 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHG--VSSYDTVIS 420 430 440 450 460 470 520 530 540 550 560 pF1KE2 -----PAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGF : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. :: NP_000 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGF 480 490 500 510 520 530 570 580 590 600 610 620 pF1KE2 VYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL .::.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:. NP_000 MYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV 540 550 560 570 580 590 630 640 650 660 670 680 pF1KE2 NGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQ :: .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . . NP_000 NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPE 600 610 620 630 640 650 690 700 710 720 730 740 pF1KE2 DIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRD :....:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :. NP_000 DMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRS 660 670 680 690 700 710 750 760 pF1KE2 CQ---------------RINVT-TAV-----SEVSVP----------------------- : :..:. ::: . :: NP_000 CLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ 720 730 740 750 760 770 770 780 790 800 810 pF1KE2 -------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK :... : .::..:::. .: .:.:.::. ::..:.::::::: : NP_000 ALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQK 780 790 800 810 820 830 820 830 840 pF1KE2 TTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA :::.. NP_000 TTEDEVHICHNQDGYSYPSRQMVSLEDDVA 840 850 860 >>NP_001182728 (OMIM: 143890,606945) low-density lipopro (819 aa) initn: 2595 init1: 1284 opt: 2702 Z-score: 1676.6 bits: 321.2 E(85289): 1.2e-86 Smith-Waterman score: 2782; 49.9% identity (73.1% similar) in 772 aa overlap (113-816:27-794) 90 100 110 120 130 140 pF1KE2 QCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDS :. .:..: .. .:: .: ::: .:.. NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQC--QDGKCISYKWVCDGSAECQD 10 20 30 40 50 150 160 170 180 190 200 pF1KE2 GEDE--ENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC : :: :.:. ::: ::: : .:.::::.:::... :: ::::: .: ::: ::: NP_001 GSDESQETCSPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQC 60 70 80 90 100 110 210 220 230 240 250 pF1KE2 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWR ..:.::: :.::.: :: : ::: ..: :.. . : : :..: ::::::..:: NP_001 NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR 120 130 140 150 160 170 260 270 280 290 300 310 pF1KE2 CDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQ ::: ::::: ::: :: :::::.:.: ::.::::::::. :: : ::::.: ::. NP_001 CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTL 180 190 200 210 220 230 320 330 340 350 360 370 pF1KE2 CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIG : ::.::::.::::: ..::::. .:::::::::.::: :::: :::::::.:.:: :: NP_001 CEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIG 240 250 260 270 280 290 380 390 400 410 420 430 pF1KE2 YECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV ::: : ::.:. .. : ::::::.: :::.:.::.:::::.: .:.:.: : .:::: NP_001 YECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV 300 310 320 330 340 350 440 450 460 470 480 490 pF1KE2 GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSAS :. :.::::...::. :.:.:: .:. .:::.::::...:.....:.::::. : :.. NP_001 GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQ 360 370 380 390 400 410 500 510 520 530 540 550 pF1KE2 IDDKVGRHVKMIDNVYN-----PAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN .: : :. :.: . : ..::::....:::::.. :.::: :.::: :: NP_001 LDRAHG--VSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFR 420 430 440 450 460 470 560 570 580 590 600 610 pF1KE2 SDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKS . .: .:.:::. ::.::.::: ::::.:.:.:: : ::: .:::::::::::... NP_001 ENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSG 480 490 500 510 520 530 620 630 640 650 660 670 pF1KE2 RLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANK ::::.::::: .::.:.:: .:. .:.. . ::::..:..:::.:.: : :::...::. NP_001 RLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANR 540 550 560 570 580 590 680 690 700 710 720 730 pF1KE2 FTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPK .:::.. :..:: . .:....:.:.:: : ::::. . ::::.:::::::::: :::: NP_001 LTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPK 600 610 620 630 640 650 740 750 760 pF1KE2 YTCSCPSGYNVEENGRDCQ---------------RINVT-TAV-----SEVSVP------ .::.::.:. . .. :.: :..:. ::: . :: NP_001 FTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLP 660 670 680 690 700 710 770 780 790 pF1KE2 ------------------------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNW :... : .::..:::. .: .:.:.:: NP_001 GATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNW 720 730 740 750 760 770 800 810 820 830 840 pF1KE2 QHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA . ::..:.::::::: ::::.. NP_001 RLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA 780 790 800 810 >>NP_059992 (OMIM: 602600,608446) low-density lipoprotei (700 aa) initn: 1635 init1: 859 opt: 2415 Z-score: 1501.7 bits: 288.6 E(85289): 6.6e-77 Smith-Waterman score: 2415; 49.8% identity (76.8% similar) in 664 aa overlap (193-843:47-697) 170 180 190 200 210 220 pF1KE2 SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQS : .::: . ::: : ::.: :: :.: NP_059 LLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHS 20 30 40 50 60 70 230 240 250 260 270 280 pF1KE2 DESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRP :: ..: .. : :.. : .:.:::..:.:::. .: ::::: ..: ...: NP_059 DE--DDCPKK-----TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPA 