FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1951, 508 aa 1>>>pF1KE1951 508 - 508 aa - 508 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3881+/-0.000384; mu= 0.7343+/- 0.024 mean_var=249.1519+/-51.685, 0's: 0 Z-trim(121.0): 183 B-trim: 1558 in 1/58 Lambda= 0.081254 statistics sampled from 36750 (36937) to 36750 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.433), width: 16 Scan time: 9.920 The best scores are: opt bits E(85289) NP_114143 (OMIM: 610020) TBC1 domain family member ( 508) 3493 422.5 1.4e-117 NP_001191169 (OMIM: 610020) TBC1 domain family mem ( 515) 3469 419.7 9.9e-117 NP_056342 (OMIM: 613620) TBC1 domain family member ( 808) 1952 242.1 4.8e-63 NP_940919 (OMIM: 610831) carabin isoform 1 [Homo s ( 446) 1384 175.3 3.4e-43 XP_006718601 (OMIM: 610831) PREDICTED: carabin iso ( 446) 1384 175.3 3.4e-43 XP_006718603 (OMIM: 610831) PREDICTED: carabin iso ( 446) 1384 175.3 3.4e-43 XP_006718602 (OMIM: 610831) PREDICTED: carabin iso ( 446) 1384 175.3 3.4e-43 XP_011544091 (OMIM: 613620) PREDICTED: TBC1 domain ( 703) 1228 157.1 1.5e-37 XP_011543304 (OMIM: 610831) PREDICTED: carabin iso ( 313) 1135 146.0 1.6e-34 XP_011544092 (OMIM: 613620) PREDICTED: TBC1 domain ( 536) 1115 143.8 1.2e-33 XP_006718605 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25 XP_006718604 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25 XP_006718606 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25 XP_006718607 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25 XP_011543303 (OMIM: 610831) PREDICTED: carabin iso ( 345) 859 113.6 9.3e-25 XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 542 76.8 2.6e-13 NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 542 76.8 2.7e-13 XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 542 76.8 3.2e-13 XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 542 76.8 3.2e-13 XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 542 76.9 3.3e-13 XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 542 76.9 3.3e-13 NP_001243437 (OMIM: 610831) carabin isoform 2 [Hom ( 310) 529 74.9 3.8e-13 NP_055503 (OMIM: 605405) USP6 N-terminal-like prot ( 828) 504 72.3 6.1e-12 NP_001073960 (OMIM: 605405) USP6 N-terminal-like p ( 845) 504 72.3 6.2e-12 XP_016872460 (OMIM: 605405) PREDICTED: USP6 N-term ( 846) 504 72.3 6.2e-12 XP_016872462 (OMIM: 605405) PREDICTED: USP6 N-term ( 851) 504 72.3 6.2e-12 XP_006717605 (OMIM: 605405) PREDICTED: USP6 N-term ( 856) 504 72.3 6.2e-12 XP_011518064 (OMIM: 605405) PREDICTED: USP6 N-term ( 856) 504 72.3 6.2e-12 XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 493 71.1 1.6e-11 XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 493 71.1 1.6e-11 XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11 XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11 XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11 NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 493 71.1 1.8e-11 XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11 XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 493 71.1 1.8e-11 NP_001254501 (OMIM: 609871) TBC1 domain family mem ( 468) 461 67.1 1.3e-10 XP_011517145 (OMIM: 609871) PREDICTED: TBC1 domain ( 468) 461 67.1 1.3e-10 XP_016870388 (OMIM: 609871) PREDICTED: TBC1 domain ( 483) 461 67.1 1.3e-10 NP_001254500 (OMIM: 609871) TBC1 domain family mem ( 928) 461 67.3 2.2e-10 XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 456 66.7 2.8e-10 XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 456 66.7 2.9e-10 XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 456 66.7 2.9e-10 NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 456 66.7 3e-10 XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 456 66.7 3e-10 NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 456 66.7 3e-10 XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 456 66.7 3e-10 XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 456 66.7 3.1e-10 XP_016857765 (OMIM: 602942) PREDICTED: ecotropic v ( 859) 456 66.7 3.1e-10 XP_016857760 (OMIM: 602942) PREDICTED: ecotropic v ( 903) 456 66.7 3.2e-10 >>NP_114143 (OMIM: 610020) TBC1 domain family member 10A (508 aa) initn: 3493 init1: 3493 opt: 3493 Z-score: 2231.9 bits: 422.5 E(85289): 1.4e-117 Smith-Waterman score: 3493; 100.0% identity (100.0% similar) in 508 aa overlap (1-508:1-508) 10 20 30 40 50 60 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 IVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 RVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 DGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 KIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 IEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 IEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSA 430 440 450 460 470 480 490 500 pF1KE1 PQDLAPQVSAHHRSQESLTSQESEDTYL :::::::::::::::::::::::::::: NP_114 PQDLAPQVSAHHRSQESLTSQESEDTYL 490 500 >>NP_001191169 (OMIM: 610020) TBC1 domain family member (515 aa) initn: 3479 init1: 3045 opt: 3469 Z-score: 2216.6 bits: 419.7 E(85289): 9.9e-117 Smith-Waterman score: 3469; 98.6% identity (98.6% similar) in 515 aa overlap (1-508:1-515) 10 20 30 40 50 60 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 IVGSQGAEGA-------LEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIP :::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 IVGSQGAEGAPCPLLHRLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 PSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 KLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 MFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE1 LPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE1 LDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKD 430 440 450 460 470 480 480 490 500 pF1KE1 SAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL ::::::::::::::::::::::::::::::::::: NP_001 SAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL 490 500 510 >>NP_056342 (OMIM: 613620) TBC1 domain family member 10B (808 aa) initn: 1965 init1: 1922 opt: 1952 Z-score: 1252.9 bits: 242.1 E(85289): 4.8e-63 Smith-Waterman score: 1969; 59.0% identity (79.0% similar) in 505 aa overlap (6-504:255-741) 10 20 30 pF1KE1 MAKSNGENGPRAPAAGESLSGTRE-SLAQGPDAAT : .:::. : ..:: :: .: . NP_056 EAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAP-DTLSYLDSVSLMSGTLESL 230 240 250 260 270 280 40 50 60 70 80 90 pF1KE1 TDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEE-VPLEVLRQRESKWLDMLNNW .:..::.::::: ::.: :. ::.::. ::: . :.:: .:..: :::: :::::..:: NP_056 ADDVSSMGSDSEINGLALRKTDKYGFLGGSQYS-GSLESSIPVDVARQRELKWLDMFSNW 290 300 310 320 330 340 100 110 120 130 140 150 pF1KE1 DKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDV :::.... .:..:::.:::: :::..::::::..: :.::::::.::. .::::::::: NP_056 DKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDV 350 360 370 380 390 400 160 170 180 190 200 210 pF1KE1 IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE ::.::::::::::::..:::::::::.:.:::::.:::.:::::::::.::::::::::: NP_056 IEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAE 410 420 430 440 450 460 220 230 240 250 260 270 pF1KE1 QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTE ::::::::::.:::::::: ::::::::::.:.::...::.::.:: ::.:::.::::: NP_056 QAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTE 470 480 490 500 510 520 280 290 300 310 320 330 pF1KE1 WFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIER :::: :.:::::.::::::::::::::::::::.::::.:.::: ::...:::.:::.:. NP_056 WFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQ 530 540 550 560 570 580 340 350 360 370 380 390 pF1KE1 LRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAI ::.: . ::: :::.::..::::: ::::. ::..:.::::::: : ::::..:: NP_056 LRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAI 590 600 610 620 630 640 400 410 420 430 440 pF1KE1 LDAEPGPRPALQPSPSI-RLPLDAPLPGSKAK---PKPPKQAQKEQRKQMKGRGQLEKPP . . .: : :: :. :: ::.: :.:: . :. : : NP_056 HEERRRQQPPLGPSSSLLSLP-GLKSRGSRAAGGAPSPPPPV----RRASAG-------P 650 660 670 680 690 450 460 470 480 490 500 pF1KE1 APNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL ::. ::.: : : : .:.: :. .. : . ...... .::.: NP_056 APGP--VVTAEG-LHPSLPSPTGNSTPLGSS-KETRKQEKERQKQEKERQKQEKEREKER 700 710 720 730 740 NP_056 QKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGGDRPSAEARQDA 750 760 770 780 790 800 >>NP_940919 (OMIM: 610831) carabin isoform 1 [Homo sapie (446 aa) initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43 Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436) 10 20 30 40 50 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG :.:.: :. :. :::::::: .: . :. :..: NP_940 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG 10 20 30 40 60 70 80 90 100 110 pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR :: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.: NP_940 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL : : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: : NP_940 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ ..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::.. NP_940 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG ::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. :: NP_940 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER ....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..:: NP_940 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA ...:: :: . .. : :: ::.::..:. : : . .: : :. .. NP_940 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP 350 360 370 380 390 420 430 440 450 460 470 pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP : .:.::.. . . : ..: :: .: :: :.. NP_940 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF 400 410 420 430 440 480 490 500 pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL >>XP_006718601 (OMIM: 610831) PREDICTED: carabin isoform (446 aa) initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43 Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436) 10 20 30 40 50 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG :.:.: :. :. :::::::: .: . :. :..: XP_006 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG 10 20 30 40 60 70 80 90 100 110 pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR :: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.: XP_006 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL : : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: : XP_006 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ ..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::.. XP_006 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG ::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. :: XP_006 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER ....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..:: XP_006 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA ...:: :: . .. : :: ::.::..:. : : . .: : :. .. XP_006 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP 350 360 370 380 390 420 430 440 450 460 470 pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP : .:.::.. . . : ..: :: .: :: :.. XP_006 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF 400 410 420 430 440 480 490 500 pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL >>XP_006718603 (OMIM: 610831) PREDICTED: carabin isoform (446 aa) initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43 Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436) 10 20 30 40 50 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG :.:.: :. :. :::::::: .: . :. :..: XP_006 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG 10 20 30 40 60 70 80 90 100 110 pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR :: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.: XP_006 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL : : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: : XP_006 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ ..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::.. XP_006 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG ::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. :: XP_006 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER ....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..:: XP_006 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA ...:: :: . .. : :: ::.::..:. : : . .: : :. .. XP_006 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP 350 360 370 380 390 420 430 440 450 460 470 pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP : .:.::.. . . : ..: :: .: :: :.. XP_006 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF 400 410 420 430 440 480 490 500 pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL >>XP_006718602 (OMIM: 610831) PREDICTED: carabin isoform (446 aa) initn: 1320 init1: 1291 opt: 1384 Z-score: 896.6 bits: 175.3 E(85289): 3.4e-43 Smith-Waterman score: 1384; 46.6% identity (74.1% similar) in 440 aa overlap (24-453:7-436) 10 20 30 40 50 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG :.:.: :. :. :::::::: .: . :. :..: XP_006 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG 10 20 30 40 60 70 80 90 100 110 pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR :: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.: XP_006 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL : : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: : XP_006 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ ..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::.. XP_006 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG ::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. :: XP_006 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER ....:::::.:.. :::. :. :: : ::. ::.. : .:: ....: . ..:: XP_006 ARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSER 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 QIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEP--GPRPALQPS-PSIRLPLDA ...:: :: . .. : :: ::.::..:. : : . .: : :. .. XP_006 DLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP--RIVVQP 350 360 370 380 390 420 430 440 450 460 470 pF1KE1 PLPGSKAKPKPPKQAQKEQRKQMKG-----RGQ-LEKPPAPNQAMVVAAAGDACPPQHVP : .:.::.. . . : ..: :: .: :: :.. XP_006 P-----EEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF 400 410 420 430 440 480 490 500 pF1KE1 PKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL >>XP_011544091 (OMIM: 613620) PREDICTED: TBC1 domain fam (703 aa) initn: 1390 init1: 1202 opt: 1228 Z-score: 795.0 bits: 157.1 E(85289): 1.5e-37 Smith-Waterman score: 1245; 58.3% identity (76.5% similar) in 336 aa overlap (173-504:317-636) 150 160 170 180 190 200 pF1KE1 MSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPI : ::::.:.:::::.:::.:::::::::. XP_011 VSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLQQDLYRILKAYTIYRPDEGYCQAQAPV 290 300 310 320 330 340 210 220 230 240 250 260 pF1KE1 AAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSR :::::::::::::::::::::.:::::::: ::::::::::.:.::...::.::.:: : XP_011 AAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRR 350 360 370 380 390 400 270 280 290 300 310 320 pF1KE1 QKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVK :.:::.::::::::: :.:::::.::::::::::::::::::::.::::.:.::: ::.. XP_011 QRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLR 410 420 430 440 450 460 330 340 350 360 370 380 pF1KE1 ACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCR .:::.:::.:.::.: . ::: :::.::..::::: ::::. ::..:.::::::: : XP_011 SCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYR 470 480 490 500 510 520 390 400 410 420 430 pF1KE1 SPPRLHGAKAILDAEPGPRPALQPSPSI-RLPLDAPLPGSKAK---PKPPKQAQKEQRKQ ::::..:: . . .: : :: :. :: ::.: :.:: . :. XP_011 PSRRLHGSRAIHEERRRQQPPLGPSSSLLSLP-GLKSRGSRAAGGAPSPPPPV----RRA 530 540 550 560 570 580 440 450 460 470 480 490 pF1KE1 MKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESL : :::. ::.: : : : .:.: :. .. : . ...... XP_011 SAG-------PAPGP--VVTAEG-LHPSLPSPTGNSTPLGSS-KETRKQEKERQKQEKER 590 600 610 620 630 500 pF1KE1 TSQESEDTYL .::.: XP_011 QKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGG 640 650 660 670 680 690 >>XP_011543304 (OMIM: 610831) PREDICTED: carabin isoform (313 aa) initn: 1096 init1: 1096 opt: 1135 Z-score: 740.9 bits: 146.0 E(85289): 1.6e-34 Smith-Waterman score: 1135; 55.2% identity (82.3% similar) in 277 aa overlap (24-299:7-280) 10 20 30 40 50 pF1KE1 MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFG :.:.: :. :. :::::::: .: . :. :..: XP_011 MAQALGEDLVQPPE--LQDDSSSLGSDSELSGPGPYRQADRYG 10 20 30 40 60 70 80 90 100 110 pF1KE1 FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR :: ::.. : . : ...:::: ::..: ..:.: :....::....:.:::: .::.: XP_011 FIGGSSAEPGPGHP-PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDL : : :..: ...:: ..:: .::::.:...: ::::::::.:::::: ::::: : XP_011 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQ ..:::::::::::.::::::.:.:::::::.: :.:::::::::: ::::::. ..::.. XP_011 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEG ::.:....::... : .::::.. . ::::. :::.: :.:.::. .:::::: :. :: XP_011 LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 VKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTER XP_011 GGLTGVAVEAWGQRGHCPQGPGYSLRSREGLEP 290 300 310 >>XP_011544092 (OMIM: 613620) PREDICTED: TBC1 domain fam (536 aa) initn: 1103 init1: 1103 opt: 1115 Z-score: 725.1 bits: 143.8 E(85289): 1.2e-33 Smith-Waterman score: 1115; 66.8% identity (86.6% similar) in 232 aa overlap (6-235:255-484) 10 20 30 pF1KE1 MAKSNGENGPRAPAAGESLSGTRE-SLAQGPDAAT : .:::. : ..:: :: .: . XP_011 EAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAP-DTLSYLDSVSLMSGTLESL 230 240 250 260 270 280 40 50 60 70 80 90 pF1KE1 TDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEE-VPLEVLRQRESKWLDMLNNW .:..::.::::: ::.: :. ::.::. ::: . :.:: .:..: :::: :::::..:: XP_011 ADDVSSMGSDSEINGLALRKTDKYGFLGGSQYS-GSLESSIPVDVARQRELKWLDMFSNW 290 300 310 320 330 340 100 110 120 130 140 150 pF1KE1 DKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDV :::.... .:..:::.:::: :::..::::::..: :.::::::.::. .::::::::: XP_011 DKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDV 350 360 370 380 390 400 160 170 180 190 200 210 pF1KE1 IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE ::.::::::::::::..:::::::::.:.:::::.:::.:::::::::.::::::::::: XP_011 IEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAE 410 420 430 440 450 460 220 230 240 250 260 270 pF1KE1 QAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTE ::::::::::.:::::::: : XP_011 QAFWCLVQICDKYLPGYYSAGLALRSSSGWPWSCCATRWAQWRSCAPAKACMRPWSSCVT 470 480 490 500 510 520 508 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:58:02 2016 done: Sun Nov 6 21:58:04 2016 Total Scan time: 9.920 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]