Result of FASTA (omim) for
pFN21AE0250
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0250, 196 aa
1>>>pF1KE0250 196 - 196 aa - 196 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6379+/-0.00036; mu= 12.2984+/- 0.023
mean_var=98.5741+/-19.435, 0's: 0 Z-trim(116.1): 152 B-trim: 50 in 2/52
Lambda= 0.129179
statistics sampled from 26799 (27092) to 26799 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.318), width: 16
Scan time: 5.410
The best scores are: opt bits E(85289)
NP_009167 (OMIM: 606988) calcineurin B homologous ( 195) 806 160.1 2.1e-39
XP_016877368 (OMIM: 606988) PREDICTED: calcineurin ( 123) 431 90.0 1.6e-18
NP_000936 (OMIM: 601302) calcineurin subunit B typ ( 170) 270 60.1 2.2e-09
XP_016875021 (OMIM: 611585) PREDICTED: calcineurin ( 251) 259 58.2 1.2e-08
NP_671709 (OMIM: 613821) calcineurin subunit B typ ( 173) 250 56.4 3e-08
NP_060369 (OMIM: 611585) calcineurin B homologous ( 214) 244 55.4 7.6e-08
XP_011536805 (OMIM: 611585) PREDICTED: calcineurin ( 202) 222 51.3 1.2e-06
XP_016875022 (OMIM: 611585) PREDICTED: calcineurin ( 216) 219 50.7 1.9e-06
NP_006374 (OMIM: 605564,609439,614869) calcium and ( 187) 182 43.8 0.00021
NP_001122298 (OMIM: 603315) neuronal calcium senso ( 172) 180 43.4 0.00025
NP_055101 (OMIM: 603315) neuronal calcium sensor 1 ( 190) 180 43.4 0.00027
XP_005254183 (OMIM: 605564,609439,614869) PREDICTE ( 210) 176 42.7 0.00049
NP_004267 (OMIM: 605563) calcium-binding protein 1 ( 167) 172 41.9 0.00069
NP_001258818 (OMIM: 605564,609439,614869) calcium ( 138) 166 40.7 0.0013
NP_001258817 (OMIM: 605564,609439,614869) calcium ( 144) 166 40.7 0.0014
XP_006720437 (OMIM: 605564,609439,614869) PREDICTE ( 144) 166 40.7 0.0014
NP_001161797 (OMIM: 611585) calcineurin B homologo ( 187) 167 41.0 0.0014
NP_001288153 (OMIM: 605564,609439,614869) calcium ( 192) 166 40.8 0.0017
NP_775285 (OMIM: 604661) Kv channel-interacting pr ( 227) 166 40.9 0.0019
NP_112482 (OMIM: 605563) calcium-binding protein 1 ( 227) 165 40.7 0.0021
NP_001028849 (OMIM: 605563) calcium-binding protei ( 370) 166 41.1 0.0027
XP_011519463 (OMIM: 605564,609439,614869) PREDICTE ( 167) 160 39.6 0.0033
XP_011512189 (OMIM: 608182) PREDICTED: Kv channel- ( 195) 157 39.1 0.0054
XP_011512191 (OMIM: 608182) PREDICTED: Kv channel- ( 195) 157 39.1 0.0054
XP_011512188 (OMIM: 608182) PREDICTED: Kv channel- ( 223) 157 39.2 0.0059
XP_011512187 (OMIM: 608182) PREDICTED: Kv channel- ( 232) 157 39.2 0.0061
XP_011512186 (OMIM: 608182) PREDICTED: Kv channel- ( 236) 157 39.2 0.0062
XP_011512185 (OMIM: 608182) PREDICTED: Kv channel- ( 240) 157 39.2 0.0063
XP_016875728 (OMIM: 605563) PREDICTED: calcium-bin ( 202) 156 39.0 0.0063
XP_011512184 (OMIM: 608182) PREDICTED: Kv channel- ( 257) 157 39.2 0.0066
XP_016858819 (OMIM: 610646) PREDICTED: calcium and ( 140) 151 37.9 0.0092
>>NP_009167 (OMIM: 606988) calcineurin B homologous prot (195 aa)
initn: 796 init1: 454 opt: 806 Z-score: 828.4 bits: 160.1 E(85289): 2.1e-39
Smith-Waterman score: 806; 61.0% identity (87.2% similar) in 195 aa overlap (1-195:1-194)
10 20 30 40 50 60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
::::.: . . :..:::::.... ::. :: .::....: ::: :.:.: ::.:
NP_009 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
:::::::..:::.: ..:.: ::.:.::::::.::.. ...: . ::::::: ::::.::
NP_009 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNE-KSKDVNGPEPLNSRSNKLHFAF
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
.:::::.: :::: :.:::::.::::....::: .:::::.::::.:::.:.::.::.:
NP_009 RLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKV
120 130 140 150 160 170
190
