FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8975, 371 aa 1>>>pF1KB8975 371 - 371 aa - 371 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0666+/-0.000347; mu= 6.7305+/- 0.022 mean_var=237.8697+/-49.240, 0's: 0 Z-trim(122.3): 228 B-trim: 687 in 2/57 Lambda= 0.083158 statistics sampled from 39967 (40243) to 39967 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.472), width: 16 Scan time: 9.890 The best scores are: opt bits E(85289) NP_003308 (OMIM: 118700,188550,600635,610978) home ( 371) 2542 317.4 3.3e-86 NP_001073136 (OMIM: 118700,188550,600635,610978) h ( 401) 2542 317.5 3.5e-86 NP_149416 (OMIM: 607808) homeobox protein Nkx-2.4 ( 354) 882 118.2 2.8e-26 NP_660328 (OMIM: 606727) homeobox protein Nkx-2.3 ( 364) 409 61.5 3.5e-09 NP_001129743 (OMIM: 217095,611770) homeobox protei ( 301) 373 57.1 6.1e-08 NP_002500 (OMIM: 604612) homeobox protein Nkx-2.2 ( 273) 368 56.5 8.7e-08 XP_006723629 (OMIM: 604612) PREDICTED: homeobox pr ( 202) 362 55.6 1.2e-07 NP_055175 (OMIM: 603245) homeobox protein Nkx-2.8 ( 239) 358 55.2 1.8e-07 NP_004378 (OMIM: 108900,187500,217095,225250,60058 ( 324) 334 52.5 1.7e-06 NP_005506 (OMIM: 142994,176450) motor neuron and p ( 401) 319 50.8 6.6e-06 NP_001180 (OMIM: 602183,613330) homeobox protein N ( 333) 300 48.4 2.8e-05 XP_016880046 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_011523009 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_016880051 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_016880050 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_016880048 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_016880047 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_016880052 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 XP_016880049 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 301 48.8 3.8e-05 NP_001243268 (OMIM: 602041) homeobox protein Nkx-3 ( 159) 283 46.0 7.1e-05 XP_011523023 (OMIM: 142966) PREDICTED: homeobox pr ( 430) 291 47.4 7.1e-05 XP_011523022 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05 XP_006721917 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05 XP_005257334 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05 XP_011523012 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05 XP_011523021 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 290 47.3 7.8e-05 NP_002137 (OMIM: 142966) homeobox protein Hox-B3 i ( 431) 290 47.3 7.8e-05 NP_001158727 (OMIM: 142994,176450) motor neuron an ( 189) 281 45.8 9.5e-05 XP_011523028 (OMIM: 142966) PREDICTED: homeobox pr ( 358) 286 46.7 9.6e-05 NP_001317251 (OMIM: 142966) homeobox protein Hox-B ( 358) 286 46.7 9.6e-05 NP_001317252 (OMIM: 142966) homeobox protein Hox-B ( 299) 284 46.4 0.0001 NP_057254 (OMIM: 604240) T-cell leukemia homeobox ( 284) 282 46.2 0.00011 XP_011523010 (OMIM: 142966) PREDICTED: homeobox pr ( 488) 284 46.7 0.00014 NP_006158 (OMIM: 602041) homeobox protein Nkx-3.1 ( 234) 278 45.6 0.00014 NP_068777 (OMIM: 142995) H2.0-like homeobox protei ( 488) 279 46.1 0.00021 XP_006712540 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 NP_008829 (OMIM: 142980) homeobox protein Hox-D3 [ ( 432) 266 44.4 0.00057 XP_005246566 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 XP_005246568 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 XP_005246570 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 XP_011509368 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 XP_005246567 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 XP_011509367 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 266 44.4 