Result of FASTA (omim) for
pFN21AB9970
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9970, 703 aa
1>>>pF1KB9970 703 - 703 aa - 703 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2010+/-0.000501; mu= 16.4251+/- 0.031
mean_var=182.2533+/-34.980, 0's: 0 Z-trim(114.6): 504 B-trim: 111 in 1/52
Lambda= 0.095003
statistics sampled from 23918 (24541) to 23918 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.288), width: 16
Scan time: 8.880
The best scores are: opt bits E(85289)
NP_006477 (OMIM: 135820,608180) fibulin-1 isoform ( 703) 5098 712.5 1.4e-204
NP_006476 (OMIM: 135820,608180) fibulin-1 isoform ( 601) 4179 586.4 1.1e-166
NP_006478 (OMIM: 135820,608180) fibulin-1 isoform ( 566) 4172 585.4 2e-166
NP_001987 (OMIM: 135820,608180) fibulin-1 isoform ( 683) 4172 585.5 2.3e-166
NP_001989 (OMIM: 135821) fibulin-2 isoform b precu (1184) 1858 268.7 9.3e-71
NP_001004019 (OMIM: 135821) fibulin-2 isoform a pr (1231) 1729 251.0 2e-65
NP_001158507 (OMIM: 135821) fibulin-2 isoform a pr (1231) 1729 251.0 2e-65
XP_006713089 (OMIM: 135821) PREDICTED: fibulin-2 i (1192) 1308 193.3 4.6e-48
XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 749 116.9 6.2e-25
XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 744 116.3 1.1e-24
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 738 115.7 2.5e-24
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912) 738 115.7 2.6e-24
XP_011508340 (OMIM: 603075,608548) PREDICTED: hemi (5518) 697 110.5 1.8e-22
XP_016857926 (OMIM: 603075,608548) PREDICTED: hemi (4976) 692 109.7 2.8e-22
NP_114141 (OMIM: 603075,608548) hemicentin-1 precu (5635) 692 109.8 3e-22
XP_011535067 (OMIM: 251750,600975,602091,613086,61 (1694) 682 107.7 3.8e-22
NP_000419 (OMIM: 251750,600975,602091,613086,61481 (1821) 682 107.8 4e-22
XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 678 107.1 5e-22
XP_016882843 (OMIM: 604710,613177) PREDICTED: late (1438) 670 106.0 1.1e-21
XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593) 670 106.0 1.1e-21
XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 658 104.3 3.4e-21
XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436) 658 104.3 3.4e-21
XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478) 658 104.3 3.4e-21
XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480) 658 104.3 3.4e-21
XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 658 104.4 3.5e-21
XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549) 658 104.4 3.5e-21
NP_001036010 (OMIM: 604710,613177) latent-transfor (1557) 658 104.4 3.5e-21
NP_003564 (OMIM: 604710,613177) latent-transformin (1587) 658 104.4 3.6e-21
XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591) 658 104.4 3.6e-21
XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593) 658 104.4 3.6e-21
XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595) 658 104.4 3.6e-21
XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611) 658 104.4 3.6e-21
NP_001036009 (OMIM: 604710,613177) latent-transfor (1624) 658 104.4 3.6e-21
XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635) 658 104.4 3.6e-21
XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662) 658 104.4 3.7e-21
XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 ( 799) 637 101.1 1.8e-20
XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 ( 818) 637 101.1 1.8e-20
NP_085072 (OMIM: 602108) matrilin-2 isoform b prec ( 937) 637 101.2 1.9e-20
NP_002371 (OMIM: 602108) matrilin-2 isoform a prec ( 956) 637 101.2 2e-20
XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595) 636 101.4 2.9e-20
XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 ( 896) 623 99.3 7.1e-20
NP_001304677 (OMIM: 602108) matrilin-2 isoform c p ( 915) 623 99.3 7.2e-20
XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639) 621 99.3 1.2e-19
XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364) 566 91.7 2e-17
NP_001400 (OMIM: 604266) multiple epidermal growth (1541) 566 91.8 2.2e-17
XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559) 566 91.8 2.2e-17
XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560) 566 91.8 2.2e-17
XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603) 566 91.8 2.3e-17
XP_011531164 (OMIM: 150390) PREDICTED: latent-tran (1248) 557 90.4 4.6e-17
NP_001159738 (OMIM: 150390) latent-transforming gr (1300) 557 90.4 4.7e-17
>>NP_006477 (OMIM: 135820,608180) fibulin-1 isoform D pr (703 aa)
initn: 5098 init1: 5098 opt: 5098 Z-score: 3793.7 bits: 712.5 E(85289): 1.4e-204
Smith-Waterman score: 5098; 100.0% identity (100.0% similar) in 703 aa overlap (1-703:1-703)
10 20 30 40 50 60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV
610 620 630 640 650 660
670 680 690 700
pF1KB9 RQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
:::::::::::::::::::::::::::::::::::::::::::
NP_006 RQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
670 680 690 700
>>NP_006476 (OMIM: 135820,608180) fibulin-1 isoform B pr (601 aa)
initn: 4541 init1: 4179 opt: 4179 Z-score: 3113.7 bits: 586.4 E(85289): 1.1e-166
Smith-Waterman score: 4179; 99.3% identity (99.8% similar) in 571 aa overlap (1-571:1-571)
10 20 30 40 50 60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
:::::::::::::::::::::::::: ...:
NP_006 TCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 ISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVV
NP_006 A
>>NP_006478 (OMIM: 135820,608180) fibulin-1 isoform A pr (566 aa)
initn: 4172 init1: 4172 opt: 4172 Z-score: 3108.8 bits: 585.4 E(85289): 2e-166
Smith-Waterman score: 4172; 100.0% identity (100.0% similar) in 566 aa overlap (1-566:1-566)
10 20 30 40 50 60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTV
::::::::::::::::::::::::::
NP_006 TCFNIQGGFRCLAFECPENYRRSAAT
550 560
>>NP_001987 (OMIM: 135820,608180) fibulin-1 isoform C pr (683 aa)
initn: 4172 init1: 4172 opt: 4172 Z-score: 3107.9 bits: 585.5 E(85289): 2.3e-166
Smith-Waterman score: 4230; 85.7% identity (90.3% similar) in 700 aa overlap (1-699:1-680)
10 20 30 40 50 60
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
490 500 510 520 530 540
550 560 570 580 590
pF1KB9 TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIK-SCRPNDVTCVFDPVHTISHT
:::::::::::::::::::::::::: :: . :. : : :.. :..
NP_001 TCFNIQGGFRCLAFECPENYRRSAAT---------RCERLPCHENR-ECSKLPLR-ITYY
550 560 570 580
600 610 620 630 640 650
pF1KB9 VISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGV
.:.:: .. : ..: . : . .. . :: :: . : : .. . ::
NP_001 HLSFPT--NIQAPA-VVF--RMGPSSAVPGDSMQLAITGGNEEGFFTT--RKVSPHS-GV
590 600 610 620 630 640
660 670 680 690 700
pF1KB9 VRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
: ..:. : .: ..:. :.:: :... ::::
NP_001 VALTKPVPEPRDLLLTVKMDLSRHGTVSSF-VAKLFIFVSAEL
650 660 670 680
>>NP_001989 (OMIM: 135821) fibulin-2 isoform b precursor (1184 aa)
initn: 2130 init1: 1039 opt: 1858 Z-score: 1391.3 bits: 268.7 E(85289): 9.3e-71
Smith-Waterman score: 1996; 41.4% identity (61.4% similar) in 736 aa overlap (61-701:472-1182)
40 50 60 70 80 90
pF1KB9 VLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
:: .:..:: : :.: : .:. :.: .
NP_001 IETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGET
450 460 470 480 490 500
100 110 120 130 140
pF1KB9 CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACC------
:.. :: : .. :.:: :: :: ..:.::::: . .:: :..:. .::
NP_001 CGAE--DNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPL
510 520 530 540 550
150
pF1KB9 -----------------VKSQETG--------------------DLD-------------
:. : . : :
NP_001 IVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHL
560 570 580 590 600 610
160 170
pF1KB9 ----VGG----------LQETDKIIEVE------EEQEDPYLN-----------------
::. ::. . . : : ..: :.
NP_001 CINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQ
620 630 640 650 660 670
180 190 200 210 220 230
pF1KB9 -DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
. :. .::::: : .: ..:::: :: ...:::::::.:::.: :.: :: :.::
NP_001 PNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNT
680 690 700 710 720 730
240 250 260 270 280 290
pF1KB9 VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS
.:::.: . .: :: : .:. :.:.::: : :.: : :.:::: ::: :. . .: .
