FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6426, 524 aa 1>>>pF1KE6426 524 - 524 aa - 524 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8769+/-0.000369; mu= 20.6442+/- 0.023 mean_var=63.2674+/-12.660, 0's: 0 Z-trim(113.9): 186 B-trim: 170 in 1/53 Lambda= 0.161244 statistics sampled from 23197 (23398) to 23197 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.274), width: 16 Scan time: 5.800 The best scores are: opt bits E(85289) NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 3608 848.2 0 NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 3070 723.0 5.2e-208 NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 3070 723.0 5.2e-208 NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 3031 713.9 2.8e-205 XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 2990 704.4 2.1e-202 NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 2990 704.4 2.1e-202 NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 2990 704.4 2.1e-202 NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 2879 678.6 1.2e-194 NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 2851 672.1 1.1e-192 XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 2561 604.5 1.8e-172 XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 2561 604.5 1.8e-172 XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 2561 604.5 1.8e-172 XP_016882661 (OMIM: 611485) PREDICTED: cytochrome ( 411) 2536 598.7 1.1e-170 XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 2397 566.3 5.1e-161 XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 2397 566.3 5.1e-161 XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 2397 566.3 5.1e-161 NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 2317 547.9 2.8e-155 XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 2317 547.9 2.8e-155 XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 2317 547.9 2.8e-155 XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 2303 544.5 1.9e-154 XP_016881721 (OMIM: 611545) PREDICTED: cytochrome ( 418) 2297 543.1 5.9e-154 XP_005259968 (OMIM: 601270) PREDICTED: docosahexae ( 371) 2206 521.9 1.3e-147 XP_011526316 (OMIM: 601270) PREDICTED: docosahexae ( 371) 2206 521.9 1.3e-147 XP_016882304 (OMIM: 601270) PREDICTED: docosahexae ( 391) 2069 490.1 5.2e-138 NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 1433 342.2 2.2e-93 NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 1372 328.0 4.1e-89 NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 1364 326.2 1.5e-88 XP_016855954 (OMIM: 601310) PREDICTED: cytochrome ( 415) 1360 325.2 2.4e-88 NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 1356 324.3 5.5e-88 NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 1341 320.8 6.2e-87 NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 1325 317.1 8e-86 NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 1323 316.6 1e-85 XP_016855955 (OMIM: 124075) PREDICTED: cytochrome ( 496) 1288 308.5 3.1e-83 NP_001306090 (OMIM: 124075) cytochrome P450 4B1 is ( 497) 1278 306.1 1.5e-82 XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 1269 304.0 6.3e-82 NP_001306092 (OMIM: 124075) cytochrome P450 4B1 is ( 348) 1129 271.4 3.2e-72 NP_001306091 (OMIM: 124075) cytochrome P450 4B1 is ( 349) 1119 269.0 1.6e-71 NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 1017 245.4 3.1e-64 XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 1010 243.8 9.4e-64 NP_001306084 (OMIM: 601310) cytochrome P450 4A11 i ( 487) 966 233.6 1.1e-60 XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 873 211.9 3e-54 XP_011539135 (OMIM: 124075) PREDICTED: cytochrome ( 278) 797 194.1 4.7e-49 XP_011539134 (OMIM: 124075) PREDICTED: cytochrome ( 296) 591 146.2 1.3e-34 NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 576 142.8 2.2e-33 NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 576 142.8 2.2e-33 NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 573 142.1 3.7e-33 NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 571 141.7 5e-33 NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 568 141.0 8.2e-33 NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 562 139.6 2.2e-32 XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 550 136.7 1.2e-31 >>NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Homo sa (524 aa) initn: 3608 init1: 3608 opt: 3608 Z-score: 4531.8 bits: 848.2 E(85289): 0 Smith-Waterman score: 3608; 99.4% identity (99.6% similar) in 524 aa overlap (1-524:1-524) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_076 MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_076 WGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ :::::::::::::::::::::::::::::::::::::::::::: NP_076 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ 490 500 510 520 >>NP_067010 (OMIM: 611517) phylloquinone omega-hydroxyla (524 aa) initn: 3114 init1: 3066 opt: 3070 Z-score: 3855.4 bits: 723.0 E(85289): 5.2e-208 Smith-Waterman score: 3070; 82.8% identity (92.9% similar) in 524 aa overlap (1-524:1-524) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF : ::: :::: ::: ::::::::: :::::::.:::::.::.:::::::::::::.::: NP_067 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK ::: ::.::::::.: ::. .:: ::: .:::: .:...::::: :: ::.::::.::: NP_067 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH : .: :::::::.:.::::::::::::::::::::::::: :. :::::.::: ::::. NP_067 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::. ::::::::::::::::::.:::.:.:::.::::::.::::::.::::.:.:: NP_067 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID : ::::::. ::.::.:::.::::::::::.::: ::::::::::.:.::::::::::: NP_067 