FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1413, 500 aa 1>>>pF1KE1413 500 - 500 aa - 500 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2951+/-0.000448; mu= 11.1083+/- 0.028 mean_var=170.9479+/-35.097, 0's: 0 Z-trim(114.7): 116 B-trim: 696 in 1/57 Lambda= 0.098094 statistics sampled from 24645 (24761) to 24645 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.29), width: 16 Scan time: 10.060 The best scores are: opt bits E(85289) NP_000053 (OMIM: 106100,120790,606860) plasma prot ( 500) 3178 462.3 1.4e-129 NP_001027466 (OMIM: 106100,120790,606860) plasma p ( 500) 3178 462.3 1.4e-129 NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmi ( 491) 613 99.3 2.7e-20 NP_001159392 (OMIM: 262850,613168) alpha-2-antipla ( 491) 613 99.3 2.7e-20 XP_016880254 (OMIM: 262850,613168) PREDICTED: alph ( 495) 613 99.3 2.7e-20 XP_005256758 (OMIM: 262850,613168) PREDICTED: alph ( 507) 613 99.3 2.7e-20 NP_001159393 (OMIM: 262850,613168) alpha-2-antipla ( 427) 551 90.5 1.1e-17 NP_002606 (OMIM: 172860,613982) pigment epithelium ( 418) 510 84.7 5.8e-16 NP_001316832 (OMIM: 172860,613982) pigment epithel ( 418) 510 84.7 5.8e-16 NP_001076 (OMIM: 107280) alpha-1-antichymotrypsin ( 423) 437 74.3 7.6e-13 NP_000615 (OMIM: 601841) plasma serine protease in ( 406) 420 71.9 3.9e-12 NP_001121179 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001121178 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001002236 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001121174 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001121175 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001002235 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001121177 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001121173 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 XP_016876859 (OMIM: 107400,606963,613490) PREDICTE ( 418) 405 69.8 1.7e-11 NP_001121176 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_001121172 (OMIM: 107400,606963,613490) alpha-1- ( 418) 405 69.8 1.7e-11 NP_000286 (OMIM: 107400,606963,613490) alpha-1-ant ( 418) 405 69.8 1.7e-11 NP_001094077 (OMIM: 605271) protein Z-dependent pr ( 444) 401 69.3 2.7e-11 XP_005267790 (OMIM: 605271) PREDICTED: protein Z-d ( 444) 401 69.3 2.7e-11 NP_057270 (OMIM: 605271) protein Z-dependent prote ( 444) 401 69.3 2.7e-11 XP_016876842 (OMIM: 605271) PREDICTED: protein Z-d ( 484) 401 69.3 2.8e-11 NP_008850 (OMIM: 600517) serpin B3 [Homo sapiens] ( 390) 394 68.2 4.8e-11 NP_006208 (OMIM: 605587) serpin I2 isoform 2 precu ( 405) 390 67.7 7.4e-11 NP_001137290 (OMIM: 173390) plasminogen activator ( 415) 390 67.7 7.5e-11 NP_001012303 (OMIM: 605587) serpin I2 isoform 1 pr ( 415) 390 67.7 7.5e-11 NP_002566 (OMIM: 173390) plasminogen activator inh ( 415) 390 67.7 7.5e-11 NP_002965 (OMIM: 600518) serpin B4 isoform 1 [Homo ( 390) 388 67.4 8.7e-11 XP_011524440 (OMIM: 600518) PREDICTED: serpin B4 i ( 390) 388 67.4 8.7e-11 XP_011524329 (OMIM: 602058) PREDICTED: serpin B10 ( 397) 382 66.5 1.6e-10 NP_005015 (OMIM: 602058) serpin B10 [Homo sapiens] ( 397) 382 66.5 1.6e-10 NP_001747 (OMIM: 122500,611489) corticosteroid-bin ( 405) 382 66.5 1.6e-10 NP_006211 (OMIM: 107410) putative alpha-1-antitryp ( 421) 378 66.0 2.5e-10 NP_006206 (OMIM: 147935) kallistatin isoform 2 pre ( 427) 376 65.7 3e-10 NP_001275962 (OMIM: 147935) kallistatin isoform 2 ( 427) 376 65.7 3e-10 NP_001275961 (OMIM: 147935) kallistatin isoform 1 ( 464) 376 65.7 3.2e-10 NP_942130 (OMIM: 601697,617115) serpin B8 isoform ( 374) 368 64.5 6e-10 NP_002631 (OMIM: 601697,617115) serpin B8 isoform ( 374) 368 64.5 6e-10 NP_000345 (OMIM: 300932,314200) thyroxine-binding ( 415) 367 64.4 7.2e-10 NP_001271204 (OMIM: 615677) serpin A9 isoform C [H ( 399) 365 64.1 8.5e-10 XP_011535016 (OMIM: 615677) PREDICTED: serpin A9 i ( 417) 365 64.1 8.7e-10 XP_011535017 (OMIM: 615677) PREDICTED: serpin A9 i ( 417) 365 64.1 8.7e-10 NP_783866 (OMIM: 