FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6251, 264 aa 1>>>pF1KE6251 264 - 264 aa - 264 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1240+/-0.00038; mu= 15.9863+/- 0.024 mean_var=65.7336+/-13.558, 0's: 0 Z-trim(112.8): 311 B-trim: 164 in 1/50 Lambda= 0.158190 statistics sampled from 21512 (21830) to 21512 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.256), width: 16 Scan time: 5.440 The best scores are: opt bits E(85289) NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 1794 418.1 7.9e-117 NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 722 173.5 3.5e-43 NP_001919 (OMIM: 134350,613912) complement factor ( 253) 628 152.0 9.8e-37 NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 628 152.0 1e-36 NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 571 139.0 8.2e-33 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 566 137.9 1.9e-32 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 561 136.7 4e-32 NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 555 135.4 9.9e-32 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 553 135.0 1.6e-31 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 533 130.3 3.3e-30 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 533 130.3 3.3e-30 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 533 130.4 3.6e-30 NP_001639 (OMIM: 176820) prostate-specific antigen ( 261) 520 127.4 2.6e-29 NP_001264010 (OMIM: 610601) kallikrein-15 isoform ( 255) 516 126.5 4.9e-29 XP_011525387 (OMIM: 610601) PREDICTED: kallikrein- ( 255) 516 126.5 4.9e-29 XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 516 126.5 4.9e-29 NP_059979 (OMIM: 610601) kallikrein-15 isoform 4 p ( 256) 516 126.5 4.9e-29 NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 509 124.9 1.4e-28 NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 509 124.9 1.4e-28 NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 509 124.9 1.5e-28 NP_005542 (OMIM: 147960) kallikrein-2 isoform 1 pr ( 261) 509 124.9 1.5e-28 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 510 125.2 1.9e-28 NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 512 125.8 2e-28 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 510 125.3 2e-28 NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 512 125.8 2e-28 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 510 125.3 2e-28 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 495 121.7 1.7e-27 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 495 121.8 2.2e-27 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 492 121.2 3.5e-27 NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 483 118.9 8.8e-27 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 483 119.0 1e-26 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 483 119.1 1.3e-26 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 483 119.1 1.3e-26 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 483 119.1 1.4e-26 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 483 119.1 1.4e-26 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 483 119.1 1.4e-26 NP_001171131 (OMIM: 188050,603924,616535) hyaluron ( 534) 484 119.4 1.4e-26 NP_004123 (OMIM: 188050,603924,616535) hyaluronan- ( 560) 484 119.4 1.5e-26 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 482 118.9 1.9e-26 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 482 118.9 2e-26 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 482 118.9 2e-26 XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 471 116.4 9.6e-26 XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 471 116.4 9.6e-26 XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 467 115.2 9.7e-26 XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 471 116.4 1e-25 XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 471 116.4 1e-25 XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 471 116.4 1e-25 NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 465 114.9 1.7e-25 NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 463 114.4 2.2e-25 