Result of FASTA (omim) for
pFN21AE0093
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0093, 1095 aa
1>>>pF1KE0093 1095 - 1095 aa - 1095 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7795+/-0.000358; mu= 16.3334+/- 0.022
mean_var=149.9074+/-29.608, 0's: 0 Z-trim(119.3): 342 B-trim: 0 in 0/55
Lambda= 0.104752
statistics sampled from 32878 (33254) to 32878 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.39), width: 16
Scan time: 15.380
The best scores are: opt bits E(85289)
NP_620688 (OMIM: 607511,613195) A disintegrin and (1095) 7898 1206.3 0
XP_011519614 (OMIM: 607511,613195) PREDICTED: A di (1145) 5155 791.8 0
XP_005254929 (OMIM: 607511,613195) PREDICTED: A di (1122) 5085 781.2 0
XP_016877473 (OMIM: 607511,613195) PREDICTED: A di ( 502) 3411 527.9 5.7e-149
XP_016877464 (OMIM: 607511,613195) PREDICTED: A di (1166) 2882 448.3 1.2e-124
XP_016877472 (OMIM: 607511,613195) PREDICTED: A di ( 580) 2833 440.6 1.2e-122
XP_016877471 (OMIM: 607511,613195) PREDICTED: A di ( 652) 2833 440.7 1.4e-122
XP_016877468 (OMIM: 607511,613195) PREDICTED: A di ( 749) 2833 440.7 1.5e-122
XP_016877469 (OMIM: 607511,613195) PREDICTED: A di ( 749) 2833 440.7 1.5e-122
XP_016877467 (OMIM: 607511,613195) PREDICTED: A di ( 823) 2833 440.8 1.6e-122
XP_016877465 (OMIM: 607511,613195) PREDICTED: A di ( 946) 2833 440.8 1.8e-122
XP_016877462 (OMIM: 607511,613195) PREDICTED: A di (1189) 2833 440.9 2.1e-122
XP_016877463 (OMIM: 607511,613195) PREDICTED: A di (1181) 2672 416.6 4.3e-115
XP_016877466 (OMIM: 607511,613195) PREDICTED: A di ( 823) 2621 408.7 7e-113
XP_016877470 (OMIM: 607511,613195) PREDICTED: A di ( 726) 2469 385.7 5.3e-106
NP_598377 (OMIM: 607513) A disintegrin and metallo (1213) 2439 381.4 1.8e-104
XP_016864665 (OMIM: 607513) PREDICTED: A disintegr ( 776) 1916 302.2 8e-81
XP_011541551 (OMIM: 607513) PREDICTED: A disintegr ( 780) 1916 302.2 8e-81
XP_016864664 (OMIM: 607513) PREDICTED: A disintegr ( 780) 1916 302.2 8e-81
XP_011541549 (OMIM: 607513) PREDICTED: A disintegr ( 827) 1916 302.2 8.3e-81
XP_011541550 (OMIM: 607513) PREDICTED: A disintegr ( 827) 1916 302.2 8.3e-81
XP_016864663 (OMIM: 607513) PREDICTED: A disintegr ( 886) 1916 302.2 8.8e-81
XP_011541548 (OMIM: 607513) PREDICTED: A disintegr ( 984) 1916 302.3 9.4e-81
XP_011541424 (OMIM: 605008) PREDICTED: A disintegr ( 827) 1321 212.3 9.8e-54
XP_011541422 (OMIM: 605008) PREDICTED: A disintegr ( 868) 1321 212.3 1e-53
XP_011541421 (OMIM: 605008) PREDICTED: A disintegr ( 892) 1321 212.3 1e-53
XP_011541419 (OMIM: 605008) PREDICTED: A disintegr ( 966) 1321 212.3 1.1e-53
XP_011541415 (OMIM: 605008) PREDICTED: A disintegr (1117) 1321 212.4 1.2e-53
XP_011541416 (OMIM: 605008) PREDICTED: A disintegr (1117) 1321 212.4 1.2e-53
NP_922932 (OMIM: 605008) A disintegrin and metallo (1117) 1321 212.4 1.2e-53
NP_055087 (OMIM: 605009) A disintegrin and metallo (1686) 1265 204.1 5.7e-51
XP_005254194 (OMIM: 605009) PREDICTED: A disintegr (1689) 1265 204.1 5.7e-51
XP_011541423 (OMIM: 605008) PREDICTED: A disintegr ( 863) 1203 194.5 2.3e-48
XP_016865395 (OMIM: 606184) PREDICTED: A disintegr (1467) 1149 186.5 9.8e-46
NP_112217 (OMIM: 606184) A disintegrin and metallo (1594) 1149 186.5 1e-45
XP_016865394 (OMIM: 606184) PREDICTED: A disintegr (1631) 1149 186.6 1.1e-45
NP_620687 (OMIM: 607510) A disintegrin and metallo (1224) 1110 180.5 5.1e-44
NP_001305710 (OMIM: 605421) A disintegrin and meta (1907) 1067 174.2 6.3e-42
NP_620686 (OMIM: 607509) A disintegrin and metallo ( 950) 1041 170.0 5.9e-41
XP_011537056 (OMIM: 611681) PREDICTED: A disintegr (1911) 1038 169.8 1.3e-40
NP_079279 (OMIM: 611681) A disintegrin and metallo (1910) 1029 168.5 3.4e-40
NP_891550 (OMIM: 605421) A disintegrin and metallo (1935) 1022 167.4 7.1e-40
XP_011541429 (OMIM: 605008) PREDICTED: A disintegr ( 612) 1011 165.3 1e-39
XP_011541428 (OMIM: 605008) PREDICTED: A disintegr ( 613) 1011 165.3 1e-39
NP_001311441 (OMIM: 606184) A disintegrin and meta (1509) 1014 166.1 1.4e-39
XP_016872634 (OMIM: 605175) PREDICTED: A disintegr ( 873) 984 161.4 2.2e-38
XP_011530724 (OMIM: 605011) PREDICTED: A disintegr (1177) 973 159.8 8.5e-38
XP_011530723 (OMIM: 605011) PREDICTED: A disintegr (1186) 973 159.8 8.6e-38
NP_055058 (OMIM: 605011) A disintegrin and metallo (1205) 973 159.8 8.7e-38
XP_016865552 (OMIM: 225410,604539) PREDICTED: A di (1046) 972 159.6 8.7e-38