615677) serpin A9 isoform A [Homo ( 435) 365 64.2 9e-10 XP_011524330 (OMIM: 602058) PREDICTED: serpin B10 ( 268) 360 63.3 1e-09 XP_011535018 (OMIM: 615677) PREDICTED: serpin A9 i ( 337) 359 63.2 1.4e-09 >>NP_000053 (OMIM: 106100,120790,606860) plasma protease (500 aa) initn: 3178 init1: 3178 opt: 3178 Z-score: 2447.1 bits: 462.3 E(85289): 1.4e-129 Smith-Waterman score: 3178; 99.8% identity (100.0% similar) in 500 aa overlap (1-500:1-500) 10 20 30 40 50 60 pF1KE1 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_000 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFV 430 440 450 460 470 480 490 500 pF1KE1 LWDQQHKFPVFMGRVYDPRA :::::::::::::::::::: NP_000 LWDQQHKFPVFMGRVYDPRA 490 500 >>NP_001027466 (OMIM: 106100,120790,606860) plasma prote (500 aa) initn: 3178 init1: 3178 opt: 3178 Z-score: 2447.1 bits: 462.3 E(85289): 1.4e-129 Smith-Waterman score: 3178; 99.8% identity (100.0% similar) in 500 aa overlap (1-500:1-500) 10 20 30 40 50 60 pF1KE1 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFV 430 440 450 460 470 480 490 500 pF1KE1 LWDQQHKFPVFMGRVYDPRA :::::::::::::::::::: NP_001 LWDQQHKFPVFMGRVYDPRA 490 500 >>NP_000925 (OMIM: 262850,613168) alpha-2-antiplasmin is (491 aa) initn: 483 init1: 172 opt: 613 Z-score: 485.4 bits: 99.3 E(85289): 2.7e-20 Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:36-436) 70 80 90 100 110 120 pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP :. :. . ..: : : . .: . NP_000 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG .: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... :: NP_000 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS : ..: :...: . . :. . : . . . ..... . . :.. :.. : NP_000 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK . :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :. NP_000 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR 190 200 210 220 230 240 310 320 330 340 350 pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV . :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.:: NP_000 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV 250 260 270 280 290 300 360 370 380 390 400 410 pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF : : .. :.:. . .. : . :: . ::.. . ..:... . .: . NP_000 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ 310 320 330 340 350 420 430 440 450 460 470 pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL .. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..::: NP_000 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL 360 370 380 390 400 410 480 490 500 pF1KE1 FMLWDQQHKFPVFMGRVYDPRA :..... .:.:.: : .: NP_000 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL 420 430 440 450 460 470 >>NP_001159392 (OMIM: 262850,613168) alpha-2-antiplasmin (491 aa) initn: 483 init1: 172 opt: 613 Z-score: 485.4 bits: 99.3 E(85289): 2.7e-20 Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:36-436) 70 80 90 100 110 120 pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP :. :. . ..: : : . .: . NP_001 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG .: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... :: NP_001 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS : ..: :...: . . :. . : . . . ..... . . :.. :.. : NP_001 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK . :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :. NP_001 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR 190 200 210 220 230 240 310 320 330 340 350 pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV . :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.:: NP_001 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV 250 260 270 280 290 300 360 370 380 390 400 410 pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF : : .. :.:. . .. : . :: . ::.. . ..:... . .: . NP_001 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ 310 320 330 340 350 420 430 440 450 460 470 pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL .. