FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8401, 953 aa 1>>>pF1KB8401 953 - 953 aa - 953 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5308+/-0.000495; mu= 20.4497+/- 0.031 mean_var=73.7745+/-15.032, 0's: 0 Z-trim(107.3): 59 B-trim: 444 in 1/54 Lambda= 0.149321 statistics sampled from 15307 (15361) to 15307 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.521), E-opt: 0.2 (0.18), width: 16 Scan time: 13.350 The best scores are: opt bits E(85289) NP_057535 (OMIM: 600959) coatomer subunit beta [Ho ( 953) 6121 1329.1 0 NP_001137534 (OMIM: 600959) coatomer subunit beta ( 953) 6121 1329.1 0 NP_001137533 (OMIM: 600959) coatomer subunit beta ( 953) 6121 1329.1 0 XP_005257998 (OMIM: 601025) PREDICTED: AP-2 comple ( 733) 266 67.8 2.4e-10 XP_016879776 (OMIM: 601025) PREDICTED: AP-2 comple ( 733) 266 67.8 2.4e-10 NP_001273 (OMIM: 601025) AP-2 complex subunit beta ( 937) 266 67.8 2.9e-10 XP_016879773 (OMIM: 601025) PREDICTED: AP-2 comple ( 937) 266 67.8 2.9e-10 XP_005257995 (OMIM: 601025) PREDICTED: AP-2 comple ( 951) 266 67.8 3e-10 XP_005257994 (OMIM: 601025) PREDICTED: AP-2 comple ( 951) 266 67.8 3e-10 NP_001025177 (OMIM: 601025) AP-2 complex subunit b ( 951) 266 67.8 3e-10 XP_011522753 (OMIM: 601025) PREDICTED: AP-2 comple ( 969) 266 67.8 3e-10 XP_011522752 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 266 67.8 3e-10 XP_011522750 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 266 67.8 3e-10 XP_011522751 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 266 67.8 3e-10 NP_001159491 (OMIM: 600157) AP-1 complex subunit b ( 919) 257 65.9 1.1e-09 NP_663782 (OMIM: 600157) AP-1 complex subunit beta ( 939) 257 65.9 1.1e-09 NP_001118 (OMIM: 600157) AP-1 complex subunit beta ( 949) 257 65.9 1.1e-09 XP_011522757 (OMIM: 601025) PREDICTED: AP-2 comple ( 880) 220 57.9 2.7e-07 XP_016879775 (OMIM: 601025) PREDICTED: AP-2 comple ( 880) 220 57.9 2.7e-07 XP_016879774 (OMIM: 601025) PREDICTED: AP-2 comple ( 894) 220 57.9 2.7e-07 XP_011522756 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 220 57.9 2.8e-07 XP_011522754 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 220 57.9 2.8e-07 XP_011522755 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 220 57.9 2.8e-07 XP_005248676 (OMIM: 603401,608233) PREDICTED: AP-3 ( 871) 189 51.2 2.7e-05 XP_005248675 (OMIM: 603401,608233) PREDICTED: AP-3 (1053) 189 51.3 3.2e-05 NP_003655 (OMIM: 603401,608233) AP-3 complex subun (1094) 189 51.3 3.3e-05 XP_016865490 (OMIM: 603401,608233) PREDICTED: AP-3 (1004) 182 49.7 8.7e-05 NP_001258698 (OMIM: 603401,608233) AP-3 complex su (1045) 182 49.8 9e-05 XP_016878130 (OMIM: 602166) PREDICTED: AP-3 comple ( 629) 170 47.0 0.00035 XP_016878129 (OMIM: 602166) PREDICTED: AP-3 comple (1058) 170 47.2 0.00054 NP_004635 (OMIM: 602166) AP-3 complex subunit beta (1082) 170 47.2 0.00055 NP_001265441 (OMIM: 602166) AP-3 complex subunit b (1101) 170 47.2 0.00056 XP_016855582 (OMIM: 607245,614066) PREDICTED: AP-4 ( 405) 163 45.4 0.0007 XP_016855578 (OMIM: 607245,614066) PREDICTED: AP-4 ( 635) 163 45.5 0.001 NP_001240781 (OMIM: 607245,614066) AP-4 complex su ( 739) 163 45.6 0.0011 NP_006585 (OMIM: 607245,614066) AP-4 complex subun ( 739) 163 45.6 0.0011 >>NP_057535 (OMIM: 600959) coatomer subunit beta [Homo s (953 aa) initn: 6121 init1: 6121 opt: 6121 Z-score: 7121.8 bits: 1329.1 E(85289): 0 Smith-Waterman score: 6121; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 850 860 870 880 890 900 910 920 930 940 950 pF1KB8 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 910 920 930 940 950 >>NP_001137534 (OMIM: 600959) coatomer subunit beta [Hom (953 aa) initn: 6121 init1: 6121 opt: 6121 Z-score: 7121.8 bits: 1329.1 E(85289): 0 Smith-Waterman score: 6121; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 850 860 870 880 890 900 910 920 930 940 950 pF1KB8 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 910 920 930 940 950 >>NP_001137533 (OMIM: 600959) coatomer subunit beta [Hom (953 aa) initn: 6121 init1: 6121 opt: 6121 Z-score: 7121.8 bits: 1329.1 E(85289): 0 Smith-Waterman score: 6121; 100.0% identity (100.0% similar) in 953 aa overlap (1-953:1-953) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDNNEAAAADV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSVMTEIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLRGFLLDGDFFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSSL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPH 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEF 