Result of FASTA (omim) for
pFN21AB4185
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4185, 385 aa
1>>>pF1KB4185 385 - 385 aa - 385 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1227+/-0.000398; mu= 12.9663+/- 0.025
mean_var=86.4529+/-17.276, 0's: 0 Z-trim(113.1): 406 B-trim: 98 in 1/54
Lambda= 0.137938
statistics sampled from 21896 (22318) to 21896 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.262), width: 16
Scan time: 8.390
The best scores are: opt bits E(85289)
NP_003260 (OMIM: 603849) nuclear receptor subfamil ( 385) 2557 519.0 7.6e-147
NP_001273031 (OMIM: 603849) nuclear receptor subfa ( 422) 2505 508.6 1.1e-143
NP_055064 (OMIM: 268100,604485,611131) photorecept ( 410) 1059 220.9 4.4e-57
NP_057430 (OMIM: 268100,604485,611131) photorecept ( 367) 880 185.2 2.1e-46
NP_001278159 (OMIM: 114480,133430,157300,608446,61 ( 597) 574 124.4 6.8e-28
NP_005645 (OMIM: 132890,615722) COUP transcription ( 423) 552 120.0 1.1e-26
XP_016865286 (OMIM: 132890,615722) PREDICTED: COUP ( 273) 541 117.7 3.3e-26
NP_066285 (OMIM: 107773,615779) COUP transcription ( 414) 541 117.8 4.7e-26
NP_005225 (OMIM: 132880) nuclear receptor subfamil ( 404) 540 117.6 5.3e-26
NP_001138629 (OMIM: 107773,615779) COUP transcript ( 261) 532 115.9 1.1e-25
NP_001138628 (OMIM: 107773,615779) COUP transcript ( 261) 532 115.9 1.1e-25
NP_001138627 (OMIM: 107773,615779) COUP transcript ( 281) 532 115.9 1.2e-25
XP_006715438 (OMIM: 114480,133430,157300,608446,61 ( 422) 476 104.9 3.8e-22
NP_000116 (OMIM: 114480,133430,157300,608446,61536 ( 595) 476 104.9 5e-22
NP_001116213 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
NP_001116214 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_011533847 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_011533845 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_016865869 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_016865867 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_016865868 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_016865866 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
NP_001116212 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_016865870 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_016865865 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
XP_011533846 (OMIM: 114480,133430,157300,608446,61 ( 595) 476 104.9 5e-22
NP_001315029 (OMIM: 114480,133430,157300,608446,61 ( 310) 437 97.0 6.3e-20
XP_006715437 (OMIM: 114480,133430,157300,608446,61 ( 466) 437 97.1 8.9e-20
XP_011533849 (OMIM: 114480,133430,157300,608446,61 ( 483) 437 97.1 9.2e-20
NP_001165290 (OMIM: 600409) peroxisome proliferato ( 402) 431 95.9 1.8e-19
XP_006715186 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_006715183 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_011513012 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_016866460 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
NP_006229 (OMIM: 600409) peroxisome proliferator-a ( 441) 431 95.9 1.9e-19
XP_016866463 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_016866461 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_016866462 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
NP_001165289 (OMIM: 600409) peroxisome proliferato ( 441) 431 95.9 1.9e-19
XP_005249250 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_011513009 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
XP_011513011 (OMIM: 600409) PREDICTED: peroxisome ( 441) 431 95.9 1.9e-19
NP_001001928 (OMIM: 170998) peroxisome proliferato ( 468) 425 94.7 4.7e-19