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..::: NP_001 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL 360 370 380 390 400 410 480 490 500 pF1KE1 FMLWDQQHKFPVFMGRVYDPRA :..... .:.:.: : .: NP_001 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL 420 430 440 450 460 470 >>XP_016880254 (OMIM: 262850,613168) PREDICTED: alpha-2- (495 aa) initn: 483 init1: 172 opt: 613 Z-score: 485.4 bits: 99.3 E(85289): 2.7e-20 Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:40-440) 70 80 90 100 110 120 pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP :. :. . ..: : : . .: . XP_016 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG .: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... :: XP_016 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS : ..: :...: . . :. . : . . . ..... . . :.. :.. : XP_016 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK . :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :. XP_016 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR 190 200 210 220 230 240 310 320 330 340 350 pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV . :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.:: XP_016 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV 250 260 270 280 290 300 360 370 380 390 400 410 pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF : : .. :.:. . .. : . :: . ::.. . ..:... . .: . XP_016 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL .. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..::: XP_016 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL 370 380 390 400 410 420 480 490 500 pF1KE1 FMLWDQQHKFPVFMGRVYDPRA :..... .:.:.: : .: XP_016 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL 430 440 450 460 470 480 >>XP_005256758 (OMIM: 262850,613168) PREDICTED: alpha-2- (507 aa) initn: 483 init1: 172 opt: 613 Z-score: 485.2 bits: 99.3 E(85289): 2.7e-20 Smith-Waterman score: 613; 28.5% identity (65.6% similar) in 410 aa overlap (95-498:52-452) 70 80 90 100 110 120 pF1KE1 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCP :. :. . ..: : : . .: . XP_005 GLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQ-EPGGQTALK 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 GPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLG .: .:: . :. :.. :. :. .. :. .. :. .::.:.: :... :: XP_005 SPPGVCSRDPTPEQTHRLARAMMAFTADLF-SLVAQTSTCPNLILSPLSVALALSHLALG 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 AGENTKTNLESILSYPKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNAS : ..: :...: . . :. . : . . . ..... . . :.. :.. : XP_005 AQNHTLQRLQQVL-HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQS 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE1 RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK . :....: :..... .: :: :: . :..::...:..:: :: :.:::::.... :. XP_005 EQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWR 200 210 220 230 240 250 310 320 330 340 350 pF1KE1 TTFDPKKTRMEPFHFKNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV . :::. :. . ::. .. .. : ::... ::. :. . . .:... ...:.:.:.:: XP_005 NKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLV 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE1 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF : : .. :.:. . .. : . :: . ::.. . ..:... . .: . XP_005 PT---HFEWNVSQVLANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQ 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE1 DFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFL .. .: :..:. .: ::..:::..:::.:.:::::::..:...: .: : :..::: XP_005 ELFQAPDLRGISEQ-SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFL 380 390 400 410 420 430 480 490 500 pF1KE1 FMLWDQQHKFPVFMGRVYDPRA :..... .:.:.: : .: XP_005 FFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKL 440 450 460 470 480 490 >>NP_001159393 (OMIM: 262850,613168) alpha-2-antiplasmin (427 