>>NP_620688 (OMIM: 607511,613195) A disintegrin and meta (1095 aa)
initn: 7898 init1: 7898 opt: 7898 Z-score: 6455.9 bits: 1206.3 E(85289): 0
Smith-Waterman score: 7898; 100.0% identity (100.0% similar) in 1095 aa overlap (1-1095:1-1095)
10 20 30 40 50 60
pF1KE0 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC
1030 1040 1050 1060 1070 1080
1090
pF1KE0 RDFYANKMRQPPPNS
:::::::::::::::
NP_620 RDFYANKMRQPPPNS
1090
>>XP_011519614 (OMIM: 607511,613195) PREDICTED: A disint (1145 aa)
initn: 5316 init1: 5090 opt: 5155 Z-score: 4215.3 bits: 791.8 E(85289): 0
Smith-Waterman score: 7651; 95.6% identity (95.6% similar) in 1127 aa overlap (1-1077:1-1127)
10 20 30 40 50 60
pF1KE0 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
610 620 630 640 650 660
670 680 690 700 710
pF1KE0 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGT--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTVKNDLCTK
670 680 690 700 710 720
720 730
pF1KE0 ------------------------------------------ALKDSGKGSINSDWKIEL
::::::::::::::::::
XP_011 VSTCVMAEAVPKCFSCYIEAAVIPAGARRIRVVEDKPAHSFLALKDSGKGSINSDWKIEL
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE0 PGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAEN
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE0 QSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE0 PQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRP
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE0 AAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDY
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE0 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCND
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE0 RINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQ
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQ
1090 1100 1110 1120 1130 1140
pF1KE0 PPPNS
XP_011 PPPNS
>>XP_005254929 (OMIM: 607511,613195) PREDICTED: A disint (1122 aa)
initn: 7884 init1: 5085 opt: 5085 Z-score: 4158.3 bits: 781.2 E(85289): 0
Smith-Waterman score: 7834; 97.6% identity (97.6% similar) in 1122 aa overlap (1-1095:1-1122)
10 20 30 40 50 60
pF1KE0 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
610 620 630 640 650 660
670 680 690 700 710
pF1KE0 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGT--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTGYIEAAVI
670 680 690 700 710 720
720 730 740 750
pF1KE0 -------------------ALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKIS
:::::::::::::::::::::::::::::::::::::::::
XP_005 PAGARRIRVVEDKPAHSFLALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKIS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 AKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCS
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 VQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPC
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE0 SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQC
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE0 SASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQ
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE0 SRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQ
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090
pF1KE0 WTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
::::::::::::::::::::::::::::::::::::::::::
XP_005 WTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
1090 1100 1110 1120
>>XP_016877473 (OMIM: 607511,613195) PREDICTED: A disint (502 aa)
initn: 3411 init1: 3411 opt: 3411 Z-score: 2795.5 bits: 527.9 E(85289): 5.7e-149
Smith-Waterman score: 3411; 100.0% identity (100.0% similar) in 469 aa overlap (244-712:1-469)
220 230 240 250 260 270
pF1KE0 RPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSL
::::::::::::::::::::::::::::::
XP_016 MVQYHGAEAAQRFILTVMNMVYNMFQHQSL
10 20 30
280 290 300 310 320 330
pF1KE0 GIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDP
40 50 60 70 80 90
340 350 360 370 380 390
pF1KE0 PLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGH
100 110 120 130 140 150
400 410 420 430 440 450
pF1KE0 NLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDP
160 170 180 190 200 210
460 470 480 490 500 510
pF1KE0 RSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLD
220 230 240 250 260 270
520 530 540 550 560 570
pF1KE0 PPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNP
280 290 300 310 320 330
580 590 600 610 620 630
pF1KE0 PPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPC
340 350 360 370 380 390
640 650 660 670 680 690
pF1KE0 ELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCS
400 410 420 430 440 450
700 710 720 730 740 750
pF1KE0 GDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKIS
:::::::::::::::::::
XP_016 GDGKTCHLVKGDFSHARGTGYIEAAVIPAGARRIRVVEDKPAHSFLGKTQMT
460 470 480 490 500
>>XP_016877464 (OMIM: 607511,613195) PREDICTED: A disint (1166 aa)
initn: 7870 init1: 2813 opt: 2882 Z-score: 2358.8 bits: 448.3 E(85289): 1.2e-124
Smith-Waterman score: 7476; 93.7% identity (93.7% similar) in 1127 aa overlap (40-1095:40-1166)
10 20 30 40 50 60
pF1KE0 LVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPP
::::::::::::::::::::::::::::::
XP_016 LVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 RVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRRKWSLTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRRKWSLTPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCH
250 260 270 280 290 300
310 320 330 340 350
pF1KE0 WQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTV-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVVPPAPFDVREG
310 320 330 340 350 360
360 370 380
pF1KE0 ---------------------------------GIAYLGGVCSAKRKCVLAEDNGLNLAF
:::::::::::::::::::::::::::
XP_016 PGSPPWWCLGRELPEANGSQRVIPDHSISKTWEGIAYLGGVCSAKRKCVLAEDNGLNLAF
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE0 TIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVS
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE0 TCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE0 TSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARF
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE0 RQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTA
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE0 VVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAK
670 680 690 700 710 720
690 700 710
pF1KE0 EDRCGVCSGDGKTCHLVKGDFSHARGT---------------------------ALKDSG
::::::::::::::::::::::::::: ::::::
XP_016 EDRCGVCSGDGKTCHLVKGDFSHARGTGYIEAAVIPAGARRIRVVEDKPAHSFLALKDSG
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE0 KGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHY
790 800 810 820 830 840
780 790 800 810 820 830
pF1KE0 EYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV
850 860 870 880 890 900
840 850 860 870 880 890
pF1KE0 NDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV
910 920 930 940 950 960
900 910 920 930 940 950
pF1KE0 ATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDAS
970 980 990 1000 1010 1020
960 970 980 990 1000 1010
pF1KE0 TRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPA
1030 1040 1050 1060 1070 1080
1020 1030 1040 1050 1060 1070
pF1KE0 PYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQ
1090 1100 1110 1120 1130 1140
1080 1090
pF1KE0 TCRDFYANKMRQPPPNS
:::::::::::::::::
XP_016 TCRDFYANKMRQPPPNS
1150 1160
>--
initn: 260 init1: 260 opt: 260 Z-score: 217.3 bits: 52.1 E(85289): 2.3e-05
Smith-Waterman score: 260; 100.0% identity (100.0% similar) in 39 aa overlap (1-39:1-39)
10 20 30 40 50 60
pF1KE0 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
:::::::::::::::::::::::::::::::::::::::
XP_016 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
XP_016 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
70 80 90 100 110 120
>>XP_016877472 (OMIM: 607511,613195) PREDICTED: A disint (580 aa)
initn: 2813 init1: 2813 opt: 2833 Z-score: 2322.6 bits: 440.6 E(85289): 1.2e-122
Smith-Waterman score: 3723; 91.2% identity (91.2% similar) in 571 aa overlap (575-1095:10-580)
550 560 570 580 590 600
pF1KE0 DWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSF
::::::::::::::::::::::::::::::
XP_016 MPPSAETWSPGPGGTHCPGASVEHAVCENLPCPKGLPSF
10 20 30
610 620 630 640 650 660
pF1KE0 RDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETD
40 50 60 70 80 90
670 680 690 700 710
pF1KE0 LCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGT------------
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTVKNDLCTKVSTC
100 110 120 130 140 150
720 730
pF1KE0 --------------------------------------ALKDSGKGSINSDWKIELPGEF
::::::::::::::::::::::
XP_016 VMAEAVPKCFSCYIEAAVIPAGARRIRVVEDKPAHSFLALKDSGKGSINSDWKIELPGEF
160 170 180 190 200 210
740 750 760 770 780 790