0.00057 NP_066305 (OMIM: 604640) T-cell leukemia homeobox ( 291) 260 43.5 0.00072 NP_000545 (OMIM: 120970,268000,602225,613829) cone ( 299) 256 43.1 0.001 XP_005249788 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002 XP_011513645 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002 XP_005249789 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002 NP_705895 (OMIM: 142954) homeobox protein Hox-A3 i ( 443) 251 42.7 0.002 XP_005249787 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 251 42.7 0.002 >>NP_003308 (OMIM: 118700,188550,600635,610978) homeobox (371 aa) initn: 2542 init1: 2542 opt: 2542 Z-score: 1668.7 bits: 317.4 E(85289): 3.3e-86 Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 AAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTM 310 320 330 340 350 360 370 pF1KB8 SCSTLLYGRTW ::::::::::: NP_003 SCSTLLYGRTW 370 >>NP_001073136 (OMIM: 118700,188550,600635,610978) homeo (401 aa) initn: 2542 init1: 2542 opt: 2542 Z-score: 1668.3 bits: 317.5 E(85289): 3.5e-86 Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:31-401) 10 20 30 pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGME :::::::::::::::::::::::::::::: NP_001 MWSGGSGKARGWEAAAGGRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGME 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 GGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGN 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 LGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 KNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 NHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB8 QAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDL 310 320 330 340 350 360 340 350 360 370 pF1KB8 AHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW ::::::::::::::::::::::::::::::::::::::::: NP_001 AHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW 370 380 390 400 >>NP_149416 (OMIM: 607808) homeobox protein Nkx-2.4 [Hom (354 aa) initn: 953 init1: 470 opt: 882 Z-score: 592.7 bits: 118.2 E(85289): 2.8e-26 Smith-Waterman score: 1207; 54.0% identity (69.3% similar) in 404 aa overlap (1-371:1-354) 10 20 30 40 pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVG--MEGG--GLGAPLAAYRQGQAAPP------- ::.::::::::::::::::.::.::: . :.:. ::::::.: .: :: NP_149 MSLSPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAA 10 20 30 40 50 60 50 60 70 80 90 pF1KB8 -TAAMQ-QHAV-GHHGAVTAA-----------YHMTAAGVPQLSHSAVGGYCNGNLGNMS .:.:: .::. ::..:..:: ::: :: :. :.:.:.::::.::::. NP_149 TVAGMQPSHAMAGHNAAAAAAAAAAAAAAAATYHMPP-GVSQFPHGAMGSYCNGGLGNMG 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 ELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAP ::: : : ::..:. ::::::::::. .:::::::..:.:..:::.: ...:..:...: NP_149 ELPAYTDGMRGGAA-TGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGP 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB8 L-----PSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ : .:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 LHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB8 NHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC ::::::::::::::::: :::. :: : : ::::::::::::::::: NP_149 NHRYKMKRQAKDKAAQQ-LQQE-------GGLGPPPPP---PPSPRRVAVPVLVKDGKPC 240 250 260 270 280 280 290 300 310 320 pF1KB8 QAGA--PAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSP : :: :.:: : : :: . .: NP_149 QNGASTPTPGQA-------------------------------------GPQPPAPTPAP 290 300 310 330 340 350 360 370 pF1KB8 DLAHHAASPAALQGQVSSLSHLNSSGSDY-GTMSCSTLLYGRTW .: . . :: ::.: ..:. :......: : . ..::::::: NP_149 ELEELSPSPPALHGPGGGLAALDAAAGEYSGGVLGANLLYGRTW 