XP_006724333 (OMIM: 170998) PREDICTED: peroxisome ( 468) 425 94.7 4.7e-19
XP_005261713 (OMIM: 170998) PREDICTED: peroxisome ( 468) 425 94.7 4.7e-19
XP_011528544 (OMIM: 170998) PREDICTED: peroxisome ( 468) 425 94.7 4.7e-19
XP_011528543 (OMIM: 170998) PREDICTED: peroxisome ( 468) 425 94.7 4.7e-19
XP_006724332 (OMIM: 170998) PREDICTED: peroxisome ( 468) 425 94.7 4.7e-19
XP_011528545 (OMIM: 170998) PREDICTED: peroxisome ( 468) 425 94.7 4.7e-19
NP_005027 (OMIM: 170998) peroxisome proliferator-a ( 468) 425 94.7 4.7e-19
>>NP_003260 (OMIM: 603849) nuclear receptor subfamily 2 (385 aa)
initn: 2557 init1: 2557 opt: 2557 Z-score: 2757.4 bits: 519.0 E(85289): 7.6e-147
Smith-Waterman score: 2557; 100.0% identity (100.0% similar) in 385 aa overlap (1-385:1-385)
10 20 30 40 50 60
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE
310 320 330 340 350 360
370 380
pF1KB4 VFFKKTIGNVPITRLLSDMYKSSDI
:::::::::::::::::::::::::
NP_003 VFFKKTIGNVPITRLLSDMYKSSDI
370 380
>>NP_001273031 (OMIM: 603849) nuclear receptor subfamily (422 aa)
initn: 2501 init1: 2501 opt: 2505 Z-score: 2700.8 bits: 508.6 E(85289): 1.1e-143
Smith-Waterman score: 2505; 98.2% identity (99.0% similar) in 385 aa overlap (1-385:41-422)
10 20 30
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGV
. .:.: :::::::::::::::::::::
NP_001 KEPSPRPECRADPGPGLGFPLGSGLPWPSLLESPGG---RILDIPCKVCGDRSSGKHYGV
20 30 40 50 60
40 50 60 70 80 90
pF1KB4 YACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB4 ERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB4 PERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB4 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB4 VVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIH
310 320 330 340 350 360
340 350 360 370 380
pF1KB4 TRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
370 380 390 400 410 420
>>NP_055064 (OMIM: 268100,604485,611131) photoreceptor-s (410 aa)
initn: 1058 init1: 377 opt: 1059 Z-score: 1145.8 bits: 220.9 E(85289): 4.4e-57
Smith-Waterman score: 1059; 44.1% identity (70.7% similar) in 392 aa overlap (4-382:38-410)
10 20 30
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYAC
:.: . .. :.:::: :::::::.:::
NP_055 LMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSP---SLQCRVCGDSSSGKHYGIYAC
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB4 DGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERG
.:::::::::.:: : :. : : :::::.:::::.::::::::...::.::::.::
NP_055 NGCSGFFKRSVRRRLIYRCQVGA-GMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ
70 80 90 100 110 120
100 110 120 130 140
pF1KB4 PRTSTIRKQVAL-YFRGHKE---ENGAAAHFPSAALP-APAFFTAVTQLEPHGLELAAVS
::... :: : .... : :. .: :.. : .:. ..:. : : . ..
NP_055 PRSTA---QVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB4 TT-----PERQTL-VSLAQPTPKYPHE--VNGTPMYLYEVATESVCESAARLLFMSIKWA
: :: ..... :..: ...: : .:. :..::::::..:::
NP_055 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL-----DSIHETSARLLFMAVKWA
190 200 210 220 230
210 220 230 240 250 260
pF1KB4 KSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNK
:..:.::.: ..::..:::.:: :::.:: ::..:.:. ::: .. . . .:.
NP_055 KNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KB4 IISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDE
: ..:::...::: : .: :::::.: .: :: : : :.... . ::::.
NP_055 ASMETRVLQETISRFRALAVDPTEFACMKALVLFK--P-----ETRGLKDPEHVEALQDQ
300 310 320 330 340
330 340 350 360 370 380
pF1KB4 AQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMY
.:. :... ....:.:: ::::::::::.:: :. :: .::.:::::.:. .:: ::.
NP_055 SQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMF
350 360 370 380 390 400
pF1KB4 KSSDI
:.