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQMWAEFEWENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSI 850 860 870 880 890 900 910 920 930 940 950 pF1KB8 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSI 910 920 930 940 950 >>XP_005257998 (OMIM: 601025) PREDICTED: AP-2 complex su (733 aa) initn: 183 init1: 105 opt: 266 Z-score: 306.8 bits: 67.8 E(85289): 2.4e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. XP_005 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . XP_005 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. XP_005 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. XP_005 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. XP_005 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. XP_005 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : XP_005 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . XP_005 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: XP_005 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: XP_005 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: XP_005 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL XP_005 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLPQK 610 620 630 640 650 660 >>XP_016879776 (OMIM: 601025) PREDICTED: AP-2 complex su (733 aa) initn: 183 init1: 105 opt: 266 Z-score: 306.8 bits: 67.8 E(85289): 2.4e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. XP_016 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . XP_016 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. XP_016 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. XP_016 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. XP_016 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. XP_016 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : XP_016 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . XP_016 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: XP_016 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: XP_016 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: XP_016 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL XP_016 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLPQK 610 620 630 640 650 660 >>NP_001273 (OMIM: 601025) AP-2 complex subunit beta iso (937 aa) initn: 183 init1: 105 opt: 266 Z-score: 305.2 bits: 67.8 E(85289): 2.9e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. NP_001 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . NP_001 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. NP_001 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. NP_001 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. NP_001 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. NP_001 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : NP_001 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . NP_001 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: NP_001 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: NP_001 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: NP_001 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL NP_001 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQ 610 620 630 640 650 660 >>XP_016879773 (OMIM: 601025) PREDICTED: AP-2 complex su (937 aa) initn: 183 init1: 105 opt: 266 Z-score: 305.2 bits: 67.8 E(85289): 2.9e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. XP_016 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . XP_016 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. XP_016 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. XP_016 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. XP_016 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. XP_016 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : XP_016 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . XP_016 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: XP_016 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: XP_016 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: XP_016 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL XP_016 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQ 610 620 630 640 650 660 >>XP_005257995 (OMIM: 601025) PREDICTED: AP-2 complex su (951 aa) initn: 183 init1: 105 opt: 266 Z-score: 305.1 bits: 67.8 E(85289): 3e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. XP_005 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . XP_005 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. XP_005 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. XP_005 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. XP_005 