FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1915, 452 aa 1>>>pF1KE1915 452 - 452 aa - 452 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1835+/-0.000375; mu= 12.8025+/- 0.023 mean_var=77.5282+/-15.681, 0's: 0 Z-trim(114.2): 95 B-trim: 525 in 1/55 Lambda= 0.145661 statistics sampled from 23848 (23945) to 23848 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.281), width: 16 Scan time: 8.390 The best scores are: opt bits E(85289) NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 3090 659.0 7.2e-189 NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 1954 420.2 3.8e-117 NP_116765 (OMIM: 600639) caspase-2 isoform 3 [Homo ( 108) 694 155.3 7.4e-38 NP_001220 (OMIM: 602234) caspase-9 isoform alpha p ( 416) 437 101.5 4.5e-21 XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 437 101.5 4.5e-21 XP_005246951 (OMIM: 114480,114550,211980,601763,60 ( 280) 427 99.3 1.4e-20 XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334) 421 98.1 3.8e-20 XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 421 98.1 5.1e-20 NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 421 98.1 5.1e-20 NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 421 98.1 5.1e-20 XP_005246945 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 421 98.2 5.2e-20 XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 XP_005246943 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 XP_005246947 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 421 98.2 5.2e-20 NP_001219 (OMIM: 114480,114550,211980,601763,60727 ( 496) 421 98.2 5.4e-20 XP_005246942 (OMIM: 114480,114550,211980,601763,60 ( 523) 421 98.2 5.7e-20 NP_001073594 (OMIM: 114480,114550,211980,601763,60 ( 538) 421 98.2 5.8e-20 NP_001217 (OMIM: 601532) caspase-6 isoform alpha p ( 293) 391 91.8 2.7e-18 NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 368 87.0 1e-16 NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 368 87.0 1e-16 XP_005246071 (OMIM: 602234) PREDICTED: caspase-9 i ( 333) 365 86.3 1.3e-16 NP_127463 (OMIM: 602234) caspase-9 isoform 3 [Homo ( 333) 365 86.3 1.3e-16 NP_150635 (OMIM: 147678) caspase-1 isoform gamma [ ( 311) 363 85.9 1.7e-16 XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 363 85.9 2e-16 XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 363 85.9 2e-16 NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 363 85.9 2e-16 NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 363 85.9 2e-16 XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 363 85.9 2.1e-16 XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 363 85.9 2.1e-16 NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 327 78.4 4.6e-14 NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 327 78.4 4.6e-14 XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272) 321 77.1 6.7e-14 XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 321 77.1 1.2e-13 NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 321 77.1 1.2e-13 NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 321 77.1 1.2e-13 NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 316 76.0 1.3e-13 NP_001129582 (OMIM: 602665) caspase-5 isoform c [H ( 292) 316 76.0 1.5e-13 NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376) 316 76.1 1.9e-13 XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 314 75.6 1.9e-13 XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 314 75.6 1.9e-13 NP_004338 (OMIM: 602665) caspase-5 isoform a precu ( 434) 316 76.1 2.1e-13 NP_150649 (OMIM: 602664) caspase-4 isoform gamma p ( 321) 314 75.6 2.1e-13 NP_001129584 (OMIM: 602665) caspase-5 isoform f pr ( 447) 316 76.1 2.2e-13 NP_001177945 (OMIM: 608633) inactive caspase-12 [H ( 341) 314 75.6 2.3e-13 NP_001216 (OMIM: 602664) caspase-4 isoform alpha p ( 377) 314 75.6 2.5e-13 >>NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepropro (452 aa) initn: 3090 init1: 3090 opt: 3090 Z-score: 3511.8 bits: 659.0 E(85289): 7.2e-189 Smith-Waterman score: 3090; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452) 10 20 30 40 50 60 pF1KE1 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY 370 380 390 400 410 420 430 440 450 pF1KE1 APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT :::::::::::::::::::::::::::::::: NP_116 APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT 430 440 450 >>NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo sap (312 aa) initn: 1954 init1: 1954 opt: 1954 Z-score: 2224.2 bits: 420.2 E(85289): 3.8e-117 Smith-Waterman score: 1954; 100.0% identity (100.0% similar) in 291 aa overlap (32-322:1-291) 10 20 30 40 50 60 pF1KE1 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLL :::::::::::::::::::::::::::::: NP_001 MHPHHQETLKKNRVVLAKQLLLSELLEHLL 10 20 30 70 80 90 100 110 120 pF1KE1 EKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 LSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTP 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 EFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVH 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 VLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFD 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 NANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTR ::::::::::::::::::::: NP_001 NANCPSLQNKPKMFFIQACRGGAIGSLGHLLLFTAATASLAL 280 290 300 310 >>NP_116765 (OMIM: 600639) caspase-2 isoform 3 [Homo sap (108 aa) initn: 694 init1: 694 opt: 694 Z-score: 800.7 bits: 155.3 E(85289): 7.4e-38 Smith-Waterman score: 694; 100.0% identity (100.0% similar) in 106 aa overlap (1-106:1-106) 10 20 30 40 50 60 pF1KE1 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT :::::::::::::::::::::::::::::::::::::::::::::: NP_116 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALHS 70 80 90 100 130 140 150 160 170 180 pF1KE1 TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT >>NP_001220 (OMIM: 602234) caspase-9 isoform alpha precu (416 aa) initn: 308 init1: 200 opt: 437 Z-score: 499.3 bits: 101.5 E(85289): 4.5e-21 Smith-Waterman score: 548; 31.3% identity (59.0% similar) in 422 aa overlap (32-430:1-410) 10 20 30 40 50 60 pF1KE1 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLL : .. :.. :. :...: ...: . :: NP_001 MDEADRRLLRRCRLRLVEELQVDQLWDALL 10 20 30 70 80 90 100 110 pF1KE1 EKDIITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDML .... .: : :: ..:: : : .:. : :: ::. : :..: : : ..: NP_001 SRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFL 40 50 60 70 80 120 130 140 150 160 170 pF1KE1 LTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKP :. .. . : : .:. :: : .: .. . . .: .: .: NP_001 RTNRQAAKLSKPTLE---NLT---PVVLR-PEIRKPEVLRPETPRPVDIGSGGFG-DVGA 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE1 CTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGY : . . .::: :. .: : :...::.: :. :. :.:...: : :. : . NP_001 L--ESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHF 150 160 170 180 190 240 250 260 270 280 290 pF1KE1 DVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLL :.: : ::..: : ..:: : . : :.:..:::: . ::.::.:: . NP_001 MVEVKGDLTAKKMVLALLELAQ-QDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPV 200 210 220 230 240 250 300 310 320 330 340 pF1KE1 QLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCE-ESDA-- ..... ..:....:::: .:::.:::::: :.. :.: . . . . ::: . : :: NP_001 SVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATP 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE1 ---GKEKLPKM----RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM : . . .. ::: ::.. .:. . : .. :. : ::::.:.: ..: . : . NP_001 FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE 320 330 340 350 360 370 410 420 430 440 450 pF1KE1 HVADMLVKV-NAL-IKDREGYAPGT-EFHRCKEMSEYCSTLCRHLYLFPGHPPT . ..:..: ::. .: :: .: : : NP_001 DLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 380 390 400 410 >>XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 isofo (421 aa) initn: 308 init1: 200 opt: 437 Z-score: 499.2 bits: 101.5 E(85289): 4.5e-21 Smith-Waterman score: 546; 31.2% identity (59.9% similar) in 401 aa overlap (32-412:1-389) 10 20 30 40 50 60 pF1KE1 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLL : .. :.. :. :...: ...: . :: XP_011 MDEADRRLLRRCRLRLVEELQVDQLWDALL 10 20 30 70 80 90 100 110 pF1KE1 EKDIITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDML .... .: : :: ..:: : : .:. : :: ::. : :..: : : ..: XP_011 SRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFL 40 50 60 70 80 120 130 140 150 160 170 pF1KE1 LTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKP :. .. . : : .:. :: : .: .. . . .: .: .: XP_011 RTNRQAAKLSKPTLE---NLT---PVVLR-PEIRKPEVLRPETPRPVDIGSGGFG-DVGA 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE1 CTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGY : . . .::: :. .: : :...::.: :. :. :.:...: : :. : . XP_011 L--ESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHF 150 160 170 180 190 240 250 260 270 280 290 pF1KE1 DVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLL :.: : ::..: : ..:: : . : :.:..:::: . ::.::.:: . XP_011 MVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPV 200 210 220 230 240 250 300 310 320 330 340 pF1KE1 QLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCE-ESDA-- ..... ..:....:::: .:::.:::::: :.. :.: . . . . ::: . : :: XP_011 SVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATP 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE1 ---GKEKLPKM----RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM : . . .. ::: ::.. .:. . : .. :. : ::::.:.: ..: . : . XP_011 FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE 320 330 340 350 360 370 410 420 430 440 450 pF1KE1 HVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT . ..:..:.: XP_011 DLQSLLLRVSAAFLCKGEGRLLRGSVSSWGWGFGVSRAGPNQG 380 390 400 410 420 >>XP_005246951 (OMIM: 114480,114550,211980,601763,607271 (280 aa) initn: 360 init1: 227 opt: 427 Z-score: 490.7 bits: 99.3 E(85289): 1.4e-20 Smith-Waterman score: 429; 30.3% identity (62.8% similar) in 274 aa overlap (184-447:19-278) 160 170 180 190 200 210 pF1KE1 LRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGE .: .. .:...:.::: :...: .:. XP_005 MKNSAKREAAALKEVLMNFQMTLDKVYQMKSKPRGYCLIINNHNFAKA 10 20 30 40 220 230 240 250 260 pF1KE1 KE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRV .: .. :.: .: ..:.: :. : .... : :.... : :. . :: : XP_005 REKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSN 50 60 70 80 90 100 270 280 290 300 310 320 pF1KE1 TDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETD : : .:::: .: :::.::. . :. . : . .:::: .:::.::::::.::. . XP_005 MDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQ 110 120 130 140 150 160 330 340 350 360 370 380 pF1KE1 RGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSDMICGYACLKGTAAMRNTKRGSW .:. . ... .: : . .. :. : .: ..:.. :.: ... ...:: .:.: XP_005 KGIPVETDSEE--QPYLEMDLSS----PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW 170 180 190 200 210 220 390 400 410 420 430 440 pF1KE1 YIEALAQVFSERACDM--HVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHL ::..: : . :: : . .:..:: ..... . :.: . :: ..: XP_005 YIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKDDKK-----NMGKQMPQPTFTLRKKL 230 240 250 260 270 450 pF1KE1 YLFPGHPPT .:: XP_005 -VFPSD 280 >>XP_011510271 (OMIM: 114480,114550,211980,601763,607271 (334 aa) initn: 360 init1: 227 opt: 421 Z-score: 482.7 bits: 98.1 E(85289): 3.8e-20 Smith-Waterman score: 423; 30.8% identity (63.2% similar) in 266 aa overlap (192-447:81-332) 170 180 190 200 210 pF1KE1 EHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKE------ :...:.::: :...: .:. .: XP_011 FSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH 60 70 80 90 100 110 220 230 240 250 260 270 pF1KE1 -LEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVAL .. :.: .: ..:.: :. : .... : :.... : :. . :: : : : . XP_011 SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCI 120 130 140 150 160 280 290 300 310 320 330 pF1KE1 LSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDG :::: .: :::.::. . :. . : . .:::: .:::.::::::.::. ..:. . XP_011 LSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD 170 180 190 200 210 220 340 350 360 370 380 390 pF1KE1 KNHAGSPGCEESDAGKEKLPKMR-LPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQV ... .: : . .. :. : .: ..:.. :.: ... ...:: .:.:::..: : XP_011 SEE--QPYLEMDLSS----PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQS 230 240 250 260 270 280 400 410 420 430 440 450 pF1KE1 FSERACDM--HVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPP . :: : . .:..:: ..... . . :.: . :: ..: .:: XP_011 LRER-CPRGDDILTILTEVNYEVSNKD-----DKKNMGKQMPQPTFTLRKKL-VFPSD 290 300 310 320 330 pF1KE1 T >>XP_005246949 (OMIM: 114480,114550,211980,601763,607271 (464 aa) initn: 321 init1: 227 opt: 421 Z-score: 480.4 bits: 98.1 E(85289): 5.1e-20 Smith-Waterman score: 424; 28.8% identity (61.0% similar) in 313 aa overlap (148-447:164-462) 120 130 140 150 160 170 pF1KE1 LLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKK--LRLSTDTVEHSLDNKD-GPVCL : .: :.. .: : : .. : . . XP_005 DDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTI 140 150 160 170 180 190 180 190 200 210 220 pF1KE1 QVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHS . .: . . .. .:...:.::: :...: .:. .: .. :.: .: . XP_005 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE1 TLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVD .:.: :. : .... : :.... : :. . :: : : : .:::: .: :::.: XP_005 ALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTD 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE1 GKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESD :. . :. . : . .:::: .:::.::::::.::. ..:. . ... .: : . XP_005 GQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEE--QPYLEMDL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE1 AGKEKLPKMR-LPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVA .. :. : .: ..:.. :.: ... ...:: .:.:::..: : . :: : . XP_005 SS----PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDIL 380 390 400 410 420 410 420 430 440 450 pF1KE1 DMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT .:..:: ..... . . :.: . :: ..: .:: XP_005 TILTEVNYEVSNKD-----DKKNMGKQMPQPTFTLRKKL-VFPSD 430 440 450 460 >>NP_001073593 (OMIM: 114480,114550,211980,601763,607271 (464 aa) initn: 321 init1: 227 opt: 421 Z-score: 480.4 bits: 98.1 E(85289): 5.1e-20 Smith-Waterman score: 424; 28.8% identity (61.0% similar) in 313 aa overlap (148-447:164-462) 120 130 140 150 160 170 pF1KE1 LLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKK--LRLSTDTVEHSLDNKD-GPVCL : .: :.. .: : : .. : . . NP_001 DDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTI 140 150 160 170 180 190 180 190 200 210 220 pF1KE1 QVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHS . .: . . .. .:...:.::: :...: .:. .: .. :.: .: . NP_001 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE1 TLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVD .:.: :. : .... : :.... : :. . :: : : : .:::: .: :::.: NP_001 ALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTD 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE1 GKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESD :. . :. . : . .:::: .:::.::::::.::. ..:. . ... .: : . NP_001 GQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEE--QPYLEMDL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE1 AGKEKLPKMR-LPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVA .. :. : .: ..:.. :.: ... ...:: .:.:::..: : . :: : . NP_001 SS----PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDIL 380 390 400 410 420 410 420 430 440 450 pF1KE1 DMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT .:..:: ..... . . :.: . :: ..: .:: NP_001 TILTEVNYEVSNKD-----DKKNMGKQMPQPTFTLRKKL-VFPSD 430 440 450 460 >>NP_203520 (OMIM: 114480,114550,211980,601763,607271) c (464 aa) initn: 321 init1: 227 opt: 421 Z-score: 480.4 bits: 98.1 E(85289): 5.1e-20 Smith-Waterman score: 424; 28.8% identity (61.0% similar) in 313 aa overlap (148-447:164-462) 120 130 140 150 160 170 pF1KE1 LLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKK--LRLSTDTVEHSLDNKD-GPVCL : .: :.. .: : : .. : . . NP_203 DDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTI 140 150 160 170 180 190 180 190 200 210 220 pF1KE1 QVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHS . .: . . .. .:...:.::: :...: .:. .: .. :.: .: . NP_203 SDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAG 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE1 TLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVD .:.: :. : .... : :.... : :. . :: : : : .:::: .: :::.: NP_203 ALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTD 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE1 GKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESD :. . :. . : . .:::: .:::.::::::.::. ..:. . ... .: : . NP_203 GQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEE--QPYLEMDL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE1 AGKEKLPKMR-LPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVA .. :. : .: ..:.. :.: ... ...:: .:.:::..: : . :: : . NP_203 SS----PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDIL 380 390 400 410 420 410 420 430 440 450 pF1KE1 DMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT .:..:: ..... . . :.: . :: ..: .:: NP_203 TILTEVNYEVSNKD-----DKKNMGKQMPQPTFTLRKKL-VFPSD 430 440 450 460 452 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:01:33 2016 done: Sun Nov 6 22:01:34 2016 Total Scan time: 8.390 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]