pF1KE0 LEKMDVEQKMSIRILK
:::.:::::::::.:
NP_009 LEKVDVEQKMSIRFLH
180 190
>>XP_016877368 (OMIM: 606988) PREDICTED: calcineurin B h (123 aa)
initn: 419 init1: 356 opt: 431 Z-score: 453.3 bits: 90.0 E(85289): 1.6e-18
Smith-Waterman score: 431; 52.0% identity (79.7% similar) in 123 aa overlap (1-123:1-122)
10 20 30 40 50 60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
::::.: . . :..:::::.... ::. :: .::....: ::: :.:.: ::.:
XP_016 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
:::::::..:::.: ..:.: ::.:.::::::.::.. ...: . ::::::: ::::
XP_016 PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNE-KSKDVNGPEPLNSRSNKLHLEE
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
. :
XP_016 ERYI
120
>>NP_000936 (OMIM: 601302) calcineurin subunit B type 1 (170 aa)
initn: 414 init1: 267 opt: 270 Z-score: 289.3 bits: 60.1 E(85289): 2.2e-09
Smith-Waterman score: 368; 35.5% identity (66.3% similar) in 172 aa overlap (23-194:15-170)
10 20 30 40 50 60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
:. . :: .::. :: ...: :: ..... : :
NP_000 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQN
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
:: .:.:. : ::. .::: :.. ...: :.. .::..::
NP_000 PLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKE----------------QKLRFAF
60 70 80 90
130 140 150 160 170 180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
..::.:.:: :: :..:::..::: .. . ::..:.:.:. .::.:::: .:: ::
NP_000 RIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAV
100 110 120 130 140 150
190
pF1KE0 LEKMDVEQKMSIRILK
. .:...:: . .
NP_000 VGGLDIHKKMVVDV
160 170
>>XP_016875021 (OMIM: 611585) PREDICTED: calcineurin B h (251 aa)
initn: 226 init1: 93 opt: 259 Z-score: 276.0 bits: 58.2 E(85289): 1.2e-08
Smith-Waterman score: 259; 29.4% identity (66.3% similar) in 187 aa overlap (20-195:70-242)
10 20 30 40
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRM
.::::. .. .::.::. :. .. . .
XP_016 PERDARPGAPAAGTMGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPT-IRKE
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE0 DLQQIGALAVNPLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTET
..... : .::. ..:...:: :.: .....: :. ....:::. :: :
XP_016 NFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-T
100 110 120 130 140 150
110 120 130 140 150
pF1KE0 QDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLR-LMVGV-QVTEEQLENIAD
.: .. : ::..::.. :..:: : ::.:. .:. .:.. :. : .. .:. ..:::
XP_016 MDEEQVE--LSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIAD
160 170 180 190 200 210
160 170 180 190
pF1KE0 RTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
...:: : . . . .:.: :: .:.:
XP_016 GAMMEAASVCMGQMIW-------QGIDIETKMHVRFLNMETMALCH
220 230 240 250
>>NP_671709 (OMIM: 613821) calcineurin subunit B type 2 (173 aa)
initn: 430 init1: 250 opt: 250 Z-score: 269.1 bits: 56.4 E(85289): 3e-08
Smith-Waterman score: 354; 35.7% identity (66.1% similar) in 168 aa overlap (23-190:18-169)
10 20 30 40 50 60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
:.. . :: .::. :: .:.: :: ..... : :
NP_671 MSTMGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHN
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
:: :.:. : ::. .::: :. ..: ::. .::..::
NP_671 PLVRRVIDVFDTDGDGEVDFKEFILGTSQFSVKGDEE----------------QKLRFAF
60 70 80 90
130 140 150 160 170 180
pF1KE0 QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
..::.:.:: :: :..:::..::: ..:. ::....:.:. :.:::: .:: ::.
NP_671 SIYDMDKDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAV
100 110 120 130 140 150
190
pF1KE0 LEKMDVEQKMSIRILK
.. .....:.