NP_001 LGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMD
740 750 760 770 780 790
300 310 320 330 340 350
pF1KB9 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVD
::.:: :::.::::: :.: :: : .:::: ::::::.: :.:::: ...::.:::
NP_001 GFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVD
800 810 820 830 840 850
360 370 380 390 400 410
pF1KB9 VDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
:.:: .. ::.:. : : :::.::.::.:. :...: :.::::: ::::: : ::
NP_001 VNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCE
860 870 880 890 900 910
420 430 440 450 460 470
pF1KB9 NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDG
:::::: :::. :: :..::. :::.::: .. :::::::.:::::::::.::::.. ::
NP_001 NTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAE-DG
920 930 940 950 960 970
480 490 500 510 520 530
pF1KB9 VTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNC
:: :::::: .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. : :::
NP_001 HTCTDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNC
980 990 1000 1010 1020 1030
540 550 560 570 580 590
pF1KB9 SINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTI
: ::: ::::.:::: :::: :: .: :: .: .. . . : .:.. :
NP_001 SEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSPAR-I
1040 1050 1060 1070 1080
600 610 620 630 640 650
pF1KB9 SHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRYMDGM
.: ... : . : .:. . : :: .. : ..: .:: . : : ....
NP_001 THYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRRLNAY
1090 1100 1110 1120 1130
660 670 680 690 700
pF1KB9 TVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
: ::: : .. : .: .::. : :. ....::: . .
NP_001 T-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
1140 1150 1160 1170 1180
>>NP_001004019 (OMIM: 135821) fibulin-2 isoform a precur (1231 aa)
initn: 2090 init1: 1039 opt: 1729 Z-score: 1295.6 bits: 251.0 E(85289): 2e-65
Smith-Waterman score: 1826; 39.5% identity (59.3% similar) in 740 aa overlap (36-701:521-1229)
10 20 30 40 50 60
pF1KB9 PSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDC-SLPYATESKECRMV
::. : :. .. ..: : : . . : :
NP_001 AGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNP--NLGYPCNHV
500 510 520 530 540
70 80 90 100 110
pF1KB9 QEQCCHSQL-----------EELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCC
. .::... : .: :. : : : .: : .. :
NP_001 MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC
550 560 570 580 590 600
120 130 140 150
pF1KB9 LLGRAAQAQGQSCEYSLM--VG-YQC-----------GQVFRACCVKSQETGDLDVGGLQ
:: :. :.. . :: :.: :.. : : . . . .
NP_001 LL-----LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS
610 620 630 640 650 660
160 170 180 190 200 210
pF1KB9 ETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED---
: ... : : :. .::::: : .: ..:::: :: ...:::::::
NP_001 EFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE
670 680 690 700 710 720
220 230
pF1KB9 --------------------------------------------VNECITGSHSCRLGES
.:::.: :.: ::
NP_001 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH
730 740 750 760 770 780
240 250 260 270 280 290
pF1KB9 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL
:.::.:::.: . .: :: : .:. :.:.::: : :.: : :.:::: ::: :. .
NP_001 CVNTLGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ
790 800 810 820 830 840
300 310 320 330 340 350
pF1KB9 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT
.: .::.:: :::.::::: :.: :: : .:::: ::::::.: :.:::: ...::
NP_001 RCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT
850 860 870 880 890 900
360 370 380 390 400 410
pF1KB9 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG
.::::.:: .. ::.:. : : :::.::.::.:. :...: :.::::: :::::
NP_001 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ
910 920 930 940 950 960
420 430 440 450 460 470
pF1KB9 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLS
: :::::::: :::. :: :..::. :::.::: .. :::::::.:::::::::.::::.
NP_001 HTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLA
970 980 990 1000 1010 1020
480 490 500 510 520 530
pF1KB9 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG
. :: :: :::::: .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. :
NP_001 E-DGHTCTDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG
1030 1040 1050 1060 1070
540 550 560 570 580 590
pF1KB9 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP
:::: ::: ::::.:::: :::: :: .: :: .: .. . . : .:
NP_001 THNCSEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSP
1080 1090 1100 1110 1120 1130
600 610 620 630 640 650
pF1KB9 VHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRY
.. :.: ... : . : .:. . : :: .. : ..: .:: . : :
NP_001 AR-ITHYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRR
1140 1150 1160 1170 1180
660 670 680 690 700
pF1KB9 MDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
....: ::: : .. : .: .::. : :. ....::: . .