80 90 100 110 120 290 300 310 320 330 pF1KE2 DQFECEDGS--CIHGSRQCNGIRDCVDGSDEVNCK-NVNQCLGPGKFKCRSGECIDISKV ... : : :. .: .:.: .:: :.::..: ... : : .:.: .: :. : NP_059 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD-EFQCGDGTCVLAIKH 130 140 150 160 170 180 340 350 360 370 380 390 pF1KE2 CNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDI ::::::: : ::: .:::: ::::::::: :: ::.:: : :::.:.:.:::::: NP_059 CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDI 190 200 210 220 230 240 400 410 420 430 440 450 pF1KE2 DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGL :::..: :::::.: :: .:::: ::.::: : :::. :: ::::::::...:.: : NP_059 DECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 250 260 270 280 290 300 460 470 480 490 500 510 pF1KE2 ERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVY ...: .:. .:.:.::::...:.....: ::: . :.:: .: : ..: . .... NP_059 VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 310 320 330 340 350 360 520 530 540 550 560 570 pF1KE2 NPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS .: ..:::::.: :::::...:::::::.:: .:. ::. .: :: .:::::: ::.::: NP_059 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 370 380 390 400 410 420 580 590 600 610 620 630 pF1KE2 DWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQD :::. :::::.:.:: ::. ::. .:.:::::::::...::::.:::::.:::.:..: . NP_059 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 430 440 450 460 470 480 640 650 660 670 680 690 pF1KE2 RRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV :. ...: .::.::.....:::.:.: : ::::...::...: :.. :..:::. .::.. NP_059 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 490 500 510 520 530 540 700 710 720 730 740 750 pF1KE2 YHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI .::: :: . . :: ... ::::::::::::::..:::::::.::. . . . . : : NP_059 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR- 550 560 570 580 590 600 760 770 780 790 800 810 pF1KE2 NVTTAVSEVSVPPKGTSAAWAIL-PLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLK : . .. :.:. .:. :...... ..:::.::::..:: :::::::::: : NP_059 ---DANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRK 610 620 630 640 650 660 820 830 840 pF1KE2 TTEEDLS--IDIGRHSASVGHTYPAISVVSTDDDLA ::::. . ::: .:..::.::: ..: .:: NP_059 TTEEEDEDELHIGR-TAQIGHVYPARVALSLEDDGLP 670 680 690 700 >>XP_005271232 (OMIM: 602600,608446) PREDICTED: low-dens (834 aa) initn: 1894 init1: 859 opt: 2187 Z-score: 1361.4 bits: 262.9 E(85289): 4.3e-69 Smith-Waterman score: 2194; 45.5% identity (70.5% similar) in 694 aa overlap (193-804:47-732) 170 180 190 200 210 220 pF1KE2 SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQS : .::: . ::: : ::.: :: :.: XP_005 LLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHS 20 30 40 50 60 70 230 240 250 260 270 280 pF1KE2 DESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRP :: ..: .. : :.. : .:.:::..:.:::. .: ::::: ..: ...: XP_005 DE--DDCPKKT-----CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPA 80 90 100 110 120 290 300 310 320 330 pF1KE2 DQFECEDGS--CIHGSRQCNGIRDCVDGSDEVNCK-NVNQCLGPGKFKCRSGECIDISKV ... : : :. .: .:.: .:: :.::..: ... : : .:.: .: :. : XP_005 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD-EFQCGDGTCVLAIKH 130 140 150 160 170 180 340 350 360 370 380 390 pF1KE2 CNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDI ::::::: : ::: .:::: ::::::::: :: ::.:: : :::.:.:.:::::: XP_005 CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDI 190 200 210 220 230 240 400 410 420 430 440 450 pF1KE2 DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGL :::..: :::::.: :: .:::: ::.::: : :::. :: ::::::::...:.: : XP_005 DECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL 250 260 270 280 290 300 460 470 480 490 500 510 pF1KE2 ERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVY ...: .:. .:.:.::::...:.....: ::: . :.:: .: : ..: . .... XP_005 VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 310 320 330 340 350 360 520 530 540 550 560 570 pF1KE2 NPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWS .: ..:::::.: :::::...:::::::.:: .:. ::. .: :: .:::::: ::.::: XP_005 SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWS 370 380 390 400 410 420 580 590 600 610 620 630 pF1KE2 DWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQD :::. :::::.:.:: ::. ::. .:.:::::::::...::::.:::::.:::.:..: . XP_005 DWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGN 430 440 450 460 470 480 640 650 660 670 680 690 pF1KE2 RRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV :. ...: .::.::.....:::.:.: : ::::...::...: :.. :..:::. .::.. XP_005 RKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVI 490 500 510 520 530 540 700 710 720 730 740 750 pF1KE2 YHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI .::: :: . . :: ... ::::::::::::::..:::::::.::. . . . . : : XP_005 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRA 550 560 570 580 590 600 760 pF1KE2 -----------------------------------------NVTTAV-SEVSVP--PK-- ..:.:: : :::: :. XP_005 PQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS 610 620 630 640 650 660 770 780 790 800 pF1KE2 ----------------------GTSAAWAIL----PLLLLVMAAVGGYLMWRNWQHKNMK :.... :.. :...... ..:::.::::..:: : XP_005 PSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK 670 680 690 700 710 720 810 820 830 840 pF1KE2 SMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA :::: XP_005 SMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPA 730 740 750 760 770 780 845 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:39:01 2016 done: Sun Nov 6 20:39:03 2016 Total Scan time: 11.670 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]