NP_671 VRDLEIHKKLVLIV
160 170
>>NP_060369 (OMIM: 611585) calcineurin B homologous prot (214 aa)
initn: 226 init1: 93 opt: 244 Z-score: 261.8 bits: 55.4 E(85289): 7.6e-08
Smith-Waterman score: 283; 29.9% identity (66.5% similar) in 197 aa overlap (20-195:17-205)
10 20 30 40 50 60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
.::::. .. .::.::. :. .. . . ..... : .:
NP_060 MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPT-IRKENFNNVPDLELN
10 20 30 40 50
70 80 90 100 110
pF1KE0 PLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNS
:. ..:...:: :.: .....: :. ....:::. :: :.: .. : :
NP_060 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-TMDEEQVE--LS
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 RRNKLHYAFQLYDLDRDGKISRHEMLQVLR-LMVGV-QVTEEQLENIADRTVQEA-----
:..::.. :..:: : ::.:. .:. .:.. :. : .. .:. ..::: ...::
NP_060 RKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCM
120 130 140 150 160 170
170 180 190
pF1KE0 -----DEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
:. .: ..: .: : . .:.: :: .:.:
NP_060 GQMEPDQVYEG-ITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
180 190 200 210
>>XP_011536805 (OMIM: 611585) PREDICTED: calcineurin B h (202 aa)
initn: 202 init1: 93 opt: 222 Z-score: 240.0 bits: 51.3 E(85289): 1.2e-06
Smith-Waterman score: 261; 29.0% identity (65.8% similar) in 193 aa overlap (24-195:9-193)
10 20 30 40 50 60
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
:. .. .::.::. :. .. . . ..... : .:
XP_011 MESSQEHVSSDQIEQLHRRFKQLSGDQPT-IRKENFNNVPDLELN
10 20 30 40
70 80 90 100 110
pF1KE0 PLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNS
:. ..:...:: :.: .....: :. ....:::. :: :.: .. : :
XP_011 PIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-TMDEEQVE--LS
50 60 70 80 90
120 130 140 150 160
pF1KE0 RRNKLHYAFQLYDLDRDGKISRHEMLQVLR-LMVGV-QVTEEQLENIADRTVQEA-----
:..::.. :..:: : ::.:. .:. .:.. :. : .. .:. ..::: ...::
XP_011 RKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCM
100 110 120 130 140 150
170 180 190
pF1KE0 -----DEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
:. .: ..: .: : . .:.: :: .:.:
XP_011 GQMEPDQVYEG-ITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
160 170 180 190 200
>>XP_016875022 (OMIM: 611585) PREDICTED: calcineurin B h (216 aa)
initn: 201 init1: 91 opt: 219 Z-score: 236.6 bits: 50.7 E(85289): 1.9e-06
Smith-Waterman score: 219; 31.0% identity (69.8% similar) in 129 aa overlap (20-139:70-191)
10 20 30 40
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRM
.::::. .. .::.::. :. .. . .
XP_016 PERDARPGAPAAGTMGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPT-IRKE
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE0 DLQQIGALAVNPLGDRIIESFF--------PDG-SQRVDFPGFVRVLAHFRPVEDEDTET
..... : .::. ..:...:: :.: .....: :. ....:::. :: :
XP_016 NFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPI---DT-T
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE0 QDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRT
.: .. : ::..::.. :..:: : ::.:. .:. .:
XP_016 MDEEQVE--LSRKEKLRFLFHMYDSDSDGRITLEEYRNVKWSRSCCRETLTSRRSPLAPS
160 170 180 190 200 210
170 180 190
pF1KE0 VQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
XP_016 PTGP
>>NP_006374 (OMIM: 605564,609439,614869) calcium and int (187 aa)
initn: 253 init1: 152 opt: 182 Z-score: 200.2 bits: 43.8 E(85289): 0.00021
Smith-Waterman score: 224; 27.9% identity (56.8% similar) in 190 aa overlap (15-194:14-187)
10 20 30 40 50
pF1KE0 MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRN------KKGYLSRMDLQ--
:. . : :.. ..:.:: :: : : .:. . .. ..
NP_006 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 -QIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNS
:. : ::. .::. .: :: . : :: ... : :.. :. :
NP_006 IQMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFS----VLCESA-------PREL--
60 70 80 90 100
120 130 140 150 160 170
pF1KE0 RRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGA
: .:::..::.. :. : .... .: .. .. ::.. . :....::: ::::
NP_006 ---KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGK
110 120 130 140 150 160
180 190
pF1KE0 VSFVEFTKSLEKM-DVEQKMSIRILK
..:..: . : : . . :::
NP_006 LGFADFEDMIAKAPDFLSTFHIRI
170 180
>>NP_001122298 (OMIM: 603315) neuronal calcium sensor 1 (172 aa)
initn: 151 init1: 113 opt: 180 Z-score: 198.6 bits: 43.4 E(85289): 0.00025
Smith-Waterman score: 180; 31.5% identity (58.0% similar) in 162 aa overlap (43-192:14-167)
20 30 40 50 60 70
pF1KE0 DGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFP
::... :. : . . .: ..:::
NP_001 MATITEKEVQQWYKGFIKDCPSGQLDAAGFQ----KIYKQFFP
10 20 30
80 90 100 110 120
pF1KE0 DGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSR---RNKLHYAFQLYDLDRDG
:. . : : :. : .: : .. . ..:: .::..::.::::: ::
NP_001 FGDP-TKFATF--VFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE0 KISRHEMLQV---LRLMVG--VQVTEEQL--ENIADRTVQEADEDGDGAVSFVEFTKSLE
:.:.:::.. . ::: :.. ::. :. .:: :...:: ... :: ..
NP_001 YITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEG-S
100 110 120 130 140 150
190
pF1KE0 KMD--VEQKMSIRILK
: : . : .:.
NP_001 KADPSIVQALSLYDGLV
160 170
196 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:14:18 2016 done: Thu Nov 3 19:14:19 2016
Total Scan time: 5.410 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]