aa) initn: 471 init1: 172 opt: 551 Z-score: 438.8 bits: 90.5 E(85289): 1.1e-17 Smith-Waterman score: 551; 30.1% identity (68.7% similar) in 335 aa overlap (170-498:45-372) 140 150 160 170 180 190 pF1KE1 AVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSY ::... .: .:: :: ..: :...: . NP_001 LQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQVQPGAQNHTLQRLQQVL-H 20 30 40 50 60 70 200 210 220 230 240 250 pF1KE1 PKDFTCVHQAL----KGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNS . :. . : . . . ..... . . :.. :.. :. :....: :.... NP_001 AGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQ 80 90 100 110 120 130 260 270 280 290 300 310 pF1KE1 DANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHF . .: :: :: . :..::...:..:: :: :.:::::.... :.. :::. :. . ::. NP_001 EDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHL 140 150 160 170 180 190 320 330 340 350 360 370 pF1KE1 KNS-VIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQAL .. .. : ::... ::. :. . . .:... ...:.:.:.::: : .. :.: NP_001 DEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVP---THFEWNVSQVL 200 210 220 230 240 250 380 390 400 410 420 430 pF1KE1 SPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDP . . .. : . :: . ::.. . ..:... . .: . .. .: :..:. NP_001 ANLSWDTLHPPLVWER--PTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQ- 260 270 280 290 300 440 450 460 470 480 490 pF1KE1 DLQVSAMQHQTVLELTETGVEAAAASAISVAR-TLLVFEVQQPFLFMLWDQQHKFPVFMG .: ::..:::..:::.:.:::::::..:...: .: : :..::::..... .:.:.: NP_001 SLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVG 310 320 330 340 350 360 500 pF1KE1 RVYDPRA : .: NP_001 SVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK 370 380 390 400 410 420 >>NP_002606 (OMIM: 172860,613982) pigment epithelium-der (418 aa) initn: 416 init1: 194 opt: 510 Z-score: 407.5 bits: 84.7 E(85289): 5.8e-16 Smith-Waterman score: 510; 25.2% identity (63.6% similar) in 404 aa overlap (106-499:18-416) 80 90 100 110 120 130 pF1KE1 TKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLES . : :.. : . . : .. : NP_002 MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFF 10 20 30 40 140 150 160 170 180 190 pF1KE1 HSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLES . :. :. .:. ::.. :. . . ::. .::.:.:. :. . ::: . :.. .. NP_002 KVPVNKLAAAVSNFGYDLYRVRSSTSPT-TNVLLSPLSVATALSALSLGAEQRTESIIHR 50 60 70 80 90 100 200 210 220 230 240 pF1KE1 ILSYP----KDFTCVHQALKGFTT---KGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSP : : :. ... : .: :.. :.:.: : :...:: . :.. : NP_002 ALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRP 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE1 RVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKT :::..: .:. ::.:: . ..:..: .:.. ..::.. .....: : :: .:: NP_002 RVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKT 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE1 RMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRL .: :.. .. ...::::.. : . . .:. :. :..:: :. ..:.....: .. . : NP_002 SLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNL 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE1 EDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNL .:..:. : : ... :.. : ..::.:..:.. .. . ...... .. . .. NP_002 TLIEESLT-SEFIHDIDR-ELKTVQ-AVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDF 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE1 CGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTL--LVFEVQQPFLFMLWDQQ .: : .... ..:.. .: .: :. .. . ... :. : ....:::.:.: : . NP_002 SKITGKP-IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTD 350 360 370 380 390 400 490 500 pF1KE1 HKFPVFMGRVYDPRA .:.:.. ::: NP_002 TGALLFIGKILDPRGP 410 >>NP_001316832 (OMIM: 172860,613982) pigment epithelium- (418 aa) initn: 416 init1: 194 opt: 510 Z-score: 407.5 bits: 84.7 E(85289): 5.8e-16 Smith-Waterman score: 510; 25.2% identity (63.6% similar) in 404 aa overlap (106-499:18-416) 