NP_001 LNAYT-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
1190 1200 1210 1220 1230
>>NP_001158507 (OMIM: 135821) fibulin-2 isoform a precur (1231 aa)
initn: 2090 init1: 1039 opt: 1729 Z-score: 1295.6 bits: 251.0 E(85289): 2e-65
Smith-Waterman score: 1826; 39.5% identity (59.3% similar) in 740 aa overlap (36-701:521-1229)
10 20 30 40 50 60
pF1KB9 PSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDC-SLPYATESKECRMV
::. : :. .. ..: : : . . : :
NP_001 AGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNP--NLGYPCNHV
500 510 520 530 540
70 80 90 100 110
pF1KB9 QEQCCHSQL-----------EELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCC
. .::... : .: :. : : : .: : .. :
NP_001 MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC
550 560 570 580 590 600
120 130 140 150
pF1KB9 LLGRAAQAQGQSCEYSLM--VG-YQC-----------GQVFRACCVKSQETGDLDVGGLQ
:: :. :.. . :: :.: :.. : : . . . .
NP_001 LL-----LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS
610 620 630 640 650 660
160 170 180 190 200 210
pF1KB9 ETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED---
: ... : : :. .::::: : .: ..:::: :: ...:::::::
NP_001 EFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE
670 680 690 700 710 720
220 230
pF1KB9 --------------------------------------------VNECITGSHSCRLGES
.:::.: :.: ::
NP_001 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH
730 740 750 760 770 780
240 250 260 270 280 290
pF1KB9 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL
:.::.:::.: . .: :: : .:. :.:.::: : :.: : :.:::: ::: :. .
NP_001 CVNTLGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ
790 800 810 820 830 840
300 310 320 330 340 350
pF1KB9 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT
.: .::.:: :::.::::: :.: :: : .:::: ::::::.: :.:::: ...::
NP_001 RCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT
850 860 870 880 890 900
360 370 380 390 400 410
pF1KB9 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG
.::::.:: .. ::.:. : : :::.::.::.:. :...: :.::::: :::::
NP_001 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ
910 920 930 940 950 960
420 430 440 450 460 470
pF1KB9 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLS
: :::::::: :::. :: :..::. :::.::: .. :::::::.:::::::::.::::.
NP_001 HTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLA
970 980 990 1000 1010 1020
480 490 500 510 520 530
pF1KB9 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG
. :: :: :::::: .: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. :
NP_001 E-DGHTCTDIDECA-QGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG
1030 1040 1050 1060 1070
540 550 560 570 580 590
pF1KB9 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP
:::: ::: ::::.:::: :::: :: .: :: .: .. . . : .:
NP_001 THNCSEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSP
1080 1090 1100 1110 1120 1130
600 610 620 630 640 650
pF1KB9 VHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRY
.. :.: ... : . : .:. . : :: .. : ..: .:: . : :
NP_001 AR-ITHYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRR
1140 1150 1160 1170 1180
660 670 680 690 700
pF1KB9 MDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
....: ::: : .. : .: .::. : :. ....::: . .
NP_001 LNAYT-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
1190 1200 1210 1220 1230
>>XP_006713089 (OMIM: 135821) PREDICTED: fibulin-2 isofo (1192 aa)
initn: 2094 init1: 870 opt: 1308 Z-score: 983.9 bits: 193.3 E(85289): 4.6e-48
Smith-Waterman score: 1518; 35.4% identity (54.9% similar) in 740 aa overlap (36-701:521-1190)
10 20 30 40 50 60
pF1KB9 PSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDC-SLPYATESKECRMV
::. : :. .. ..: : : . . : :
XP_006 AGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNP--NLGYPCNHV
500 510 520 530 540
70 80 90 100 110
pF1KB9 QEQCCHSQL-----------EELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCC
. .::... : .: :. : : : .: : .. :
XP_006 MLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDEC
550 560 570 580 590 600
120 130 140 150
pF1KB9 LLGRAAQAQGQSCEYSLM--VG-YQC-----------GQVFRACCVKSQETGDLDVGGLQ
:: :. :.. . :: :.: :.. : : . . . .
