FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6998, 217 aa 1>>>pF1KB6998 217 - 217 aa - 217 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4939+/-0.000366; mu= 12.6670+/- 0.023 mean_var=64.5694+/-12.817, 0's: 0 Z-trim(113.6): 45 B-trim: 0 in 0/52 Lambda= 0.159610 statistics sampled from 23047 (23080) to 23047 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.271), width: 16 Scan time: 6.110 The best scores are: opt bits E(85289) NP_001308 (OMIM: 150200) chorionic somatomammotrop ( 217) 1448 341.9 4.6e-94 NP_066271 (OMIM: 118820) chorionic somatomammotrop ( 217) 1437 339.4 2.7e-93 NP_072101 (OMIM: 603515) chorionic somatomammotrop ( 222) 1284 304.2 1.1e-82 NP_000506 (OMIM: 139250,173100,262400,262650,61278 ( 217) 1228 291.3 8.3e-79 NP_002050 (OMIM: 139240) growth hormone variant is ( 217) 1129 268.5 6e-72 NP_072170 (OMIM: 118820) chorionic somatomammotrop ( 167) 996 237.8 7.9e-63 NP_001307998 (OMIM: 603515) chorionic somatomammot ( 183) 965 230.7 1.2e-60 NP_001307996 (OMIM: 603515) chorionic somatomammot ( 162) 957 228.8 3.9e-60 XP_011522646 (OMIM: 603515) PREDICTED: chorionic s ( 261) 872 209.3 4.6e-54 NP_072053 (OMIM: 139250,173100,262400,262650,61278 ( 202) 837 201.2 9.8e-52 NP_072103 (OMIM: 603515) chorionic somatomammotrop ( 199) 828 199.2 4.1e-51 NP_072102 (OMIM: 603515) chorionic somatomammotrop ( 139) 819 197.0 1.3e-50 NP_001307997 (OMIM: 603515) chorionic somatomammot ( 160) 819 197.1 1.4e-50 NP_072050 (OMIM: 139240) growth hormone variant is ( 202) 782 188.6 6.4e-48 NP_001309 (OMIM: 603515) chorionic somatomammotrop ( 128) 774 186.7 1.5e-47 NP_072052 (OMIM: 139240) growth hormone variant is ( 245) 735 177.8 1.4e-44 NP_072051 (OMIM: 139240) growth hormone variant is ( 256) 732 177.1 2.3e-44 NP_072054 (OMIM: 139250,173100,262400,262650,61278 ( 177) 714 172.9 2.9e-43 XP_011522648 (OMIM: 603515) PREDICTED: chorionic s ( 201) 545 134.0 1.7e-31 NP_072171 (OMIM: 118820) chorionic somatomammotrop ( 122) 446 111.1 8e-25 NP_000939 (OMIM: 176760) prolactin precursor [Homo ( 227) 249 65.9 6.3e-11 NP_001157030 (OMIM: 176760) prolactin precursor [H ( 227) 249 65.9 6.3e-11 XP_011513055 (OMIM: 176760) PREDICTED: prolactin i ( 228) 249 65.9 6.3e-11 XP_011513056 (OMIM: 176760) PREDICTED: prolactin i ( 228) 249 65.9 6.3e-11 >>NP_001308 (OMIM: 150200) chorionic somatomammotropin h (217 aa) initn: 1448 init1: 1448 opt: 1448 Z-score: 1809.6 bits: 341.9 E(85289): 4.6e-94 Smith-Waterman score: 1448; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD 130 140 150 160 170 180 190 200 210 pF1KB6 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF ::::::::::::::::::::::::::::::::::::: NP_001 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF 190 200 210 >>NP_066271 (OMIM: 118820) chorionic somatomammotropin h (217 aa) initn: 1437 init1: 1437 opt: 1437 Z-score: 1796.0 bits: 339.4 E(85289): 2.7e-93 Smith-Waterman score: 1437; 99.5% identity (99.5% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD 130 140 150 160 170 180 190 200 210 pF1KB6 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF ::::::::::::::::::::::::::::::::::::: NP_066 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF 190 200 210 >>NP_072101 (OMIM: 603515) chorionic somatomammotropin h (222 aa) initn: 1292 init1: 957 opt: 1284 Z-score: 1605.4 bits: 304.2 E(85289): 1.1e-82 Smith-Waterman score: 1284; 90.1% identity (93.2% similar) in 222 aa overlap (1-217:1-222) 10 20 30 40 50 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEF--- :: ::::::::::::::::::::::::::::::::: .::::::::::::::::::: NP_072 MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFKEAMLQAHRAHQLAIDTYQEFISS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 --EETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEP :.:: :.::::::::::::::::::::: :::::::::::::::.:::::::: ::: NP_072 WGMEAYITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLIESRLEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 VRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTN :::::: :.:::::::::::::::::::::::: :::::::::. ::: ::::::::::: NP_072 VRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTN 130 140 150 160 170 180 180 190 200 210 pF1KB6 SHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF ::::::::::::::.::::::::::::::::::::::::::: NP_072 SHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF 190 200 210 220 >>NP_000506 (OMIM: 139250,173100,262400,262650,612781) s (217 aa) initn: 1228 init1: 1228 opt: 1228 Z-score: 1535.9 bits: 291.3 E(85289): 8.3e-79 Smith-Waterman score: 1228; 85.3% identity (94.9% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :: ::::::::::.:::::::::..: :.:::::::.:::.::: ::::.::::::::. NP_000 MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR ::::.::::::.. :::.:::.::::::: :::::::::::::::::::.::::::.::: NP_000 YIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD :.:::.::: .:::. : :::::::::::::::::::: :::::.::::::::::::: : NP_000 SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD 130 140 150 160 170 180 190 200 210 pF1KB6 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF ::::::::::::::::::::::::.:::::::::::: NP_000 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 190 200 210 >>NP_002050 (OMIM: 139240) growth hormone variant isofor (217 aa) initn: 1129 init1: 1129 opt: 1129 Z-score: 1412.7 bits: 268.5 E(85289): 6e-72 Smith-Waterman score: 1129; 79.7% identity (92.6% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :: ::::::::::.:::: ::::..: :.:::::::.:::.:.: .::: ::::::::. NP_002 MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR :: :.::::::.. :::.:::.::::::: .:::::::::::::::::.::::::..:: NP_002 YILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD :.:::.::: .:::. :. :::::::::::: :::::: :::::..:.::::::.::: : NP_002 SVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDD 130 140 150 160 170 180 190 200 210 pF1KB6 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF ::::::::::::::::::::::::.:::::::::::: NP_002 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 190 200 210 >>NP_072170 (OMIM: 118820) chorionic somatomammotropin h (167 aa) initn: 991 init1: 991 opt: 996 Z-score: 1248.9 bits: 237.8 E(85289): 7.9e-63 Smith-Waterman score: 996; 93.4% identity (94.0% similar) in 166 aa overlap (1-165:1-166) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMG-RLEDGSRRTGQILKQTYSKFDTNSHNH :::::::::::::::::::::::::::::::: :. : : : NP_072 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGVRVAPGVANPGTPLA 130 140 150 160 180 190 200 210 pF1KB6 DALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF >>NP_001307998 (OMIM: 603515) chorionic somatomammotropi (183 aa) initn: 963 init1: 963 opt: 965 Z-score: 1209.7 bits: 230.7 E(85289): 1.2e-60 Smith-Waterman score: 1030; 77.9% identity (80.6% similar) in 217 aa overlap (1-217:1-183) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :: :::::::::::::::::::: ::. NP_001 MAAGSRTSLLLAFALLCLPWLQE----------------------------------EEA 10 20 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR :: :.::::::::::::::::::::: :::::::::::::::.:::::::: :::::::: NP_001 YITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLIESRLEPVRFLR 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD : :.:::::::::::::::::::::::: :::::::::. ::: :::::::::::::::: NP_001 STFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSHLTGQTLKQTYSKFDTNSHNHD 90 100 110 120 130 140 190 200 210 pF1KB6 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF :::::::::.::::::::::::::::::::::::::: NP_001 ALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGSCGF 150 160 170 180 >>NP_001307996 (OMIM: 603515) chorionic somatomammotropi (162 aa) initn: 957 init1: 957 opt: 957 Z-score: 1200.6 bits: 228.8 E(85289): 3.9e-60 Smith-Waterman score: 957; 91.8% identity (95.6% similar) in 159 aa overlap (59-217:4-162) 30 40 50 60 70 80 pF1KB6 TVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPS :.:: :.::::::::::::::::::::: : NP_001 MAAEAYITKEQKYSFLHDSQTSFCFSDSIPTSS 10 20 30 90 100 110 120 130 140 pF1KB6 NMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQ ::::::::::::::.:::::::: ::::::::: :.:::::::::::::::::::::::: NP_001 NMEETQQKSNLELLHISLLLIESRLEPVRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQ 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 TLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQC :::::::::. ::: :::::::::::::::::::::::::.:::::::::::::::::: NP_001 MLMGRLEDGSHLTGQTLKQTYSKFDTNSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQC 100 110 120 130 140 150 210 pF1KB6 RSVEGSCGF ::::::::: NP_001 RSVEGSCGF 160 >>XP_011522646 (OMIM: 603515) PREDICTED: chorionic somat (261 aa) initn: 875 init1: 540 opt: 872 Z-score: 1091.6 bits: 209.3 E(85289): 4.6e-54 Smith-Waterman score: 872; 83.6% identity (87.7% similar) in 171 aa overlap (1-165:1-171) 10 20 30 40 50 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEF--- :: ::::::::::::::::::::::::::::::::: .::::::::::::::::::: XP_011 MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFKEAMLQAHRAHQLAIDTYQEFISS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 --EETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEP :.:: :.::::::::::::::::::::: :::::::::::::::.:::::::: ::: XP_011 WGMEAYITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLHISLLLIESRLEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 VRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMG-RLEDGSRRTGQILKQTYSKFDT :::::: :.:::::::::::::::::::::::: ::: :. : :. : XP_011 VRFLRSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGVRVAPGVPNPGSPLASRAGGEKH 130 140 150 160 170 180 180 190 200 210 pF1KB6 NSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF XP_011 CCPLFSSQALTQENSPYSSFPLVNPPGLSLHPEGEGGKWINERGREQCPSAWSLLLLLHF 190 200 210 220 230 240 >>NP_072053 (OMIM: 139250,173100,262400,262650,612781) s (202 aa) initn: 1131 init1: 837 opt: 837 Z-score: 1049.8 bits: 201.2 E(85289): 9.8e-52 Smith-Waterman score: 1105; 79.7% identity (88.0% similar) in 217 aa overlap (1-217:1-202) 10 20 30 40 50 60 pF1KB6 MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET :: ::::::::::.:::::::::..: :.:::::::.:::.::: ::::.:::::: NP_072 MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEF--- 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR . :::.:::.::::::: :::::::::::::::::::.::::::.::: NP_072 ------------NPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD :.:::.::: .:::. : :::::::::::::::::::: :::::.::::::::::::: : NP_072 SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD 110 120 130 140 150 160 190 200 210 pF1KB6 ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF ::::::::::::::::::::::::.:::::::::::: NP_072 ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF 170 180 190 200 217 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:17:03 2016 done: Sat Nov 5 02:17:04 2016 Total Scan time: 6.110 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]