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.::::::.::::::: NP_067 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.: ::::::::::::::::.:::::::::.: ::::::::.::::::::::::.: NP_067 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::.:::.:.::::::::::::::::: :: : :::::::::::::::::::::::::::: NP_067 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ :::: :::::.:: ::::::: :::.:::::::::::::... : NP_067 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ 490 500 510 520 >>NP_001122404 (OMIM: 611517) phylloquinone omega-hydrox (524 aa) initn: 3114 init1: 3066 opt: 3070 Z-score: 3855.4 bits: 723.0 E(85289): 5.2e-208 Smith-Waterman score: 3070; 82.8% identity (92.9% similar) in 524 aa overlap (1-524:1-524) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF : ::: :::: ::: ::::::::: :::::::.:::::.::.:::::::::::::.::: NP_001 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK ::: ::.::::::.: ::. .:: ::: .:::: .:...::::: :: ::.::::.::: NP_001 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH : .: :::::::.:.::::::::::::::::::::::::: :. :::::.::: ::::. NP_001 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::. ::::::::::::::::::.:::.:.:::.::::::.::::::.::::.:.:: NP_001 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID : ::::::. ::.::.:::.::::::::::.::: ::::::::::.:.::::::::::: NP_001 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.::::::.::::::: NP_001 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.: ::::::::::::::::.:::::::::.: ::::::::.::::::::::::.: NP_001 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::.:::.:.::::::::::::::::: :: : :::::::::::::::::::::::::::: NP_001 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ :::: :::::.:: ::::::: :::.:::::::::::::... : NP_001 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ 490 500 510 520 >>NP_001073 (OMIM: 604426) phylloquinone omega-hydroxyla (520 aa) initn: 3055 init1: 3031 opt: 3031 Z-score: 3806.4 bits: 713.9 E(85289): 2.8e-205 Smith-Waterman score: 3031; 81.9% identity (92.7% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF :: ::: :::: ::: ::::::::: .:::::..::::::::.:::::.::::::.:::: NP_001 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK ::: :...:::::.. ::. ::: ::: ::.::: :.. ::::: :::. ::::::::: NP_001 WGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH :..: ::.::::.:.:::.::::::::::::::::::::: :. :::.:.::: ::: NP_001 DKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::.:::::::::::::::::::.:::::::::.::::::.:::::::: :: ..:: NP_001 LASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID :.::::::. ::.::.::::::::::::::.:::::::.::.:::.. ::::::::::: NP_001 LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.:::::::::::::: NP_001 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.::::::::::.:::::::.:::::::::.: ::: :::::::::::::::: : NP_001 LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::...:.::::.::::::::::::::::: : :::::::::::::::::::.:::::::: NP_001 LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ :::: ::.:: :::::::::: ::..:::::::::::::. NP_001 VLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 490 500 510 520 >>XP_016882303 (OMIM: 601270) PREDICTED: docosahexaenoic (520 aa) initn: 3010 init1: 2986 opt: 2990 Z-score: 3754.9 bits: 704.4 E(85289): 2.1e-202 Smith-Waterman score: 2990; 81.3% identity (92.3% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF : ::: ::: :.: ::::::::: .::::::::::::.::.:: ::.::::::::::: XP_016 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK :::::.::::.:.. ::. ::: ::: ::.:::.: : .:::. :::. ::::::.:: XP_016 LGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH :..: :::::::.:.:::.:.::::::::::::::::::: :. :::.:.::: ::: XP_016 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::. ::::::::::::::::::.:::::::::.::::::.:::::::: :: :.:: XP_016 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID ..::::::. ::.::.::::::::::::::.:::::::.::.:::.. ::::::::::: XP_016 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.:::::::::::::: XP_016 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.::::::::::::::::::.:::::::::.: .:::::::::::::::::::: : XP_016 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::...:.::::.:::::::::::::::.: : :::::::::::::::::::::::::::: XP_016 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ ::.: ::.:: :::::::::: ::..:::::::::::::. XP_016 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 490 500 510 520 >>NP_001186137 (OMIM: 601270) docosahexaenoic acid omega (520 aa) initn: 3010 init1: 2986 opt: 2990 Z-score: 3754.9 bits: 704.4 E(85289): 2.1e-202 Smith-Waterman score: 2990; 81.3% identity (92.3% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF : ::: ::: :.: ::::::::: .::::::::::::.::.:: ::.::::::::::: NP_001 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK :::::.::::.:.. ::. ::: ::: ::.:::.: : .:::. :::. ::::::.:: NP_001 LGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH :..: :::::::.:.:::.:.::::::::::::::::::: :. :::.:.::: ::: NP_001 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::. ::::::::::::::::::.:::::::::.::::::.:::::::: :: :.:: NP_001 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID ..::::::. ::.::.::::::::::::::.:::::::.::.:::.. ::::::::::: NP_001 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.:::::::::::::: NP_001 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.::::::::::::::::::.:::::::::.: .:::::::::::::::::::: : NP_001 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::...:.::::.:::::::::::::::.: : :::::::::::::::::::::::::::: NP_001 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ ::.: ::.:: :::::::::: ::..:::::::::::::. NP_001 