NP_055 KN
410
>>NP_057430 (OMIM: 268100,604485,611131) photoreceptor-s (367 aa)
initn: 874 init1: 377 opt: 880 Z-score: 954.1 bits: 185.2 E(85289): 2.1e-46
Smith-Waterman score: 880; 41.8% identity (69.1% similar) in 349 aa overlap (4-339:38-367)
10 20 30
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYAC
:.: . .. :.:::: :::::::.:::
NP_057 LMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSP---SLQCRVCGDSSSGKHYGIYAC
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB4 DGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERG
.:::::::::.:: : :. : : :::::.:::::.::::::::...::.::::.::
NP_057 NGCSGFFKRSVRRRLIYRCQVGA-GMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ
70 80 90 100 110 120
100 110 120 130 140
pF1KB4 PRTSTIRKQVAL-YFRGHKE---ENGAAAHFPSAALP-APAFFTAVTQLEPHGLELAAVS
::... :: : .... : :. .: :.. : .:. ..:. : : . ..
NP_057 PRSTA---QVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB4 TT-----PERQTL-VSLAQPTPKYPHE--VNGTPMYLYEVATESVCESAARLLFMSIKWA
: :: ..... :..: ...: : .:. :..::::::..:::
NP_057 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL-----DSIHETSARLLFMAVKWA
190 200 210 220 230
210 220 230 240 250 260
pF1KB4 KSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNK
:..:.::.: ..::..:::.:: :::.:: ::..:.:. ::: .. . . .:.
NP_057 KNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KB4 IISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDE
: ..:::...::: : .: :::::.: .: :: : : :.... . ::::.
NP_057 ASMETRVLQETISRFRALAVDPTEFACMKALVLFK--P-----ETRGLKDPEHVEALQDQ
300 310 320 330 340
330 340 350 360 370 380
pF1KB4 AQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMY
.:. :... ....:.:: :
NP_057 SQVMLSQHSKAHHPSQPVR
350 360
>>NP_001278159 (OMIM: 114480,133430,157300,608446,615363 (597 aa)
initn: 474 init1: 287 opt: 574 Z-score: 621.8 bits: 124.4 E(85289): 6.8e-28
Smith-Waterman score: 574; 32.4% identity (60.9% similar) in 373 aa overlap (16-379:185-545)
10 20 30 40
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIR
: ::.: .:: ::::..:.::..::::::.
NP_001 DNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQ
160 170 180 190 200 210
50 60 70 80 90 100
pF1KB4 RNR--TYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHER-GPRTSTIRKQ
:: :.: . :: : .::..:..:.::::.:: ::.: : .....: : : ..:
NP_001 GNRHNDYMCPATNQ--CTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
220 230 240 250 260 270
110 120 130 140 150 160
pF1KB4 VALYFRGH-KEENGAAAHFPSAAL-PAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLA
:. . : :.:. . .: : :.: . . . . ..: :.: : .... . :
NP_001 RD---DGEGRGEVGSAGDMRAANLWPSPLM---IKRSKKNSL---ALSLTADQMVSALLD
280 290 300 310 320
170 180 190 200 210 220
pF1KB4 QPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLED
: : . : . . . : : : :.::: ::.: :.:.::. :::
NP_001 AEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLEC
330 340 350 360 370 380
230 240 250 260 270 280
pF1KB4 AWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRL
:: :....:.. : . :: . .. : .... .. .. .. : . .:::.. :
NP_001 AWLEILMIGLV-WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNL
390 400 410 420 430 440
290 300 310 320 330
pF1KB4 DATEFACLKCIVTFKA-VPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPT---Q
.. ::.::: :. ... : : .: :.:... : . :. :: . : :
NP_001 QGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQ
450 460 470 480 490 500
340 350 360 370 380
pF1KB4 PCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
:...:::.: .: .: . .:... : . ::. :: .:
NP_001 HQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASV
510 520 530 540 550 560
NP_001 EETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
570 580 590
>>NP_005645 (OMIM: 132890,615722) COUP transcription fac (423 aa)
initn: 951 init1: 302 opt: 552 Z-score: 600.4 bits: 120.0 E(85289): 1.1e-26
Smith-Waterman score: 880; 38.1% identity (65.5% similar) in 383 aa overlap (4-382:74-409)
10 20 30
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYAC
: :: . : : ::::.::::::: ..:
NP_005 AGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTC
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB4 DGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERG
.::..:::::.::: ::.:... .::.:. :::::. :::::::.:.: ..:::. :
NP_005 EGCKSFFKRSVRRNLTYTCRANR--NCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRM
110 120 130 140 150 160
100 110 120 130 140
pF1KB4 PRTSTIRKQVALY----FRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVST
: :. : :: . :: .: ... . . ::.