XP_006 LL-----LPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS
610 620 630 640 650 660
160 170 180 190 200 210
pF1KB9 ETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCED---
: ... : : :. .::::: : .: ..:::: :: ...:::::::
XP_006 EFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE
670 680 690 700 710 720
220 230
pF1KB9 --------------------------------------------VNECITGSHSCRLGES
.:::.: :.: ::
XP_006 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH
730 740 750 760 770 780
240 250 260 270 280 290
pF1KB9 CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL
:.::.:::.: . .: :: : .:. :.:.::: : :.: : :.:::: ::: :. .
XP_006 CVNTLGSFHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ
790 800 810 820 830 840
300 310 320 330 340 350
pF1KB9 QCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGT
.: .::.:: :::.::::: :.: :: : .:::: ::::::.: :.:::: ...::
XP_006 RCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGT
850 860 870 880 890 900
360 370 380 390 400 410
pF1KB9 RCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCG
.::::.:: .. ::.:. : : :::.::.::.:. :...: :.::::: :::::
XP_006 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQ
910 920 930 940 950 960
420 430 440 450 460 470
pF1KB9 HKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLS
: :::::::: :::. :: :..::. ::::.::...
XP_006 HTCENTLGSYRCSCASGFLLAADGKRCEDIDECAQG------------------------
970 980 990
480 490 500 510 520 530
pF1KB9 DVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTG
.: .:..::.:.:::.::.:: .:: .. :::.:.:.:::. :
XP_006 -----------------AGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALG
1000 1010 1020 1030 1040
540 550 560 570 580 590
pF1KB9 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP
:::: ::: ::::.:::: :::: :: .: :: .: .. . . : .:
XP_006 THNCSEAETCHNIQGSFRCLRFECPPNY------VQVSKT---KCERTTCHDFLECQNSP
1050 1060 1070 1080 1090
600 610 620 630 640 650
pF1KB9 VHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANII-FDITEGNLRDSFDIIKRY
.. :.: ... : . : .:. . : :: .. : ..: .:: . : :
XP_006 AR-ITHYQLNFQT--GLLVPAHIFRI----GPAPAFTGDTIALNIIKGNEEGYFG--TRR
1100 1110 1120 1130 1140
660 670 680 690 700
pF1KB9 MDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
....: ::: : .. : .: .::. : :. ....::: . .
XP_006 LNAYT-GVVYLQRAVLEPRDFALDVEMKLWRQGSVT-TFLAKMHIFFTTFAL
1150 1160 1170 1180 1190
>>XP_011525684 (OMIM: 604710,613177) PREDICTED: latent-t (1554 aa)
initn: 666 init1: 369 opt: 749 Z-score: 568.6 bits: 116.9 E(85289): 6.2e-25
Smith-Waterman score: 910; 37.5% identity (57.8% similar) in 424 aa overlap (178-588:600-995)
150 160 170 180 190 200
pF1KB9 QETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRG-GGPCKQ-QCRDTGDEVVCSCFVGY
:.:: :: .:... : : :.
XP_011 GRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGF
570 580 590 600 610 620
210 220 230 240 250 260
pF1KB9 QLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDID
. .. : ::.:: : ::. : :: ::: : : .::. . . ::.:.:
XP_011 RAGPRAAECLDVDECHRVPPPCDLGR-CENTPGSFLC----VCPAGYQAAPHGASCQDVD
630 640 650 660 670 680
270 280 290 300 310 320
pF1KB9 ECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGH
:: . : :.:: :::.: : :: .. :. : :..:: . : :: :.
