Result of FASTA (omim) for
pFN21AB6997
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6997, 211 aa
1>>>pF1KB6997 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4049+/-0.000294; mu= 14.2365+/- 0.018
mean_var=75.5375+/-15.227, 0's: 0 Z-trim(119.2): 35 B-trim: 33 in 1/53
Lambda= 0.147568
statistics sampled from 32847 (32882) to 32847 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.386), width: 16
Scan time: 6.570
The best scores are: opt bits E(85289)
XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 1388 304.0 1.2e-82
NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 1388 304.0 1.2e-82
XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 992 219.6 2.2e-57
NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 231 57.6 1.7e-08
NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 225 56.4 4.5e-08
XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 217 54.6 1.3e-07
XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 217 54.7 1.4e-07
NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 209 52.9 4e-07
NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07
NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07
NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07
NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07
NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 210 53.2 4.1e-07
XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 210 53.2 4.1e-07
NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07
NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07
XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 210 53.2 4.1e-07
NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 208 52.8 5.2e-07
XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 205 52.0 6.7e-07
NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 205 52.1 7.3e-07
NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 205 52.1 7.3e-07
NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 204 51.8 8e-07
NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 202 51.5 1.3e-06
NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 198 50.6 1.9e-06
NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 185 48.0 2.2e-05
NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 180 46.8 3e-05
XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-relat ( 212) 171 44.9 0.00012
NP_115904 (OMIM: 605404) bcl-2-related ovarian kil ( 212) 171 44.9 0.00012
NP_001108207 (OMIM: 601056) bcl-2-related protein ( 163) 167 43.9 0.00017
NP_004040 (OMIM: 601056) bcl-2-related protein A1 ( 175) 167 44.0 0.00018
NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 158 41.9 0.00049
NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 158 42.0 0.00059
NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 157 41.8 0.00067
XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 150 40.3 0.0018
XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 150 40.3 0.0018
>>XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homologou (211 aa)
initn: 1388 init1: 1388 opt: 1388 Z-score: 1604.8 bits: 304.0 E(85289): 1.2e-82
Smith-Waterman score: 1388; 97.2% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYHHQQEQEAEGAAAPADPEM
:::::::::::::::::::::::::::::::::::::::::.:::::::::.::::::::
XP_011 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_011 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
::::::::::::::.::::::.::.:::::::::::::::::::::::::::::::::::
XP_011 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
130 140 150 160 170 180
190 200 210
pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
:::::::::::::::::::::::::::::::
XP_011 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
190 200 210
>>NP_001179 (OMIM: 600516) bcl-2 homologous antagonist/k (211 aa)
initn: 1388 init1: 1388 opt: 1388 Z-score: 1604.8 bits: 304.0 E(85289): 1.2e-82
Smith-Waterman score: 1388; 97.2% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYHHQQEQEAEGAAAPADPEM
:::::::::::::::::::::::::::::::::::::::::.:::::::::.::::::::
NP_001 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
::::::::::::::.::::::.::.:::::::::::::::::::::::::::::::::::
NP_001 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA
130 140 150 160 170 180
190 200 210
pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
:::::::::::::::::::::::::::::::
NP_001 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
190 200 210
>>XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homologou (152 aa)
initn: 992 init1: 992 opt: 992 Z-score: 1151.2 bits: 219.6 E(85289): 2.2e-57
Smith-Waterman score: 992; 97.4% identity (100.0% similar) in 152 aa overlap (60-211:1-152)
30 40 50 60 70 80
pF1KB6 DTEEVFRSYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRY
::::::::::::::::::::::::::::::
XP_011 MVTLPLQPSSTMGQVGRQLAIIGDDINRRY
10 20 30
90 100 110 120 130 140
pF1KB6 DSEFQTMLQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTG
::::::::::::::::::::::::::.::::::::::::::::::.::::::.::.::::
XP_011 DSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTG
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF
100 110 120 130 140 150
210
pF1KB6 KS
::
XP_011 KS
>>NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 bet (205 aa)
initn: 267 init1: 152 opt: 231 Z-score: 273.7 bits: 57.6 E(85289): 1.7e-08
Smith-Waterman score: 242; 28.6% identity (57.1% similar) in 175 aa overlap (7-181:46-199)
10 20 30
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR
:: .. :. :.::.. ::. .
NP_000 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP----
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM
: : :::: : . .: :. :.: ::..::: .: :
NP_000 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQAG-------DDFSRRYRRDFAEM
80 90 100 110
100 110 120 130 140 150
pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR
..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ...
NP_000 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
...... .: . :: . ::::.::
NP_000 WMTEYLNRH-LHTWIQDNGGWVGALGDVSLG
180 190 200
>>NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 alp (239 aa)
initn: 254 init1: 152 opt: 225 Z-score: 265.9 bits: 56.4 E(85289): 4.5e-08
Smith-Waterman score: 236; 28.0% identity (55.9% similar) in 186 aa overlap (7-192:46-209)
10 20 30
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR
:: .. :. :.::.. ::. .