320 330 340 350 >>NP_660328 (OMIM: 606727) homeobox protein Nkx-2.3 [Hom (364 aa) initn: 538 init1: 342 opt: 409 Z-score: 285.8 bits: 61.5 E(85289): 3.5e-09 Smith-Waterman score: 523; 38.1% identity (57.6% similar) in 370 aa overlap (1-355:2-336) 10 20 30 40 50 pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVG : :: .:::::.:::. ::..... ..:. : : : .. ..:: : : : NP_660 MMLPSPVTSTPFSVKDILN-LEQQHQH--FHGAHLQADLE--HHFHSAP---CMLAAAEG 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 HHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPP-YQDT-MRNSASGPGWYGAN . . . : .::. . .:. :. . : : : .:.: : : . . NP_660 TQFSDGGEEDEEDEG-EKLSYLNSLAAADGH-GDSGLCPQGYVHTVLRDSCSEPKEHEEE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELE :. . : . : . ... :. . .. : : . ::: :::::::::.::: NP_660 PE-----VVRDRSQKSCQLKKSLETAGDCKAAEESERPKPRS-RRKPRVLFSQAQVFELE 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 RRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGG ::::::.:::::::::::: ..:: :::::::::.::: ::: .::. . NP_660 RRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLEL---------- 170 180 190 200 210 240 250 260 270 280 pF1KB8 GGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPC-----QA-GAPAPGAASLQGH----AQ :. : ::::::::::.::::: :: ::: .:: .. : NP_660 ---GAHAPPPP------PRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYNSFPAY 220 230 240 250 260 290 300 310 320 330 340 pF1KB8 QQAQHQAQAAQAAAAAISVGSGGAGLG-AHP-GHQPGSAGQSP-DLAHHAASPAALQGQV .. : :: ::::: .... ... : :.: : :..: : : . : :: : NP_660 GYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGGGGGGGTSAATTAMQPACSAAGGGPF 270 280 290 300 310 320 350 360 370 pF1KB8 SSLSHLNSSGSDYGTMSCSTLLYGRTW ..:.:.. :: NP_660 VNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQGIRAW 330 340 350 360 >>NP_001129743 (OMIM: 217095,611770) homeobox protein Nk (301 aa) initn: 496 init1: 332 opt: 373 Z-score: 263.5 bits: 57.1 E(85289): 6.1e-08 Smith-Waterman score: 498; 36.8% identity (54.1% similar) in 353 aa overlap (1-342:1-297) 10 20 30 40 50 60 pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH : .:: .:::::.::: ::. :. :: : ... . NP_001 MLLSPVTSTPFSVKDILR-LERE------------------RSCPAASPHPRVRKSPENF 10 20 30 40 70 80 90 100 110 pF1KB8 HGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELP--PYQDTMRNSASGPGWYGANP . .: : . :.: :: . .: . :: : : . ... .: : .: NP_001 Q-----YLRMDAEPRGSEVHNAGGGGGDRKL-DGSEPPGGPCEAVLEMDAERMG----EP 50 60 70 80 90 120 130 140 150 160 170 pF1KB8 DPRFPAISRFMGPASGMNMSGMGGLGSLGD-VSKNMAPLPSA-PRRKRRVLFSQAQVYEL .: . : : : .: . :.:. :: : . . :.: ::: ::::::::: : NP_001 QPGLNAAS----PLGGGTRVPERGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLAL 100 110 120 130 140 180 190 200 210 220 230 pF1KB8 ERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGG :::::::.:::::::::::: ..:: :::::::::.::: ::: .::. . NP_001 ERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYKCKRQRQDKSLEL--------- 150 160 170 180 190 240 250 260 270 280 290 pF1KB8 GGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQA .: : .::::::::::.::::: . :.::: .. . . .. . NP_001 -----AGHPL-------TPRRVAVPVLVRDGKPCLG--PGPGAPAFPSPYSAAVSPYSCY 200 210 220 230 240 300 310 320 330 340 pF1KB8 AQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAH--HAASP-----AALQGQVSSLSH . ..: ..: : :: : : . : ..: . :.: :.::: NP_001 GGYSGAPYGAGYGTCYAGAPSGPAPHTPLASAGFGHGGQNATPQGHLAATLQGVRAW 250 260 270 280 290 300 350 360 370 pF1KB8 LNSSGSDYGTMSCSTLLYGRTW >>NP_002500 (OMIM: 604612) homeobox protein Nkx-2.2 [Hom (273 aa) initn: 491 init1: 357 opt: 368 Z-score: 260.8 bits: 