80 90 100 110 120 130 pF1KE1 TKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLES . : :.. : . . : .. : NP_001 MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFF 10 20 30 40 140 150 160 170 180 190 pF1KE1 HSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLES . :. :. .:. ::.. :. . . ::. .::.:.:. :. . ::: . :.. .. NP_001 KVPVNKLAAAVSNFGYDLYRVRSSTSPT-TNVLLSPLSVATALSALSLGAEQRTESIIHR 50 60 70 80 90 100 200 210 220 230 240 pF1KE1 ILSYP----KDFTCVHQALKGFTT---KGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSP : : :. ... : .: :.. :.:.: : :...:: . :.. : NP_001 ALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRP 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE1 RVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKT :::..: .:. ::.:: . ..:..: .:.. ..::.. .....: : :: .:: NP_001 RVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKT 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE1 RMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRL .: :.. .. ...::::.. : . . .:. :. :..:: :. ..:.....: .. . : NP_001 SLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNL 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE1 EDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNL .:..:. : : ... :.. : ..::.:..:.. .. . ...... .. . .. NP_001 TLIEESLT-SEFIHDIDR-ELKTVQ-AVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDF 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE1 CGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTL--LVFEVQQPFLFMLWDQQ .: : .... ..:.. .: .: :. .. . ... :. : ....:::.:.: : . NP_001 SKITGKP-IKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTD 350 360 370 380 390 400 490 500 pF1KE1 HKFPVFMGRVYDPRA .:.:.. ::: NP_001 TGALLFIGKILDPRGP 410 >>NP_001076 (OMIM: 107280) alpha-1-antichymotrypsin prec (423 aa) initn: 345 init1: 155 opt: 437 Z-score: 351.6 bits: 74.3 E(85289): 7.6e-13 Smith-Waterman score: 500; 28.4% identity (63.8% similar) in 412 aa overlap (122-499:17-421) 100 110 120 130 140 pF1KE1 TEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPG-------PV---TLCSDLESHSTEAV :::. :. .: .. ....:.. NP_001 MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVD 10 20 30 40 150 160 170 180 190 pF1KE1 LG--DALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSY :: .: :::...::. . ..: . :. :::.::.. :. . ::: ..: :.. . :.. NP_001 LGLASANVDFAFSLYKQL-VLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKF 50 60 70 80 90 100 200 210 220 230 240 pF1KE1 PKDFTC---VHQALKGFTTKGVTSVSQI--------FHSPDLAIRDTFVNASRTLYSSSP : .::... . : ... : . .:.. : :.. .. ::.: NP_001 NLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEA 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE1 RVLS-NNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKK . . ..: : .::: .: ..: .::. :. .: :.: .::.: :...:::. :::. NP_001 FATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQD 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE1 TRMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHR :.. :.. :.. . ::::. .. . .: :. :. : .:. . : : ....:. . . NP_001 THQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPD--QDK 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE1 LEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD-FSYDL .:..: : : ..: ..::. .. : ::..... . .. .:. .: . . :. NP_001 MEEVEAMLLPETLKRWRDSLEFREIGE--LYLPKFSISRDYNLNDILLQLGIEEAFTSKA 290 300 310 320 330 340 430 440 450 460 470 pF1KE1 NLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVA------RTLLVFEVQQPFLF .: :.: .: :: . :..::.. : :.::.::.:.... .: . . ..:::. NP_001 DLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLM 350 360 370 380 390 400 480 490 500 pF1KE1 MLW--DQQHKFPVFMGRVYDPRA .. : :. : ::..: .:. NP_001 IIVPTDTQNIF--FMSKVTNPKQA 410 420 500 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:16:52 2016 done: Sun Nov 6 21:16:53 2016 Total Scan time: 10.060 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]