FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1183, 703 aa 1>>>pF1KE1183 703 - 703 aa - 703 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3184+/-0.000319; mu= 11.3787+/- 0.020 mean_var=122.6043+/-24.199, 0's: 0 Z-trim(119.8): 93 B-trim: 65 in 1/56 Lambda= 0.115830 statistics sampled from 34227 (34332) to 34227 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.729), E-opt: 0.2 (0.403), width: 16 Scan time: 13.040 The best scores are: opt bits E(85289) XP_011535609 (OMIM: 603526) PREDICTED: metastasis- ( 759) 4681 793.4 0 XP_016877243 (OMIM: 603526) PREDICTED: metastasis- ( 783) 4353 738.6 2.2e-212 XP_011535612 (OMIM: 603526) PREDICTED: metastasis- ( 742) 4210 714.7 3.2e-205 NP_004680 (OMIM: 603526) metastasis-associated pro ( 715) 4034 685.3 2.2e-196 XP_016877246 (OMIM: 603526) PREDICTED: metastasis- ( 743) 4020 682.9 1.2e-195 XP_011535608 (OMIM: 603526) PREDICTED: metastasis- ( 771) 3975 675.4 2.2e-193 XP_016877242 (OMIM: 603526) PREDICTED: metastasis- ( 795) 3975 675.4 2.3e-193 XP_011535607 (OMIM: 603526) PREDICTED: metastasis- ( 775) 3961 673.1 1.1e-192 XP_016877241 (OMIM: 603526) PREDICTED: metastasis- ( 799) 3961 673.1 1.2e-192 XP_016877245 (OMIM: 603526) PREDICTED: metastasis- ( 772) 3814 648.5 2.8e-185 XP_011535611 (OMIM: 603526) PREDICTED: metastasis- ( 754) 3504 596.7 1.1e-169 XP_016877247 (OMIM: 603526) PREDICTED: metastasis- ( 726) 3490 594.4 5.3e-169 XP_011535610 (OMIM: 603526) PREDICTED: metastasis- ( 758) 3490 594.4 5.4e-169 XP_016877244 (OMIM: 603526) PREDICTED: metastasis- ( 782) 3490 594.4 5.6e-169 XP_016877248 (OMIM: 603526) PREDICTED: metastasis- ( 657) 3461 589.5 1.4e-167 NP_001190187 (OMIM: 603526) metastasis-associated ( 430) 2625 449.7 1.1e-125 NP_004730 (OMIM: 603947) metastasis-associated pro ( 668) 2163 372.6 2.8e-102 NP_065795 (OMIM: 609050) metastasis-associated pro ( 515) 1968 339.9 1.4e-92 XP_005264516 (OMIM: 609050) PREDICTED: metastasis- ( 538) 1968 340.0 1.5e-92 NP_001317371 (OMIM: 609050) metastasis-associated ( 594) 1968 340.0 1.6e-92 NP_001269685 (OMIM: 609050) metastasis-associated ( 537) 1955 337.8 6.7e-92 NP_001269684 (OMIM: 609050) metastasis-associated ( 537) 1955 337.8 6.7e-92 NP_001317372 (OMIM: 609050) metastasis-associated ( 593) 1955 337.8 7.3e-92 NP_001317221 (OMIM: 603947) metastasis-associated ( 495) 1665 289.3 2.4e-77 XP_016860051 (OMIM: 609050) PREDICTED: metastasis- ( 341) 1510 263.3 1.1e-69 NP_001317373 (OMIM: 609050) metastasis-associated ( 530) 867 156.0 3.6e-37 XP_011539813 (OMIM: 605226,616975) PREDICTED: argi (1181) 416 80.8 3.4e-14 XP_011539812 (OMIM: 605226,616975) PREDICTED: argi (1524) 416 80.8 4.3e-14 NP_001036146 (OMIM: 605226,616975) arginine-glutam (1566) 416 80.8 4.4e-14 XP_016856847 (OMIM: 605226,616975) PREDICTED: argi (1566) 416 80.8 4.4e-14 NP_036234 (OMIM: 605226,616975) arginine-glutamic (1566) 416 80.8 4.4e-14 XP_016856848 (OMIM: 605226,616975) PREDICTED: argi (1566) 416 80.8 4.4e-14 XP_005263521 (OMIM: 605226,616975) PREDICTED: argi (1566) 416 80.8 4.4e-14 XP_005263523 (OMIM: 605226,616975) PREDICTED: argi (1298) 330 66.4 7.9e-10 NP_055971 (OMIM: 607675) REST corepressor 1 [Homo ( 485) 187 42.3 0.0053 >>XP_011535609 (OMIM: 603526) PREDICTED: metastasis-asso (759 aa) initn: 4681 init1: 4681 opt: 4681 Z-score: 4230.5 bits: 793.4 E(85289): 0 Smith-Waterman score: 4681; 99.9% identity (100.0% similar) in 694 aa overlap (10-703:66-759) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_011 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 LGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWI ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_011 LGKRSYEQHNGVDGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWI 640 650 660 