pF1KE0 QIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEP
220 230 240 250 260 270
800 810 820 830 840 850
pF1KE0 EKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVR
280 290 300 310 320 330
860 870 880 890 900 910
pF1KE0 RCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ
340 350 360 370 380 390
920 930 940 950 960 970
pF1KE0 SCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCY
400 410 420 430 440 450
980 990 1000 1010 1020 1030
pF1KE0 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINA
460 470 480 490 500 510
1040 1050 1060 1070 1080 1090
pF1KE0 NTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPN
520 530 540 550 560 570
pF1KE0 S
:
XP_016 S
580
>>XP_016877471 (OMIM: 607511,613195) PREDICTED: A disint (652 aa)
initn: 2813 init1: 2813 opt: 2833 Z-score: 2322.0 bits: 440.7 E(85289): 1.4e-122
Smith-Waterman score: 4368; 92.3% identity (92.3% similar) in 652 aa overlap (494-1095:1-652)
470 480 490 500 510 520
pF1KE0 KLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGA
::::::::::::::::::::::::::::::
XP_016 MCAGLWCLVEGDTSCKTKLDPPLDGTECGA
10 20 30
530 540 550 560 570 580
pF1KE0 DKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCP
40 50 60 70 80 90
590 600 610 620 630 640
pF1KE0 GASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKE
100 110 120 130 140 150
650 660 670 680 690 700
pF1KE0 SPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVK
160 170 180 190 200 210
710
pF1KE0 GDFSHARGT--------------------------------------------------A
::::::::: :
XP_016 GDFSHARGTVKNDLCTKVSTCVMAEAVPKCFSCYIEAAVIPAGARRIRVVEDKPAHSFLA
220 230 240 250 260 270
720 730 740 750 760 770
pF1KE0 LKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQD
280 290 300 310 320 330
780 790 800 810 820 830
pF1KE0 YGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNK
340 350 360 370 380 390
840 850 860 870 880 890
pF1KE0 TTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQ
400 410 420 430 440 450
900 910 920 930 940 950
pF1KE0 NGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQG
460 470 480 490 500 510
960 970 980 990 1000 1010
pF1KE0 KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPA
520 530 540 550 560 570
1020 1030 1040 1050 1060 1070
pF1KE0 LSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWY
580 590 600 610 620 630
1080 1090
pF1KE0 QRCCQTCRDFYANKMRQPPPNS
::::::::::::::::::::::
XP_016 QRCCQTCRDFYANKMRQPPPNS
640 650
>>XP_016877468 (OMIM: 607511,613195) PREDICTED: A disint (749 aa)
initn: 2813 init1: 2813 opt: 2833 Z-score: 2321.2 bits: 440.7 E(85289): 1.5e-122
Smith-Waterman score: 5064; 93.3% identity (93.3% similar) in 749 aa overlap (397-1095:1-749)
370 380 390 400 410 420
pF1KE0 CSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDL
::::::::::::::::::::::::::::::
XP_016 MNHDDDHSSCAGRSHIMSGEWVKGRNPSDL
10 20 30
430 440 450 460 470 480
pF1KE0 SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATF
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE0 CRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDW
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE0 SPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRD
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE0 QQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLC
220 230 240 250 260 270
670 680 690 700 710
pF1KE0 VHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGT--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTVKNDLCTKVSTCVM
280 290 300 310 320 330
720 730
pF1KE0 ------------------------------------ALKDSGKGSINSDWKIELPGEFQI
::::::::::::::::::::::::
XP_016 AEAVPKCFSCYIEAAVIPAGARRIRVVEDKPAHSFLALKDSGKGSINSDWKIELPGEFQI
340 350 360 370 380 390
740 750 760 770 780 790
pF1KE0 AGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEK
400 410 420 430 440 450
800 810 820 830 840 850
pF1KE0 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC
460 470 480 490 500 510
860 870 880 890 900 910
pF1KE0 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC
520 530 540 550 560 570
920 930 940 950 960 970
pF1KE0 EGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEW
580 590 600 610 620 630
980 990 1000 1010 1020 1030
pF1KE0 KTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANT
640 650 660 670 680 690
1040 1050 1060 1070 1080 1090
pF1KE0 ITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
700 710 720 730 740