NP_000 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP----
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM
: : :::: : . .: :. :.: ::..::: .: :
NP_000 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQAG-------DDFSRRYRRDFAEM
80 90 100 110
100 110 120 130 140 150
pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR
..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ...
NP_000 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
...... .: . :: . ::: : ..: :: . :
NP_000 WMTEYLNRH-LHTWIQDNGGWDAFVEL-YGPSMRPLFDFSWLSLKTLLSLALVGACITLG
180 190 200 210 220 230
NP_000 AYLGHK
>>XP_016881406 (OMIM: 151430) PREDICTED: apoptosis regul (198 aa)
initn: 251 init1: 152 opt: 217 Z-score: 257.8 bits: 54.6 E(85289): 1.3e-07
Smith-Waterman score: 228; 27.3% identity (56.4% similar) in 172 aa overlap (7-178:46-196)
10 20 30
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR
:: .. :. :.::.. ::. .
XP_016 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP----
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM
: : :::: : . .: :. :. :::..::: .: :
XP_016 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQA-------GDDFSRRYRRDFAEM
80 90 100 110
100 110 120 130 140 150
pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR
..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ...
XP_016 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
...... .: . :: . :::.
XP_016 WMTEYLNRH-LHTWIQDNGGWLYM
180 190
>>XP_011524437 (OMIM: 151430) PREDICTED: apoptosis regul (224 aa)
initn: 251 init1: 152 opt: 217 Z-score: 257.1 bits: 54.7 E(85289): 1.4e-07
Smith-Waterman score: 228; 27.7% identity (56.1% similar) in 173 aa overlap (7-179:46-197)
10 20 30
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR
:: .. :. :.::.. ::. .
XP_011 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP----
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM
: : :::: : . .: :. :. :::..::: .: :
XP_011 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQA-------GDDFSRRYRRDFAEM
80 90 100 110
100 110 120 130 140 150
pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR
..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ...
XP_011 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
...... .: . :: . ::: :
XP_011 WMTEYLNRH-LHTWIQDNGGWDALVLFAGLREFQHGPGNYFLKRNLNAKF
180 190 200 210 220
>>NP_620116 (OMIM: 600040) apoptosis regulator BAX isofo (192 aa)
initn: 160 init1: 87 opt: 209 Z-score: 248.8 bits: 52.9 E(85289): 4e-07
Smith-Waterman score: 209; 23.2% identity (63.3% similar) in 177 aa overlap (31-205:16-187)
10 20 30 40 50 60
pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYHHQQEQEAEGAAAPADPEM
.:..... .. . :. : . ::.
NP_620 MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPEL
10 20 30 40
70 80 90 100 110 120
pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFE
. :. ... .... : :::... . :.: :. .. ... : : ..:...:
NP_620 ALDPVPQDASTKKLSECLKRIGDELDS--NMELQRMIAAVD--TDSPREVFFRVAADMFS
50 60 70 80 90 100
130 140 150 160 170
pF1KB6 SG-INWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVA
.: .::::::::. :. .:.:. . .. . ...::. .. .. :: ..::: .
NP_620 DGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLG-WIQDQGGWDG
110 120 130 140 150 160
180 190 200 210
pF1KB6 ALN-LGNGPILNVLVVLGVVLLGQFVVRRFFKS
:. .:. .: . .. :: .....
NP_620 LLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
170 180 190
>>NP_001309169 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa)
initn: 231 init1: 164 opt: 210 Z-score: 248.8 bits: 53.2 E(85289): 4.1e-07
Smith-Waterman score: 222; 27.6% identity (62.5% similar) in 152 aa overlap (71-207:83-233)
50 60 70 80 90 100
pF1KB6 YHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL
:. : . : ::... :: :. . ..:
NP_001 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 QPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVD
. : .::. : .... ::..:.::::.::...:. : .. .. . ...... ...
NP_001 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT
120 130 140 150 160 170
170 180 190 200
pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV
.. : . :: . ::: . ..: ::. .:. ..: ::::::..
NP_001 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS
180 190 200 210 220 230
210
pF1KB6 RRFFKS
:.
NP_001 RK
>>NP_001304848 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa)
initn: 231 init1: 164 opt: 210 Z-score: 248.8 bits: 53.2 E(85289): 4.1e-07
Smith-Waterman score: 222; 27.6% identity (62.5% similar) in 152 aa overlap (71-207:83-233)
50 60 70 80 90 100
pF1KB6 YHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL
:. : . : ::... :: :. . ..:
NP_001 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 QPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVD
. : .::. : .... ::..:.::::.::...:. : .. .. . ...... ...
NP_001 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT
120 130 140 150 160 170
170 180 190 200
pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV
.. : . :: . ::: . ..: ::. .:. ..: ::::::..
NP_001 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS
180 190 200 210 220 230
210
pF1KB6 RRFFKS
:.
NP_001 RK
211 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:18:13 2016 done: Sat Nov 5 02:18:14 2016
Total Scan time: 6.570 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]