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. XP_005 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : XP_005 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . XP_005 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: XP_005 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: XP_005 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: XP_005 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL XP_005 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGS 610 620 630 640 650 660 >>XP_005257994 (OMIM: 601025) PREDICTED: AP-2 complex su (951 aa) initn: 183 init1: 105 opt: 266 Z-score: 305.1 bits: 67.8 E(85289): 3e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. XP_005 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . XP_005 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. XP_005 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. XP_005 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. XP_005 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. XP_005 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : XP_005 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . XP_005 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: XP_005 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: XP_005 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: XP_005 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL XP_005 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGS 610 620 630 640 650 660 >>NP_001025177 (OMIM: 601025) AP-2 complex subunit beta (951 aa) initn: 183 init1: 105 opt: 266 Z-score: 305.1 bits: 67.8 E(85289): 3e-10 Smith-Waterman score: 296; 19.8% identity (52.1% similar) in 606 aa overlap (26-604:18-577) 10 20 30 40 50 60 pF1KB8 MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLM :: .:.. ... ::.:::: . :. . .:. NP_001 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFP 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 TIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGST .. . .. .:::. .. :. :: :.. ... :: . :: .::. . NP_001 DVVN-CMQTDNLELKKLVYLYLMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALA 60 70 80 90 100 130 140 150 160 170 pF1KB8 LRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IH .: . .. .. : : .: ::. . :::..:.. . .. ... : : .. NP_001 VRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 DFLVNEKDASCKRNAFMMLIHADQDRA----LDYLSTCIDQVQT-FGDILQLVIVELIYK : :. ... :: : . .... :: :... : ... . . .. NP_001 D-LIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 170 180 190 200 210 220 240 250 260 270 280 pF1KB8 VCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIK-----AAAQCYIDL . . ::.. : .. . .: ... :.. :.::.. . .: . : .. NP_001 LSNYNPKDD----REAQSICERVTPRLSH--ANSAVVLSAVKVLMKFLELLPKDSDYYNM 230 240 250 260 270 290 300 310 320 330 pF1KB8 IIKE----------SDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRK ..:. .. .:. ..: : :.: . : . :.. .. : . . :. NP_001 LLKKLAPPLVTLLSGEPEVQYVAL-RNINLIVQKRPEILKQEI--KVFFVKYNDPIYVKL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB8 KTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMA . :.. . :.:. :. ... ::. . .. :.: :. ::.. :... . : NP_001 EKLDIMIRLASQANIAQVLAELKEYATEV-------DVDFVRKA-VRAIGRCAIKVEQSA 340 350 360 370 380 400 410 420 430 440 450 pF1KB8 ANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGA . .:..... . . .. ... .:. .... : :. . : . .. . NP_001 ERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAM 390 400 410 420 430 440 460 470 480 490 500 510 pF1KB8 LWILGEYCSTKEDIQSVMTEIRRSL-GEIPIVESEIKKEAGEL---KPEEEITVGPVQKL .::.::: .. . .. . ... : :. . .: :: : .:.: NP_001 IWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQEL 450 460 470 480 490 500 520 530 540 550 560 570 pF1KB8 VTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQE : .. . :::. :. : . :: . ::. : .: ...: :..: NP_001 VQQVLSLATQD---SDNPDLR--DRGYIYWRLLSTD-------PVTAKEVVLSEKPLISE 510 520 530 540 550 580 590 600 610 620 630 pF1KB8 KKKQNSFVAEAMLLMATILHLGK-SSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNK . . : :: : :.:. .:. .:: NP_001 ETD----LIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSP 560 570 580 590 600 640 650 660 670 680 690 pF1KB8 ECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL NP_001 VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGS 610 620 630 640 650 660 953 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:17:14 2016 done: Sun Nov 6 22:17:16 2016 Total Scan time: 13.350 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]