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 490 500 510 520 >>NP_001186138 (OMIM: 601270) docosahexaenoic acid omega (520 aa) initn: 3010 init1: 2986 opt: 2990 Z-score: 3754.9 bits: 704.4 E(85289): 2.1e-202 Smith-Waterman score: 2990; 81.3% identity (92.3% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF : ::: ::: :.: ::::::::: .::::::::::::.::.:: ::.::::::::::: NP_001 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK :::::.::::.:.. ::. ::: ::: ::.:::.: : .:::. :::. ::::::.:: NP_001 LGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH :..: :::::::.:.:::.:.::::::::::::::::::: :. :::.:.::: ::: NP_001 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::. ::::::::::::::::::.:::::::::.::::::.:::::::: :: :.:: NP_001 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID ..::::::. ::.::.::::::::::::::.:::::::.::.:::.. ::::::::::: NP_001 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.:::::::::::::: NP_001 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.::::::::::::::::::.:::::::::.: .:::::::::::::::::::: : NP_001 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::...:.::::.:::::::::::::::.: : :::::::::::::::::::::::::::: NP_001 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ ::.: ::.:: :::::::::: ::..:::::::::::::. NP_001 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 490 500 510 520 >>NP_009184 (OMIM: 611545) cytochrome P450 4F8 precursor (520 aa) initn: 2879 init1: 2879 opt: 2879 Z-score: 3615.3 bits: 678.6 E(85289): 1.2e-194 Smith-Waterman score: 2879; 78.4% identity (91.1% similar) in 519 aa overlap (1-519:1-519) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF :::::: :::::::: :::::::.: .:::::::::::::::.: :::.::::: :.::: NP_009 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK :::::.:::::::. ::. ::: :::. ::::: :.: ::::: .::. :.: ::. : NP_009 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH : .: . ::::::.:.::: :::: .:::.::::::::::: :: ::.:::::: :::. NP_009 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL :: :::.:::.:::::::::::::::::::::.:::.:::::..:.:::::: ::..... NP_009 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID .. ::::.:. :::::::::::::::::::.:::::: .::.:::.. ::::::::::: NP_009 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE :::::.:..:: :::::::::::::::::::::::::::::::::::::::::::::::: NP_009 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.::::::::::::::::::.::::::::: : ..: ::::.::::.:::::: .: NP_009 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV :.:...::::.:::::::::::::::::.. :::.::::::::::::::: :::::::: NP_009 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ :::: ::.::.:::: :::: :...::: ::::::::: NP_009 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG 490 500 510 520 >>NP_000887 (OMIM: 601270) docosahexaenoic acid omega-hy (520 aa) initn: 2871 init1: 2847 opt: 2851 Z-score: 3580.1 bits: 672.1 E(85289): 1.1e-192 Smith-Waterman score: 2851; 78.3% identity (90.0% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KE6 MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF : ::: ::: :.: ::::::::: .::::::::::::.::.:: ::.::::::::::: NP_000 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK :::::: .:::: . ... :... :.:: .. . :: :. . : :::.:: NP_000 LGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH :..: :::::::.:.:::.:.::::::::::::::::::: :. :::.:.::: ::: NP_000 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL ::::::. ::::::::::::::::::.:::::::::.::::::.:::::::: :: :.:: NP_000 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID ..::::::. ::.::.::::::::::::::.:::::::.::.:::.. ::::::::::: NP_000 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE ::::::::::: ::::::::::::::: ::::::::::::::.::.:::::::::::::: NP_000 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC :::::.::::::::::::::::::.:::::::::.: .:::::::::::::::::::: : NP_000 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV ::...:.::::.:::::::::::::::.: : :::::::::::::::::::::::::::: NP_000 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 430 440 450 460 470 480 490 500 510 520 pF1KE6 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ ::.: ::.:: :::::::::: ::..:::::::::::::. NP_000 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 490 500 510 520 >>XP_006722913 (OMIM: 611485) PREDICTED: cytochrome P450 (375 aa) initn: 2561 init1: 2561 opt: 2561 Z-score: 3217.5 bits: 604.5 E(85289): 1.8e-172 Smith-Waterman score: 2561; 99.7% identity (99.7% similar) in 375 aa overlap (150-524:1-375) 120 130 140 150 160 170 pF1KE6 KDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQ :::::::::::::::::::::::::::::: XP_006 MLTPAFHFNILKSYITIFNKSANIMLDKWQ 10 20 30 180 190 200 210 220 230 pF1KE6 HLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHI :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHI 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE6 LQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFI 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE6 DVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQ 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE6 ELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGIT 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE6 CLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMK 280 290 300 310 320 330 480 490 500 510 520 pF1KE6 VVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ ::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ 340 350 360 370 524 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:10:39 2016 done: Tue Nov 8 13:10:40 2016 Total Scan time: 5.800 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]