XP_011 ECARSPPPCTYGR-CENTEGSFQCV----CPMGFQPNTAGSECEDVDECENHLA-CP-GQ
690 700 710 720 730
330 340 350 360 370 380
pF1KB9 TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCE
:.:. ::. :. .: :.::.. : ::.:::::. : ::: .:.:. :::::
XP_011 ECVNSPGSFQCR----TCPSGHHLHR-G-RCTDVDECSSGAPPCGPHGHCTNTEGSFRCS
740 750 760 770 780 790
390 400 410 420 430 440
pF1KB9 CKTGYYF-DGISRMCVDVNECQRYPGRLC-GH-KCENTLGSYLCSCSVGFRLSVDGRSCE
: :: .: :.::::: . : .: : .: :: ::. :.:. :.: . : ::
XP_011 CAPGYRAPSGRPGPCADVNECLE--GDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCL
800 810 820 830 840
450 460 470 480 490
pF1KB9 DINECSSSPCSQE--CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYR
:..::: : :.:. ::..: : :.. . : ..: :.::: : .: : :
XP_011 DVDECSEEDLCQSGICTNTDGSFECICPPGHR-AGPDLASCLDVDECR-ERGPALCGSQR
850 860 870 880 890 900
500 510 520 530 540 550
pF1KB9 CINIPGSFQC--SCPSSGYRLAPNGRNCQDIDECVT-GIHNCSINETCFNIQGGFRCLAF
: : :::..: .: . ::. .:.: .:.:.::: : . :. . : : :..::
XP_011 CENSPGSYRCVRDC-DPGYHAGPEG-TCDDVDECQEYGPEICGA-QRCENTPGSYRCTP-
910 920 930 940 950 960
560 570 580 590 600 610
pF1KB9 ECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEE
: .:. . . :. .: : . : . : :
XP_011 ACDPGYQPTPGGGCQD-VDECRNRSFCGAHAV-CQNLPGSFQCLCDQGYEGARDGRHCVD
970 980 990 1000 1010 1020
620 630 640 650 660 670
pF1KB9 IIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVL
XP_011 VNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPA
1030 1040 1050 1060 1070 1080
>>XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 iso (1948 aa)
initn: 599 init1: 236 opt: 744 Z-score: 563.9 bits: 116.3 E(85289): 1.1e-24
Smith-Waterman score: 1004; 34.1% identity (55.8% similar) in 593 aa overlap (19-589:38-568)
10 20 30 40
pF1KB9 MERAAPSRRVPLPLLLLGGLALLAAG-VDADVLLEACCADGHRMATHQ
:: : :.: . .:: :: : . .
XP_016 DVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCF-----LRWDE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 KDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVK
.:.. : . :: . :: :. : . : . : :. ::: :..
XP_016 DECGV---TLPGKYRM--DVCC--------CSIGAVWGVECEACPDPE----SLE--FAS
70 80 90 100
110 120 130 140 150 160
pF1KB9 RCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV
: . :: :.. .. . :. .: .:: . : .. : ::... . .
XP_016 LCPRG--LGFASRDFLSGRPFYKDVN-EC-KVFPGLC--THGTCRNTVGSFHCACAGGFA
110 120 130 140 150
170 180 190 200 210 220
pF1KB9 EEEQEDPYLN-DRCRGGGP-CKQ-QCRDTGDEVVCSCFVGYQ---LLSDGVSCEDVNECI
. :: . :.:: . : : : .: : :: ::. .: .: ::.::
XP_016 LDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMK--NCMDVDECA
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB9 TGSHSCRLGESCINTVGSFRCQRDSSCGTGYELT-EDNSCKDIDECESGIHNCLPDFICQ
:: : .: :: ::..:: : :.::: . ..:.::::: . : : :
XP_016 RDPLLCR-GGTCTNTDGSYKCQ----CPPGHELTAKGTACEDIDECSLSDGLC-PHGQCV
220 230 240 250 260
290 300 310 320 330
pF1KB9 NTLGSFRCRPKLQCKSGF--IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNV
:..:.:.: .:..:: : : :.::::: .. : . : :::::::: :
XP_016 NVIGAFQC----SCHAGFQSTPDRQG-CVDINECRVQNGGCDV-H-CINTEGSYRC----
270 280 290 300 310
340 350 360 370 380 390
pF1KB9 PNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCV
.::.:: : .: :.::::: . : .:: :.: ::. :: : :.. : ::
XP_016 -SCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTCV
320 330 340 350 360 370
400 410 420 430 440 450
pF1KB9 DVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDINEC--SSSPCSQE--
::.::. : ..: : :::: ::..: :..:. . . .: :..:: .. :...
XP_016 DVDECDLNP-HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHAS
380 390 400 410 420 430
460 470 480 490 500 510
pF1KB9 CANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYR--CINIPGSFQCSCPS
: :. ::..: : :. :: :.:.:::. . : :: : :.:.:::..:.:
XP_016 CLNIPGSFSCRCLPGWVG---DGFECHDLDECV--SQEHRCSPRGDCLNVPGSYRCTC-R
440 450 460 470 480
520 530 540 550 560
pF1KB9 SGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC---LAFECPENYRRSAATLQ
.:. : .: :.: :::. .. :. : :.: ::.:: ..:. : . .:. ..