NP_005 PPTQPNPGQYALTNGDPLNGHCYLSG--------------YISLLLRAEPY---------
170 180 190
150 160 170 180 190 200
pF1KB4 TPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTL
:: .: . : .. . :..:: :::::: ...::...: : :
NP_005 ------------PTSRYGSQCM-QPNNIMGI--ENICELAARLLFSAVEWARNIPFFPDL
200 210 220 230 240
210 220 230 240 250 260
pF1KB4 SLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQ
.. ::. ::. .: :::::. :: ..:. . :::..:.... ..... ....:. .:
NP_005 QITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQ
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB4 EVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYI
: : ... :..:..:..::: :: : :. .. .:: : .::...: .:. :.
NP_005 EQVEKLKALHVDSAEYSCLKAIVLFT-------SDACGLSDAAHIESLQEKSQCALEEYV
310 320 330 340 350
330 340 350 360 370 380
pF1KB4 HTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
...::.:: ::::::: ::.::..: :.::..:: . .:..:: :. :: :
NP_005 RSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWP
360 370 380 390 400 410
NP_005 YMSIQCS
420
>>XP_016865286 (OMIM: 132890,615722) PREDICTED: COUP tra (273 aa)
initn: 564 init1: 302 opt: 541 Z-score: 591.4 bits: 117.7 E(85289): 3.3e-26
Smith-Waterman score: 541; 38.5% identity (72.4% similar) in 221 aa overlap (162-382:49-259)
140 150 160 170 180 190
pF1KB4 TAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAAR
:: .: . : .. . :..:: :::
XP_016 GQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCM-QPNNIMGI--ENICELAAR
20 30 40 50 60 70
200 210 220 230 240 250
pF1KB4 LLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGD
::: ...::...: : :.. ::. ::. .: :::::. :: ..:. . :::..:....
XP_016 LLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHAS
80 90 100 110 120 130
260 270 280 290 300 310
pF1KB4 NTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNA
..... ....:. .:: : ... :..:..:..::: :: : :. .. .:
XP_016 PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------SDACGLSDA
140 150 160 170 180
320 330 340 350 360 370
pF1KB4 AAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVP
: : .::...: .:. :....::.:: ::::::: ::.::..: :.::..:: . .:..:
XP_016 AHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTP
190 200 210 220 230 240
380
pF1KB4 ITRLLSDMYKSSDI
: :. :: :
XP_016 IETLIRDMLLSGSSFNWPYMSIQCS
250 260 270
>>NP_066285 (OMIM: 107773,615779) COUP transcription fac (414 aa)
initn: 924 init1: 312 opt: 541 Z-score: 588.7 bits: 117.8 E(85289): 4.7e-26
Smith-Waterman score: 863; 37.7% identity (67.2% similar) in 369 aa overlap (14-382:77-402)
10 20 30 40
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRS
: : ::::.::::::: ..:.::..:::::
NP_066 GPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRS
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB4 IRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQV
.::: .:.:... . ::.:. :::::. :::::::.:.: ..:::. : : :. . :
NP_066 VRRNLSYTCRANRN--CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQF
110 120 130 140 150 160
110 120 130 140 150 160
pF1KB4 ALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPT
:: :: . : .... . . ::. : . . ::
NP_066 AL-------TNGDPLNCHSYL---SGYISLLLRAEPY----------PTSRFGSQCMQP-
170 180 190 200
170 180 190 200 210 220
pF1KB4 PKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWR
... : :..:: :::.:: ...::...: : :.. ::. ::. .:
NP_066 ----NNIMGI---------ENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWS
210 220 230 240 250
230 240 250 260 270 280
pF1KB4 ELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDAT
:::::. :: ..:. . :::..:.... ..... ....:. .:: : ... :..:..