>>XP_016877469 (OMIM: 607511,613195) PREDICTED: A disint (749 aa)
initn: 2813 init1: 2813 opt: 2833 Z-score: 2321.2 bits: 440.7 E(85289): 1.5e-122
Smith-Waterman score: 5064; 93.3% identity (93.3% similar) in 749 aa overlap (397-1095:1-749)
370 380 390 400 410 420
pF1KE0 CSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDL
::::::::::::::::::::::::::::::
XP_016 MNHDDDHSSCAGRSHIMSGEWVKGRNPSDL
10 20 30
430 440 450 460 470 480
pF1KE0 SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATF
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE0 CRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDW
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE0 SPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRD
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE0 QQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLC
220 230 240 250 260 270
670 680 690 700 710
pF1KE0 VHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGT--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTVKNDLCTKVSTCVM
280 290 300 310 320 330
720 730
pF1KE0 ------------------------------------ALKDSGKGSINSDWKIELPGEFQI
::::::::::::::::::::::::
XP_016 AEAVPKCFSCYIEAAVIPAGARRIRVVEDKPAHSFLALKDSGKGSINSDWKIELPGEFQI
340 350 360 370 380 390
740 750 760 770 780 790
pF1KE0 AGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEK
400 410 420 430 440 450
800 810 820 830 840 850
pF1KE0 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC
460 470 480 490 500 510
860 870 880 890 900 910
pF1KE0 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC
520 530 540 550 560 570
920 930 940 950 960 970
pF1KE0 EGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEW
580 590 600 610 620 630
980 990 1000 1010 1020 1030
pF1KE0 KTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANT
640 650 660 670 680 690
1040 1050 1060 1070 1080 1090
pF1KE0 ITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
700 710 720 730 740
>>XP_016877467 (OMIM: 607511,613195) PREDICTED: A disint (823 aa)
initn: 2847 init1: 2813 opt: 2833 Z-score: 2320.7 bits: 440.8 E(85289): 1.6e-122
Smith-Waterman score: 5319; 93.6% identity (93.6% similar) in 787 aa overlap (359-1095:37-823)
330 340 350 360 370 380
pF1KE0 GKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIA
::::::::::::::::::::::::::::::
XP_016 HLGWIYFSSTKKTQEALVTSRATECFPLFEGIAYLGGVCSAKRKCVLAEDNGLNLAFTIA
10 20 30 40 50 60
390 400 410 420 430 440
pF1KE0 HELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCL
70 80 90 100 110 120
450 460 470 480 490 500
pF1KE0 LVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSC
130 140 150 160 170 180
510 520 530 540 550 560
pF1KE0 KTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQR
190 200 210 220 230 240
570 580 590 600 610 620
pF1KE0 KCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVV
250 260 270 280 290 300
630 640 650 660 670 680
pF1KE0 DDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDR
310 320 330 340 350 360
690 700 710
pF1KE0 CGVCSGDGKTCHLVKGDFSHARGT------------------------------------
::::::::::::::::::::::::
XP_016 CGVCSGDGKTCHLVKGDFSHARGTVKNDLCTKVSTCVMAEAVPKCFSCYIEAAVIPAGAR
370 380 390 400 410 420
720 730 740 750
pF1KE0 --------------ALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPT
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIRVVEDKPAHSFLALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPT
430 440 450 460 470 480
760 770 780 790 800 810
pF1KE0 KLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGG
490 500 510 520 530 540
820 830 840 850 860 870
pF1KE0 GERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCE
550 560 570 580 590 600
880 890 900 910 920 930
pF1KE0 KGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCG
610 620 630 640 650 660
940 950 960 970 980 990
pF1KE0 KGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQ
670 680 690 700 710 720
1000 1010 1020 1030 1040 1050
pF1KE0 CMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYC
730 740 750 760 770 780
1060 1070 1080 1090
pF1KE0 RVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
:::::::::::::::::::::::::::::::::::::
XP_016 RVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS
790 800 810 820
1095 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:33:38 2016 done: Fri Nov 4 03:33:41 2016
Total Scan time: 15.380 Total Display time: 0.360
Function used was FASTA [36.3.4 Apr, 2011]