56.5 E(85289): 8.7e-08 Smith-Waterman score: 456; 38.9% identity (59.1% similar) in 257 aa overlap (62-303:26-255) 40 50 60 70 80 90 pF1KB8 GGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNL :.:. . . : :. .. : : .: : NP_002 MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEG-PEPAKRA-GPLGQGAL 10 20 30 40 50 100 110 120 130 140 pF1KB8 GNMSELP---PYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGD .. :: :. :. : . : ... .. .. . . : .. :. . : . NP_002 DAVQSLPLKNPFYDSSDNPYT--RWLASTEGLQY-SLHGLAAGAPPQDSSSKSPEPSADE 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB8 VSKNMAPLP-----SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPT : : .. .::::::::.::.:::::::.::.::::::::::::.:.:::: NP_002 SPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPT 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB8 QVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVL ::::::::::::::: .:. . : : :::::::::: NP_002 QVKIWFQNHRYKMKRARAEKGMEV--------------TPLP--------SPRRVAVPVL 180 190 200 270 280 290 300 310 pF1KB8 VKDGKPCQA-GAPAPGAASLQG------HAQQQAQHQAQAAQAAAAAISVGSGGAGLGAH :.:::::.: : .::..:. .. :. ::. :: ..:. NP_002 VRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQA 210 220 230 240 250 260 320 330 340 350 360 370 pF1KB8 PGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW NP_002 QQWTW 270 >>XP_006723629 (OMIM: 604612) PREDICTED: homeobox protei (202 aa) initn: 466 init1: 357 opt: 362 Z-score: 258.4 bits: 55.6 E(85289): 1.2e-07 Smith-Waterman score: 450; 44.7% identity (63.1% similar) in 206 aa overlap (114-303:3-184) 90 100 110 120 130 pF1KB8 GGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRF-PAISRFMGPASG---MNMSG ..:. :.: :.. . : :.: .. :. XP_006 MIFSATSPPKFSPTL--LHGLAAGAPPQDSSS 10 20 30 140 150 160 170 180 190 pF1KB8 MGGLGSLGDVSKNMAPLP-----SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHL . : . : : .. .::::::::.::.:::::::.::.:::::::::: XP_006 KSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHL 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB8 ASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQS ::.:.::::::::::::::::::: .:. . : : : XP_006 ASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEV--------------TPLP--------S 100 110 120 260 270 280 290 300 pF1KB8 PRRVAVPVLVKDGKPCQA-GAPAPGAASLQG------HAQQQAQHQAQAAQAAAAAISVG ::::::::::.:::::.: : .::..:. .. :. ::. :: ..:. XP_006 PRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQY 130 140 150 160 170 180 310 320 330 340 350 360 pF1KB8 SGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLY XP_006 PTAHPLVQAQQWTW 190 200 >>NP_055175 (OMIM: 603245) homeobox protein Nkx-2.8 [Hom (239 aa) initn: 452 init1: 325 opt: 358 Z-score: 255.0 bits: 55.2 E(85289): 1.8e-07 Smith-Waterman score: 446; 39.0% identity (58.3% similar) in 264 aa overlap (82-338:2-233) 60 70 80 90 100 110 pF1KB8 AMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGP :..: . .. .. .:: ::... : NP_055 MATSGRLSFTVRSLLDLPE-QDAQHLPRREP 10 20 30 120 130 140 150 160 pF1KB8 GWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAP------RRKRR . .::: .. : . . :.. : : :. . :..: :.::: NP_055 EPRAPQPDPCAAWLDSERGHYPSSDESSLE--TSPPDSSQRPSARPASPGSDAEKRKKRR 40 50 60 70 80 170 180 190 200 210 220 pF1KB8 VLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAA ::::.::. ::::::.::.::::::::.:::...::::::::::::::::.:: :: NP_055 VLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAA 90 100 110 120 130 140 230 240 250 260 270 280 pF1KB8 QQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGH .. :. . .: :::.:::::.::.:: .: :.. . : NP_055 