XP_016 QGF--AGDGFFCEDRDECAENVDLCD-NGQCLNAPGGYRCECEMGFD-PTEDHRACQDVD
490 500 510 520 530 540
570 580 590 600 610 620
pF1KB9 QEKTDTVRCIKSCR--PNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHP
. .. . ::. :. :.
XP_016 ECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGS
550 560 570 580 590 600
>--
initn: 405 init1: 234 opt: 775 Z-score: 586.8 bits: 120.5 E(85289): 6e-26
Smith-Waterman score: 870; 30.8% identity (49.9% similar) in 617 aa overlap (60-608:863-1442)
30 40 50 60 70
pF1KB9 DVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQC----CHSQLEELHCA------
:: . : : .:. ..:
XP_016 PISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFN
840 850 860 870 880 890
80 90 100 110 120 130
pF1KB9 -TGISLANEQ-DRCAT---PHGDNAS-LEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVG
..: :: :. :.:.. : .::. .. :: : : . : .: ::
XP_016 YNSILLACEDVDECGSRESPCQQNADCINIPGSYRC--KCTRGYKL-SPGGAC-----VG
900 910 920 930 940
140 150 160 170 180 190
pF1KB9 Y-QCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQ-QCR
.: .. .: . . : . . . . ... .: . :.: :: . :.
XP_016 RNECREIPNVC--SHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC-DRQPCGNGTCK
950 960 970 980 990 1000
200 210 220 230 240 250
pF1KB9 DTGDEVVCSCFVGYQLLSDGVSCEDVNECITG-SHSCRLGESCINTVGSFRCQRDSSCGT
. : :: :. . .: .: : .:: : .. ::.:. :.::.:::.: :
XP_016 NIIGSYNCLCFPGFVVTHNG-DCVDFDECTTLVGQVCRFGH-CLNTAGSFHCL----CQD
1010 1020 1030 1040 1050
260 270 280 290 300
pF1KB9 GYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDI
:.::: :. .: : .:: : .::: ::: ::::: : :: : .::::
XP_016 GFELTADGKNCVDTNECLSLAGTCLPG-TCQNLEGSFRC----ICPPGF-QVQSDHCIDI
1060 1070 1080 1090 1100
310 320 330 340 350
pF1KB9 NECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDE----------
.:: : .: :: :. ::. : : :. :...: :: :. .
XP_016 DECSEEPNLCLFG-TCTNSPGSFQCL-----CPPGFVLSDNGHRCFDTRQSFCFTRFEAG
1110 1120 1130 1140 1150 1160
360 370 380 390
pF1KB9 -CAPPAEPCGKGHRCVNS--PG----------------SFRCECKTGY-YFDGISRMCVD
:. : :: : :: .:. : :. : . :
XP_016 KCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSRED
1170 1180 1190 1200 1210 1220
400 410 420 430 440 450
pF1KB9 VNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQ-ECANV
:::: . :: . : :: ::. : : :. :. : .: : .::: . ::.: :.::
XP_016 VNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNV
1230 1240 1250 1260 1270 1280
460 470 480 490 500 510
pF1KB9 YGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLA
:...: : :.. . . .::::::::.: . .:..:: : ::. :.::. :: :
XP_016 IGGFECACADGFEPGLM--MTCEDIDECSL--NPLLCAFRCHNTEGSYLCTCPA-GYTLR
1290 1300 1310 1320 1330
520 530 540 550 560 570
pF1KB9 PNGRNCQDIDECVTGIHNCSI-NETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTV-
.: :.:.:::. : ..: . : :. : : :. :: ..: .. . :.
XP_016 EDGAMCRDVDECADGQQDCHARGMECKNLIGTFACV---CPPGMRPLPGSGEGCTDDNEC
1340 1350 1360 1370 1380 1390
580 590 600 610 620
pF1KB9 ----------RCIKSCRPNDVTCV--FDPVHTIS--HTVISLPTFREFTRPEEIIFLRAI
::... : :.: :.. : . . : : :
XP_016 HAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSS
1400 1410 1420 1430 1440 1450
630 640 650 660 670 680
pF1KB9 TPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYV
XP_016 EAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAH
1460 1470 1480 1490 1500 1510
>--
initn: 533 init1: 202 opt: 723 Z-score: 548.3 bits: 113.4 E(85289): 8.4e-24
Smith-Waterman score: 834; 36.8% identity (57.9% similar) in 399 aa overlap (181-569:1469-1835)
160 170 180 190 200
pF1KB9 GDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS-CFVGYQLLS
:: :: . : : . . : : .