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 469 116.1 2.6e-25 >>NP_002095 (OMIM: 600784) granzyme K precursor [Homo sa (264 aa) initn: 1794 init1: 1794 opt: 1794 Z-score: 2218.4 bits: 418.1 E(85289): 7.9e-117 Smith-Waterman score: 1794; 100.0% identity (100.0% similar) in 264 aa overlap (1-264:1-264) 10 20 30 40 50 60 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 KLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 CNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKP 190 200 210 220 230 240 250 260 pF1KE6 GIYTLLTKKYQTWIKSNLVPPHTN :::::::::::::::::::::::: NP_002 GIYTLLTKKYQTWIKSNLVPPHTN 250 260 >>NP_006135 (OMIM: 140050) granzyme A precursor [Homo sa (262 aa) initn: 720 init1: 405 opt: 722 Z-score: 896.2 bits: 173.5 E(85289): 3.5e-43 Smith-Waterman score: 722; 45.1% identity (73.8% similar) in 237 aa overlap (21-254:25-254) 10 20 30 40 50 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVL :: .::::.::.:::::.:. .. . .:.:.: NP_006 MRNSYRFLASSLSVVVSLLLIPEDVC--EKIIGGNEVTPHSRPYMVLLSLDRKTICAGAL 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 IDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSND : .::::::::. .. :.:::::....: .:: . .:: .:. . .: NP_006 IAKDWVLTAAHCNL----NKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 IMLVKLQTAAKLNKHVKMLHIRSK-TSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTV . :..: ::.::.: .::. .: ... :: :.:.::: : .: :::::::..:. NP_006 LKLLQLTEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTH-NSASWSDTLREVNITI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 LSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHE-- ..::.::....:: .: : .:::::. .: .:::.::::.::.:.:::....: : : NP_006 IDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENK 180 190 200 210 220 230 240 250 260 pF1KE6 CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN :: ::.: ::.::. .:: NP_006 CGDPRGPGVYILLSKKHLNWIIMTIKGAV 240 250 260 >>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa) initn: 429 init1: 224 opt: 628 Z-score: 780.5 bits: 152.0 E(85289): 9.8e-37 Smith-Waterman score: 628; 42.7% identity (69.2% similar) in 234 aa overlap (27-258:26-252) 10 20 30 40 50 60 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ :.::.:. :.::.:::.: .: :.:::::. : NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQ 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLV :::.:::: . :. :.:::::::. : ::. .. . .: : ..:..:. NP_001 WVLSAAHCLEDAADGKVQ-VLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLL 60 70 80 90 100 110 130 140 150 160 170 pF1KE6 KLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRK .:. : :. :. : : .. :: : :.::: .. . :: :.:..: . ::.: NP_001 QLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRP-DSLQHVLLPVLDRA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 LCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIV-SGGHECGVAT :: .....: ::. ..:: ....:::::::::::.: ::....: ::.. :: NP_001 TCNRRTHHDGA--ITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK 180 190 200 210 220 230 240 250 260 pF1KE6 KPGIYTLLTKKYQTWIKSNLVPPHTN :::::: ... : .:: : : NP_001 KPGIYTRVAS-YAAWIDSVLA 240 250 >>NP_001304264 (OMIM: 134350,613912) complement factor D (260 aa) initn: 412 init1: 224 opt: 628 Z-score: 780.3 bits: 152.0 E(85289): 1e-36 Smith-Waterman score: 628; 42.7% identity (69.2% similar) in 234 aa overlap (27-258:33-259) 10 20 30 40 50 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVL :.::.:. :.::.:::.: .: :.::::: NP_001 SWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 IDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSND . ::::.:::: . :. :.:::::::. : ::. .. . .: : ..: NP_001 VAEQWVLSAAHCLEDAADGKVQ-VLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 IMLVKLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTV ..:..:. : :. :. : : .. :: : :.::: .. . :: :.:..: . : NP_001 LLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRP-DSLQHVLLPV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 LSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIV-SGGHEC :.: :: .....: ::. ..:: ....:::::::::::.: ::....: ::.. : NP_001 LDRATCNRRTHHDGA--ITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVC 190 200 210 220 230 240 250 260 pF1KE6 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN : :::::: ... : .:: : : NP_001 GNRKKPGIYTRVAS-YAAWIDSVLA 240 250 260 >>NP_005308 (OMIM: 600311) granzyme M isoform 1 prepropr (257 aa) initn: 446 init1: 272 opt: 571 Z-score: 710.1 bits: 139.0 E(85289): 8.2e-33 Smith-Waterman score: 571; 40.2% identity (66.9% similar) in 254 aa overlap (8-255:7-250) 10 20 30 40 50 60 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ ::. : .:: . :. .::::.:: :::::.:::.: .: :.:::::. :. NP_005 MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPK 10 20 30 40 50 70 80 90 100 110 pF1KE6 WVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQ-SNDIML :::::::: . . . .::: :.: .. :..:: : : : ::. : NP_005 WVLTAAHCLAQ--RMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALENDLAL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 VKLQTAAKLNKHVKMLHIRSKTSL-RSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSR ..:. .: .. .. : . :: .. .::.:...::: : . : : .:::. . ::. NP_005 LQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 KLCNSQSYYNGDPFITKDMVC-AGDAKGQKDSCKGDSGGPLIC-KG-VFHAIVS-GGHEC ..::.. ..::. .. .::: :.:.: : :::::::::.: :: :. ...: ... : NP_005 RMCNNSRFWNGS--LSPSMVCLAADSKDQAP-CKGDSGGPLVCGKGRVLAGVLSFSSRVC 180 190 200 210 220 230 240 250 260 pF1KE6 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN :: . : .. : .::. NP_005 TDIFKPPVATAVAP-YVSWIRKVTGRSA 240 250 >>NP_056411 (OMIM: 605505) kallikrein-13 precursor [Homo (277 aa) initn: 555 init1: 172 opt: 566 Z-score: 703.5 bits: 137.9 E(85289): 1.9e-32 Smith-Waterman score: 566; 38.3% identity (66.4% similar) in 235 aa overlap (29-258:38-262) 10 20 30 40 50 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLID :: :::.:..:.. :. .:::::. NP_056 IASLTLALSGGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 PQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDP----QS :.:::::::: . : : :: :.:.. ::..:. :. . :: . .: .. NP_056 PKWVLTAAHCLKEGLK-----VYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 NDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVT .::::..::. ..:. ... : . .. : :: :.:.:::.: .. ::. ... NP_056 HDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 VLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVS-GGHE . : . : .. : : :: .:.::: .: ::::.:::::::.:. ....::: : NP_056 LRSDEEC--RQVYPGK--ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFP 190 200 210 220 230 240 250 260 pF1KE6 CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN :: .::.:: ... : ::. .. NP_056 CGQPDRPGVYTRVSR-YVLWIRETIRKYETQQQKWLKGPQ 240 250 260 270 >>NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 prepro (260 aa) initn: 401 init1: 171 opt: 561 Z-score: 697.7 bits: 136.7 E(85289): 4e-32 Smith-Waterman score: 561; 38.6% identity (68.1% similar) in 254 aa overlap (9-255:13-253) 10 20 30 40 50 pF1KE6 MTKFSSFSLFFLIVG-AYMTHVCFNME-IIGGKEVSPHSRPFMASIQYGGHHVCGG .:.:..: :. : . . ..::.: .:::.:..:.. : . .::: NP_009 MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 VLIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIP---FSRVTSD ::. .:::::::: : . :: :: :::..... .: . . . :: .. . NP_009 VLVGGNWVLTAAHC-----KKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVE 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 PQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGA-TDPDSLRPSDTLRE ...:.::..:. :.:...:: . . .. . . : :: :.:::. :.: : ::: NP_009 DHNHDLMLLQLRDQASLGSKVKPISLADHCT-QPGQKCTVSGWGTVTSPRENFP-DTLNC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 VTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSG . : .. .: : .. : :. :: :::::..:: :.:.:::::::.: :....:.: NP_009 AEVKIFPQKKC--EDAYPGQ--ITDGMVCAGSSKGA-DTCQGDSGGPLVCDGALQGITSW 180 190 200 210 220 240 250 260 pF1KE6 GHE-CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN : . :: . :::.:: . . : ::: NP_009 GSDPCGRSDKPGVYTNICR-YLDWIKKIIGSKG 230 240 250 260 >>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa) initn: 371 init1: 139 opt: 555 Z-score: 690.7 bits: 135.4 E(85289): 9.9e-32 Smith-Waterman score: 555; 37.9% identity (68.8% similar) in 253 aa overlap (10-258:4-243) 10 20 30 40 50 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQY---GGHHVCGGVLI :.:... .: . :::::.:..:::::.:: .:. ... :::.:. NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILV 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 DPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDI ..:::::::: :.: .:.::::.....: ..: . .:. :: . :::: NP_219 RKDFVLTAAHCQ-----GSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDI 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 MLVKLQTAAKLNKHVKMLHI-RSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVL ::..:. :: . :. :.. ::.... : :.:.::: .. ..: . ::.:: .:: NP_219 MLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTL--ATTLQEVLLTV- 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGV .: :. . ..:. . .:.:: : . . ::::::::.:: : ..:.: :.. : NP_219 -QKDCQCERLFHGN-YSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKG- 170 180 190 200 210 220 240 250 260 pF1KE6 ATKPGIYTLLTKKYQTWIKSNLVPPHTN : ::.: . .... ::: .. NP_219 -TPPGVY-IKVSHFLPWIKRTMKRL 230 240 >>NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 precur (305 aa) initn: 441 init1: 171 opt: 553 Z-score: 686.8 bits: 135.0 E(85289): 1.6e-31 Smith-Waterman score: 553; 39.6% identity (68.9% similar) in 235 aa overlap (26-255:77-298) 10 20 30 40 50 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGV ...::.: .:::.:..:.. : . .:::: NP_653 QWPSQPSHCPRGWRSNPLPPAAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGV 50 60 70 80 90 100 60 70 80 90 100 110 pF1KE6 LIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIP---FSRVTSDP :. .:::::::: : . :: :: :::..... .: . . . :: .. . NP_653 LVGGNWVLTAAHC-----KKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVED 110 120 130 140 150 160 120 130 140 150 160 170 pF1KE6 QSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGA-TDPDSLRPSDTLREV ...:.::..:. :.:...:: . . .. . . : :: :.:::. :.: : ::: . NP_653 HNHDLMLLQLRDQASLGSKVKPISLADHCT-QPGQKCTVSGWGTVTSPRENFP-DTLNCA 170 180 190 200 210 180 190 200 210 220 230 pF1KE6 TVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGG : .. .: : .. : :. :: :::::..:: :.:.:::::::.: :....:.: : NP_653 EVKIFPQKKC--EDAYPGQ--ITDGMVCAGSSKGA-DTCQGDSGGPLVCDGALQGITSWG 220 230 240 250 260 270 240 250 260 pF1KE6 HE-CGVATKPGIYTLLTKKYQTWIKSNLVPPHTN . :: . :::.:: . . : ::: NP_653 SDPCGRSDKPGVYTNICR-YLDWIKKIIGSKG 280 290 300 >>NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 precu (250 aa) initn: 476 init1: 180 opt: 533 Z-score: 663.4 bits: 130.3 E(85289): 3.3e-30 Smith-Waterman score: 533; 37.8% identity (67.6% similar) in 238 aa overlap (27-258:22-247) 10 20 30 40 50 60 pF1KE6 MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQ :: : : .:::.:..:.. . .::..:: :. NP_006 MRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPR 10 20 30 40 50 70 80 90 100 110 pF1KE6 WVLTAAHC-QYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPF----SRVTSDPQSN :.:::::: . :. : :: :.:.:.:. .:: . .: . . . . : NP_006 WLLTAAHCLKPRYI------VHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRN 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 DIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTV ::::::. . .... :. : . :. . .::.: ..:::.:. .:: ::: ...:. NP_006 DIMLVKMASPVSITWAVRPLTLSSRC-VTAGTSCLISGWGSTSSPQLRLPHTLRCANITI 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 LSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHE-C . .. : .. : :. :: ::::. .: ::::.:::::::.:. ...:.: :.. : NP_006 IEHQKC--ENAYPGN--ITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPC 170 180 190 200 210 220 240 250 260 pF1KE6 GVATKPGIYTLLTKKYQTWIKSNLVPPHTN ... :::.:: . : : ::. .. NP_006 AITRKPGVYTKVCK-YVDWIQETMKNN 230 240 250 264 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:28:29 2016 done: Tue Nov 8 11:28:30 2016 Total Scan time: 5.440 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]