NP_066 ELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSA
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB4 EFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKL
:..::: :: : :. .. ..: . .::...: .:. :....::.:: :::::
NP_066 EYSCLKAIVLFT-------SDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKL
320 330 340 350 360
350 360 370 380
pF1KB4 LLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
:: ::.::..: :.::..:: . .:..:: :. :: :
NP_066 LLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
370 380 390 400 410
>>NP_005225 (OMIM: 132880) nuclear receptor subfamily 2 (404 aa)
initn: 846 init1: 300 opt: 540 Z-score: 587.8 bits: 117.6 E(85289): 5.3e-26
Smith-Waterman score: 858; 37.7% identity (66.5% similar) in 382 aa overlap (2-382:42-392)
10 20 30
pF1KB4 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVY
..:. :.. : ::::.::::::::.
NP_005 GGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVF
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB4 ACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHE
.:.::..::::::::: .:.:.:. . : .:. :::::. ::::::..:.: :.:::.
NP_005 TCEGCKSFFKRSIRRNLSYTCRSNRD--CQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRG
80 90 100 110 120
100 110 120 130 140 150
pF1KB4 RGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTP
: : :. ...:: :.. : . ..::.. : .: . .
NP_005 RIP---------------HSLPGAVAA---SSGSPPGSALAAVAS----GGDLFPGQPVS
130 140 150 160
160 170 180 190 200 210
pF1KB4 ERQTLVSLAQPTPKYPHEVN-GTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLS
: . . :.: : . . : .. ..::: :::::: ...::. .: : :
NP_005 ELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELP
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB4 LQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQE
. ::. ::. .: :::::. :: :.:. . :::..:... ... ......:.::
NP_005 VADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQE
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB4 VVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIH
: .. .:..:..:..::: :. : .: : . . : . .::..::..:. :..
NP_005 QVDKLGRLQVDSAEYGCLKAIALF--TPDACG-----LSDPAHVESLQEKAQVALTEYVR
290 300 310 320 330 340
340 350 360 370 380
pF1KB4 TRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
..::.:: :::.::: :::::.. : : ..:: . .:..:: :. :: :
NP_005 AQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPY
350 360 370 380 390 400
NP_005 GSGQ
>>NP_001138629 (OMIM: 107773,615779) COUP transcription (261 aa)
initn: 553 init1: 312 opt: 532 Z-score: 582.0 bits: 115.9 E(85289): 1.1e-25
Smith-Waterman score: 532; 36.4% identity (71.5% similar) in 228 aa overlap (157-382:29-249)
130 140 150 160 170 180
pF1KB4 APAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYE--VATES
.:: . :: :. . . .. :.
NP_001 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIEN
10 20 30 40 50
190 200 210 220 230 240
pF1KB4 VCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLA
.:: :::.:: ...::...: : :.. ::. ::. .: :::::. :: ..:. . :::
NP_001 ICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLA
60 70 80 90 100 110
250 260 270 280 290 300
pF1KB4 VSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSE
..:.... ..... ....:. .:: : ... :..:..:..::: :: : :.
NP_001 AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------SD
120 130 140 150 160 170
310 320 330 340 350 360
pF1KB4 LRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFK
.. ..: . .::...: .:. :....::.:: ::::::: ::.::..: :.::..::
NP_001 ACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFV
180 190 200 210 220 230
370 380
pF1KB4 KTIGNVPITRLLSDMYKSSDI
. .:..:: :. :: :
NP_001 RLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
240 250 260
385 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 22:57:10 2016 done: Fri Nov 4 22:57:11 2016
Total Scan time: 8.390 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]