XP_016 CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTA
1440 1450 1460 1470 1480 1490
210 220 230 240 250 260
pF1KB9 DGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED---NSCKDIDEC
.: .::.:: .: : :: :::..:::::. : .:: : : ..: :.:::
XP_016 EG---RDVDECRMLAHLCAHGE-CINSLGSFRCH----CQAGY--TPDATATTCLDMDEC
1500 1510 1520 1530 1540
270 280 290 300 310 320
pF1KB9 ESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTC
. . : :.:.:: ::: : .: :.. . : .: :..:: : . : . :
XP_016 SQVPKPC--TFLCKNTKGSFLC----SCPRGYLLEEDGRTCKDLDECTSRQHNCQF--LC
1550 1560 1570 1580 1590 1600
330 340 350 360 370 380
pF1KB9 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK
.:: :..::. : :. .... : : :::. ::: .: :.::::::::.
XP_016 VNTVGAFTCR-----CPPGFTQHHQA--CFDNDECSAQPGPCGAHGHCHNTPGSFRCECH
1610 1620 1630 1640 1650
390 400 410 420 430 440
pF1KB9 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC
:. . . .. : :::::. : : : : :.: ::.: ::: :: . .: : :::
XP_016 QGFTLVSSGHGCEDVNECDG-PHR-CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENEC
1660 1670 1680 1690 1700 1710
450 460 470 480 490 500
pF1KB9 SSSP--C-SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIP
. :: : : : :. :...: : :...... : :...:::: : ::: : : :
XP_016 ALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALG-GCQEVDECAGRRGP--CSYSCANTP
1720 1730 1740 1750 1760
510 520 530 540 550 560
pF1KB9 GSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC-LAFECPENY-
:.: :.::. :: : .: .: . : .. .: .. .. ..: . :..
XP_016 GGFLCGCPQ-GYFRAGQG-HCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRP
1770 1780 1790 1800 1810 1820
570 580 590 600 610 620
pF1KB9 RRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRA
:::: .:
XP_016 RRSAHRDHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQ
1830 1840 1850 1860 1870 1880
>--
initn: 347 init1: 227 opt: 318 Z-score: 248.3 bits: 57.9 E(85289): 4.3e-07
Smith-Waterman score: 446; 32.0% identity (54.0% similar) in 278 aa overlap (294-562:569-825)
270 280 290 300 310 320
pF1KB9 DECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQD-ALGNCIDINECLSISAPCPIG
:..:. : . ::: ::::: . . : :.
XP_016 RACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECAD-PVNC-IN
540 550 560 570 580 590
330 340 350 360 370 380
pF1KB9 HTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRC
.:::: ::: : .: . ..:: :. :::. : .: .. :
XP_016 GVCINTPGSYLC-----SCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGIS------C
600 610 620 630 640
390 400 410 420 430 440
pF1KB9 ECKTGYYFDGISRM--CVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE
. : :..: : .... : .:: ..: :: . ::. . :
XP_016 SAEIGV---GVTRASCCCSLGRAWGNPCELCPMA-NTTEYRTLCPGGEGFQPNRITVILE
650 660 670 680 690 700
450 460 470 480 490
pF1KB9 DINECSSSP--CSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY-
::.::. : :. .:.:..::.:: : ::.::. . :::::::. .: ::.
XP_016 DIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRI-CEDIDECSTHSG--ICGPG
710 720 730 740 750
500 510 520 530 540 550
pF1KB9 RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDE--CVTGIHNCSINETCFNIQGGFRCLAF
: : :.. : ::. : . .: ::.:. . : .. :: ::. . : ..
XP_016 TCYNTLGNYTCVCPAE-YLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSY
760 770 780 790 800 810
560 570 580 590 600 610
pF1KB9 ECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEE
. . . :
XP_016 NIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICI
820 830 840 850 860 870
703 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 09:06:16 2016 done: Fri Nov 4 09:06:17 2016
Total Scan time: 8.880 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]