ESPDLAASA------------ELHAAPGLLRRVVVPVLVRDGQPCGGG----GGGEV-GT 150 160 170 180 190 290 300 310 320 330 340 pF1KB8 AQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSA-GQSPDLAHHAASPAALQGQV : ::.. : ::: : ..:. :::: : : .: :::: NP_055 A--AAQEKCGAPPAAACP---------LPGYPAFGPGSALGLFPAY-QHLASPALVSWNW 200 210 220 230 350 360 370 pF1KB8 SSLSHLNSSGSDYGTMSCSTLLYGRTW >>NP_004378 (OMIM: 108900,187500,217095,225250,600584,61 (324 aa) initn: 484 init1: 331 opt: 334 Z-score: 237.8 bits: 52.5 E(85289): 1.7e-06 Smith-Waterman score: 474; 35.0% identity (52.9% similar) in 374 aa overlap (1-371:1-324) 10 20 30 40 50 pF1KB8 MSMSPKHT-TPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVG : :: : :::::.:::. ::.. .... : :.: .. :: . . NP_004 MFPSPALTPTPFSVKDILN-LEQQQRSLAAAG-----ELSARLEATLAPSSCMLAAFKPE 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 HHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPD ... :: : :.:.: : : . : .: . . : : : NP_004 AYAGPEAA----APGLPELR--AELGRAPSPAKCASAFPAAPAFYPRAYSDPD---PAKD 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 PRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKR-RVLFSQAQVYELER :: : .. .. : . . : : : ::.. :::::::::::::: NP_004 PR----------AEKKELCALQKAVELEKTEADNAERPRARRRRKPRVLFSQAQVYELER 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 RFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGG :::::.:::::::..:::...:: :::::::::.::: ::: .: : :. NP_004 RFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQD----QTLEL------- 160 170 180 190 200 240 250 260 270 280 290 pF1KB8 GGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQ .: : ::.::::::.::::: : :: : . : . . ..: : NP_004 ---VGLPPPPPPP---ARRIAVPVLVRDGKPCL-GDSAPYAPAY-GVGLNPYGYNAYPAY 210 220 230 240 250 300 310 320 330 340 350 pF1KB8 AAAAAISVGSGGAGLGAHPGHQPGSAGQSPDL-AHHAASPAALQGQVSSLSHLNSSGSDY . .. . . : . .:.: :: :: : ::. .. :..:. ..: : NP_004 PGYGGAACSPGYSCTAAYP------AGPSPAQPATAAANNNFVNFGVGDLNAVQSPGIPQ 260 270 280 290 300 310 360 370 pF1KB8 GTMSCSTLLYGRTW .. . ::: :.: NP_004 SNSGVSTLHGIRAW 320 >>NP_005506 (OMIM: 142994,176450) motor neuron and pancr (401 aa) initn: 326 init1: 269 opt: 319 Z-score: 227.0 bits: 50.8 E(85289): 6.6e-06 Smith-Waterman score: 319; 34.9% identity (59.1% similar) in 235 aa overlap (28-249:104-332) 10 20 30 40 50 pF1KB8 MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHA : ::: :.: . : :: .:: : NP_005 RAESPSPPRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPGAAAAAAAAAAAAA 80 90 100 110 120 130 60 70 80 90 100 110 pF1KB8 VGHHG-AVTAAYHMTAAGVPQLSHSAVGG---YCNGNLGNMSELPPYQDTMRNSASGPGW .: . .. . . .::.: ...:. : : . . . : . .. : : : NP_005 AGGLALGLHPGGAQGGAGLP--AQAALYGHPVYGYSAAAAAAALAGQHPAL--SYSYPQV 140 150 160 170 180 120 130 140 150 160 pF1KB8 YGANP----DP-RFPAISRFMGPASGMNMSGMGGLGSLGDV-SKNMAPLPSAPRRKRRVL ::.: :: .. : . . . .:: : .. : :. .. : . :: : .. NP_005 QGAHPAHPADPIKLGAGTFQLDQWLRASTAGMI-LPKMPDFNSQAQSNLLGKCRRPRTAF 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB8 FSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR--QAKDKAA :: :. :::..:: .:::: :.: ..:. . :: :::::::::.:.: :: .::..:: NP_005 TSQ-QLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAA 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB8 QQQLQQDSGGGGGG-GGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQG :. .: .::::.: ::. : .. NP_005 QEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDEDEDDEDH 310 320 330 340 350 360 371 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:26:10 2016 done: Sun Nov 6 21:26:12 2016 Total Scan time: 9.890 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]