670 680 690 640 650 660 670 680 690 pF1KE1 DAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPI 700 710 720 730 740 750 700 pF1KE1 VIED :::: XP_011 VIED >>XP_016877243 (OMIM: 603526) PREDICTED: metastasis-asso (783 aa) initn: 4352 init1: 4352 opt: 4353 Z-score: 3934.1 bits: 738.6 E(85289): 2.2e-212 Smith-Waterman score: 4623; 96.5% identity (96.7% similar) in 718 aa overlap (10-703:66-783) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_016 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE1 LGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWI ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_016 LGKRSYEQHNGVDGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWI 640 650 660 670 680 690 640 650 660 670 pF1KE1 DAPDDVFYMATEETR------------------------KIRKLLSSSETKRAARRPYKP ::::::::::::::: ::::::::::::::::::::: XP_016 DAPDDVFYMATEETRWGLPRAGGRAPHSVPALTTTSAHRKIRKLLSSSETKRAARRPYKP 700 710 720 730 740 750 680 690 700 pF1KE1 IALRQSQALPPRPPPPAPVNDEPIVIED :::::::::::::::::::::::::::: XP_016 IALRQSQALPPRPPPPAPVNDEPIVIED 760 770 780 >>XP_011535612 (OMIM: 603526) PREDICTED: metastasis-asso (742 aa) initn: 4541 init1: 4210 opt: 4210 Z-score: 3805.3 bits: 714.7 E(85289): 3.2e-205 Smith-Waterman score: 4510; 97.3% identity (97.4% similar) in 694 aa overlap (10-703:66-742) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_011 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::: :::::::::::::::::: XP_011 AKVVCFYRRRDISSTLIALADKHAR-----------------EIEEEMENPEMVDLPEKL 100 110 120 130 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 440 450 460 470 480 490 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 500 510 520 530 540 550 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 560 570 580 590 600 610 580 590 600 610 620 630 pF1KE1 LGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWI ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_011 LGKRSYEQHNGVDGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWI 620 630 640 650 660 670 640 650 660 670 680 690 pF1KE1 DAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPI 680 690 700 710 720 730 700 pF1KE1 VIED :::: XP_011 VIED 740 >>NP_004680 (OMIM: 603526) metastasis-associated protein (715 aa) initn: 3996 init1: 3996 opt: 4034 Z-score: 3646.6 bits: 685.3 E(85289): 2.2e-196 Smith-Waterman score: 4706; 98.2% identity (98.3% similar) in 715 aa overlap (1-703:1-715) 10 20 30 40 50 60 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 KPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 WTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 WTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 IARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRY 490 500 510 520 530 540 550 560 570 580 590 pF1KE1 LETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDG------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLL 550 560 570 580 590 600 600 610 620 630 640 pF1KE1 -----LANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYM ::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYM 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE1 ATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED 670 680 690 700 710 >>XP_016877246 (OMIM: 603526) PREDICTED: metastasis-asso (743 aa) initn: 4319 init1: 3996 opt: 4020 Z-score: 3633.7 bits: 682.9 E(85289): 1.2e-195 Smith-Waterman score: 4587; 94.4% identity (94.6% similar) in 735 aa overlap (1-695:1-735) 10 20 30 40 50 60 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 KPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 WTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 IARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRY 490 500 510 520 530 540 550 560 570 580 590 pF1KE1 LETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDG------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLL 550 560 570 580 590 600 600 610 620 630 640 pF1KE1 ---------LANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDD ::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_016 MPSRGTYLGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDD 610 620 630 640 650 660 650 660 670 680 pF1KE1 VFYMATEETR------------------------KIRKLLSSSETKRAARRPYKPIALRQ :::::::::: :::::::::::::::::::::::::: XP_016 VFYMATEETRWGLPRAGGRAPHSVPALTTTSAHRKIRKLLSSSETKRAARRPYKPIALRQ 670 680 690 700 710 720 690 700 pF1KE1 SQALPPRPPPPAPVNDEPIVIED ::::::::::::::: XP_016 SQALPPRPPPPAPVNDEPIVIED 730 740 >>XP_011535608 (OMIM: 603526) PREDICTED: metastasis-asso (771 aa) initn: 3937 init1: 3937 opt: 3975 Z-score: 3592.8 bits: 675.4 E(85289): 2.2e-193 Smith-Waterman score: 4647; 98.2% identity (98.3% similar) in 706 aa overlap (10-703:66-771) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_011 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 580 590 600 610 620 630 580 590 600 610 620 pF1KE1 LGKRSYEQHNGVDG------------LANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGS :::::::::::::: ::::::.::::::::::::::::::::::::::: XP_011 LGKRSYEQHNGVDGNMKKRLLMPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGS 640 650 660 670 680 690 630 640 650 660 670 680 pF1KE1 LPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPR 700 710 720 730 740 750 690 700 pF1KE1 PPPPAPVNDEPIVIED :::::::::::::::: XP_011 PPPPAPVNDEPIVIED 760 770 >>XP_016877242 (OMIM: 603526) PREDICTED: metastasis-asso (795 aa) initn: 4260 init1: 3937 opt: 3975 Z-score: 3592.6 bits: 675.4 E(85289): 2.3e-193 Smith-Waterman score: 4565; 94.9% identity (95.0% similar) in 726 aa overlap (10-699:66-791) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_016 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 580 590 600 610 620 630 580 590 600 610 620 pF1KE1 LGKRSYEQHNGVDG------------LANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGS :::::::::::::: ::::::.::::::::::::::::::::::::::: XP_016 LGKRSYEQHNGVDGNMKKRLLMPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGS 640 650 660 670 680 690 630 640 650 660 pF1KE1 LPPVKRRRMNWIDAPDDVFYMATEETR------------------------KIRKLLSSS ::::::::::::::::::::::::::: ::::::::: XP_016 LPPVKRRRMNWIDAPDDVFYMATEETRWGLPRAGGRAPHSVPALTTTSAHRKIRKLLSSS 700 710 720 730 740 750 670 680 690 700 pF1KE1 ETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED :::::::::::::::::::::::::::::::::::: XP_016 ETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED 760 770 780 790 >>XP_011535607 (OMIM: 603526) PREDICTED: metastasis-asso (775 aa) initn: 3937 init1: 3937 opt: 3961 Z-score: 3580.1 bits: 673.1 E(85289): 1.1e-192 Smith-Waterman score: 4639; 97.6% identity (97.7% similar) in 710 aa overlap (10-703:66-775) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_011 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 580 590 600 610 620 630 580 590 600 610 620 pF1KE1 LGKRSYEQHNGVDG----------------LANHGQTRHMGPSRNLLLNGKSYPTKVRLI :::::::::::::: ::::::.::::::::::::::::::::::: XP_011 LGKRSYEQHNGVDGNMKKRLLMPSRGTYLGLANHGQARHMGPSRNLLLNGKSYPTKVRLI 640 650 660 670 680 690 630 640 650 660 670 680 pF1KE1 RGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQA 700 710 720 730 740 750 690 700 pF1KE1 LPPRPPPPAPVNDEPIVIED :::::::::::::::::::: XP_011 LPPRPPPPAPVNDEPIVIED 760 770 >>XP_016877241 (OMIM: 603526) PREDICTED: metastasis-asso (799 aa) initn: 4260 init1: 3937 opt: 3961 Z-score: 3579.9 bits: 673.1 E(85289): 1.2e-192 Smith-Waterman score: 4528; 94.4% identity (94.5% similar) in 726 aa overlap (10-695:66-791) 10 20 30 pF1KE1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVE :::::::::::::::::::::::::::::: XP_016 CVCSPWSLWPGVLGAVRPPTCPPRGLPLPADYVYFENSSSNPYLIRRIEELNKTANGNVE 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKT 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE1 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE1 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE1 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE1 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTT 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE1 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSG 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE1 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEA 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE1 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTI 580 590 600 610 620 630 580 590 600 610 620 pF1KE1 LGKRSYEQHNGVDG----------------LANHGQTRHMGPSRNLLLNGKSYPTKVRLI :::::::::::::: ::::::.::::::::::::::::::::::: XP_016 LGKRSYEQHNGVDGNMKKRLLMPSRGTYLGLANHGQARHMGPSRNLLLNGKSYPTKVRLI 640 650 660 670 680 690 630 640 650 pF1KE1 RGGSLPPVKRRRMNWIDAPDDVFYMATEETR------------------------KIRKL ::::::::::::::::::::::::::::::: ::::: XP_016 RGGSLPPVKRRRMNWIDAPDDVFYMATEETRWGLPRAGGRAPHSVPALTTTSAHRKIRKL 700 710 720 730 740 750 660 670 680 690 700 pF1KE1 LSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED :::::::::::::::::::::::::::::::::::: XP_016 LSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED 760 770 780 790 >>XP_016877245 (OMIM: 603526) PREDICTED: metastasis-asso (772 aa) initn: 4113 init1: 3790 opt: 3814 Z-score: 3447.4 bits: 648.5 E(85289): 2.8e-185 Smith-Waterman score: 4381; 94.0% identity (94.3% similar) in 704 aa overlap (32-695:61-764) 10 20 30 40 50 60 pF1KE1 AANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALADK .::::::::::::::::::::::::::::: XP_016 PDAHHVEKNPQACDRVRPVPSTPRSSRRGFQTANGNVEAKVVCFYRRRDISSTLIALADK 40 50 60 70 80 90 70 80 90 100 110 120 pF1KE1 HATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPATH 100 110 120 130 140 150 130 140 150 160 170 180 pF1KE1 IRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLL 160 170 180 190 200 210 190 200 210 220 230 240 pF1KE1 KEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMS 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE1 AAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALE 280 290 300 310 320 330 310 320 330 340 350 360 pF1KE1 KYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNK 340 350 360 370 380 390 370 380 390 400 410 420 pF1KE1 PNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCW 400 410 420 430 440 450 430 440 450 460 470 480 pF1KE1 TYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTRI 460 470 480 490 500 510 490 500 510 520 530 540 pF1KE1 ARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRYL 520 530 540 550 560 570 550 560 570 580 590 pF1KE1 ETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDG-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLLM 580 590 600 610 620 630 600 610 620 630 640 pF1KE1 --------LANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDV ::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRGTYLGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDV 640 650 660 670 680 690 650 660 670 680 pF1KE1 FYMATEETR------------------------KIRKLLSSSETKRAARRPYKPIALRQS ::::::::: ::::::::::::::::::::::::::: XP_016 FYMATEETRWGLPRAGGRAPHSVPALTTTSAHRKIRKLLSSSETKRAARRPYKPIALRQS 700 710 720 730 740 750 690 700 pF1KE1 QALPPRPPPPAPVNDEPIVIED :::::::::::::: XP_016 QALPPRPPPPAPVNDEPIVIED 760 770 703 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:02:41 2016 done: Sun Nov 6 22:02:43 2016 Total Scan time: 13.040 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]